{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:44:55Z","timestamp":1786365895082,"version":"build-2736575974"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T00:00:00Z","timestamp":1460332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0153191","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T17:53:47Z","timestamp":1460397227000},"page":"e0153191","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Potential Inhibitory Profile of Liver CD68+ Cells during HCV Infection as Observed by an Increased CD80 and PD-L1 but Not CD86 Expression"],"prefix":"10.1371","volume":"11","author":[{"given":"Elias A.","family":"Said","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Al-Reesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Al-Riyami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Al-Naamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadia","family":"Al-Sinawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Al-Balushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal Y.","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juma Z.","family":"Al-Busaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Idris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"Al-Jabri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,4,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/hep.27259","article-title":"Global Distribution and Prevalence of Hepatitis C Virus Genotypes","volume":"61","author":"JP Messina","year":"2015","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jhep.2014.04.026","article-title":"The role of Kupffer cells in hepatitis B and hepatitis C virus infections","volume":"61","author":"A Boltjes","year":"2014","journal-title":"Journal of Hepatology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1053\/j.gastro.2011.05.006","article-title":"Delayed Induction, Not Impaired Recruitment, of Specific CD8(+) T Cells Causes the Late Onset of Acute Hepatitis C","volume":"141","author":"EC Shin","year":"2011","journal-title":"Gastroenterology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1574-6976.2011.00319.x","article-title":"Failure of innate and adaptive immune responses in controlling hepatitis C virus infection","volume":"36","author":"R Thimme","year":"2012","journal-title":"Fems Microbiology Reviews"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.autrev.2013.07.002","article-title":"CTLA-4 and autoimmunity: New insights into the dual regulator of tolerance","volume":"12","author":"J Romo-Tena","year":"2013","journal-title":"Autoimmunity Reviews"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/eji.200535170","article-title":"Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86","volume":"36","author":"CN Manzotti","year":"2006","journal-title":"European Journal of Immunology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2567.2000.00121.x","article-title":"CD28, CTLA-4 and their ligands: who does what and to whom?","volume":"101","author":"DM Sansom","year":"2000","journal-title":"Immunology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.4049\/jimmunol.1302951","article-title":"Cutaneous T Cell Lymphoma Expresses Immunosuppressive CD80 (B7-1) Cell Surface Protein in a STAT5-Dependent Manner","volume":"192","author":"Q Zhang","year":"2014","journal-title":"Journal of Immunology"},{"key":"ref9","first-page":"142","article-title":"Vitamin-D antagonises the suppressive effect of inflammatory cytokines on CTLA-4 expression and regulatory function","volume":"143","author":"LE Jeffery","year":"2014","journal-title":"Immunology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.1202947","article-title":"Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4","volume":"332","author":"OS Qureshi","year":"2011","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nm.2106","article-title":"Programmed death-1-induced interleukin-10 production by monocytes impairs CD4(+) T cell activation during HIV infection","volume":"16","author":"EA Said","year":"2010","journal-title":"Nature Medicine"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/1521-4141(200203)32:3<634::AID-IMMU634>3.0.CO;2-9","article-title":"PD-1: PD-L inhibitory pathway affects both CD4(+)and CD8(+) T cells and is overcome by IL-2","volume":"32","author":"LL Carter","year":"2002","journal-title":"European Journal of Immunology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/hep.510270620","article-title":"Expression of co-stimulatory molecules by Kupffer cells in chronic hepatitis of hepatitis C virus etiology","volume":"27","author":"VL Burgio","year":"1998","journal-title":"Hepatology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/hep.23173","article-title":"Chronically Inflamed Livers Up-Regulate Expression of Inhibitory B7 Family Members","volume":"50","author":"R Kassel","year":"2009","journal-title":"Hepatology"},{"key":"ref15","article-title":"The Clinical Significance of the CD163+and CD68+Macrophages in Patients with Hepatocellular Carcinoma","volume":"8","author":"LQ Kong","year":"2013","journal-title":"Plos One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1136\/gut.46.2.260","article-title":"Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection","volume":"46","author":"PH McGuinness","year":"2000","journal-title":"Gut"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/hep.26937","article-title":"The Portal Inflammatory Infiltrate and Ductular Reaction in Human Nonalcoholic Fatty Liver Disease","volume":"59","author":"VL Gadd","year":"2014","journal-title":"Hepatology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1182\/blood.V95.12.3823","article-title":"LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-alpha","volume":"95","author":"J Xaus","year":"2000","journal-title":"Blood"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Munteanu F, Nemes C (2014) Availability Evaluation of Wind as a Repairable System. 2014 International Conference on Optimization of Electrical and Electronic Equipment (Optim): 756\u2013761.","DOI":"10.1109\/OPTIM.2014.6850917"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1053\/j.gastro.2011.06.063","article-title":"Host Response to Translocated Microbial Products Predicts Outcomes of Patients With HBV or HCV Infection","volume":"141","author":"NG Sandler","year":"2011","journal-title":"Gastroenterology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1365-2893.2010.01335.x","article-title":"Early IL-10 predominant responses are associated with progression to chronic hepatitis C virus infection in injecting drug users","volume":"18","author":"JK Flynn","year":"2011","journal-title":"Journal of Viral Hepatitis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0168-8278(97)80409-6","article-title":"Serum interleukin 4 and interleukin 10 levels in patients with chronic hepatitis C virus infection","volume":"26","author":"M Reiser","year":"1997","journal-title":"Journal of Hepatology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1046\/j.1365-2567.2001.01171.x","article-title":"Interleukin-10 induces macrophage apoptosis and expression of CD16 (Fc gamma RIII) whose engagement blocks the cell death programme and facilitates differentiation","volume":"102","author":"ZQ Wang","year":"2001","journal-title":"Immunology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1189\/jlb.1210680","article-title":"Role for IL-10 in inducing functional impairment of monocytes upon TLR4 ligation in patients with chronic HCV infections","volume":"89","author":"BS Liu","year":"2011","journal-title":"Journal of Leukocyte Biology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1080\/09537100701777295","article-title":"Platelet microparticles contain active caspase 3","volume":"19","author":"AN Boing","year":"2008","journal-title":"Platelets"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s10495-005-2941-5","article-title":"The release of microparticles by apoptotic cells and their effects on macrophages","volume":"10","author":"JHW Distler","year":"2005","journal-title":"Apoptosis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10495-006-0622-7","article-title":"The role of membrane lipids in the induction of macrophage apoptosis by microparticles","volume":"12","author":"LC Huber","year":"2007","journal-title":"Apoptosis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1099\/vir.0.065862-0","article-title":"Hepatitis C virus-induced hepatocyte cell death and protection by inhibition of apoptosis","volume":"95","author":"EJ Lim","year":"2014","journal-title":"Journal of General Virology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/liv.12050","article-title":"Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C","volume":"33","author":"VL Gadd","year":"2013","journal-title":"Liver International"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/hep.510250337","article-title":"B7\/BB-1 expression and hepatitis activity in liver tissues of patients with chronic hepatitis C","volume":"25","author":"K Mochizuki","year":"1997","journal-title":"Hepatology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nm.3253","article-title":"Regulation of hepatic innate immunity by hepatitis C virus","volume":"19","author":"SM Horner","year":"2013","journal-title":"Nature Medicine"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1016\/j.molimm.2006.12.008","article-title":"B7-1 mediated costimulation regulates pancreatic autoimmunity","volume":"44","author":"D Yadav","year":"2007","journal-title":"Molecular Immunology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1128\/JVI.02248-06","article-title":"Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection","volume":"81","author":"E Larrea","year":"2007","journal-title":"Journal of Virology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jhep.2010.07.014","article-title":"Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection","volume":"54","author":"JI Riezu-Boj","year":"2011","journal-title":"Journal of Hepatology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jhep.2013.02.022","article-title":"A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C","volume":"59","author":"B Sangro","year":"2013","journal-title":"Journal of Hepatology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0153191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T13:07:43Z","timestamp":1600434463000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0153191"}},"subtitle":[],"editor":[{"given":"Jean-Pierre","family":"Vartanian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,11]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0153191","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,11]]}}}