{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:50:37Z","timestamp":1790740237622,"version":"4.1.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI107290"],"award-info":[{"award-number":["R21AI107290"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR000146"],"award-info":[{"award-number":["KL2TR000146"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K08AI114883"],"award-info":[{"award-number":["K08AI114883"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0153247","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T14:58:17Z","timestamp":1461855497000},"page":"e0153247","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":139,"title":["Intra-Abdominal Candidiasis: The Importance of Early Source Control and Antifungal Treatment"],"prefix":"10.1371","volume":"11","author":[{"given":"Pascalis","family":"Vergidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius J.","family":"Clancy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan K.","family":"Shields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett N.","family":"Wildfeuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Hong","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1093\/cid\/cit006","article-title":"Finding the &quot;missing 50%&quot; of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care","volume":"56","author":"CJ Clancy","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1586\/14787210.2014.919853","article-title":"Undiagnosed invasive candidiasis: incorporating non-culture diagnostics into rational prophylactic and preemptive antifungal strategies","volume":"12","author":"CJ Clancy","year":"2014","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1007\/s00134-013-3109-3","article-title":"A research agenda on the management of intra-abdominal candidiasis: results from a consensus of multinational experts","volume":"39","author":"M Bassetti","year":"2013","journal-title":"Intensive Care Med"},{"issue":"15","key":"ref4","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1056\/NEJMra1315399","article-title":"Invasive Candidiasis","volume":"373","author":"BJ Kullberg","year":"2015","journal-title":"N Engl J Med"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/MCC.0b013e328028fd92","article-title":"<italic>Candida<\/italic> peritonitis","volume":"13","author":"SI Blot","year":"2007","journal-title":"Curr Opin Crit Care"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1007\/s00134-015-3894-y","article-title":"Intra-abdominal candidiasis: it&apos;s still a long way to get unquestionable data","volume":"41","author":"P Montravers","year":"2015","journal-title":"Intensive Care Med"},{"key":"ref7","article-title":"A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality","author":"M Bassetti","year":"2015","journal-title":"Intensive Care Med"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1097\/01.CCM.0000202129.19154.64","article-title":"<italic>Candida<\/italic> in the peritoneum: passenger or pathogen?","volume":"34","author":"JH Rex","year":"2006","journal-title":"Crit Care Med"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/01.CCM.0000201889.39443.D2","article-title":"<italic>Candida<\/italic> as a risk factor for mortality in peritonitis","volume":"34","author":"P Montravers","year":"2006","journal-title":"Critical Care Medicine"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012","volume":"39","author":"RP Dellinger","year":"2013","journal-title":"Intensive Care Med"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.2165\/11599800-000000000-00000","article-title":"Essentials for selecting antimicrobial therapy for intra-abdominal infections","volume":"72","author":"S Blot","year":"2012","journal-title":"Drugs"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1086\/378702","article-title":"Guidelines for the selection of anti-infective agents for complicated intra-abdominal infections","volume":"37","author":"JS Solomkin","year":"2003","journal-title":"Clin Infect Dis"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1007\/s00268-005-0333-1","article-title":"Clinical predictors of ongoing infection in secondary peritonitis: systematic review","volume":"30","author":"B Lamme","year":"2006","journal-title":"World J Surg"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/bjs.1800820429","article-title":"Outcome of patients with abdominal sepsis treated in an intensive care unit","volume":"82","author":"GJ McLauchlan","year":"1995","journal-title":"Br J Surg"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1001\/archsurg.137.12.1341","article-title":"Predictive factors of mortality due to polymicrobial peritonitis with <italic>Candida<\/italic> isolation in peritoneal fluid in critically ill patients","volume":"137","author":"H Dupont","year":"2002","journal-title":"Arch Surg"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/00003246-200203000-00008","article-title":"Significance of <italic>Candida<\/italic> recovered from intraoperative specimens in patients with intra-abdominal perforations","volume":"30","author":"P Sandven","year":"2002","journal-title":"Crit Care Med"},{"issue":"1","key":"ref17","first-page":"45","article-title":"Abdominal candidiasis in surgical patients","volume":"55","author":"SM Alden","year":"1989","journal-title":"Am Surg"},{"issue":"8677","key":"ref18","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0140-6736(89)92043-6","article-title":"Clinical significance of <italic>Candida<\/italic> isolated from peritoneum in surgical patients","volume":"2","author":"T Calandra","year":"1989","journal-title":"Lancet"},{"issue":"6","key":"ref19","first-page":"832","article-title":"<italic>Candida<\/italic> peritonitis. Report of 22 cases and review of the English literature","volume":"61","author":"AS Bayer","year":"1976","journal-title":"Am J Med"},{"issue":"4","key":"ref20","first-page":"524","article-title":"The role of <italic>Candida<\/italic> in intraperitoneal infections","volume":"88","author":"JS Solomkin","year":"1980","journal-title":"Surgery"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF01646895","article-title":"Secondary mycosis in surgery: treatment with fluconazole","volume":"17","author":"P Kujath","year":"1989","journal-title":"Infection"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1097\/00003246-199906000-00019","article-title":"Fluconazole prophylaxis prevents intra-abdominal candidiasis in high-risk surgical patients","volume":"27","author":"P Eggimann","year":"1999","journal-title":"Crit Care Med"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/cc6212","article-title":"Bench-to-bedside review: <italic>Candida<\/italic> infections in the intensive care unit","volume":"12","author":"M Mean","year":"2008","journal-title":"Crit Care"},{"key":"ref24","article-title":"A randomized, placebo-controlled trial of pre-emptive antifungal therapy for the prevention of invasive candidiasis following gastrointestinal surgery for intra-abdominal infections","author":"W Knitsch","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0732-8893(02)00419-4","article-title":"<italic>Candida<\/italic> peritonitis due to peptic ulcer perforation: incidence rate, risk factors, prognosis and susceptibility to fluconazole and amphotericin B","volume":"44","author":"SC Lee","year":"2002","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"Suppl 7","key":"ref26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/1469-0691.12039","article-title":"ESCMID guideline for the diagnosis and management of <italic>Candida<\/italic> diseases 2012: non-neutropenic adult patients","volume":"18","author":"OA Cornely","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"ref27","article-title":"Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America","author":"PG Pappas","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1086\/514504","article-title":"International Conference for the Development of a Consensus on the Management and Prevention of Severe Candidal Infections","volume":"25","author":"JE Edwards Jr.","year":"1997","journal-title":"Clin Infect Dis"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1128\/AAC.49.9.3640-3645.2005","article-title":"Delaying the empiric treatment of <italic>Candida<\/italic> bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality","volume":"49","author":"M Morrell","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1086\/504810","article-title":"Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study","volume":"43","author":"KW Garey","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/cid\/cis023","article-title":"The end of an era in defining the optimal treatment of invasive candidiasis","volume":"54","author":"CJ Clancy","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"9","key":"ref32","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1093\/cid\/cis200","article-title":"Performance of <italic>Candida<\/italic> real-time polymerase chain reaction, beta-D-glucan assay, and blood cultures in the diagnosis of invasive candidiasis","volume":"54","author":"MH Nguyen","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1164\/rccm.201211-2069OC","article-title":"\u03b2-Glucan antigenemia anticipates diagnosis of blood culture-negative intraabdominal candidiasis","volume":"188","author":"F Tissot","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1469-0691.2010.03360.x","article-title":"A multicentre study of antifungal strategies and outcome of <italic>Candida<\/italic> spp. peritonitis in intensive-care units","volume":"17","author":"P Montravers","year":"2011","journal-title":"Clin Microbiol Infect"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0002-9343(95)00010-0","article-title":"The changing face of candidemia: emergence of non-<italic>Candida albicans<\/italic> species and antifungal resistance","volume":"100","author":"MH Nguyen","year":"1996","journal-title":"Am J Med"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"e0116705","DOI":"10.1371\/journal.pone.0116705","article-title":"Complementary amplicon-based genomic approaches for the study of fungal communities in humans","volume":"10","author":"T Heisel","year":"2015","journal-title":"PLoS One"},{"issue":"12","key":"ref37","doi-asserted-by":"crossref","first-page":"7601","DOI":"10.1128\/AAC.04134-14","article-title":"Abdominal candidiasis is a hidden reservoir of echinocandin resistance","volume":"58","author":"RK Shields","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1097\/CCM.0b013e31819efac0","article-title":"Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005\u20132006)","volume":"37","author":"O Leroy","year":"2009","journal-title":"Crit Care Med"},{"issue":"9","key":"ref39","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1093\/infdis\/jit335","article-title":"Profiling of <italic>Candida albicans<\/italic> gene expression during intra-abdominal candidiasis identifies biologic processes involved in pathogenesis","volume":"208","author":"S Cheng","year":"2013","journal-title":"J Infect Dis"},{"issue":"7","key":"ref40","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1128\/IAI.00062-14","article-title":"<italic>Candida glabrata<\/italic> intra-abdominal candidiasis is characterized by persistence within the peritoneal cavity and abscesses","volume":"82","author":"S Cheng","year":"2014","journal-title":"Infect Immun"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0153247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T16:32:09Z","timestamp":1692289929000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0153247"}},"subtitle":[],"editor":[{"given":"David R.","family":"Andes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,28]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0153247","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,28]]}}}