{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:31:40Z","timestamp":1758123100143,"version":"3.37.3"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T00:00:00Z","timestamp":1460332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EUCOMMTOOLS","award":["261492"],"award-info":[{"award-number":["261492"]}]},{"name":"Spanish MICINN","award":["BFU-2008-00588"],"award-info":[{"award-number":["BFU-2008-00588"]}]},{"name":"Spanish MICINN","award":["CONSOLIDER (CSD2007-00023)"],"award-info":[{"award-number":["CONSOLIDER (CSD2007-00023)"]}]},{"name":"Spanish MICINN","award":["SAF2014-59347-C2-1-R"],"award-info":[{"award-number":["SAF2014-59347-C2-1-R"]}]},{"name":"Institute of Health Carlos III, TERCEL and CIBERSAM, Generalitat Valenciana","award":["11\/2011\/042"],"award-info":[{"award-number":["11\/2011\/042"]}]},{"name":"Institute of Health Carlos III, TERCEL and CIBERSAM, Generalitat Valenciana","award":["PROMETEO 2009\/028"],"award-info":[{"award-number":["PROMETEO 2009\/028"]}]},{"DOI":"10.13039\/100008062","name":"Fundaci\u00f3n Alicia Koplowitz","doi-asserted-by":"publisher","award":["Psiquiatria Infantil-2009"],"award-info":[{"award-number":["Psiquiatria Infantil-2009"]}],"id":[{"id":"10.13039\/100008062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0153262","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T13:34:54Z","timestamp":1460381694000},"page":"e0153262","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rett Syndrome Mutant Neural Cells Lacks MeCP2 Immunoreactive Bands"],"prefix":"10.1371","volume":"11","author":[{"given":"Carlos","family":"Bueno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Tabares-Seisdedos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M.","family":"Moraleda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvador","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,4,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(92)90610-O","article-title":"Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA","volume":"69","author":"JD Lewis","year":"1992","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0092-8674(00)81887-5","article-title":"MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin","volume":"88","author":"X Nan","year":"1997","journal-title":"Cell"},{"key":"ref3","first-page":"219","article-title":"Recent advances in MeCP2 structure and function","volume":"87","author":"KC Hite","year":"2009","journal-title":"Biochem Cell Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.molmed.2014.03.004","article-title":"MeCP2: the long trip from a chromatin protein to neurological disorders","volume":"20","author":"J Ausi\u00f3","year":"2014","journal-title":"Trends Mol Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrg3897","article-title":"Rett syndrome: a complex disorder with simple roots","volume":"16","author":"MJ Lyst","year":"2015","journal-title":"Nat Rev Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12017-014-8295-9","article-title":"Rett Syndrome and MeCP2","volume":"16","author":"VR Liyanage","year":"2014","journal-title":"Neuromolecular Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1093\/nar\/gkh349","article-title":"The major form of MeCP2 has a novel N-terminus generated by alternative splicing","volume":"32","author":"S Kriaucionis","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/ng1327","article-title":"A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome","volume":"36","author":"GN Mnatzakanian","year":"2004","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"46490","DOI":"10.1074\/jbc.M408284200","article-title":"MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex","volume":"279","author":"RJ Klose","year":"2004","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1177\/08830738030180101001","article-title":"MeCP2 expression in human cerebral cortex and lymphoid cells: immunochemical characterization of a novel higher-molecular-weight form","volume":"18","author":"MH Jarrar","year":"2003","journal-title":"J Child Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"RZ Chen","year":"2001","journal-title":"Nat Genet"},{"key":"ref12","first-page":"8","article-title":"Cerebellar gene expression profiles of mouse models for Rett syndrome reveal novel MeCP2 targets","volume":"20","author":"C Jordan","year":"2007","journal-title":"BMC Med Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nn.2275","article-title":"Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology","volume":"12","author":"N Ballas","year":"2009","journal-title":"Nat Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1093\/nar\/gkt213","article-title":"Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain","volume":"41","author":"DP Stuss","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref15","article-title":"Isoform-specific anti-MeCP2 antibodies confirm that expression of the e1 isoform strongly predominates in the brain","author":"L Kaddoum","year":"2013","journal-title":"F1000Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1128\/MCB.16.1.414","article-title":"DNA methylation specifies chromosomal localization of MeCP2","volume":"16","author":"X Nan","year":"1996","journal-title":"Mol Cell Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2350-3-12","article-title":"Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations","volume":"3","author":"J Traynor","year":"2002","journal-title":"BMC Med Genet"},{"key":"ref18","article-title":"MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome","author":"DJ Tai","year":"2016","journal-title":"Nat Commun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1096\/fj.01-0995fje","article-title":"Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells","volume":"16","author":"G Shaw","year":"2002","journal-title":"FASEB J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/hmg\/11.2.115","article-title":"Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation","volume":"11","author":"MD Shahbazian","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1136\/jmg.2006.045260","article-title":"Correlation between clinical severity in patients with Rett syndrome with a p.R168X or p.T158M MECP2 mutation, and the direction and degree of skewing of X-chromosome inactivation","volume":"44","author":"H Archer","year":"2007","journal-title":"J Med Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fncel.2014.00236","article-title":"MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?","volume":"8","author":"E Bellini","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology","volume":"56","author":"M Chahrour","year":"2007","journal-title":"Neuron"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1093\/nar\/gkn591","article-title":"MECP2 genomic structure and function: insights from ENCODE","volume":"36","author":"J Sigh","year":"2008","journal-title":"Nucleic Acids Research"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1138389","article-title":"Reversal of neurological defects in a mouse model of Rett syndrome","volume":"315","author":"J Guy","year":"2007","journal-title":"Science"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0153262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T09:46:43Z","timestamp":1567763203000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0153262"}},"subtitle":[],"editor":[{"given":"Maurizio","family":"D'Esposito","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,11]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0153262","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,4,11]]}}}