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Wettst ameliorates behavioral alterations and oxidative markers in sodium valproate induced autism in rats","volume":"37","author":"T Sandhya","year":"2012","journal-title":"Neurochemical research"},{"issue":"2","key":"ref76","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11689-009-9023-x","article-title":"Common circuit defect of excitatory-inhibitory balance in mouse models of autism","volume":"1","author":"N Gogolla","year":"2009","journal-title":"Journal of neurodevelopmental disorders"},{"issue":"4","key":"ref77","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1254\/jphs.12025SC","article-title":"Effect of prenatal valproic acid exposure on cortical morphology in female mice","volume":"118","author":"Y Hara","year":"2012","journal-title":"Journal of pharmacological sciences"},{"issue":"1\u20132","key":"ref78","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.brainres.2003.08.022","article-title":"Post-weaning social isolation of rats leads to a diminution of LTP in the CA1 to subiculum pathway","volume":"991","author":"L Roberts","year":"2003","journal-title":"Brain research"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ntt.2013.01.004","article-title":"In utero exposure to valproic acid and autism\u2014a current review of clinical and animal studies","volume":"36","author":"FI Roullet","year":"2013","journal-title":"Neurotoxicology and teratology"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.brainres.2010.07.090","article-title":"Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice","volume":"1355","author":"AW Grossman","year":"2010","journal-title":"Brain research"},{"issue":"1","key":"ref81","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.brainres.2006.02.044","article-title":"Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines","volume":"1084","author":"AW Grossman","year":"2006","journal-title":"Brain research"},{"issue":"1","key":"ref82","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1523\/JNEUROSCI.2623-05.2006","article-title":"Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome","volume":"26","author":"P Moretti","year":"2006","journal-title":"J Neurosci"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1038\/ncomms5742","article-title":"Enhanced synapse remodelling as a common phenotype in mouse models of autism","volume":"5","author":"M Isshiki","year":"2014","journal-title":"Nature communications"},{"issue":"2","key":"ref84","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.neuroimage.2009.04.069","article-title":"Abnormalities of intrinsic functional connectivity in autism spectrum disorders","volume":"47","author":"CS Monk","year":"2009","journal-title":"NeuroImage"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0157202","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0153298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T06:41:05Z","timestamp":1589006465000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0153298"}},"subtitle":[],"editor":[{"given":"Valerie W","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,12]]},"references-count":84,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0153298","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0157202","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,12]]}}}