{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:13:20Z","timestamp":1789931600034,"version":"4.0.1"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T00:00:00Z","timestamp":1460678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korean Healthcare Technology R&D Project","award":["HI13C1964"],"award-info":[{"award-number":["HI13C1964"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0153491","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T17:36:43Z","timestamp":1460741803000},"page":"e0153491","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Monitoring the Intracellular Tacrolimus Concentration in Kidney Transplant Recipients with Stable Graft Function"],"prefix":"10.1371","volume":"11","author":[{"given":"Seung Seok","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hee","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Chang","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Youn","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Il","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Pyo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongwon","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yon Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,4,15]]},"reference":[{"issue":"23","key":"ref1","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1056\/NEJM199912023412303","article-title":"Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant","volume":"341","author":"RA Wolfe","year":"1999","journal-title":"N Engl J Med"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/00007890-199708150-00012","article-title":"Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: a report of the European Tacrolimus Multicenter Renal Study Group","volume":"64","author":"AD Mayer","year":"1997","journal-title":"Transplantation"},{"issue":"Suppl 1","key":"ref3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/ajt.12579","article-title":"OPTN\/SRTR 2012 Annual Data Report: kidney","volume":"14","author":"AJ Matas","year":"2014","journal-title":"Am J Transplant"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/TP.0b013e318255f839","article-title":"The implications of acute rejection and reduced allograft function on health care expenditures in contemporary US kidney transplantation","volume":"94","author":"A Gheorghian","year":"2012","journal-title":"Transplantation"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1097\/00007890-200010150-00018","article-title":"Increased impact of acute rejection on chronic allograft failure in recent era","volume":"70","author":"HU Meier-Kriesche","year":"2000","journal-title":"Transplantation"},{"key":"ref6","first-page":"CD003961","article-title":"Tacrolimus versus cyclosporin as primary immunosuppression for kidney transplant recipients","author":"A Webster","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"issue":"25","key":"ref7","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1056\/NEJMoa067411","article-title":"Reduced exposure to calcineurin inhibitors in renal transplantation","volume":"357","author":"H Ekberg","year":"2007","journal-title":"N Engl J Med"},{"issue":"Suppl 3","key":"ref8","first-page":"S1","article-title":"KDIGO clinical practice guideline for the care of kidney transplant recipients","volume":"9","year":"2009","journal-title":"Am J Transplant"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/FTD.0b013e31828c1581","article-title":"Genetic polymorphisms in ABCB1 influence the pharmacodynamics of tacrolimus","volume":"35","author":"R Vafadari","year":"2013","journal-title":"Ther Drug Monit"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"703","DOI":"10.2217\/pgs.10.43","article-title":"CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation","volume":"11","author":"A Capron","year":"2010","journal-title":"Pharmacogenomics"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2165\/00002018-200225100-00003","article-title":"Drug interactions with tacrolimus","volume":"25","author":"T van Gelder","year":"2002","journal-title":"Drug safety"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/FTD.0b013e3181905aaa","article-title":"Validation of a liquid chromatography-mass spectrometric assay for tacrolimus in peripheral blood mononuclear cells","volume":"31","author":"A Capron","year":"2009","journal-title":"Ther Drug Monit"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1681\/ASN.2005070707","article-title":"How can we measure immunologic tolerance in humans?","volume":"17","author":"N Najafian","year":"2006","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1432-2277.2011.01365.x","article-title":"Correlation of tacrolimus levels in peripheral blood mononuclear cells with histological staging of rejection after liver transplantation: preliminary results of a prospective study","volume":"25","author":"A Capron","year":"2012","journal-title":"Transpl Int"},{"issue":"15","key":"ref15","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.clinbiochem.2013.02.011","article-title":"Monitoring of tacrolimus concentrations in peripheral blood mononuclear cells: Application to cardiac transplant recipients","volume":"46","author":"F Lemaitre","year":"2013","journal-title":"Clin Biochem"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.genm.2011.01.003","article-title":"Gender differences in pharmacokinetics of tacrolimus and their clinical significance in kidney transplant recipients","volume":"8","author":"R Velickovic-Radovanovic","year":"2011","journal-title":"Gend Med"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/sj.clpt.6100226","article-title":"The current state of knowledge on age, sex, and their interactions on clinical pharmacology","volume":"82","author":"JB Schwartz","year":"2007","journal-title":"Clin Pharmacol Ther"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0009-9236(95)90153-1","article-title":"Pharmacokinetics of tacrolimus in liver transplant patients","volume":"57","author":"WJ Jusko","year":"1995","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/sj.tpj.6500001","article-title":"Polymorphisms in the ABC drug transporter gene MDR1","volume":"1","author":"U Brinkmann","year":"2001","journal-title":"Pharmacogenomics J"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1096\/fasebj.14.3.511","article-title":"P-glycoprotein-overexpressing multidrug-resistant cells are resistant to infection by enveloped viruses that enter via the plasma membrane","volume":"14","author":"Y Raviv","year":"2000","journal-title":"FASEB J"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/FPC.0b013e3283385a1c","article-title":"Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein)","volume":"21","author":"LM Hodges","year":"2011","journal-title":"Pharmacogenet Genomics"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0153491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T19:16:17Z","timestamp":1567797377000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0153491"}},"subtitle":[],"editor":[{"given":"Valquiria","family":"Bueno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,15]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0153491","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,15]]}}}