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Engineering"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/(SICI)1520-684X(200004)31:4<22::AID-SCJ3>3.0.CO;2-W","article-title":"A method for monitoring autonomic nervous activity by pupillary flash response","volume":"31","author":"K Yamaji","year":"2000","journal-title":"Systems and Computers in Japan"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1109\/TBME.2010.2080678","article-title":"Modeling transient pupillary light reflex induced by a short light flash","volume":"58","author":"X Fan","year":"2011","journal-title":"IEEE Trans Biomed Eng"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1053\/euhj.1998.1084","article-title":"Heart rate variability and heart rate in healthy volunteers. Is the female autonomic nervous system cardioprotective?","volume":"19","author":"D Ramaekers","year":"1998","journal-title":"Eur Heart J"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-149-1-200807010-00231","article-title":"Diabetes and Hearing Impairment in the United States: Audiometric Evidence from the National Health and Nutrition Examination Survey, 1999 to 2004","volume":"149","author":"KE Bainbridge","year":"2008","journal-title":"Annals of Internal Medicine"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1001\/jama.1989.03420130084028","article-title":"RElationship of hearing impairment to dementia and cognitive dysfunction in older adults","volume":"261","author":"RF Uhlmann","year":"1989","journal-title":"JAMA"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1097\/AUD.0b013e31820512bb","article-title":"Cognitive load during speech perception in noise: the influence of age, hearing loss, and cognition on the pupil response","volume":"32","author":"AA Zekveld","year":"2011","journal-title":"Ear & Hearing"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/AUD.0b013e3181d4f251","article-title":"Pupil response as an indication of effortful listening: the influence of sentence intelligibility","volume":"31","author":"AA Zekveld","year":"2010","journal-title":"Ear & Hearing"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1080\/01690965.2011.642267","article-title":"Processing load during listening: The influence of task characteristics on the pupil response","volume":"28","author":"SE Kramer","year":"2013","journal-title":"Language & Cognitive Processes"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijpsycho.2003.12.005","article-title":"Sympathetic and parasympathetic innervation of pupillary dilation during sustained processing","volume":"52","author":"SR Steinhauer","year":"2004","journal-title":"Int J Psychophysiol"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0167-8760(00)00119-7","article-title":"Cognitive modulation of midbrain function: Task-induced reduction of the pupillary light reflex","volume":"39","author":"SR Steinhauer","year":"2000","journal-title":"International Journal of Psychophysiology"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/026988119601000404","article-title":"The inhibition of the pupillary light reflex by the threat of an electric shock: a potential laboratory model of human anxiety","volume":"10","author":"P Bitsios","year":"1996","journal-title":"J Psychopharmacol"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1088\/0967-3334\/34\/8\/873","article-title":"Effects of cold-pressor and mental arithmetic on pupillary light reflex","volume":"34","author":"BC Davis","year":"2013","journal-title":"Physiol Meas"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0153566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T20:47:28Z","timestamp":1718484448000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0153566"}},"subtitle":[],"editor":[{"given":"Zoi","family":"Kapoula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,18]]},"references-count":107,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0153566","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,18]]}}}