{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:23:56Z","timestamp":1763684636862,"version":"3.37.3"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004515","name":"Universiti Kebangsaan Malaysia","doi-asserted-by":"publisher","award":["DLP-2013-039"],"award-info":[{"award-number":["DLP-2013-039"]}],"id":[{"id":"10.13039\/501100004515","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0153752","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T17:34:39Z","timestamp":1461346479000},"page":"e0153752","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Clinical Significance of Interleukin\u20131 Receptor Antagonist +2018 Polymorphism in Rheumatoid Arthritis"],"prefix":"10.1371","volume":"11","author":[{"given":"Endom","family":"Ismail","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omimah Khaled Jaber","family":"Nofal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajalingham","family":"Sakthiswary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syahrul Sazliyana","family":"Shaharir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika","family":"Sridharan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM200103223441207","article-title":"Cytokine pathways and joint inflammation in rheumatoid arthritis","volume":"344","author":"EH Choy","year":"2001","journal-title":"N Engl J Med"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/ar304","article-title":"Genetic epidemiology. Approaches to the genetic analysis of rheumatoid arthritis","volume":"3","author":"S John","year":"2001","journal-title":"Arthritis Res"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/1529-0131(199906)42:6<1093::AID-ANR5>3.0.CO;2-P","article-title":"Interleukin-1\u03b2, interleukin-1 receptor antagonist, interleukin-4, and interleukin-10 gene polymorphisms: Relationship to occurrence and severity of rheumatoid arthritis","volume":"42","author":"A Cantagrel","year":"1999","journal-title":"Arthritis & Rheumatism"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/art.1780380202","article-title":"Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis","volume":"38","author":"WP Arend","year":"1995","journal-title":"Arthritis Rheum"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/0888-7543(92)90137-H","article-title":"The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14\u2013q21, in the region of the IL-1\u03b1 and IL-1\u03b2 loci","volume":"13","author":"A Steinkasserer","year":"1992","journal-title":"Genomics"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/art.1780370917","article-title":"Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus","volume":"37","author":"AI Blakemore","year":"1994","journal-title":"Arthritis and rheumatism"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/sj.gene.6364032","article-title":"Functional correlates of the interleukin-1 receptor antagonist gene polymorphism in the colonic mucosa in ulcerative colitis","volume":"5","author":"MJ Carter","year":"2004","journal-title":"Genes Immun"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10067-002-8292-5","article-title":"Interleukin-1 receptor antagonist gene polymorphism in chinese patients with systemic lupus erythematosus","volume":"21","author":"CM Huang","year":"2002","journal-title":"Clinical rheumatology"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1093\/rheumatology\/ken374","article-title":"Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A\/G variant reveals association with rheumatoid arthritis","volume":"47","author":"P Harrison","year":"2008","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00296-003-0337-9","article-title":"Interleukin-1 receptor antagonist gene polymorphism and rheumatoid arthritis","volume":"24","author":"YH Lee","year":"2004","journal-title":"Rheumatology international"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.kjms.2014.02.010","article-title":"Interleukin-23 and its correlation with disease activity, joint damage, and functional disability in rheumatoid arthritis","volume":"30","author":"AS Dalila","year":"2014","journal-title":"Kaohsiung J Med Sci"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/BOR.0b013e328336474d","article-title":"Recent advances in the genetics of rheumatoid arthritis","volume":"22","author":"S Raychaudhuri","year":"2010","journal-title":"Curr Opin Rheumatol"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/ng.2462","article-title":"High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis","volume":"44","author":"S Eyre","year":"2012","journal-title":"Nat Genet"},{"issue":"6","key":"ref14","first-page":"894","article-title":"Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes","volume":"30","author":"Y Chen","year":"2012","journal-title":"Clin Exp Rheumatol"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1002\/art.27589","article-title":"A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis","volume":"62","author":"W Tan","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/ard.2007.071662","article-title":"Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study","volume":"67","author":"EW Karlson","year":"2008","journal-title":"Ann Rheum Dis"},{"issue":"suppl 5","key":"ref17","doi-asserted-by":"crossref","first-page":"v3","DOI":"10.1093\/rheumatology\/kes113","article-title":"Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis","volume":"51","author":"E Choy","year":"2012","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/sj.gene.6363645","article-title":"Cytokine gene polymorphism in human disease: on-line databases","volume":"1","author":"J Bidwell","year":"1999","journal-title":"Genes Immun"},{"issue":"4","key":"ref19","first-page":"894","article-title":"The impact of IL-1Ra and MBL gene polymorphisms on joint damage after 5 and 10 years in patients with early rheumatoid arthritis","volume":"34","author":"MC Kapetanovic","year":"2007","journal-title":"J Rheumatol"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1002\/art.21287","article-title":"Polymorphism of the interleukin-1 receptor antagonist gene: a factor in susceptibility to rheumatoid arthritis in a Spanish population","volume":"52","author":"PE Carreira","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/030097401316909576","article-title":"Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in rheumatoid arthritis","volume":"30","author":"CM Huang","year":"2001","journal-title":"Scand J Rheumatol"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2217\/14622416.7.5.683","article-title":"IL-1B and IL-1RN gene polymorphisms in rheumatoid arthritis: relationship with protein plasma levels and response to therapy","volume":"7","author":"B Tolusso","year":"2006","journal-title":"Pharmacogenomics"},{"issue":"5","key":"ref23","first-page":"654","article-title":"No association of interleukin-1 receptor antagonist VNTR polymorphism and rheumatoid arthritis susceptibility: a meta analysis","volume":"28","author":"ML Xue J","year":"2010","journal-title":"Clin Exp Rheumatol"},{"issue":"6","key":"ref24","first-page":"643","article-title":"Interleukin-1 receptor antagonist (IL-1RN) and interleukin-1B gene polymorphisms in Turkish patients with rheumatoid arthritis","volume":"24","author":"A Arman","year":"2006","journal-title":"Clin Exp Rheumatol"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/iub.1205","article-title":"Interleukin-1 receptor antagonist gene polymorphism and hepcidin in rheumatoid arthritis: Correlations with clinical and laboratory indices of disease activity","volume":"65","author":"M Swellam","year":"2013","journal-title":"IUBMB Life"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2249.1995.tb05549.x","article-title":"Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism","volume":"99","author":"VA Danis","year":"1995","journal-title":"Clin Exp Immunol"},{"issue":"5","key":"ref27","first-page":"574","article-title":"Influence of Interleukine-1 Beta and Interleukine-1 Receptor Antagonist Genes Polymorphism on Rheumatoid Arthritis","volume":"27","author":"T Gaafar","year":"2013","journal-title":"World Applied Sci J"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/1529-0131(199906)42:6<1093::AID-ANR5>3.0.CO;2-P","article-title":"Interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4, and interleukin-10 gene polymorphisms: relationship to occurrence and severity of rheumatoid arthritis","volume":"42","author":"A Cantagrel","year":"1999","journal-title":"Arthritis Rheum"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/sj.gene.6363766","article-title":"IL-1B and IL-1Ra gene polymorphisms and disease severity in rheumatoid arthritis: interaction with their plasma levels","volume":"2","author":"N Buchs","year":"2001","journal-title":"Genes Immun"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1136\/ard.2004.033829","article-title":"Rheumatoid arthritis and genetic markers in Syrian and French populations: different effect of the shared epitope","volume":"66","author":"L Kazkaz","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jbspin.2007.09.015","article-title":"Interleukin-1 receptor antagonist gene polymorphisms are associated with disease severity in Black South Africans with rheumatoid arthritis","volume":"75","author":"S Lubbe","year":"2008","journal-title":"Joint Bone Spine"},{"issue":"9","key":"ref32","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1093\/hmg\/8.9.1707","article-title":"Combined sib-TDT and TDT provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritis","volume":"8","author":"A Cox","year":"1999","journal-title":"Hum Mol Genet"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/1529-0131(199811)41:11<2004::AID-ART16>3.0.CO;2-Z","article-title":"Interleukin-1alpha and tumor necrosis factor alpha synergistically stimulate prostaglandin E2-dependent production of interleukin-11 in rheumatoid synovial fibroblasts","volume":"41","author":"T Mino","year":"1998","journal-title":"Arthritis and rheum"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0153752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T22:47:35Z","timestamp":1718491655000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0153752"}},"subtitle":[],"editor":[{"given":"Yongshuai","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,22]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0153752","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,4,22]]}}}