{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:21:32Z","timestamp":1789172492788,"version":"build-2803163510"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T00:00:00Z","timestamp":1461110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0153887","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T17:35:48Z","timestamp":1461173748000},"page":"e0153887","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure"],"prefix":"10.1371","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-7411","authenticated-orcid":false,"given":"Mani","family":"Sadredini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tore Kristian","family":"Danielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Magnus","family":"Aronsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinea","family":"Manotheepan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Hougen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivar","family":"Sjaastad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathis Korseberg","family":"Stokke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,4,20]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0002-9149(84)90299-6","article-title":"Risk factors for sudden death after acute myocardial infarction: two-year follow-up","volume":"54","author":"J Mukharji","year":"1984","journal-title":"The American journal of cardiology"},{"issue":"5313","key":"ref2","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1126\/science.276.5313.800","article-title":"Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure","volume":"276","author":"AM Gomez","year":"1997","journal-title":"Science"},{"issue":"39","key":"ref3","doi-asserted-by":"crossref","first-page":"14104","DOI":"10.1073\/pnas.0504298102","article-title":"Abnormal intrastore calcium signaling in chronic heart failure","volume":"102","author":"Z Kubalova","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/01.CIR.85.3.1046","article-title":"Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure","volume":"85","author":"DJ Beuckelmann","year":"1992","journal-title":"Circulation"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.RES.86.5.558","article-title":"Changes in Ca(2+) cycling proteins underlie cardiac action potential prolongation in a pressure-overloaded guinea pig model with cardiac hypertrophy and failure","volume":"86","author":"GU Ahmmed","year":"2000","journal-title":"Circulation research"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1161\/01.CIR.103.11.1577","article-title":"Decreased Sarcoplasmic Reticulum Calcium Content Is Responsible for Defective Excitation-Contraction Coupling in Canine Heart Failure","volume":"103","author":"IA Hobai","year":"2001","journal-title":"Circulation"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1161\/01.RES.0000062469.83985.9B","article-title":"Cellular Basis of Abnormal Calcium Transients of Failing Human Ventricular Myocytes","volume":"92","author":"V Piacentino","year":"2003","journal-title":"Circulation research"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1161\/01.RES.0000091871.54907.6B","article-title":"Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport","volume":"93","author":"DM Bers","year":"2003","journal-title":"Circulation research"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/cvr\/cvr025","article-title":"The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function","volume":"90","author":"AE Belevych","year":"2011","journal-title":"Cardiovascular research"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"H1636","DOI":"10.1152\/ajpheart.00742.2011","article-title":"Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?","volume":"302","author":"Z Zhao","year":"2012","journal-title":"American Journal of Physiology\u2014Heart and Circulatory Physiology"},{"issue":"13","key":"ref11","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1113\/jphysiol.2009.172155","article-title":"Store overload-induced Ca2+ release as a triggering mechanism for CPVT and MH episodes caused by mutations in RYR and CASQ genes","volume":"587","author":"DH MacLennan","year":"2009","journal-title":"The Journal of physiology"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nm.3440","article-title":"The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias","volume":"20","author":"W Chen","year":"2014","journal-title":"Nat Med"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1113\/jphysiol.2014.279638","article-title":"Decreased inward rectifying K+ current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart","volume":"593","author":"RC Myles","year":"2015","journal-title":"The Journal of physiology"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1073\/pnas.0510113103","article-title":"Ryanodine receptor\/calcium release channel PKA phosphorylation: A critical mediator of heart failure progression","volume":"103","author":"XHT Wehrens","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"Part B","key":"ref15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.yjmcc.2015.11.009","article-title":"Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy","volume":"89","author":"Q Wang","year":"2015","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.yjmcc.2015.06.009","article-title":"Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity","volume":"85","author":"T Oda","year":"2015","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1161\/CIRCRESAHA.111.260455","article-title":"Shortened Ca2+ Signaling Refractoriness Underlies Cellular Arrhythmogenesis in a Postinfarction Model of Sudden Cardiac Death","volume":"110","author":"AE Belevych","year":"2012","journal-title":"Circulation research"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/ejhf.163","article-title":"Ca2+\/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy","volume":"16","author":"TH Fischer","year":"2014","journal-title":"European Journal of Heart Failure"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1113\/jphysiol.2013.264689","article-title":"Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca2+-dependent cardiomyopathy by exacerbating diastolic Ca2+ release","volume":"592","author":"B Liu","year":"2014","journal-title":"The Journal of physiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1177\/000331976001100505","article-title":"Simple techniques for the surgical occlusion of coronary vessels in the rat","volume":"11","author":"H Selye","year":"1960","journal-title":"Angiology"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1152\/jappl.2000.89.4.1445","article-title":"Echocardiographic criteria for detection of postinfarction congestive heart failure in rats","volume":"89","author":"I Sjaastad","year":"2000","journal-title":"Journal of applied physiology"},{"key":"ref22","first-page":"162","article-title":"Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure","author":"IG Lunde","year":"2012","journal-title":"Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.yjmcc.2006.12.007","article-title":"Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII","volume":"42","author":"S Huke","year":"2007","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.yjmcc.2013.01.014","article-title":"Slow Ca2 + sparks de-synchronize Ca2 + release in failing cardiomyocytes: Evidence for altered configuration of Ca2 + release units?","volume":"58","author":"WE Louch","year":"2013","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"ref25","first-page":"380","article-title":"Altered Cardiac Myocyte Ca Regulation In Heart Failure","author":"DM Bers","year":"2006","journal-title":"Altered Cardiac Myocyte Ca Regulation In Heart Failure"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s00395-008-0719-y","article-title":"Slow contractions characterize failing rat hearts","volume":"103","author":"J B\u00f8kenes","year":"2008","journal-title":"Basic Res Cardiol"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1161\/01.CIR.96.11.3974","article-title":"Isolated Myocyte Contractile Function Is Normal in Postinfarct Remodeled Rat Heart With Systolic Dysfunction","volume":"96","author":"IS Anand","year":"1997","journal-title":"Circulation"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.jtcvs.2006.07.016","article-title":"Strain-related regional alterations of calcium-handling proteins in myocardial remodeling","volume":"132","author":"A Kilic","year":"2006","journal-title":"The Journal of Thoracic and Cardiovascular Surgery"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0735-1097(99)00222-3","article-title":"Cardiomyocytes from hearts with left ventricular dysfunction after ischemia-reperfusion do not manifest contractile abnormalities","volume":"34","author":"Y Chandrashekhar","year":"1999","journal-title":"Journal of the American College of Cardiology"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0008-6363(02)00230-4","article-title":"Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure","volume":"54","author":"G Chu","year":"2002","journal-title":"Cardiovascular research"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijcard.2011.07.092","article-title":"Increased enddiastolic wall stress precedes left ventricular hypertrophy in dilative heart failure\u2014Use of the volume-based wall stress index","volume":"157","author":"P Alter","year":"2012","journal-title":"International Journal of Cardiology"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0008-6363(00)00248-0","article-title":"Regional heterogeneity of function in nonischemic dilated cardiomyopathy","volume":"49","author":"AA Young","year":"2001","journal-title":"Cardiovascular research"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"H798","DOI":"10.1152\/ajpheart.2000.279.2.H798","article-title":"Altered E-C coupling in rat ventricular myocytes from failing hearts 6 wk after MI","volume":"279","author":"JA Wasserstrom","year":"2000","journal-title":"American Journal of Physiology\u2014Heart and Circulatory Physiology"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0022-3565(24)29420-9","article-title":"Effects of Ca2+ Sensitizers on Contraction, [Ca2+]i Transient and Myofilament Ca2+ Sensitivity in Diabetic Rat Myocardium: Potential Usefulness as Inotropic Agents","volume":"298","author":"T Ishitani","year":"2001","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0008-6363(01)00210-3","article-title":"Increased contractility and calcium sensitivity in cardiac myocytes isolated from endurance trained rats","volume":"50","author":"U Wisl\u00f8ff","year":"2001","journal-title":"Cardiovascular research"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.yjmcc.2008.07.004","article-title":"Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: Increased or decreased?","volume":"45","author":"SB Marston","year":"2008","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"8","key":"ref37","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1161\/01.CIR.0000139336.69955.AB","article-title":"Remodeling of Sinus Node Function in Patients With Congestive Heart Failure: Reduction in Sinus Node Reserve","volume":"110","author":"P Sanders","year":"2004","journal-title":"Circulation"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/01.CIR.74.2.431","article-title":"Endurance training in rats with chronic heart failure induced by myocardial infarction","volume":"74","author":"TI Musch","year":"1986","journal-title":"Circulation"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1161\/01.CIR.0000105721.71640.DA","article-title":"Vagal Nerve Stimulation Markedly Improves Long-Term Survival After Chronic Heart Failure in Rats","volume":"109","author":"M Li","year":"2004","journal-title":"Circulation"},{"issue":"3\u20134","key":"ref40","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ceca.2005.06.017","article-title":"The control of sarcoplasmic reticulum Ca content in cardiac muscle","volume":"38","author":"ME Diaz","year":"2005","journal-title":"Cell calcium"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/oxfordjournals.jbchem.a002843","article-title":"Regulation of the Activities of Multifunctional Ca2+\/Calmodulin-Dependent Protein Kinases","volume":"129","author":"H Fujisawa","year":"2001","journal-title":"Journal of Biochemistry"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/jmcc.1996.0271","article-title":"Increased Expression of Cardiac Phosphatases in Patients with End-stage Heart Failure","volume":"29","author":"J Neumann","year":"1997","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"ref43","first-page":"H2373","article-title":"Cardiac SR-coupled PP1 activity and expression are increased and inhibitor 1 protein expression is decreased in failing hearts","author":"RC Gupta","year":"2003","journal-title":"Cardiac SR-coupled PP1 activity and expression are increased and inhibitor 1 protein expression is decreased in failing hearts"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1113\/jphysiol.2003.046367","article-title":"Protein Phosphatases Decrease Sarcoplasmic Reticulum Calcium Content by Stimulating Calcium Release in Cardiac Myocytes","volume":"552","author":"D Terentyev","year":"2003","journal-title":"The Journal of physiology"},{"issue":"7","key":"ref45","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(03)00434-3","article-title":"FKBP12.6 Deficiency and Defective Calcium Release Channel (Ryanodine Receptor) Function Linked to Exercise-Induced Sudden Cardiac Death","volume":"113","author":"XHT Wehrens","year":"2003","journal-title":"Cell"},{"issue":"20","key":"ref46","doi-asserted-by":"crossref","first-page":"7906","DOI":"10.1073\/pnas.0602133103","article-title":"Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias","volume":"103","author":"SE Lehnart","year":"2006","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/cvr\/cvm009","article-title":"The sarcoplasmic reticulum and arrhythmogenic calcium release","volume":"77","author":"LA Venetucci","year":"2008","journal-title":"Cardiovascular research"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.yjmcc.2008.12.005","article-title":"What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis?","volume":"46","author":"DA Eisner","year":"2009","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"17","key":"ref49","doi-asserted-by":"crossref","first-page":"15516","DOI":"10.1021\/am5042324","article-title":"Stable, Covalent Attachment of Laminin to Microposts Improves the Contractility of Mouse Neonatal Cardiomyocytes","volume":"6","author":"AJS Ribeiro","year":"2014","journal-title":"ACS Applied Materials & Interfaces"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.yjmcc.2011.06.012","article-title":"Methods in cardiomyocyte isolation, culture, and gene transfer","volume":"51","author":"WE Louch","journal-title":"Journal of Molecular and Cellular Cardiology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0153887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T20:43:16Z","timestamp":1748896996000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0153887"}},"subtitle":[],"editor":[{"given":"Xander H.T.","family":"Wehrens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,20]]},"references-count":50,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0153887","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,20]]}}}