{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:05:49Z","timestamp":1759032349206,"version":"3.37.3"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T00:00:00Z","timestamp":1461024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Psychaid","award":["IAPP 286334"],"award-info":[{"award-number":["IAPP 286334"]}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["91212044"],"award-info":[{"award-number":["91212044"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0153892","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T14:20:27Z","timestamp":1461075627000},"page":"e0153892","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Aberrant Levels of Hematopoietic\/Neuronal Growth and Differentiation Factors in Euthyroid Women at Risk for Autoimmune Thyroid Disease"],"prefix":"10.1371","volume":"11","author":[{"given":"Elske T.","family":"Massolt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigoris","family":"Effraimidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim I. M.","family":"Korevaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilmar M.","family":"Wiersinga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Edward","family":"Visser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin P.","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemmo A.","family":"Drexhage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,4,19]]},"reference":[{"issue":"4\u20135","key":"ref1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.autrev.2014.01.007","article-title":"Hashimoto thyroiditis: clinical and diagnostic criteria","volume":"13","author":"P Caturegli","year":"2014","journal-title":"Autoimmun Rev"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1089\/105072502761016458","article-title":"Epidemiology and prevention of clinical and subclinical hypothyroidism","volume":"12","author":"MP Vanderpump","year":"2002","journal-title":"Thyroid"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1210\/jc.2003-032089","article-title":"The thyroid epidemiology, audit, and research study: thyroid dysfunction in the general population","volume":"89","author":"RW Flynn","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1210\/jcem.83.3.4624","article-title":"Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark","volume":"83","author":"P Laurberg","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1001\/archinte.160.4.526","article-title":"The Colorado thyroid disease prevalence study","volume":"160","author":"GJ Canaris","year":"2000","journal-title":"Arch Intern Med"},{"issue":"9411","key":"ref6","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0140-6736(04)15696-1","article-title":"Hypothyroidism","volume":"363","author":"CG Roberts","year":"2004","journal-title":"Lancet"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2265.1995.tb01894.x","article-title":"The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey","volume":"43","author":"MP Vanderpump","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.1365-2265.2003.01862.x","article-title":"Risk factors for and prevalence of thyroid disorders in a cross-sectional study among healthy female relatives of patients with autoimmune thyroid disease","volume":"59","author":"TG Strieder","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"15","key":"ref9","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1001\/archinte.168.15.1657","article-title":"Prediction of progression to overt hypothyroidism or hyperthyroidism in female relatives of patients with autoimmune thyroid disease using the Thyroid Events Amsterdam (THEA) score","volume":"168","author":"TG Strieder","year":"2008","journal-title":"Arch Intern Med"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1210\/jc.2008-1548","article-title":"Discontinuation of smoking increases the risk for developing thyroid peroxidase antibodies and\/or thyroglobulin antibodies: a prospective study","volume":"94","author":"G Effraimidis","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1210\/jc.2012-4122","article-title":"Changes in serum adhesion molecules, chemokines, cytokines, and tissue remodeling factors in euthyroid women without thyroid antibodies who are at risk for autoimmune thyroid disease: a hypothesis on the early phases of the endocrine autoimmune reaction","volume":"98","author":"W Beumer","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1001\/jamapsychiatry.2013.1111","article-title":"Autoimmune diseases and severe infections as risk factors for mood disorders: a nationwide study","volume":"70","author":"ME Benros","year":"2013","journal-title":"JAMA Psychiatry"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1210\/jcem.86.8.7749","article-title":"Cerebral blood flow and glucose metabolism in hypothyroidism: a positron emission tomography study","volume":"86","author":"EL Constant","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-244X-4-25","article-title":"The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future","volume":"4","author":"MG Carta","year":"2004","journal-title":"BMC Psychiatry"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.biopsych.2006.08.041","article-title":"Is autoimmune thyroiditis part of the genetic vulnerability (or an endophenotype) for bipolar disorder?","volume":"62","author":"R Vonk","year":"2007","journal-title":"Biol Psychiatry"},{"issue":"6\u20137","key":"ref16","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.euroneuro.2006.10.005","article-title":"Signs of a higher prevalence of autoimmune thyroiditis in female offspring of bipolar parents","volume":"17","author":"MH Hillegers","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0006-3223(01)01217-3","article-title":"High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure","volume":"51","author":"RW Kupka","year":"2002","journal-title":"Biol Psychiatry"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.biopsych.2004.07.003","article-title":"A high prevalence of organ-specific autoimmunity in patients with bipolar disorder","volume":"56","author":"RC Padmos","year":"2004","journal-title":"Biol Psychiatry"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/pmic.201000291","article-title":"Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival","volume":"11","author":"M Herberth","year":"2011","journal-title":"Proteomics"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.euroneuro.2012.10.012","article-title":"Electroconvulsive therapy exerts mainly acute molecular changes in serum of major depressive disorder patients","volume":"23","author":"V Stelzhammer","year":"2013","journal-title":"Eur Neuropsychopharmacol"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"e9166","DOI":"10.1371\/journal.pone.0009166","article-title":"Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections","volume":"5","author":"E Domenici","year":"2010","journal-title":"PLoS One"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/mp.2011.42","article-title":"Identification of a biological signature for schizophrenia in serum","volume":"17","author":"E Schwarz","year":"2012","journal-title":"Mol Psychiatry"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.metabol.2014.10.026","article-title":"Biomarkers of psychiatric diseases: current status and future prospects","volume":"64","author":"M Kalia","year":"2015","journal-title":"Metabolism"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-1-61779-442-1_18","article-title":"Functional analysis of Rho GTPase activation and inhibition in a bead-based miniaturized format","volume":"827","author":"M Schmohl","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"18","key":"ref25","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.4161\/cc.7.18.6752","article-title":"Emerging functions of c-kit and its ligand stem cell factor in dendritic cells: regulators of T cell differentiation","volume":"7","author":"P Ray","year":"2008","journal-title":"Cell Cycle"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"e75562","DOI":"10.1371\/journal.pone.0075562","article-title":"The effects of hematopoietic growth factors on neurite outgrowth","volume":"8","author":"Y Su","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.immuni.2012.09.023","article-title":"Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor","volume":"38","author":"DM Zaiss","year":"2013","journal-title":"Immunity"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.humimm.2004.10.014","article-title":"Effects of insulin-like growth factors and insulin-like growth factor binding protein-2 on the in vitro proliferation of peripheral blood mononuclear cells","volume":"66","author":"S Hettmer","year":"2005","journal-title":"Hum Immunol"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s10571-009-9406-2","article-title":"Epidermal growth factor (EGF) promotes the in vitro differentiation of neural crest cells to neurons and melanocytes","volume":"29","author":"RC Garcez","year":"2009","journal-title":"Cell Mol Neurobiol"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn3379","article-title":"Neurotrophin regulation of neural circuit development and function","volume":"14","author":"H Park","year":"2013","journal-title":"Nat Rev Neurosci"},{"issue":"Pt C","key":"ref31","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.neuropharm.2013.04.011","article-title":"Synaptic regulation of affective behaviors; role of BDNF","volume":"76","author":"I Ninan","year":"2014","journal-title":"Neuropharmacology"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrn1078","article-title":"Neurotrophins and their receptors: a convergence point for many signalling pathways","volume":"4","author":"MV Chao","year":"2003","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0301-0082(02)00016-3","article-title":"Neurotrophin signaling through the p75 neurotrophin receptor","volume":"67","author":"PP Roux","year":"2002","journal-title":"Prog Neurobiol"},{"issue":"8","key":"ref34","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1017\/S1461145708009309","article-title":"A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression","volume":"11","author":"AR Brunoni","year":"2008","journal-title":"Int J Neuropsychopharmacol"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000135626","article-title":"Immune-endocrine interactions in autoimmune thyroid diseases","volume":"15","author":"AJ Klecha","year":"2008","journal-title":"Neuroimmunomodulation"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1210\/jc.2004-0977","article-title":"High levels of circulating CXC chemokine ligand 10 are associated with chronic autoimmune thyroiditis and hypothyroidism","volume":"89","author":"A Antonelli","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1210\/jc.2012-2555","article-title":"Interferon-gamma and tumor necrosis factor-alpha sustain secretion of specific CXC chemokines in human thyrocytes: a first step toward a differentiation between autoimmune and tumor-related inflammation?","volume":"98","author":"M Rotondi","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"17989","DOI":"10.1038\/srep17989","article-title":"A method for reproducible measurements of serum BDNF: comparison of the performance of six commercial assays","volume":"5","author":"A Polacchini","year":"2015","journal-title":"Sci Rep"},{"issue":"8","key":"ref39","doi-asserted-by":"crossref","first-page":"e42676","DOI":"10.1371\/journal.pone.0042676","article-title":"Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder","volume":"7","author":"T Yoshida","year":"2012","journal-title":"PLoS One"},{"issue":"Pt 19","key":"ref40","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1242\/jcs.00786","article-title":"Novel functions and signalling pathways for GDNF","volume":"116","author":"H Sariola","year":"2003","journal-title":"J Cell Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0153892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T01:25:47Z","timestamp":1540344347000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0153892"}},"subtitle":[],"editor":[{"given":"Joseph","family":"Najbauer","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,19]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0153892","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,4,19]]}}}