{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:43:56Z","timestamp":1790502236447,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0154209","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T17:31:05Z","timestamp":1461346265000},"page":"e0154209","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Proteomic Profile of Brucella abortus-Infected Bovine Chorioallantoic Membrane Explants"],"prefix":"10.1371","volume":"11","author":[{"given":"Juliana P. S.","family":"Mol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone F.","family":"Pires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander D.","family":"Chapeaurouge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Perales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato L.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lida M.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey P.","family":"Lage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S1369-5274(00)00165-X","article-title":"Brucellosis: A worldwide zoonosis","volume":"4","author":"ML Boschiroli","year":"2001","journal-title":"Curr Opin Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jcpa.2008.10.004","article-title":"Pathology, immunohistochemistry and bacteriology of tissues and milk of cows and fetuses experimentally infected with <italic>Brucella abortus<\/italic>","volume":"140","author":"MN Xavier","year":"2009","journal-title":"J Comp Pathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1128\/IAI.66.5.2387-2392.1998","article-title":"Virulent <italic>Brucella abortus<\/italic> prevents lysossome fusion and is distributed within auto phagosome-like compartments","volume":"66","author":"J Pizarro-Cerd\u00e1","year":"1998","journal-title":"Infect Immun"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0378-1135(02)00214-6","article-title":"<italic>Brucella<\/italic> intracellular life: from invasion to intracellular replication","volume":"90","author":"J Gorvel","year":"2002","journal-title":"Vet Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1348-0421.2006.tb03810.x","article-title":"Characterization of biological activities of <italic>Brucella melitensis<\/italic> lipopolysaccharide","volume":"50","author":"G Tumurkhuu","year":"2006","journal-title":"Microbiol Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.4049\/jimmunol.173.7.4635","article-title":"Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed <italic>Brucella abortus<\/italic>","volume":"173","author":"GH Giambartolomei","year":"2004","journal-title":"J Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0378-1135(02)00219-5","article-title":"Type IV secretion and <italic>Brucella<\/italic> virulence","volume":"90","author":"ML Boschiroli","year":"2002","journal-title":"Vet Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mib.2003.11.001","article-title":"Organelle robbery: <italic>Brucella<\/italic> interactions with the endoplasmic reticulum","volume":"7","author":"J Celli","year":"2004","journal-title":"Curr Opin Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1073\/pnas.0406873102","article-title":"<italic>Brucella<\/italic> coopts the small GTPase Sar1 for intracellular replication","volume":"102","author":"J Celli","year":"2005","journal-title":"Proc Natl Acad Sci. U.S.A"},{"key":"ref10","first-page":"399","article-title":"Subversion of toll-like receptor signaling by a unique family of bacterial toll\/interleukin-1 receptor domain-containing proteins","volume":"14","author":"C Cirl","year":"2008","journal-title":"Nature"},{"key":"ref11","first-page":"e21","article-title":"<italic>Brucella<\/italic> control of dendritic cell maturation is dependent on the Tir-containing protein btp1","volume":"4","author":"S Salcedo","year":"2008","journal-title":"PlosPathog"},{"key":"ref12","first-page":"3","article-title":"BtpB a novel <italic>Brucella<\/italic> TIR-containing effector protein with immune modulatory functions","volume":"8","author":"SP Salcedo","year":"2013","journal-title":"Front Cell Infect Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0378-1135(02)00239-0","article-title":"<italic>Brucella<\/italic> proteomes\u2014A Review","volume":"90","author":"G Delvecchio","year":"2002","journal-title":"Vet Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1002\/pmic.200800026","article-title":"Quantitative analysis of the intramacrophagic <italic>Brucella suis<\/italic> proteome reveals metabolic adaptation to late stage of cellular infection","volume":"8","author":"S Al Dahouk","year":"2008","journal-title":"Proteomics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1021\/pr800978p","article-title":"Intracellular adaptation of <italic>Brucella abortus<\/italic>","volume":"8","author":"J Lamontagne","year":"2009","journal-title":"J Proteome Res"},{"key":"ref16","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.016378","article-title":"Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome","volume":"11","author":"FX Campbell-Valois","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/elps.201300378","article-title":"Comparative proteomics analysis of host cells infected with <italic>Brucella abortus<\/italic> A19","volume":"35","author":"Y Wu","year":"2014","journal-title":"Electrophoresis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e91706","DOI":"10.1371\/journal.pone.0091706","article-title":"Proteomic analysis of detergent resistant membrane domains during early interaction of macrophages with rough and smooth <italic>Brucella melitensis<\/italic>","volume":"9","author":"SA Lauer","year":"2014","journal-title":"PLoSOne"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1017\/S002217240001158X","article-title":"The estimation of the bacterial power of the blood","volume":"38","author":"AA Miles","year":"1938","journal-title":"J Hyg Com"},{"key":"ref20","first-page":"85","volume":"86","author":"JY Richmond","year":"1993"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1128\/IAI.01554-07","article-title":"Modulation of bovine trophoblastic innate immune response by <italic>Brucella abortus<\/italic>","volume":"76","author":"AV Carvalho-Neta","year":"2008","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1439-0264.1973.tb00253.x","article-title":"Prenatal development of domestic and laboratory mammals: growth curves, external features and selected references","volume":"2","author":"HE Evans","year":"1973","journal-title":"Anatomy, Histology, Embryology"},{"key":"ref23","first-page":"221","article-title":"Estat\u00edstica Aplicada \u00e0 Experimenta\u00e7\u00e3o Animal","author":"IBM Sampaio","year":"1998"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/elps.200305844","article-title":"Blue silver: a very sensitive colloidal Coomassie G-250 staining for proteome analysis","volume":"25","author":"G Candiano","year":"2004","journal-title":"Electrophoresis"},{"key":"ref25","article-title":"Two-dimensional electrophoresis with immobilized pH gradients for proteome analysis","author":"A G\u00f6rg","year":"2007"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.micinf.2011.08.018","article-title":"Tollip: A multitasking protein in innate immunity and protein trafficking","volume":"14","author":"GS Capelluto","year":"2012","journal-title":"Microb Infect"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e108606","DOI":"10.1371\/journal.pone.0108606","article-title":"Early transcriptional responses of bovine chorioallantoic membrane explants to wild type, \u0394<italic>virB2<\/italic> or \u0394<italic>btpB Brucella abortus<\/italic> infection","volume":"26","author":"JP Mol","year":"2014","journal-title":"PLoSOne"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1182\/blood-2004-10-3906","article-title":"Nk\/Idc interaction results in Il-18 secretion by Dcs at the synaptic cleft followed by Nk cell activation and release of the dc maturation factor Hmgb1","volume":"106","author":"C Semino","year":"2005","journal-title":"Blood"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12017-009-8094-x","article-title":"A clear and present danger: endogenous ligands of Toll-like receptors","volume":"12","author":"JA Sloane","year":"2010","journal-title":"Neuro Molecular Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1600-0854.2005.00336.x","article-title":"Rab proteins, connecting transport and vesicle fusion","volume":"6","author":"I Jordens","year":"2005","journal-title":"Traffic"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.immuni.2010.09.010","article-title":"The Rab11a GTPase controls toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes","volume":"33","author":"H Husebye","year":"2010","journal-title":"Immunity"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"E23135","DOI":"10.1371\/journal.pone.0023135","article-title":"Myd88 and STING: signaling pathways are required for Irf3-mediated Ifn-B induction in response to <italic>Brucella abortus<\/italic> infection","volume":"6","author":"LA de Almeida","year":"2011","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1091\/mbc.E02-03-0136","article-title":"Role of secretory carrier membrane protein Scamp2 in granule exocytosis","volume":"13","author":"L Liu","year":"2002","journal-title":"Mol Biol Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/j.1462-5822.2009.01329.x","article-title":"Scamp3 is a component of the <italic>Salmonella<\/italic>-induced tubular network and reveals an interaction between bacterial effectors and Post-Golgi trafficking","volume":"11","author":"LJ Mota","year":"2009","journal-title":"Cell Microbiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.cbi.2011.02.023","article-title":"Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders","volume":"191","author":"SK Srivastava","year":"2011","journal-title":"Chembiol Interact"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"E6535","DOI":"10.1371\/journal.pone.0006535","article-title":"Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice","volume":"4","author":"UC Yadav","year":"2009","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1128\/IAI.73.5.2873-2880.2005","article-title":"The <italic>Brucella abortus<\/italic> Cu\/Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected mice","volume":"73","author":"JM Gee","year":"2005","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1007\/s00125-011-2197-2","article-title":"Biliverdin protects against the deterioration of glucose tolerance in db\/db mice","volume":"54","author":"N Ikeda","year":"2011","journal-title":"Diabetologia"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1034\/j.1600-065X.2001.1800106.x","article-title":"Gc1q-R\/P33 a member of a new class of multifunctional and multicompartmental cellular proteins is involved in inflammation and infection","volume":"180","author":"B Ghebrehiwet","year":"2001","journal-title":"Immunol Rep"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1002\/pmic.200900572","article-title":"Proteomic analysis of colonic mucosa in a rat model of irritable bowel syndrome","volume":"10","author":"Y Ding","year":"2010","journal-title":"Proteomics"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1021\/pr060668y","article-title":"Retinal Mueller glial cells trigger the hallmark inflammatory process in autoimmune uveitis","volume":"6","author":"SM Hauck","year":"2007","journal-title":"J Proteome Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1124\/jpet.104.080416","article-title":"Inhibition of S-Adenosyl- L-Homocysteine hydrolase induces immunosuppression","volume":"313","author":"QL Wu","year":"2005","journal-title":"J Pharmacol Exp Ther"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0154209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T01:05:03Z","timestamp":1600477503000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0154209"}},"subtitle":[],"editor":[{"given":"Esteban","family":"Chaves-Olarte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,22]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0154209","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,22]]}}}