{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:16:20Z","timestamp":1773296180451,"version":"3.50.1"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002958","name":"Drug Applied Research Center of Tabriz University of Medical Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002958","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0154400","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T17:47:11Z","timestamp":1462988831000},"page":"e0154400","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["The Effect of High Dose Folic Acid throughout Pregnancy on Homocysteine (Hcy) Concentration and Pre-Eclampsia: A Randomized Clinical Trial"],"prefix":"10.1371","volume":"11","author":[{"given":"Manizheh","family":"Sayyah-Melli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Ghorbanihaghjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahasti","family":"Alizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryamalsadat","family":"Kazemi-Shishvan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morteza","family":"Ghojazadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanam","family":"Bidadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e1001589","DOI":"10.1371\/journal.pmed.1001589","article-title":"A Risk Prediction Model for the Assessment and Triage of Women with Hypertensive Disorders of Pregnancy in Low-Resourced Settings: The miniPIERS (Pre-eclampsia Integrated Estimate of Risk) Multi-country Prospective Cohort Study","volume":"11","author":"BA Payne","year":"2014","journal-title":"PLoS Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.12659\/MSM.883932","article-title":"A comparison of maternal plasma levels of endothelial nitric oxide synthase, asymmetric dimethylarginine, and Hcy in normal and preeclamptic pregnancies","volume":"19","author":"M Laskowska","year":"2013","journal-title":"Med Sci Monit"},{"key":"ref3","first-page":"101","article-title":"Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease?","volume":"51","author":"JC Guilland","year":"2003","journal-title":"Pathol Biol (Paris)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s00404-013-2851-7","article-title":"Erythrocyte folate content and plasma folic acid and Hcy levels in preeclamptic primigravidae teenagers living at high altitude","volume":"288","author":"P Yanez","year":"2013","journal-title":"Arch Gynecol Obstet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1053\/plac.1999.0417","article-title":"Folic acid and Hcy metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review","volume":"20","author":"JG Ray","year":"1999","journal-title":"Placenta"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0301-2115(02)00367-6","article-title":"Plasma total Hcy in uncomplicated pregnancy and in preeclampsia","volume":"108","author":"E1 L\u00f3pez-Quesada","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref7","article-title":"Birth Outcomes of Newborns after Folic Acid Supplementation in Pregnant Women with Early and Late Pre-Eclampsia: A Population-Based Study","author":"F B\u00e1nhidy","year":"2011","journal-title":"Adv Prev Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"45.e1","DOI":"10.1016\/j.ajog.2007.06.067","article-title":"Folic acid supplementation in early second trimester and the risk of pre-eclampsia","volume":"198","author":"SW Wen","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1365-3016.2005.00633.x","article-title":"Folic acid supplements in pregnancy and birth outcome: re-analysis of a large randomised controlled trial and update of Cochrane review","volume":"19","author":"DH Charles","year":"2005","journal-title":"Paediatr Perinat Epidemiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/HYPERTENSIONAHA.111.00230","article-title":"Folic acid supplementation during early pregnancy and the risk of gestational hypertension and pre-eclmpsia","volume":"61","author":"Z Li","year":"2013","journal-title":"Hypertension"},{"key":"ref11","first-page":"775","article-title":"Hcy metabolism disorders as a potential predictor of preeclamsia","volume":"79","author":"A1 Kajdy","year":"2008","journal-title":"Ginekol Pol"},{"key":"ref12","first-page":"294312","article-title":"Effect of folic acid supplementation in pregnancy on preeclampsia: the folic acid clinical trial study","volume":"2013","author":"SW Wen","year":"2013","journal-title":"J Pregnancy"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.preghy.2012.04.041","article-title":"Effect of folic acid supplementation in pregnancy on preeclampsia- Folic acid clinical trial (FACT)","volume":"2","author":"SW Wen","year":"2012","journal-title":"Pregnancy Hypertens"},{"issue":"1","key":"ref14","first-page":"1","article-title":"A brief overview of preeclampsia","volume":"6","author":"N Al-Jameil","year":"2014","journal-title":"J Clin Med Res"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1097\/AOG.0b013e3182571669","article-title":"First-trimester prediction of preeclampsia in nulliparous women at low risk","volume":"119","author":"L Myatt","year":"2012","journal-title":"Obstet Gynecol"},{"key":"ref16","first-page":"88","article-title":"Comparison study on the effect of prenatal administration of high dose and low dose folic acid","volume":"30","author":"SM Manizheh","year":"2009","journal-title":"Saudi Med J"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0022-3565(24)36853-3","article-title":"Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans","volume":"282","author":"FM Loehrer","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/ajcn\/71.4.962","article-title":"Plasma total Hcy, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Hcy study","volume":"71","author":"SE Vollset","year":"2000","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.thromres.2014.05.025","article-title":"Relationship between homocysteine and coronary artery disease. Results from a large prospective cohort study","volume":"134","author":"A Schaffer","year":"2014","journal-title":"Thromb Res"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1524-6175.2004.03643.x","article-title":"Relationship of homocysteine with cardiovascular disease and blood pressure","volume":"6","author":"R Dinavahi","year":"2004","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"ref21","first-page":"187","article-title":"Plasma Hcy concentration and its relationship with the development of preeclampsia. Effect of prenatal administration of folic acid","volume":"46","author":"M Fernandez","year":"2005","journal-title":"Invest Clin"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.17772\/gp\/2075","article-title":"The evaluation of homocysteine level in patients with preeclampsia","volume":"86","author":"F \u015eanl\u0131kan","year":"2015","journal-title":"Ginekol Pol"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"5900","DOI":"10.3390\/nu6125900","article-title":"Distribution and determinants of plasma homocysteine levels in rural Chinese twins across the lifespan","volume":"6","author":"Y Ji","year":"2014","journal-title":"Nutrients"},{"key":"ref24","first-page":"394","article-title":"Identifying women who might benefit from higher doses of folic acid in pregnancy","volume":"58","author":"D Kennedy","year":"2012","journal-title":"Can Fam Physician"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1161\/HYPERTENSIONAHA.107.108837","article-title":"Recent Progress Toward the Understanding of the Pathophysiology of Hypertension During Preeclampsia","volume":"51","author":"BD LaMarca","year":"2008","journal-title":"Hypertension"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1055\/s-2005-872404","article-title":"Hcy and folic acid: implications for pregnancy","volume":"5","author":"S Daly","year":"2005","journal-title":"Semin Vasc Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1093\/aje\/kwp052","article-title":"Association of periconceptional multivitamin use with reduced risk of preeclampsia among normal-weight women in the Danish National Birth Cohort","volume":"169","author":"JM Catov","year":"2009","journal-title":"Am J Epidemiol"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1007\/s00415-008-0029-1","article-title":"Spontaneous abortion and the prophylactic effect of folic acid supplementation in epileptic women undergoing antiepileptic therapy","volume":"255","author":"S Pittschieler","year":"2008","journal-title":"J Neurol"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.3945\/ajcn.111.026690","article-title":"Folic acid supplementation and risk reduction in preterm birth","volume":"94","author":"AE Czeizel","year":"2011","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1017\/S0007114509288994","article-title":"Periconception folic acid supplementation, fetal growth and the risks of low birth weight and preterm birth: the Generation R Study","volume":"102","author":"S Timmermans","year":"2009","journal-title":"Br J Nutr"},{"key":"ref31","first-page":"605","article-title":"Protective effects and its mechanism on neural cells after folic acid intervention in pre-eclampsiarat model","volume":"46","author":"J Wang","year":"2011","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12291-011-0109-3","article-title":"study of plasma hemocystein, folic acid and vitamin B12 in patients with pre-eclmpsia","volume":"26","author":"Shahid A. Mujawar","year":"2011","journal-title":"Indian J Clin Biochem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejogrb.2009.10.016","article-title":"Possible association of folic acid supplementation during pregnancy with reduction of preterm birth: a population-based study","volume":"148","author":"AE Czeizel","year":"2010","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1447-0756.2010.01317.x","article-title":"Hcy, folic acid and vitamin B12 levels in maternal and umbilical cord plasma and Hcy levels in placenta in pregnant women with pre-eclampsia","volume":"37","author":"YG Acilmis","year":"2011","journal-title":"J Obstet Gynaecol Res"},{"issue":"6","key":"ref35","first-page":"461","article-title":"Association of the folic acid consumption and its serum levels with preeclampsia in pregnant women","volume":"17","author":"H Salehi-PourMehr","year":"2012","journal-title":"Iran J Nurs Midwifery Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/ijc.28038","article-title":"Folic acid supplementation and cancer risk: a meta-analysis of randomized controlled trials","volume":"133","author":"X Qin","year":"2013","journal-title":"Int J Cancer"},{"issue":"8","key":"ref37","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/jech-2014-205324","article-title":"Folic acid in pregnancy and mortality from cancer and cardiovascular disease: further follow-up of the Aberdeen folic acid supplementation trial","volume":"69","author":"CM Taylor","year":"2015","journal-title":"J Epidemiol Community Health"},{"issue":"9871","key":"ref38","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0140-6736(12)62001-7","article-title":"Effects of folic acid on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50 000 individuals","volume":"381","author":"SE Vollset","year":"2013","journal-title":"Lancet"},{"issue":"11","key":"ref39","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1158\/1940-6207.CAPR-14-0143","article-title":"Folate and vitamin B12 may play a critical role in lowering the HPV 16 methylation-associated risk of developing higher grades of CIN","volume":"7","author":"CJ Piyathilake","year":"2014","journal-title":"Cancer Prev Res (Phila)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0154400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T03:40:40Z","timestamp":1748922040000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0154400"}},"subtitle":[],"editor":[{"given":"D William","family":"Cameron","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,11]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0154400","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,11]]}}}