{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:59:25Z","timestamp":1767877165156,"version":"3.49.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0154405","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T19:00:01Z","timestamp":1461870001000},"page":"e0154405","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Moderate Exercise Attenuates Lipopolysaccharide-Induced Inflammation and Associated Maternal and Fetal Morbidities in Pregnant Rats"],"prefix":"10.1371","volume":"11","author":[{"given":"Karina T.","family":"Kasawara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Cotechini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannyn K.","family":"Macdonald-Goodfellow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda G.","family":"Surita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o L.","family":"Pinto e Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandrakant","family":"Tayade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha","family":"Othman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence R. S.","family":"Ozolin\u0161","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"issue":"8788","key":"ref1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0140-6736(92)91342-6","article-title":"Customised antenatal growth charts","volume":"339","author":"J Gardosi","year":"1992","journal-title":"Lancet"},{"issue":"8\u20139","key":"ref2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.placenta.2004.02.004","article-title":"Fetal growth restriction: a workshop report","volume":"25","author":"I Cetin","year":"2004","journal-title":"Placenta"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00003081-199203000-00015","article-title":"Intrauterine growth retardation: definition, classification, and etiology","volume":"35","author":"RN Pollack","year":"1992","journal-title":"Clin Obstet Gynecol"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.semnephrol.2004.07.005","article-title":"Preeclampsia and the systemic inflammatory response","volume":"24","author":"CW Redman","year":"2004","journal-title":"Semin Nephrol"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3109\/14767051003774942","article-title":"Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by preeclampsia","volume":"23","author":"M Tosun","year":"2010","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/01443615.2012.721821","article-title":"Serum levels of adrenomedullin and inflammatory cytokines in women with term idiopathic intrauterine growth restriction","volume":"33","author":"AK Elfayomy","year":"2013","journal-title":"J Obstet Gynaecol"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1084\/jem.20130295","article-title":"Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia","volume":"211","author":"T Cotechini","year":"2014","journal-title":"J Exp Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1471-2172-11-59","article-title":"Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array","volume":"11","author":"A Szarka","year":"2010","journal-title":"BMC Immunol"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s11906-007-0088-1","article-title":"Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia","volume":"9","author":"BD LaMarca","year":"2007","journal-title":"Curr Hypertens Rep"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.siny.2006.04.001","article-title":"Inflammation and pre-eclampsia","volume":"11","author":"AM Borzychowski","year":"2006","journal-title":"Semin Fetal Neonatal Med"},{"issue":"2 Pt 1","key":"ref11","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0002-9378(99)70239-5","article-title":"Preeclampsia: an excessive maternal inflammatory response to pregnancy","volume":"180","author":"CW Redman","year":"1999","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"ref12","first-page":"533","article-title":"Placental pathology in pregnancy-induced hypertension (PIH) with or without intrauterine growth retardation","volume":"50","author":"K Jain","year":"2007","journal-title":"Indian J Pathol Microbiol"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1161\/01.HYP.33.1.83","article-title":"Evidence for peroxynitrite formation in the vasculature of women with preeclampsia","volume":"33","author":"AM Roggensack","year":"1999","journal-title":"Hypertension"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1006\/niox.2000.0296","article-title":"Nitric oxide dysfunction in the pathophysiology of preeclampsia","volume":"4","author":"DT Lowe","year":"2000","journal-title":"Nitric Oxide"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s11845-011-0737-x","article-title":"Coagulation and prothrombotic state parameters: a clinical analysis during early pregnancy","volume":"180","author":"H Chen","year":"2011","journal-title":"Ir J Med Sci"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.bpobgyn.2013.08.002","article-title":"Managing haematological disorders during pregnancy","volume":"27","author":"MB Koh","year":"2013","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"e114488","DOI":"10.1371\/journal.pone.0114488","article-title":"Blood coagulation parameters and platelet indices: changes in normal and preeclamptic pregnancies and predictive values for preeclampsia","volume":"9","author":"L Han","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1160\/TH11-09-0626","article-title":"Abnormal inflammation leads to maternal coagulopathies associated with placental haemostatic alterations in a rat model of foetal loss","volume":"107","author":"BJ Falcon","year":"2012","journal-title":"Thromb Haemost"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1160\/TH11-10-0730","article-title":"Nitroglycerin prevents coagulopathies and foetal death associated with abnormal maternal inflammation in rats","volume":"107","author":"T Cotechini","year":"2012","journal-title":"Thromb Haemost"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1447-0756.2009.01079.x","article-title":"Recurrent pregnancy loss: a disease of inflammation and coagulation","volume":"35","author":"J Kwak-Kim","year":"2009","journal-title":"J Obstet Gynaecol Res"},{"key":"ref21","first-page":"Artn Cd006780","article-title":"Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction","volume":"7","author":"JM Dodd","year":"2013","journal-title":"Cochrane Db Syst Rev"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/01.AOG.0000248537.89739.96","article-title":"Fetal death","volume":"109","author":"RM Silver","year":"2007","journal-title":"Obstet Gynecol"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.4049\/jimmunol.1002679","article-title":"Spontaneous pregnancy loss mediated by abnormal maternal inflammation in rats is linked to deficient uteroplacental perfusion","volume":"186","author":"SJ Renaud","year":"2011","journal-title":"J Immunol"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nri3041","article-title":"The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease","volume":"11","author":"M Gleeson","year":"2011","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1152\/japplphysiol.00164.2004","article-title":"The anti-inflammatory effect of exercise","volume":"98","author":"AM Petersen","year":"2005","journal-title":"J Appl Physiol (1985)"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/HCR.0000000000000015","article-title":"Effect of exercise training and weight loss on platelet reactivity in overweight patients with coronary artery disease","volume":"33","author":"FK Keating","year":"2013","journal-title":"J Cardiopulm Rehabil Prev"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1152\/japplphysiol.00017.2011","article-title":"Thrombosis, physical activity, and acute coronary syndromes","volume":"111","author":"A Kumar","year":"2011","journal-title":"J Appl Physiol (1985)"},{"issue":"Suppl 3","key":"ref28","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1016\/j.hlc.2007.03.014","article-title":"Exercise\u2014is it possible to have too much of a good thing?","volume":"16","author":"A La Gerche","year":"2007","journal-title":"Heart Lung Circ"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1139\/cjpp-2013-0486","article-title":"Exercise and vascular function: how much is too much?","volume":"92","author":"MJ Durand","year":"2014","journal-title":"Can J Physiol Pharmacol"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1139\/h06-060","article-title":"Exercise in the prevention and treatment of maternal-fetal disease: a review of the literature","volume":"31","author":"TL Weissgerber","year":"2006","journal-title":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1067\/mob.2000.107096","article-title":"Beginning regular exercise in early pregnancy: effect on fetoplacental growth","volume":"183","author":"JF Clapp 3rd","year":"2000","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"H576","DOI":"10.1152\/ajpheart.00946.2008","article-title":"Sarcalumenin is essential for maintaining cardiac function during endurance exercise training","volume":"297","author":"Q Jiao","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1113\/expphysiol.2009.047621","article-title":"Can physical exercise during gestation attenuate the effects of a maternal perinatal low-protein diet on oxygen consumption in rats?","volume":"94","author":"MF Amorim","year":"2009","journal-title":"Exp Physiol"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0890-6238(92)90009-I","article-title":"Relationship between fetal weight and litter size in rats: application to reproductive toxicology studies","volume":"6","author":"A Romero","year":"1992","journal-title":"Reprod Toxicol"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1161\/HYPERTENSIONAHA.113.01983","article-title":"Novel role of the renin-angiotensin system in preeclampsia superimposed on chronic hypertension and the effects of exercise in a mouse model","volume":"62","author":"DS Genest","year":"2013","journal-title":"Hypertension"},{"issue":"12","key":"ref36","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1097\/HJH.0b013e32833e97d0","article-title":"Exercise training can attenuate preeclampsia-like features in an animal model","volume":"28","author":"S Falcao","year":"2010","journal-title":"J Hypertens"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1161\/HYPERTENSIONAHA.112.202275","article-title":"Exercise training attenuates placental ischemia-induced hypertension and angiogenic imbalance in the rat","volume":"60","author":"JS Gilbert","year":"2012","journal-title":"Hypertension"},{"issue":"9","key":"ref38","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1590\/S0102-8650201400150002","article-title":"Effect of exercise on the maternal outcome in pregnancy of spontaneously hypertensive rats","volume":"29","author":"R Rocha","year":"2014","journal-title":"Acta Cir Bras"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"R1321","DOI":"10.1152\/ajpregu.2000.279.4.R1321","article-title":"Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats","volume":"279","author":"A Moraska","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0020-7292(02)80004-2","article-title":"ACOG committee opinion. Exercise during pregnancy and the postpartum period. Number 267, January 2002. American College of Obstetricians and Gynecologists","volume":"77","year":"2002","journal-title":"Int J Gynaecol Obstet"},{"issue":"6","key":"ref41","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1590\/S0100-879X2004000600017","article-title":"Effect of strenuous maternal exercise before and during pregnancy on rat progeny renal function","volume":"37","author":"AO Oliveira","year":"2004","journal-title":"Braz J Med Biol Res"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"179.e1","DOI":"10.1016\/j.ajog.2012.07.021","article-title":"Strenuous exercise during pregnancy: is there a limit?","volume":"207","author":"LM Szymanski","year":"2012","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.thromres.2004.09.019","article-title":"Coagulation status and complications of pregnancy","volume":"115","author":"FM Miall","year":"2005","journal-title":"Thromb Res"},{"issue":"12","key":"ref44","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1093\/humrep\/deg494","article-title":"Thromboelastography, whole-blood haemostasis and recurrent miscarriage","volume":"18","author":"R Rai","year":"2003","journal-title":"Hum Reprod"},{"issue":"6","key":"ref45","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s11373-006-9105-7","article-title":"Exercise prescription and thrombogenesis","volume":"13","author":"JS Wang","year":"2006","journal-title":"J Biomed Sci"},{"key":"ref46","article-title":"Short- and Long-term exercise induced alterations in haemostasis: a review of the literature","author":"JJ Posthuma","year":"2014","journal-title":"Blood Rev"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2147\/IJGM.S29197","article-title":"The interactions between hemostasis and resistance training: a review","volume":"5","author":"C Nascimento Dda","year":"2012","journal-title":"Int J Gen Med"},{"issue":"6","key":"ref48","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.thromres.2007.10.011","article-title":"Physical activity in patients with deep venous thrombosis: a systematic review","volume":"122","author":"SR Kahn","year":"2008","journal-title":"Thromb Res"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"e227","DOI":"10.1016\/j.thromres.2013.02.014","article-title":"Beneficial effects of habitual resistance exercise training on coagulation and fibrinolytic responses","volume":"131","author":"BR Kupchak","year":"2013","journal-title":"Thromb Res"},{"issue":"8","key":"ref50","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.placenta.2015.05.016","article-title":"Aberrant maternal inflammation as a cause of pregnancy complications: A potential therapeutic target?","volume":"36","author":"T Cotechini","year":"2015","journal-title":"Placenta"},{"issue":"5","key":"ref51","first-page":"1510","article-title":"Glomerular inflammation in pregnant rats after infusion of low dose endotoxin. An immunohistological study in experimental pre-eclampsia","volume":"147","author":"MM Faas","year":"1995","journal-title":"Am J Pathol"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0002-9378(94)90463-4","article-title":"A new animal model for human preeclampsia: ultra-low-dose endotoxin infusion in pregnant rats","volume":"171","author":"MM Faas","year":"1994","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/S0002-9378(11)90785-6","article-title":"Does &quot;idiopathic&quot; preterm labor resulting in preterm birth exist?","volume":"168","author":"L Lettieri","year":"1993","journal-title":"Am J Obstet Gynecol"},{"issue":"9","key":"ref54","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/01.ogx.0000279292.63435.40","article-title":"Periodontal disease and pregnancy outcomes: state-of-the-science","volume":"62","author":"X Xiong","year":"2007","journal-title":"Obstetrical & gynecological survey"},{"issue":"2","key":"ref55","doi-asserted-by":"crossref","first-page":"135.e1","DOI":"10.1016\/j.ajog.2006.09.028","article-title":"Preterm low birth weight and maternal periodontal status: a meta-analysis","volume":"196","author":"JN Vergnes","year":"2007","journal-title":"Am J Obstet Gynecol"},{"issue":"12","key":"ref56","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1600-051X.2010.01636.x","article-title":"Periodontal disease and pre-eclampsia: a systematic review","volume":"37","author":"A Kunnen","year":"2010","journal-title":"J Clin Periodontol"},{"issue":"6","key":"ref57","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/odi.12177","article-title":"The effect of Porphyromonas gingivalis lipopolysaccharide on pregnancy in the rat","volume":"20","author":"A Kunnen","year":"2014","journal-title":"Oral Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0154405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T02:08:07Z","timestamp":1655604487000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0154405"}},"subtitle":[],"editor":[{"given":"Victor","family":"Sanchez-Margalet","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,4,28]]},"references-count":57,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0154405","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,28]]}}}