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Munn","year":"2005","journal-title":"Immunity"},{"issue":"1","key":"ref76","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/jcp.22220","article-title":"High expression of IMPACT protein promotes resistance to indoleamine 2,3-dioxygenase-induced cell death","volume":"225","author":"D Habibi","year":"2010","journal-title":"J Cell Physiol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0014-5793(99)00956-4","article-title":"Ap<sub>4<\/sub>A induces apoptosis in cultured human cells","volume":"456","author":"A Vartanian","year":"1999","journal-title":"FEBS Lett"},{"issue":"8","key":"ref78","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/ijc.25505","article-title":"Nudix-type motif 2 in human breast carcinoma: a potent prognostic factor associated with cell proliferation","volume":"128","author":"K Oka","year":"2011","journal-title":"Int J Cancer"},{"issue":"23","key":"ref79","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1007\/s00018-014-1722-0","article-title":"The FHIT gene product: tumor suppressor and genome &quot;caretaker&quot;","volume":"71","author":"CE Waters","year":"2014","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"ref80","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.18632\/oncotarget.3040","article-title":"DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance","volume":"6","author":"RM Huber","year":"2015","journal-title":"Oncotarget"},{"issue":"14","key":"ref81","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.1158\/0008-5472.CAN-06-4394","article-title":"BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor\/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines","volume":"67","author":"A Naderi","year":"2007","journal-title":"Cancer Res"},{"issue":"19","key":"ref82","doi-asserted-by":"crossref","first-page":"E2008","DOI":"10.1073\/pnas.1402944111","article-title":"GFRalpha1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling","volume":"111","author":"S He","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref83","doi-asserted-by":"crossref","first-page":"e76773","DOI":"10.1371\/journal.pone.0076773","article-title":"Transcription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancer","volume":"8","author":"H Roca","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"ref84","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jhep.2015.05.005","article-title":"EDIL3 is a novel regulator of epithelial-mesenchymal transition controlling early recurrence of hepatocellular carcinoma","volume":"63","author":"H Xia","year":"2015","journal-title":"J Hepatol"},{"issue":"13","key":"ref85","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1158\/0008-5472.CAN-12-4150","article-title":"Identification of two distinct carcinoma-associated fibroblast subtypes with differential tumor-promoting abilities in oral squamous cell carcinoma","volume":"73","author":"DE Costea","year":"2013","journal-title":"Cancer Res"},{"issue":"13","key":"ref86","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1093\/nar\/gkt410","article-title":"IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG)","volume":"41","author":"A Zirkel","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"ref87","first-page":"309","article-title":"Cervical squamous cancer mRNA profiles reveal the key genes of metastasis and invasion","volume":"36","author":"Y Cheng","year":"2015","journal-title":"Eur J Gynaecol Oncol"},{"issue":"4","key":"ref88","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s10456-014-9437-2","article-title":"TM4SF1: a new vascular therapeutic target in cancer","volume":"17","author":"CI Lin","year":"2014","journal-title":"Angiogenesis"},{"issue":"8","key":"ref89","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/WNR.0000000000000370","article-title":"Transmembrane-4-L-six-family-1, a potential predictor for poor prognosis, overexpressed in human glioma","volume":"26","author":"P Wang","year":"2015","journal-title":"Neuroreport"},{"issue":"2","key":"ref90","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3892\/ijo.2013.2189","article-title":"hsa-miR-141 downregulates TM4SF1 to inhibit pancreatic cancer cell invasion and migration","volume":"44","author":"L Xu","year":"2014","journal-title":"Int J Oncol"},{"issue":"3","key":"ref91","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1210\/en.2006-0905","article-title":"Bone morphogenetic protein and retinoic acid-inducible neural specific protein-3 is expressed in gonadotrope cell pituitary adenomas and induces proliferation, migration, and invasion","volume":"148","author":"L Shorts-Cary","year":"2007","journal-title":"Endocrinol"},{"issue":"1","key":"ref92","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3892\/mmr.2014.2691","article-title":"PACE4 regulates proliferation, migration and invasion in human breast cancer MDA-MB-231 cells","volume":"11","author":"F Wang","year":"2015","journal-title":"Mol Med Rep"},{"issue":"370","key":"ref93","doi-asserted-by":"crossref","first-page":"ra32","DOI":"10.1126\/scisignal.2005840","article-title":"PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion","volume":"8","author":"SM Mense","year":"2015","journal-title":"Sci Signal"},{"issue":"17","key":"ref94","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1158\/1078-0432.CCR-12-1662","article-title":"Molecular pathways: P-Rex in cancer","volume":"19","author":"A Pandiella","year":"2013","journal-title":"Clin Cancer Res"},{"issue":"3","key":"ref95","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.yexmp.2015.03.029","article-title":"Overexpression of DNAJC12 predicts poor response to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer","volume":"98","author":"HL He","year":"2015","journal-title":"Exp Mol Pathol"},{"issue":"2","key":"ref96","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.bbrc.2014.03.019","article-title":"FoxD3 deficiency promotes breast cancer progression by induction of epithelial-mesenchymal transition","volume":"446","author":"TL Chu","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"ref97","first-page":"670","article-title":"Downregulation of the transcription factor, FoxD3, is associated with lymph node metastases in invasive ductal carcinomas of the breast","volume":"7","author":"H Zhao","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"issue":"11","key":"ref98","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.18632\/oncotarget.1579","article-title":"FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma","volume":"4","author":"D Li","year":"2013","journal-title":"Oncotarget"},{"issue":"1","key":"ref99","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1053\/j.gastro.2012.11.014","article-title":"FoxD3 is a novel, epigenetically regulated tumor suppressor in gastric carcinogenesis","volume":"144","author":"CA Schmid","year":"2013","journal-title":"Gastroenterology"},{"issue":"26","key":"ref100","doi-asserted-by":"crossref","first-page":"22126","DOI":"10.18632\/oncotarget.4244","article-title":"Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth","volume":"6","author":"Y Dong","year":"2015","journal-title":"Oncotarget"},{"issue":"39","key":"ref101","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1038\/onc.2014.429","article-title":"NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma","volume":"34","author":"S Zhao","year":"2015","journal-title":"Oncogene"},{"issue":"10","key":"ref102","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/carcin\/bgv108","article-title":"LIFR functions as a metastasis suppressor in hepatocellular carcinoma by negatively regulating phosphoinositide 3-kinase\/AKT pathway","volume":"36","author":"Q Luo","year":"2015","journal-title":"Carcinogenesis"},{"issue":"19","key":"ref103","doi-asserted-by":"crossref","first-page":"17366","DOI":"10.18632\/oncotarget.3953","article-title":"MicroRNA-125a influences breast cancer stem cells by targeting leukemia inhibitory factor receptor which regulates the Hippo signaling pathway","volume":"6","author":"SB Nandy","year":"2015","journal-title":"Oncotarget"},{"issue":"1","key":"ref104","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/BJ20131587","article-title":"Mechanisms of transcriptional regulation by WT1 (Wilms&apos; tumour 1)","volume":"461","author":"E Toska","year":"2014","journal-title":"Biochem J"},{"issue":"1","key":"ref105","first-page":"61","article-title":"Wilms&apos; tumor 1 is involved in tumorigenicity of glioblastoma by regulating cell proliferation and apoptosis","volume":"34","author":"N Kijima","year":"2014","journal-title":"Anticancer Res"},{"issue":"43","key":"ref106","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1038\/onc.2013.447","article-title":"Prohibitin is required for transcriptional repression by the WT1-BASP1 complex","volume":"33","author":"E Toska","year":"2014","journal-title":"Oncogene"},{"issue":"6","key":"ref107","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.18632\/oncotarget.1444","article-title":"Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer","volume":"5","author":"JA Puig-Butille","year":"2014","journal-title":"Oncotarget"},{"issue":"3","key":"ref108","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1158\/0008-5472.CAN-07-2608","article-title":"Tumor immunobiological differences in prostate cancer between African-American and European-American men","volume":"68","author":"TA Wallace","year":"2008","journal-title":"Cancer Res"},{"issue":"9","key":"ref109","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/labinvest.2015.80","article-title":"Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors","volume":"95","author":"AE Sarver","year":"2015","journal-title":"Lab Invest"},{"issue":"5","key":"ref110","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1158\/1541-7786.MCR-14-0680","article-title":"The Tumor Suppressor NKX3.1 Is Targeted for Degradation by DYRK1B Kinase","volume":"13","author":"LN Song","year":"2015","journal-title":"Mol Cancer Res"},{"issue":"32","key":"ref111","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1038\/onc.2014.357","article-title":"Coiled-coil domain containing 68 (CCDC68) demonstrates a tumor-suppressive role in pancreatic ductal adenocarcinoma","volume":"34","author":"N Radulovich","year":"2015","journal-title":"Oncogene"},{"issue":"17","key":"ref112","doi-asserted-by":"crossref","first-page":"7131","DOI":"10.1073\/pnas.0902232106","article-title":"Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer","volume":"106","author":"M Sheffer","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1101\/sqb.2013.78.020321","article-title":"The IRF family transcription factors at the interface of innate and adaptive immune responses","volume":"78","author":"H Ikushima","year":"2013","journal-title":"Cold Spring Harb Symp Quant Biol"},{"issue":"20","key":"ref114","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1182\/blood-2014-05-578575","article-title":"The oncogenic transcription factor IRF4 is regulated by a novel CD30\/NF-\u03baB positive feedback loop in peripheral T-cell lymphoma","volume":"125","author":"RL Boddicker","year":"2015","journal-title":"Blood"},{"issue":"7201","key":"ref115","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature07064","article-title":"IRF4 addiction in multiple myeloma","volume":"454","author":"AL Shaffer","year":"2008","journal-title":"Nature"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1756-8722-7-21","article-title":"Cysteine- rich secretory protein 3 (CRISP3), ERG and PTEN define a molecular subtype of prostate cancer with implication to patients&apos; prognosis","volume":"7","author":"S Al Bashir","year":"2014","journal-title":"J Hematol Oncol"},{"issue":"1","key":"ref117","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3892\/ol.2011.418","article-title":"Copy number changes of CRISP3 in oral squamous cell carcinoma","volume":"3","author":"WC Ko","year":"2012","journal-title":"Oncol Lett"},{"issue":"2","key":"ref118","doi-asserted-by":"crossref","first-page":"e87761","DOI":"10.1371\/journal.pone.0087761","article-title":"A gene expression and pre-mRNA splicing signature that marks the adenoma-adenocarcinoma progression in colorectal cancer","volume":"9","author":"M Pesson","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"ref119","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3892\/ol.2011.300","article-title":"The emerging role of CXCL10 in cancer (Review)","volume":"2","author":"M Liu","year":"2011","journal-title":"Oncol Lett"},{"issue":"6","key":"ref120","doi-asserted-by":"crossref","first-page":"971","DOI":"10.4161\/onci.20034","article-title":"The role of tumor expression of CD200 in tumor formation, metastasis and susceptibility to T lymphocyte adoptive transfer therapy","volume":"1","author":"F Talebian","year":"2012","journal-title":"Oncoimmunol"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fonc.2014.00004","article-title":"Syndecans as modulators and potential pharmacological targets in cancer progression","volume":"4","author":"D Barbouri","year":"2014","journal-title":"Front Oncol"},{"issue":"6","key":"ref122","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1517\/14728222.2013.773313","article-title":"Targeting syndecans: a promising strategy for the treatment of cancer","volume":"17","author":"S Choi","year":"2013","journal-title":"Expert Opin Ther Targets"},{"issue":"3","key":"ref123","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/leu.2012.280","article-title":"Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma","volume":"27","author":"V Bohle","year":"2013","journal-title":"Leukemia"},{"issue":"6","key":"ref124","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/mt.2012.59","article-title":"Lentiviral vector induced insertional haploinsufficiency of Ebf1 causes murine leukemia","volume":"20","author":"D Heckl","year":"2012","journal-title":"Mol Ther"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2015.07.007","article-title":"CD70: An emerging target in cancer immunotherapy","volume":"155","author":"J Jacobs","year":"2015","journal-title":"Pharmacol Ther"},{"issue":"10","key":"ref126","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/mc.22375","article-title":"Transglutaminase is a tumor cell and cancer stem cell survival factor","volume":"54","author":"RL Eckert","year":"2015","journal-title":"Mol Carcinog"},{"issue":"12","key":"ref127","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/cgt.2015.41","article-title":"Tumor suppressor microRNA-31 inhibits gastric carcinogenesis by targeting Smad4 and SGPP2","volume":"22","author":"W Ruoming","year":"2015","journal-title":"Cancer Gene Ther"},{"issue":"10","key":"ref128","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/nm934","article-title":"Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase","volume":"9","author":"C Uyttenhove","year":"2003","journal-title":"Nat Med"},{"issue":"3","key":"ref129","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nm1196","article-title":"Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy","volume":"11","author":"AJ Muller","year":"2005","journal-title":"Nat Med"},{"issue":"18","key":"ref130","doi-asserted-by":"crossref","first-page":"8065","DOI":"10.1158\/0008-5472.CAN-05-2213","article-title":"Marrying immunotherapy with chemotherapy: why say IDO?","volume":"65","author":"AJ Muller","year":"2005","journal-title":"Cancer Res"},{"issue":"2","key":"ref131","first-page":"179","article-title":"O(6)-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: enzyme activity, promoter methylation and immunohistochemistry","volume":"1816","author":"M Christmann","year":"2011","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"ref132","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3892\/ijo.2015.3026","article-title":"Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review)","volume":"47","author":"G Cabrini","year":"2015","journal-title":"Int J Oncol"},{"issue":"5","key":"ref133","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/emboj.2013.11","article-title":"hCAF1\/CNOT7 regulates interferon signalling by targeting STAT1","volume":"32","author":"C Chapat","year":"2013","journal-title":"EMBO J"},{"key":"ref134","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pharmthera.2015.05.008","article-title":"Sp1 transcription factor: A long-standing target in cancer chemotherapy","volume":"152","author":"C Vizcaino","year":"2015","journal-title":"Pharmacol Ther"},{"issue":"2","key":"ref135","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/febs.13148","article-title":"Sp1 and the &apos;hallmarks of cancer&apos;","volume":"282","author":"K Beishline","year":"2015","journal-title":"FEBS J"},{"issue":"8","key":"ref136","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.4049\/jimmunol.1100688","article-title":"Cohesin regulates MHC class II genes through interactions with MHC class II insulators","volume":"187","author":"P Majumder","year":"2011","journal-title":"J Immunol"},{"issue":"1","key":"ref137","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1091\/mbc.E13-06-0306","article-title":"PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome","volume":"25","author":"RA Bowe","year":"2014","journal-title":"Mol Biol Cell"},{"issue":"6","key":"ref138","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1755-148X.2008.00505.x","article-title":"Novel MITF targets identified using a two-step DNA microarray strategy","volume":"21","author":"KS Hoek","year":"2008","journal-title":"Pig Cell Mel Res"},{"issue":"11","key":"ref139","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.4161\/cc.20765","article-title":"The tumor suppressor HINT1 regulates MITF and \u03b2-catenin transcriptional activity in melanoma cells","volume":"11","author":"G Genovese","year":"2012","journal-title":"Cell Cycle"},{"issue":"7","key":"ref140","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/ijc.24072","article-title":"HINT1 inhibits \u03b2-catenin\/TCF4, USF2 and NF\u03baB activity in human hepatoma cells","volume":"124","author":"L Wang","year":"2009","journal-title":"Int J Cancer"},{"issue":"Pt 14","key":"ref141","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1242\/jcs.02437","article-title":"The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-\u03b2-catenin-mediated transcription","volume":"118","author":"J Weiske","year":"2005","journal-title":"J Cell Sci"},{"issue":"2","key":"ref142","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1083\/jcb.200711150","article-title":"The HINT1 tumor suppressor regulates both \u03b3-H2AX and ATM in response to DNA damage","volume":"183","author":"H Li","year":"2008","journal-title":"J Cell Biol"},{"issue":"4","key":"ref143","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s11302-014-9427-2","article-title":"Purinergic signalling and immune cells","volume":"10","author":"G Burnstock","year":"2014","journal-title":"Purinergic Signal"},{"issue":"5","key":"ref144","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00424-006-0066-5","article-title":"Dinucleoside polyphosphates and their interaction with other nucleotide signaling pathways","volume":"452","author":"EG Delicado","year":"2006","journal-title":"Pflugers Archiv-Eur J Physiol"},{"issue":"6","key":"ref145","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.mam.2013.01.005","article-title":"PARP-1 and gene regulation: progress and puzzles","volume":"34","author":"WL Kraus","year":"2013","journal-title":"Mol Aspects Med"},{"key":"ref146","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0006-291X(81)91240-7","article-title":"Inhibition of ADP-ribosylation of histone by diadenosine 5&apos;,5\u2034-P<sup>1<\/sup>,P<sup>4<\/sup>- tetraphosphate","volume":"99","author":"Y Tanaka","year":"1981","journal-title":"Biochem Biophys Res Commun"},{"issue":"13","key":"ref147","doi-asserted-by":"crossref","first-page":"6756","DOI":"10.1016\/S0021-9258(19)69056-3","article-title":"ADP-ribosylation of diadenosine 5&apos;,5\u2034-<italic>P<\/italic><sup>1<\/sup>,<italic>P<\/italic><sup>4<\/sup>- tetraphosphate by poly(ADP-ribose) polymerase <italic>in vitro<\/italic>","volume":"256","author":"Y Yoshihara","year":"1981","journal-title":"J Biol Chem"},{"issue":"5600","key":"ref148","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","article-title":"The protein kinase complement of the human genome","volume":"298","author":"G Manning","year":"2002","journal-title":"Science"},{"issue":"10","key":"ref149","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1093\/nar\/gkn079","article-title":"Crystal structure of the 25 kDa subunit of human cleavage factor I<sub>m<\/sub>","volume":"36","author":"M Coseno","year":"2008","journal-title":"Nucleic Acids Res"},{"issue":"7505","key":"ref150","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nature13261","article-title":"CFIm25 links alternative polyadenylation to glioblastoma tumour suppression","volume":"510","author":"CP Masamha","year":"2014","journal-title":"Nature"},{"issue":"8","key":"ref151","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1021\/bm500872g","article-title":"Synthesis and evaluation of chromogenic and fluorogenic substrates for high-throughput detection of enzymes that hydrolyze inorganic polyphosphate","volume":"15","author":"CF Hebbard","year":"2014","journal-title":"Biomacromol"},{"issue":"49","key":"ref152","doi-asserted-by":"crossref","first-page":"47313","DOI":"10.1074\/jbc.M209795200","article-title":"Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate","volume":"277","author":"DI Fisher","year":"2002","journal-title":"J Biol Chem"},{"issue":"3","key":"ref153","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.molcel.2010.10.010","article-title":"Multiple mRNA decapping enzymes in mammalian cells","volume":"40","author":"MG Song","year":"2010","journal-title":"Mol Cell"},{"issue":"3","key":"ref154","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1261\/rna.037309.112","article-title":"Multiple Nudix family proteins possess mRNA decapping activity","volume":"19","author":"MG Song","year":"2013","journal-title":"RNA"},{"issue":"5","key":"ref155","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.biocel.2007.01.017","article-title":"Characterisation of a bis(5 &apos;-nucleosyl)-tetraphosphatase (asymmetrical) from <italic>Drosophila melanogaster<\/italic>","volume":"39","author":"L Winward","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"issue":"6220","key":"ref156","doi-asserted-by":"crossref","first-page":"1260419.1","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"M Uhlen","year":"2015","journal-title":"Science"},{"issue":"5","key":"ref157","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.cell.2014.10.050","article-title":"A proteome-scale map of the human interactome network","volume":"159","author":"T Rolland","year":"2014","journal-title":"Cell"},{"issue":"11","key":"ref158","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1002\/pmic.201400404","article-title":"Identification of cytoplasmic proteins interacting with unliganded estrogen receptor \u03b1 and \u03b2 in human breast cancer cells","volume":"15","author":"C Stellato","year":"2015","journal-title":"Proteomics"},{"issue":"11","key":"ref159","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/ng1901","article-title":"Genome-wide analysis of estrogen receptor binding sites","volume":"38","author":"JS Carroll","year":"2006","journal-title":"Nat Genet"},{"issue":"24","key":"ref160","doi-asserted-by":"crossref","first-page":"14784","DOI":"10.1016\/S0021-9258(17)43729-X","article-title":"Catabolism of diadenosine 5&apos;,5\u2034-P<sup>1<\/sup>,P<sup>4<\/sup>-tetraphosphate in procaryotes. Purification and properties of a diadenosine 5&apos;,5\u2034-P<sup>1<\/sup>,P<sup>4<\/sup>-tetraphosphate (<italic>symmetrical<\/italic>) pyrophosphohydrolase from <italic>Escherichia coli<\/italic> K12","volume":"258","author":"A Guranowski","year":"1983","journal-title":"J Biol Chem"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1042\/bj20011591","article-title":"PrpE, a PPP protein phosphatase from <italic>Bacillus subtilis<\/italic> with unusual substrate specificity","volume":"366","author":"A Iwanicki","year":"2002","journal-title":"Biochem J"},{"key":"ref162","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1042\/bj2680791","article-title":"Variation in intracellular P<sup>1<\/sup>,P<sup>4<\/sup>-bis(5&apos;-adenosyl) tetraphosphate (Ap<sub>4<\/sub>A) in virus-infected cells","volume":"268","author":"DJ Johnston","year":"1990","journal-title":"Biochem J"},{"key":"ref163","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1743-422X-7-31","article-title":"SARS coronavirus protein 7a interacts with human Ap4A hydrolase","volume":"7","author":"N Vasilenko","year":"2010","journal-title":"Virol J"},{"issue":"6253","key":"ref164","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1126\/science.aab3632","article-title":"Viruses transfer the antiviral second messenger cGAMP between cells","volume":"349","author":"A Bridgeman","year":"2015","journal-title":"Science"},{"issue":"6253","key":"ref165","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1126\/science.aab3628","article-title":"Transmission of innate immune signaling by packaging of cGAMP in viral particles","volume":"349","author":"M Gentili","year":"2015","journal-title":"Science"},{"issue":"1","key":"ref166","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1046\/j.1365-2958.2000.01840.x","article-title":"Identification of <italic>Escherichia coli<\/italic> K1 genes contributing to human brain microvascular endothelial cell invasion by differential fluorescence induction","volume":"36","author":"JL Badger","year":"2000","journal-title":"Mol Microbiol"},{"issue":"3","key":"ref167","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1074\/mcp.M100030-MCP200","article-title":"The <italic>Rickettsia prowazekii<\/italic> invasion gene homolog (<italic>invA<\/italic>) encodes a Nudix hydrolase active on adenosine (5&apos;)-pentaphospho-(5&apos;)-adenosine","volume":"1","author":"J Gaywee","year":"2002","journal-title":"Mol Cell Proteom"},{"issue":"35","key":"ref168","doi-asserted-by":"crossref","first-page":"32602","DOI":"10.1074\/jbc.M305994200","article-title":"Regulation of dinucleoside polyphosphate pools by the <italic>YgdP<\/italic> and <italic>ApaH<\/italic> hydrolases is essential for the ability of <italic>Salmonella enteric<\/italic>a serovar Typhimurium to invade cultured mammalian cells","volume":"278","author":"T Ismail","year":"2003","journal-title":"J Biol Chem"},{"issue":"4","key":"ref169","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4161\/viru.28589","article-title":"The <italic>invA<\/italic> gene of <italic>Brucella melitensis<\/italic> is involved in intracellular invasion and is required to establish infection in a mouse model","volume":"5","author":"J Alva-Perez","year":"2014","journal-title":"Virulence"},{"issue":"2\u20133","key":"ref170","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0014-5793(94)00764-0","article-title":"<italic>P<\/italic><sup>1<\/sup>,<italic>P<\/italic><sup>3<\/sup>-bis(5&apos;-adenosyl)triphosphate (Ap<sub>3<\/sub>A) as a substrate and a product of mammalian tryptophanyl-tRNA synthetase","volume":"350","author":"T Merkulova","year":"1994","journal-title":"FEBS Lett"},{"issue":"1","key":"ref171","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/cyto.1995.1009","article-title":"Differential regulation of the human, interferon inducible tryptophanyl-tRNA synthetase by various cytokines in cell lines","volume":"7","author":"J Fleckner","year":"1995","journal-title":"Cytokine"},{"issue":"1\u20132","key":"ref172","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0014-5793(96)00073-7","article-title":"Interferons induce accumulation of diadenosine triphosphate (Ap<sub>3<\/sub>A) in human cultured cells","volume":"381","author":"A Vartanian","year":"1996","journal-title":"FEBS Lett"},{"issue":"4","key":"ref173","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1182\/blood-2004-06-2089","article-title":"Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells","volume":"105","author":"A Boasso","year":"2005","journal-title":"Blood"},{"issue":"7495","key":"ref174","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature13194","article-title":"Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy","volume":"508","author":"KV Huber","year":"2014","journal-title":"Nature"},{"issue":"1","key":"ref175","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/anie.201307849","article-title":"An organometallic inhibitor for the human repair enzyme 7,8-dihydro-8-oxoguanosine triphosphatase","volume":"53","author":"M Streib","year":"2014","journal-title":"Angew Chem Int Ed"}],"container-title":["PLOS 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