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[Barriers to the treatment of latent tuberculosis infection (LTBI) in the child: a case study]","volume":"18","author":"AR Silva","year":"2014","journal-title":"Esc Anna Nery"},{"key":"ref8","unstructured":"Gomes SMJ. (2012) An\u00e1lise do tratamento da infec\u00e7\u00e3o latente pelo Mycobacterium tuberculosis<\/italic> na faixa et\u00e1ria de 0 a 15 anos nos programas de refer\u00eancias para tuberculose nos munic\u00edpios da Grande Vit\u00f3ria\/ES [Analysis of treatment of latent infection by Mycobacterium tuberculosis<\/italic> in individuals aged 0 to 15 years old enrolled in reference programmes for tuberculosis in Grande Vit\u00f3ria municipalities, state of Esp\u00edrito Santo] M.Sc. Thesis, Universidade Federal do Esp\u00edrito Santo, Centro de Ci\u00eancias da Sa\u00fade."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1097\/01.aids.0000391022.95412.a6","article-title":"The implementation of isoniazid preventive therapy in HIV clinics: the experience from the TB\/HIV in Rio (THRio) Study","volume":"24","author":"B Durovni","year":"2010","journal-title":"AIDS"},{"key":"ref10","first-page":"21","article-title":"Latent tuberculosis infection: adherence to treatment and evolution of cases","author":"EM Dessunti","year":"2013","journal-title":"Rev Enferm"},{"key":"ref11","first-page":"1235","article-title":"Adherence to treatment for latent tuberculosis infection: systematic review of studies in the US and Canada","volume":"12","author":"Y Hirsch-Moverman","year":"2008","journal-title":"Int J Tuberc Lung Di"},{"key":"ref12","first-page":"13","article-title":"Adherence to anti-tuberculosis chemoprophylaxis and treatment in children","volume":"10","author":"S Van Zyl","year":"2006","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.ccm.2009.08.012","article-title":"Screening and preventive therapy for tuberculosis","volume":"30","author":"BJ Marais","year":"2009","journal-title":"Clin Chest Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"932","DOI":"10.2471\/BLT.13.118414","article-title":"Management of children exposed to Mycobacterium tuberculosis<\/italic>: a public health evaluation in west Java, Indonesia","volume":"91","author":"ME Rutherford","year":"2013","journal-title":"Bull World Health Organ"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0140-6736(13)60715-1","article-title":"Effect of a conditional cash transfer programme on childhood mortality: a nationwide analysis of Brazilian municipalities","volume":"382","author":"D Rasella","year":"2013","journal-title":"Lancet"},{"key":"ref16","unstructured":"Soares CW. (2012) \u00cdndice de desenvolvimento humano e tuberculose: modelagem e mapeamento da incid\u00eancia dos casos na Para\u00edba no per\u00edodo de 2001\u20132011 [Human development index and tuberculosis: modelling and mapping the incidence of cases in Para\u00edba from; 2001 to 2011]. M.Sc. Thesis, Universidade Federal da Para\u00edba."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1590\/S1413-81232007000500018","article-title":"A contribui\u00e7\u00e3o da vulnerabilidade na determina\u00e7\u00e3o do \u00edndice de desenvolvimento humano: estudando o estado de Santa Catarina [The contribution of vulnerability to determining the human development index: studying Santa Catarina State, Brazil]","volume":"12","author":"OMPD Silva","year":"2007","journal-title":"Ci\u00eancia Sa\u00fade Coletiva"},{"key":"ref18","unstructured":"Minist\u00e9rio da Sa\u00fade, Secretaria de Vigil\u00e2ncia em Sa\u00fade [Ministry of Health, Health Surveillance Secretariat]. S\u00e9rie hist\u00f3rica da taxa de incid\u00eancia de tuberculose. Brasil, Regi\u00f5es e Unidades Federadas de resid\u00eancia por ano de diagn\u00f3stico (1990 a 2012). Available: http:\/\/portalsaude.saude.gov.br\/index.php\/o-ministerio\/principal\/leia-mais-o-ministerio\/741-secretaria-svs\/vigilancia-de-a-a-z\/tuberculose\/11485-situacao-epidemiologica-dados<\/ext-link>."},{"key":"ref19","unstructured":"Programa das Na\u00e7\u00f5es Unidas para o Desenvolvimento. PNUD 2011. [UNDP; 2011. Available: http:\/\/www.pnud.org.br\/HDR\/Relatorios-Desenvolvimento-Humano-Brasil.aspx?indiceAccordion=2&li=li_RDHBrasil<\/ext-link>. Accessed November 5, 2014."},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s11606-010-1286-0","article-title":"Primary non-adherence of medications: lifting the veil on prescription-filling behaviors","volume":"25","author":"MD Solomon","year":"2010","journal-title":"Gen Intern Med"},{"key":"ref21","unstructured":"Minist\u00e9rio da Sa\u00fade, Comit\u00ea T\u00e9cnico-cient\u00edfico de Assessoramento \u00e0 tuberculose e Comit\u00ea assessor para Coinfec\u00e7\u00e3o HIV-Tuberculose. [Ministry of Health, Technical and Scientific Advisory Committee on Tuberculosis and Advisory Committee on HIV-Tuberculosis Coinfection]. (2002) Guia: Tuberculose de vigil\u00e2ncia epidemiol\u00f3gica [Tuberculosis\u2014Guide of epidemiological surveillance]. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade: Funda\u00e7\u00e3o Nacional de Sa\u00fade [Ministry of Health, National Health Foundation]. pp. 100."},{"key":"ref22","article-title":"Applied Regression analysis and other multivariable methods","author":"DG Kleinbaum","year":"1988"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"340","DOI":"10.2105\/AJPH.79.3.340","article-title":"Modeling and variable selection in epidemiologic analysis","volume":"79","author":"S Greenland","year":"1989","journal-title":"AJPH"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1136\/adc.74.2.140","article-title":"Transmission of tuberculosis to contacts of sputum positive adults in Malawi","volume":"74","author":"JM Topley","year":"1996","journal-title":"Arch Dis Child"},{"key":"ref25","first-page":"109","article-title":"Quimioprofilaxia da tuberculose na inf\u00e2ncia [Antituberculosis chemoprophylaxis in children]","volume":"76","author":"SG David","year":"2000","journal-title":"J Pediatr"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1097\/INF.0b013e318257f7c6","article-title":"Successful treatment of pediatric latent tuberculosis infection in a community health center clinic","volume":"31","author":"J Young","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e48900","DOI":"10.1371\/journal.pone.0048900","article-title":"Completion of treatment for latent tuberculosis infection with monthly drug dispensation directly through the tuberculosis clinic","volume":"7","author":"CC Dobler","year":"2012","journal-title":"PLOS ONE"},{"key":"ref28","article-title":"Guidance for national tuberculosis programmes on the management of tuberculosis in children","year":"2006"},{"key":"ref29","article-title":"Guidelines on the management of latent tuberculosis infection global tuberculosis report","year":"2015"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.5588\/ijtld.11.0092","article-title":"Screening and follow-up of children exposed to tuberculosis cases, Luanda, Angola","volume":"15","author":"I Fortunato","year":"2011","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1097\/INF.0b013e31814523e4","article-title":"Failure of chemoprophylaxis with standard antituberculosis agents in child contacts of multidrug-resistant tuberculosis cases","volume":"26","author":"DB Sneag","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.5588\/ijtld.10.0558","article-title":"Adherence to isoniazid preventive therapy in children exposed to tuberculosis: a prospective study from Guinea-Bissau","volume":"15","author":"VF Gomes","year":"2011","journal-title":"Int J Tuberc Lung 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