{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:33:32Z","timestamp":1789997612740,"version":"4.0.1"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T00:00:00Z","timestamp":1462320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0154863","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T18:06:31Z","timestamp":1462385191000},"page":"e0154863","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":55,"title":["Computer Aided Diagnosis for Confocal Laser Endomicroscopy in Advanced Colorectal Adenocarcinoma"],"prefix":"10.1371","volume":"11","author":[{"given":"Daniela","family":"\u015etef\u0103nescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costin","family":"Streba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Tatiana","family":"C\u00e2r\u0163\u00e2n\u0103","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"S\u0103ftoiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Gruionu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucian Gheorghe","family":"Gruionu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,5,4]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012","volume":"65","author":"LA Torre","year":"2015","journal-title":"CA Cancer J Clin"},{"issue":"4 Suppl","key":"ref2","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.gie.2006.02.021","article-title":"Quality indicators for colonoscopy","volume":"63","author":"DK Rex","year":"2006","journal-title":"Gastrointest Endosc"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1053\/gast.2003.50044","article-title":"Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence","volume":"124","author":"S Winawer","year":"2003","journal-title":"Gastroenterology"},{"issue":"1","key":"ref4","first-page":"103","article-title":"Colorectal cancer\u2014clinical and morphological aspects","volume":"55","author":"SS Mogoanta","year":"2014","journal-title":"Rom J Morphol Embryol"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3748\/wjg.v17.i1.21","article-title":"Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies","volume":"17","author":"DI Gheonea","year":"2011","journal-title":"World J Gastroenterol"},{"issue":"Suppl 1","key":"ref6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/den.12152","article-title":"Confocal laser endomicroscopy in gastrointestinal and pancreatobiliary diseases","volume":"26","author":"Y Nakai","year":"2014","journal-title":"Dig Endosc"},{"key":"ref7","article-title":"Confocal Laser Microscopy\u2014Principles and Applications in Medicine, Biology, and the Food Sciences","author":"A WW Basil","year":"2013"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"e52815","DOI":"10.1371\/journal.pone.0052815","article-title":"Confocal laser endomicroscopy for the morphometric evaluation of microvessels in human colorectal cancer using targeted anti-CD31 antibodies","volume":"7","author":"T Cartana","year":"2012","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1137\/060659041","article-title":"Modeling occlusion and scaling in natural images","volume":"6","author":"Y Gousseau","year":"2007","journal-title":"SIAM J Multiscale Model Simul"},{"issue":"1","key":"ref10","first-page":"29","article-title":"The fractal geometry of life","volume":"102","author":"GA Losa","year":"2009","journal-title":"Riv Biol"},{"issue":"4 Pt 1","key":"ref11","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1053\/jhep.2002.35533","article-title":"Fractal dimension can distinguish models and pharmacologic changes in liver fibrosis in rats","volume":"36","author":"F Moal","year":"2002","journal-title":"Hepatology"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1007\/s00330-011-2182-7","article-title":"Quantitative analysis and prediction of regional lymph node status in rectal cancer based on computed tomography imaging","volume":"21","author":"C Cui","year":"2011","journal-title":"Eur Radiol"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.micron.2008.12.004","article-title":"Quantifying the architectural complexity of microscopic images of histology specimens","volume":"40","author":"M Tambasco","year":"2009","journal-title":"Micron"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1007\/s00535-011-0459-x","article-title":"Quantitative analysis of colorectal lesions observed on magnified endoscopy images","volume":"46","author":"K Onji","year":"2011","journal-title":"J Gastroenterol"},{"key":"ref15","unstructured":"Gruionu LG. Computer Aided Diagnosis Module V1. for NAVICAD Project 2016 [cited 2016 04\/13]. Available from: http:\/\/navicad.ro\/navicad-cad-module<\/ext-link>."},{"key":"ref16","unstructured":"MathWorks. Image Processing Toolbox Functions: MathWorks; 2016 [cited 2016 04\/13]. Available from: http:\/\/www.mathworks.com\/help\/images\/functionlist.html<\/ext-link>."},{"key":"ref17","unstructured":"Kroon D-J. Isocontour: MathWorks; 2011 [cited 2016 04\/13]. Available from: http:\/\/www.mathworks.com\/matlabcentral\/fileexchange\/30525-isocontour<\/ext-link>."},{"key":"ref18","unstructured":"Sommer HJ. Poligeom: MathWorks; 2008 [cited 2016 04\/13]. Available from: http:\/\/www.mathworks.com\/matlabcentral\/fileexchange\/?utf8=%E2%9C%93&term=polygeom<\/ext-link>."},{"key":"ref19","unstructured":"MathWorks. Graycomatrix: MathWorks; 2016 [cited 2016 04\/13]. Available from: http:\/\/www.mathworks.com\/help\/images\/ref\/graycomatrix.html<\/ext-link>\u2014description."},{"issue":"3","key":"ref20","first-page":"845","article-title":"Fractal analysis differentiation of nuclear and vascular patterns in hepatocellular carcinomas and hepatic metastasis","volume":"52","author":"CT Streba","year":"2011","journal-title":"Rom J Morphol Embryol"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1055\/s-0034-1365348","article-title":"Advanced imaging for detection and differentiation of colorectal neoplasia: European Society of Gastrointestinal Endoscopy (ESGE) Guideline","volume":"46","author":"MF Kaminski","year":"2014","journal-title":"Endoscopy"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.gie.2015.08.004","article-title":"Computer-aided diagnosis of colorectal polyp histology by using a real-time image recognition system and narrow-band imaging magnifying colonoscopy","volume":"83","author":"Y Kominami","year":"2016","journal-title":"Gastrointest Endosc"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.gie.2011.08.051","article-title":"Computer-aided system for predicting the histology of colorectal tumors by using narrow-band imaging magnifying colonoscopy (with video)","volume":"75","author":"Y Takemura","year":"2012","journal-title":"Gastrointest Endosc"},{"issue":"3B","key":"ref24","first-page":"2141","article-title":"Fractal dimension as a prognostic factor for laryngeal carcinoma","volume":"25","author":"A Delides","year":"2005","journal-title":"Anticancer Res"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.oraloncology.2007.04.005","article-title":"Nuclear fractal dimension as a prognostic factor in oral squamous cell carcinoma","volume":"44","author":"L Goutzanis","year":"2008","journal-title":"Oral Oncol"},{"issue":"5","key":"ref26","first-page":"284","article-title":"Basic principles and applications of fractal geometry in pathology: a review","volume":"27","author":"P Dey","year":"2005","journal-title":"Anal Quant Cytol Histol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"239706","DOI":"10.1155\/2014\/239706","article-title":"Diagnosis system for hepatocellular carcinoma based on fractal dimension of morphometric elements integrated in an artificial neural network","volume":"2014","author":"DI Gheonea","year":"2014","journal-title":"Biomed Res Int"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0154863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:19:09Z","timestamp":1588983549000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0154863"}},"subtitle":[],"editor":[{"given":"Francisco J.","family":"Esteban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,4]]},"references-count":27,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0154863","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,4]]}}}