{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T08:33:13Z","timestamp":1648801993432},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T00:00:00Z","timestamp":1463616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0154912","type":"journal-article","created":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:41:58Z","timestamp":1463704918000},"page":"e0154912","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hepatocyte Nuclear Factor-1\u03b2 Induces Redifferentiation of Dedifferentiated Tubular Epithelial Cells"],"prefix":"10.1371","volume":"11","author":[{"given":"Mitsugu","family":"Omata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Doke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikaomi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumiko","family":"Sho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Furuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Inomata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1056\/NEJMra1300575","article-title":"Fibrosis\u2014A Common Pathway to Organ Injury and Failure","volume":"372","author":"DC Rockey","year":"2015","journal-title":"New England Journal of Medicine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nri1412","article-title":"Fibrotic disease and the T(H)1\/T(H)2 paradigm","volume":"4","author":"TA Wynn","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","article-title":"Chronic kidney disease: global dimension and perspectives","volume":"382","author":"V Jha","year":"2013","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0272-6386(12)80312-X","article-title":"Tubulointerstitial changes as a major determinant in the progression of renal damage","volume":"20","author":"KA Nath","year":"1992","journal-title":"Am J Kidney Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000313946","article-title":"Renal interstitial fibrosis: a critical evaluation of the origin of myofibroblasts","volume":"169","author":"JL Barnes","year":"2011","journal-title":"Contrib Nephrol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0140-6736(68)90589-8","article-title":"Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis","volume":"2","author":"RA Risdon","year":"1968","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0046-8177(70)80061-2","article-title":"Structural-functional correlations in renal disease. II. The correlations","volume":"1","author":"LI Schainuck","year":"1970","journal-title":"Hum Pathol"},{"key":"ref8","first-page":"167","article-title":"Correlations between renal cortical interstitial fibrosis, atrophy of the proximal tubules and impairment of the glomerular filtration rate","volume":"15","author":"S Mackensen-Haen","year":"1981","journal-title":"Clin Nephrol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ki.2012.20","article-title":"Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis","volume":"82","author":"I Grgic","year":"2012","journal-title":"Kidney Int"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00467-011-1992-9","article-title":"Tubulointerstitial injury and the progression of chronic kidney disease","volume":"27","author":"KS Hodgkins","year":"2012","journal-title":"Pediatr Nephrol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nm.3901","article-title":"Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease","volume":"21","author":"MT Grande","year":"2015","journal-title":"Nat Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm.3902","article-title":"Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis","volume":"21","author":"S Lovisa","year":"2015","journal-title":"Nat Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/sj.ki.5002277","article-title":"Nestin expression in the kidney with an obstructed ureter","volume":"72","author":"T Sakairi","year":"2007","journal-title":"Kidney Int"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1172\/JCI45161","article-title":"Cellular pathophysiology of ischemic acute kidney injury","volume":"121","author":"JV Bonventre","year":"2011","journal-title":"J Clin Invest"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ajpath.2012.09.009","article-title":"Transforming growth factor beta-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis","volume":"182","author":"CF Wu","year":"2013","journal-title":"Am J Pathol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1172\/JCI36150","article-title":"Macrophage diversity in renal injury and repair","volume":"118","author":"SD Ricardo","year":"2008","journal-title":"J Clin Invest"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nm.2208","article-title":"Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment","volume":"16","author":"V Barry-Hamilton","year":"2010","journal-title":"Nat Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1046\/j.1523-1755.2001.0590041304.x","article-title":"Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy","volume":"59","author":"S Mizuno","year":"2001","journal-title":"Kidney Int"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1681\/ASN.2005040385","article-title":"N-acetyl-seryl-aspartyl-lysyl-proline ameliorates the progression of renal dysfunction and fibrosis in WKY rats with established anti-glomerular basement membrane nephritis","volume":"17","author":"M Omata","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"C807","DOI":"10.1152\/ajpcell.00301.2006","article-title":"Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney","volume":"292","author":"A Vogetseder","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref21","article-title":"Chronic kidney disease progression is mainly associated with non-recovery of acute kidney injury","author":"E D'Hoore","year":"2015","journal-title":"J Nephrol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrneph.2015.3","article-title":"Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD","volume":"11","author":"DA Ferenbach","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000313738","article-title":"Pathophysiology of AKI: injury and normal and abnormal repair","volume":"165","author":"JV Bonventre","year":"2010","journal-title":"Contrib Nephrol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.canlet.2013.04.018","article-title":"EMT-MET in renal disease: should we curb our enthusiasm?","volume":"341","author":"P Galichon","year":"2013","journal-title":"Cancer Lett"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nm.2144","article-title":"Epithelial cell cycle arrest in G2\/M mediates kidney fibrosis after injury","volume":"16","author":"L Yang","year":"2010","journal-title":"Nat Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nm888","article-title":"BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury","volume":"9","author":"M Zeisberg","year":"2003","journal-title":"Nat Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/j.1460-2075.1991.tb07665.x","article-title":"vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1","volume":"10","author":"J Rey-Campos","year":"1991","journal-title":"EMBO J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.2337\/diacare.27.5.1102","article-title":"Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations","volume":"27","author":"ER Pearson","year":"2004","journal-title":"Diabetes Care"},{"key":"ref29","first-page":"34","article-title":"Expression of hepatocyte nuclear factor-1beta in human urogenital tract during the embryonic stage","volume":"31","author":"N Kato","year":"2009","journal-title":"Anal Quant Cytol Histol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1681\/ASN.2012070756","article-title":"HNF1beta is essential for nephron segmentation during nephrogenesis","volume":"24","author":"RW Naylor","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"c71","DOI":"10.1159\/000334954","article-title":"Expression of renal cystic genes in patients with HNF1B mutations","volume":"120","author":"S Faguer","year":"2012","journal-title":"Nephron Clin Pract"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1042\/BJ20051106","article-title":"The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells","volume":"393","author":"MK Phanish","year":"2006","journal-title":"Biochem J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"F1210","DOI":"10.1152\/ajprenal.00660.2011","article-title":"PTEN loss defines a TGF-beta-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis","volume":"302","author":"R Lan","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/ki.2011.77","article-title":"Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition","volume":"80","author":"SE Quaggin","year":"2011","journal-title":"Kidney Int"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0154912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T22:18:46Z","timestamp":1567894726000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0154912"}},"subtitle":[],"editor":[{"given":"Jean-Claude","family":"Dussaule","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,19]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0154912","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,19]]}}}