{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:07:51Z","timestamp":1792292871661,"version":"4.4.0"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:00:00Z","timestamp":1463702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Prodex\/ESA","award":["C90-303"],"award-info":[{"award-number":["C90-303"]}]},{"name":"Prodex\/ESA","award":["C90-391"],"award-info":[{"award-number":["C90-391"]}]},{"name":"Prodex\/ESA","award":["C0-90-11-2801-02"],"award-info":[{"award-number":["C0-90-11-2801-02"]}]},{"name":"Sardinian government","award":["AF-DR-A2008-67"],"award-info":[{"award-number":["AF-DR-A2008-67"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0155260","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T23:47:09Z","timestamp":1463874429000},"page":"e0155260","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Combined Exposure to Simulated Microgravity and Acute or Chronic Radiation Reduces Neuronal Network Integrity and Survival"],"prefix":"10.1371","volume":"11","author":[{"given":"Giuseppe","family":"Pani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieke","family":"Verslegers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Quintens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Samari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"de Saint-Georges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"van Oostveldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Baatout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Abderrafi","family":"Benotmane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,5,20]]},"reference":[{"issue":"12","key":"ref1","first-page":"1185","article-title":"Space motion sickness during 24 flights of the space shuttle","volume":"59","author":"JR Davis","year":"1988","journal-title":"Aviat Space Environ Med"},{"issue":"2","key":"ref2","first-page":"107","article-title":"The effect of space flight on human cellular immunity","volume":"37","author":"A Cogoli","year":"1993","journal-title":"Environ Med"},{"issue":"9","key":"ref3","first-page":"A91","article-title":"Space shuttle inflight and postflight fluid shifts measured by leg volume changes","volume":"58","author":"TP Moore","year":"1987","journal-title":"Aviat Space Environ Med"},{"issue":"3\u20134","key":"ref4","first-page":"332","article-title":"Man in weightlessness: physiological problems, clinical aspects, prevention and protection. Related bio-medical research in micro-gravity during the forecoming SPACELAB missions","volume":"43","author":"HS Fuchs","year":"1980","journal-title":"Riv Med Aeronaut Spaz"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0094-5765(88)90022-7","article-title":"Assessment of the efficacy of medical countermeasures in space flight","volume":"17","author":"A Nicogossian","year":"1988","journal-title":"Acta Astronaut"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1096\/fj.11-199406","article-title":"5-Lipoxygenase-dependent apoptosis of human lymphocytes in the International Space Station: data from the ROALD experiment","volume":"26","author":"N Battista","year":"2012","journal-title":"FASEB J"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/cm.20499","article-title":"Space flight affects motility and cytoskeletal structures in human monocyte cell line J-111","volume":"68","author":"MA Meloni","year":"2011","journal-title":"Cytoskeleton (Hoboken)"},{"issue":"2\u20134","key":"ref8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00709-006-0210-2","article-title":"Cytoskeleton changes and impaired motility of monocytes at modelled low gravity","volume":"229","author":"MA Meloni","year":"2006","journal-title":"Protoplasma"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"e32361","DOI":"10.1371\/journal.pone.0032361","article-title":"Effects of long-term space flight on erythrocytes and oxidative stress of rodents","volume":"7","author":"AM Rizzo","year":"2012","journal-title":"PLoS One"},{"key":"ref10","first-page":"46","article-title":"Radiation effects and shielding requirements in human missions to the moon and Mars","volume":"2006","author":"R Donald","journal-title":"Mars 2"},{"issue":"1\u20132","key":"ref11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0168-583X(01)00748-0","article-title":"Space radiation dosimetry in low-Earth orbit and beyond","volume":"184","author":"ER Benton","year":"2001","journal-title":"Nucl Instrum Methods Phys Res B"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1667\/RR1330.1","article-title":"Physical and biological organ dosimetry analysis for international space station astronauts","volume":"170","author":"FA Cucinotta","year":"2008","journal-title":"Radiat Res"},{"issue":"6136","key":"ref13","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1126\/science.1235989","article-title":"Measurements of energetic particle radiation in transit to Mars on the Mars Science Laboratory","volume":"340","author":"C Zeitlin","year":"2013","journal-title":"Science"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1350-4487(00)00152-9","article-title":"Predictions of secondary neutrons and their importance to radiation effects inside the International Space Station","volume":"33","author":"TW Armstrong","year":"2001","journal-title":"Radiat Meas"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1109\/23.983167","article-title":"Neutron production from polyethylene and common spacecraft materials","volume":"48","author":"RH Maurer","year":"2001","journal-title":"IEEE Trans Nucl Sci"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1269\/jrr.10128","article-title":"Biological effects of space radiation on human cells: history, advances and outcomes","volume":"52","author":"M Maalouf","year":"2011","journal-title":"J Radiat Res"},{"issue":"3\u20134","key":"ref17","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s10548-011-0196-8","article-title":"Characterizing brain cortical plasticity and network dynamics across the age-span in health and disease with TMS-EEG and TMS-fMRI","volume":"24","author":"A Pascual-Leone","year":"2011","journal-title":"Brain Topogr"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3892\/ijmm.2014.1785","article-title":"Chronic exposure to simulated space conditions predominantly affects cytoskeleton remodeling and oxidative stress response in mouse fetal fibroblasts","volume":"34","author":"M Beck","year":"2014","journal-title":"Int J Mol Med"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/rpd\/ncs183","article-title":"Chronic radiation syndrome among residents of the Techa riverside villages","volume":"151","author":"AV Akleyev","year":"2012","journal-title":"Radiation Protection Dosimetry"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2307\/3579035","article-title":"Description of the chronic radiation syndrome in humans irradiated in the former Soviet Union","volume":"142","author":"GI Reeves","year":"1995","journal-title":"Radiat Res"},{"issue":"3","key":"ref21","article-title":"The growth cone cytoskeleton in axon outgrowth and guidance","volume":"3","author":"EW Dent","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1667\/RR1682.1","article-title":"High content analysis of human fibroblast cell cultures after exposure to space radiation","volume":"172","author":"B Dieriks","year":"2009","journal-title":"Radiat Res"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/HP.0b013e3181d11303","article-title":"Long-term cellular effects in humans chronically exposed to ionizing radiation","volume":"99","author":"G Veremeyeva","year":"2010","journal-title":"Health Phys"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mrgentox.2010.03.009","article-title":"mBAND analysis of chromosome aberrations in human epithelial cells induced by gamma-rays and secondary neutrons of low dose rate","volume":"701","author":"M Hada","year":"2010","journal-title":"Mutat Res-Gen Tox En"},{"issue":"8","key":"ref25","article-title":"A Novel ATM\/TP53\/p21-Mediated Checkpoint Only Activated by Chronic gamma-Irradiation","volume":"9","author":"LL Cao","year":"2014","journal-title":"Plos One"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"e73857","DOI":"10.1371\/journal.pone.0073857","article-title":"Morphological and physiological changes in mature in vitro neuronal networks towards exposure to short-, middle- or long-term simulated microgravity","volume":"8","author":"G Pani","year":"2013","journal-title":"PLoS One"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/pmic.201400019","article-title":"Differential expression of specific cellular defense proteins in rat hypothalamus under simulated microgravity induced conditions: comparative proteomics","volume":"14","author":"J Iqbal","year":"2014","journal-title":"Proteomics"},{"issue":"2\u20133","key":"ref28","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/pmic.201300337","article-title":"Distortion of homeostatic signaling proteins by simulated microgravity in rat hypothalamus: A(16) O\/(18) O-labeled comparative integrated proteomic approach","volume":"14","author":"J Iqbal","year":"2014","journal-title":"Proteomics"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1021\/pr050274r","article-title":"Proteomic analysis of mice hippocampus in simulated microgravity environment","volume":"5","author":"P Sarkar","year":"2006","journal-title":"J Proteome Res"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1007\/s11064-008-9738-1","article-title":"Proteomic analysis of mouse hypothalamus under simulated microgravity","volume":"33","author":"P Sarkar","year":"2008","journal-title":"Neurochem Res"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"e40112","DOI":"10.1371\/journal.pone.0040112","article-title":"Evaluation of gene, protein and neurotrophin expression in the brain of mice exposed to space environment for 91 days","volume":"7","author":"D Santucci","year":"2012","journal-title":"PloS one"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"e96099","DOI":"10.1371\/journal.pone.0096099","article-title":"Space radiation risks for astronauts on multiple International Space Station missions","volume":"9","author":"FA Cucinotta","year":"2014","journal-title":"PloS one"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.lssr.2014.06.003","article-title":"Space radiation risks to the central nervous system","volume":"2","author":"FA Cucinotta","year":"2014","journal-title":"Life Sciences in Space Research"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1667\/RR1741.1","article-title":"Effect of radiation on the development of immature hippocampal neurons in vitro","volume":"172","author":"M Okamoto","year":"2009","journal-title":"Radiat Res"},{"key":"ref35","article-title":"Non-conventional apoptotic response to ionising radiation mediated by N-methyl D-aspartate receptors in immature neuronal cells","author":"N Samari","year":"2013","journal-title":"Int J Mol Med"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2307\/3578484","article-title":"Possible "accelerated striatal aging" induced by 56Fe heavy-particle irradiation: implications for manned space flights","volume":"130","author":"JA Joseph","year":"1992","journal-title":"Radiat Res"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2307\/3577371","article-title":"An assessment of the behavioral toxicity of high-energy iron particles compared to other qualities of radiation","volume":"119","author":"BM Rabin","year":"1989","journal-title":"Radiat Res"},{"issue":"Pt 3","key":"ref38","first-page":"1177","article-title":"The effect of high energy (HZE) particle radiation (40Ar) on aging parameters of mouse hippocampus and retina","author":"DE Philpott","year":"1985","journal-title":"Scan Electron Microsc"},{"issue":"5","key":"ref39","first-page":"479","article-title":"Synaptic plasticity in the cerebral cortex of mice: effects of radiation and anesthesia","volume":"24","author":"FE D'Amelio","year":"1983","journal-title":"J Hirnforsch"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1600-079X.2008.00611.x","article-title":"Space radiation-induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment in mice: ameliorative potential of the melatonin metabolite, AFMK","volume":"45","author":"K Manda","year":"2008","journal-title":"J Pineal Res"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbr.2007.09.033","article-title":"Memory impairment, oxidative damage and apoptosis induced by space radiation: ameliorative potential of alpha-lipoic acid","volume":"187","author":"K Manda","year":"2008","journal-title":"Behav Brain Res"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bbr.2006.11.013","article-title":"Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: Protective effect of \u03b1-lipoic acid","volume":"177","author":"K Manda","year":"2007","journal-title":"Behavioural Brain Research"},{"issue":"12","key":"ref43","doi-asserted-by":"crossref","first-page":"e53275","DOI":"10.1371\/journal.pone.0053275","article-title":"Galactic cosmic radiation leads to cognitive impairment and increased abeta plaque accumulation in a mouse model of Alzheimer's disease","volume":"7","author":"JD Cherry","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1400256","article-title":"What happens to your brain on the way to Mars","volume":"1","author":"VK Parihar","year":"2015","journal-title":"Sci Adv"},{"key":"ref45","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-45117-1","article-title":"Chronic Radiation Syndrome","author":"AV Akleyev","year":"2014"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3892\/ijmm.2012.1001","article-title":"Simulated microgravity decreases apoptosis in fetal fibroblasts","volume":"30","author":"M Beck","year":"2012","journal-title":"International journal of molecular medicine"},{"issue":"1\u20132","key":"ref47","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mrfmmm.2009.01.002","article-title":"DNA repair in modeled microgravity: double strand break rejoining activity in human lymphocytes irradiated with gamma-rays","volume":"663","author":"M Mognato","year":"2009","journal-title":"Mutation research"},{"issue":"5","key":"ref48","doi-asserted-by":"crossref","first-page":"051906","DOI":"10.1103\/PhysRevE.73.051906","article-title":"Growth of cortical neuronal network in vitro: modeling and analysis","volume":"73","author":"PY Lai","year":"2006","journal-title":"Phys Rev E Stat Nonlin Soft Matter Phys"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/cyto.a.22408","article-title":"MorphoNeuroNet: an automated method for dense neurite network analysis","volume":"85","author":"G Pani","year":"2014","journal-title":"Cytometry A"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/4548","article-title":"Miniature synaptic events maintain dendritic spines via AMPA receptor activation","volume":"2","author":"RA McKinney","year":"1999","journal-title":"Nat Neurosci"},{"issue":"5","key":"ref51","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1152\/jn.1998.80.5.2608","article-title":"Development of glycinergic synaptic transmission to rat brain stem motoneurons","volume":"80","author":"JH Singer","year":"1998","journal-title":"J Neurophysiol"},{"issue":"6","key":"ref52","first-page":"1135","article-title":"Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium","volume":"21","author":"WR Mundy","year":"2000","journal-title":"Neurotoxicology"},{"issue":"6","key":"ref53","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1128\/JVI.79.6.3438-3447.2005","article-title":"Characterization of an in vitro model of alphavirus infection of immature and mature neurons","volume":"79","author":"PS Vernon","year":"2005","journal-title":"J Virol"},{"issue":"33","key":"ref54","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.1523\/JNEUROSCI.1627-06.2006","article-title":"Dynamics and effective topology underlying synchronization in networks of cortical neurons","volume":"26","author":"D Eytan","year":"2006","journal-title":"J Neurosci"},{"issue":"48","key":"ref55","doi-asserted-by":"crossref","first-page":"16332","DOI":"10.1523\/JNEUROSCI.4859-10.2010","article-title":"Dynamics of excitability over extended timescales in cultured cortical neurons","volume":"30","author":"A Gal","year":"2010","journal-title":"J Neurosci"},{"issue":"22","key":"ref56","doi-asserted-by":"crossref","first-page":"8782","DOI":"10.1523\/JNEUROSCI.21-22-08782.2001","article-title":"Learning in networks of cortical neurons","volume":"21","author":"G Shahaf","year":"2001","journal-title":"J Neurosci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s12217-008-9043-2","article-title":"Technologyand Developments for the Random Positioning Machine, RPM","volume":"21","author":"A.G. B","year":"2009","journal-title":"Microgravity Science and Technology"},{"issue":"12","key":"ref58","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/ismej.2009.74","article-title":"Experimental design and environmental parameters affect Rhodospirillum rubrum S1H response to space flight","volume":"3","author":"F Mastroleo","year":"2009","journal-title":"ISME J"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1350-4487(98)00071-7","article-title":"A combined use of the BD-PND and BDT bubble detectors in neutron dosimetry1","volume":"29","author":"F Vanhavere","year":"1998","journal-title":"Radiation Measurements"},{"key":"ref60","first-page":"124","article-title":"Morphological features of cell death","volume":"19","author":"U Ziegler","year":"2004","journal-title":"News Physiol Sci"},{"issue":"3","key":"ref61","first-page":"209","article-title":"Microgravity-induced apoptosis in cultured glial cells","volume":"46","author":"BM Uva","year":"2002","journal-title":"Eur J Histochem"},{"issue":"1","key":"ref62","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1523\/JNEUROSCI.18-01-00147.1998","article-title":"Response of postmitotic neurons to X-irradiation: implications for the role of DNA damage in neuronal apoptosis","volume":"18","author":"GT Gobbel","year":"1998","journal-title":"J Neurosci"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1866-1955-7-3","article-title":"A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis","volume":"7","author":"T Verreet","year":"2015","journal-title":"Journal of neurodevelopmental disorders"},{"issue":"1\u20132","key":"ref64","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Y Benjamini","year":"2001","journal-title":"Behavioural brain research"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1471-2105-10-48","article-title":"GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists","volume":"10","author":"E Eden","year":"2009","journal-title":"BMC bioinformatics"},{"issue":"7","key":"ref66","doi-asserted-by":"crossref","first-page":"e21800","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"F Supek","year":"2011","journal-title":"PloS one"},{"issue":"9","key":"ref67","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"MW Pfaffl","year":"2001","journal-title":"Nucleic acids research"},{"issue":"6","key":"ref68","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0273-1177(99)00078-2","article-title":"Influence of microgravity on mitogen binding and cytoskeleton in Jurkat cells","volume":"24","author":"L Sciola","year":"1999","journal-title":"Adv Space Res"},{"issue":"2\u20134","key":"ref69","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00709-006-0202-2","article-title":"Effects of altered gravity on the actin and microtubule cytoskeleton of human SH-SY5Y neuroblastoma cells","volume":"229","author":"H Rosner","year":"2006","journal-title":"Protoplasma"},{"issue":"3","key":"ref70","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1523\/JNEUROSCI.12-03-00924.1992","article-title":"Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics","volume":"12","author":"FM Benes","year":"1992","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"2","key":"ref71","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.nbd.2010.10.009","article-title":"Increased vesicular glutamate transporter expression causes excitotoxic neurodegeneration","volume":"41","author":"RW Daniels","year":"2011","journal-title":"Neurobiology of disease"},{"key":"ref72","article-title":"Cortical reorganization in an astronaut's brain after long-duration spaceflight","author":"A Demertzi","year":"2015","journal-title":"Brain structure & function"},{"issue":"3","key":"ref73","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s00429-014-0747-3","article-title":"MMP-2 mediates Purkinje cell morphogenesis and spine development in the mouse cerebellum","volume":"220","author":"M Verslegers","year":"2015","journal-title":"Brain structure & function"},{"issue":"6","key":"ref74","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.celrep.2014.02.010","article-title":"Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins","volume":"6","author":"JW Um","year":"2014","journal-title":"Cell reports"},{"issue":"8","key":"ref75","doi-asserted-by":"crossref","first-page":"e71757","DOI":"10.1371\/journal.pone.0071757","article-title":"Leukocyte activity is altered in a ground based murine model of microgravity and proton radiation exposure","volume":"8","author":"JK Sanzari","year":"2013","journal-title":"PLoS One"},{"key":"ref76","article-title":"The combined effects of X-ray radiation and hindlimb suspension on bone loss","author":"D Xu","year":"2014","journal-title":"Journal of radiation research"},{"issue":"9","key":"ref77","first-page":"726","article-title":"Simulated microgravity conditions and carbon ion irradiation induce spermatogenic cell apoptosis and sperm DNA damage","volume":"26","author":"HY Li","year":"2013","journal-title":"Biomedical and environmental sciences: BES"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0155260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T09:39:44Z","timestamp":1567935584000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0155260"}},"subtitle":[],"editor":[{"given":"Michal","family":"Hetman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,20]]},"references-count":77,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0155260","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,20]]}}}