{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:04:58Z","timestamp":1789902298077,"version":"4.0.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI079002"],"award-info":[{"award-number":["R01 AI079002"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01 GM111384"],"award-info":[{"award-number":["R01 GM111384"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000182","name":"U.S. Army Medical Research and Materiel Command","doi-asserted-by":"publisher","award":["W81XWH-14-1-0171"],"award-info":[{"award-number":["W81XWH-14-1-0171"]}],"id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0155311","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T17:33:51Z","timestamp":1462988031000},"page":"e0155311","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["YY1 Is Required for Germinal Center B Cell Development"],"prefix":"10.1371","volume":"11","author":[{"given":"Anupam","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Sindhava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Vuyyuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibha","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchita","family":"Hodewadekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Manser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Atchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nri3804","article-title":"Dynamics of B cells in germinal centres","volume":"15","author":"NS De Silva","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nri3814","article-title":"Germinal centres and B cell lymphomagenesis","volume":"15","author":"K Basso","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/cei.12702","article-title":"Transcription factors regulating B cell fate in the germinal centre","volume":"183","author":"T Recaldin","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nature07345","article-title":"SAP-controlled T-B cell interactions underlie germinal centre formation","volume":"455","author":"H Qi","year":"2008","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e150","DOI":"10.1371\/journal.pbio.0030150","article-title":"Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells","volume":"3","author":"T Okada","year":"2005","journal-title":"PLoS Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.immuni.2011.03.025","article-title":"Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity","volume":"34","author":"M Kitano","year":"2011","journal-title":"Immunity"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.immuni.2011.03.024","article-title":"Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone","volume":"34","author":"SM Kerfoot","year":"2011","journal-title":"Immunity"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1126\/science.276.5312.589","article-title":"Control of inflammation, cytokine expression, and germinal center formation by BCL-6","volume":"276","author":"AL Dent","year":"1997","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ccr.2013.04.011","article-title":"EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation","volume":"23","author":"W B\u00e9guelin","year":"2013","journal-title":"Cancer Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.immuni.2007.07.009","article-title":"Germinal-center organizaton and cellular dynamics","volume":"27","author":"CDC Allen","year":"2007","journal-title":"Immunity"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1073\/pnas.1019537108","article-title":"Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program","volume":"108","author":"MR Green","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.4049\/jimmunol.1202547","article-title":"Multiple transcription factor binding sites predict AID targeting in non-Ig genes","volume":"190","author":"JL Duke","year":"2013","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1128\/MCB.05989-11","article-title":"YY1 controls immunoglobulin class switch recombination and nuclear activation-induced deaminase levels","volume":"32","author":"K Zaprazna","year":"2012","journal-title":"Mol Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1101\/gad.1529307","article-title":"Yin Yang 1 is a critical regulator of B-cell development","volume":"21","author":"H Liu","year":"2007","journal-title":"Genes Dev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/emboj.2013.66","article-title":"YY1 controls Ig\u03ba repertoire and B-cell development, and localizes with condensin on the Ig\u03ba locus","volume":"32","author":"X Pan","year":"2013","journal-title":"EMBO J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"7396","DOI":"10.1073\/pnas.0602353103","article-title":"Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditinoal gene targeting","volume":"103","author":"S Casola","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1126\/science.1076997","article-title":"Role of histone H3 lysine 27 methylation in Polycomb-group silencing","volume":"298","author":"R Cao","year":"2002","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.molcel.2013.02.013","article-title":"Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put","volume":"49","author":"JA Simon","year":"2013","journal-title":"Molec Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.gde.2004.02.001","article-title":"The functions of E(z)\/EZH2-mediated methylation of lysine 27 in histone H3","volume":"14","author":"R Cao","year":"2004","journal-title":"Curr Opin Genet Dev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1146\/annurev-genet-110711-155603","article-title":"Memories from the Polycomb Group proteins","volume":"46","author":"C Lanzuolo","year":"2012","journal-title":"Ann Rev Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1101\/gad.1200204","article-title":"Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27","volume":"18","author":"A Kirmizis","year":"2004","journal-title":"Genes Dev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1101\/gad.1035902","article-title":"Histone methyltransferase activity associated with a human multiprotein complex containing enhancer of Zeste protein","volume":"16","author":"A Kuzmichev","year":"2002","journal-title":"Genes Dev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1182\/blood-2010-04-280149","article-title":"EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis","volume":"116","author":"I Velichutina","year":"2010","journal-title":"Blood"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.164.1.1","article-title":"Cutting edge: polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers","volume":"164","author":"FM Raaphorst","year":"2000","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.1172\/JCI70626","article-title":"Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis","volume":"123","author":"M Caganova","year":"2013","journal-title":"J Clin Invest"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1182\/blood.V97.12.3896","article-title":"Coexpression of BMI-1 and EZH2 polycomb-group proteins associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma","volume":"97","author":"FJ van Kemenade","year":"2001","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/emboj\/cdg124","article-title":"The YY1 transcription factor functions as a PcG protein in vivo","volume":"22","author":"L Atchison","year":"2003","journal-title":"EMBO J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1101\/gad.1228204","article-title":"YY1 DNA Binding and PcG Recruitment Requires CtBP","volume":"18","author":"L Srinivasan","year":"2004","journal-title":"Genes Dev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/jcb.22424","article-title":"PcG recruitment by the YY1 REPO domain can be mediated by Yaf2","volume":"109","author":"F Wilkinson","year":"2010","journal-title":"J Cell Biochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"19296","DOI":"10.1073\/pnas.0603564103","article-title":"Polycomb recruitment to DNA in vivo by the YY1 REPO domain","volume":"103","author":"FH Wilkinson","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1093\/nar\/gkt1187","article-title":"YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment","volume":"42","author":"A Basu","year":"2014","journal-title":"Nuc Acids Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/jcb.20562","article-title":"Transient requirements of YY1 expression for PcG transcriptional rescue and phenotypic rescue","volume":"96","author":"L Srinivasan","year":"2005","journal-title":"J Cell Biochem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/ni.2418","article-title":"The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers","volume":"13","author":"DP Calado","year":"2012","journal-title":"Nat Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/ni.2428","article-title":"The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry","volume":"13","author":"D Dominguez-Sola","year":"2012","journal-title":"Nat Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.cell.2011.08.049","article-title":"Two forms of loops generate the chromatin conformation of the immunoglobulin heavy-chain gene locus","volume":"147","author":"C Guo","year":"2011","journal-title":"Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.immuni.2013.08.011","article-title":"Flexible Long-Range Loops in the VH Gene Region of the Igh Locus Facilitate the Generation of a Diverse Antibody Repertoire","volume":"39","author":"J Medvedovic","year":"2013","journal-title":"Immunity"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0378-1119(99)00261-9","article-title":"Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?","volume":"236","author":"MJ Thomas","year":"1999","journal-title":"Gene"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/sj.onc.1209080","article-title":"Transcription factor YY1: structure, function, and therapeutic implications in cancer biology","volume":"25","author":"S Gordon","year":"2006","journal-title":"Oncogene"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1101\/gad.1559007","article-title":"YY1 helps bring loose ends together","volume":"21","author":"K Calame","year":"2007","journal-title":"Genes Dev"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"7237","DOI":"10.1128\/MCB.19.10.7237","article-title":"Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality","volume":"19","author":"ME Donohoe","year":"1999","journal-title":"Molec Cell Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0155311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T09:46:47Z","timestamp":1718531207000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0155311"}},"subtitle":[],"editor":[{"given":"Yolande","family":"Richard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,11]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0155311","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,11]]}}}