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(2016) IUPHAR\/BPS Guide to PHARMACOLOGY. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/wwwguidetopharmacologyorg\/GRAC\/FamilyDisplayForward?familyId=78\" xlink:type=\"simple\">http:\/\/wwwguidetopharmacologyorg\/GRAC\/FamilyDisplayForward?familyId=78<\/ext-link>."},{"key":"ref69","doi-asserted-by":"crossref","first-page":"11085","DOI":"10.1523\/JNEUROSCI.1690-14.2014","article-title":"Characterization of transcriptomes of cochlear inner and outer hair cells","volume":"34","author":"H Liu","year":"2014","journal-title":"J Neurosci"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuron.2006.03.042","article-title":"TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction","volume":"50","author":"KY Kwan","year":"2006","journal-title":"Neuron"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neulet.2015.10.052","article-title":"The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing","volume":"610","author":"JE Sexton","year":"2016","journal-title":"Neurosci Lett"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.neulet.2005.03.035","article-title":"Hearing impairment in TRPV4 knockout mice","volume":"382","author":"K Tabuchi","year":"2005","journal-title":"Neurosci Lett"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"e77213","DOI":"10.1371\/journal.pone.0077213","article-title":"Transient receptor potential melastatin 1: a hair cell transduction channel candidate","volume":"8","author":"J Gerka-Stuyt","year":"2013","journal-title":"PLoS One"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"e19183","DOI":"10.1371\/journal.pone.0019183","article-title":"Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells","volume":"6","author":"KN Alagramam","year":"2011","journal-title":"PLoS One"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/dvg.20632","article-title":"Gfi1-Cre knock-in mouse line: A tool for inner ear hair cell-specific gene deletion","volume":"48","author":"H Yang","year":"2010","journal-title":"Genesis"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1523\/JNEUROSCI.23-10-04054.2003","article-title":"Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels","volume":"23","author":"JR Meyers","year":"2003","journal-title":"J Neurosci"},{"key":"ref77","article-title":"Disruption of Polycystin-L causes Hippocampal Hyperexcitability","author":"G Yao","year":"2015","journal-title":"Hum Mol Genet"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1073\/pnas.94.13.6965","article-title":"Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2","volume":"94","author":"L Tsiokas","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"20763","DOI":"10.1074\/jbc.M107788200","article-title":"Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex","volume":"277","author":"LJ Newby","year":"2002","journal-title":"J Biol Chem"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.1074\/jbc.M411496200","article-title":"Genomic organization and functional analysis of murine PKD2L1","volume":"280","author":"M Murakami","year":"2005","journal-title":"J Biol Chem"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1096\/fj.10-162925","article-title":"Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae","volume":"24","author":"Y Ishimaru","year":"2010","journal-title":"Faseb J"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/dvdy.20551","article-title":"Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit","volume":"234","author":"V Matei","year":"2005","journal-title":"Dev Dyn"},{"key":"ref83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012821","article-title":"Pkd1 and Pkd2 are required for normal placental development","volume":"5","author":"MA Garcia-Gonzalez","year":"2010","journal-title":"PLoS One"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nature05084","article-title":"The cells and logic for mammalian sour taste detection","volume":"442","author":"AL Huang","year":"2006","journal-title":"Nature"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"12569","DOI":"10.1073\/pnas.0602702103","article-title":"Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor","volume":"103","author":"Y Ishimaru","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"E229","DOI":"10.1073\/pnas.1514282112","article-title":"The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction","volume":"113","author":"W Ye","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/chemse\/bjq070","article-title":"Taste function in mice with a targeted mutation of the pkd1l3 gene","volume":"35","author":"TM Nelson","year":"2010","journal-title":"Chem Senses"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev-neuro-062012-170412","article-title":"Transient receptor potential channels and mechanosensation","volume":"36","author":"N Eijkelkamp","year":"2013","journal-title":"Annu Rev Neurosci"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.conb.2005.05.012","article-title":"TRP channels in mechanosensation","volume":"15","author":"SY Lin","year":"2005","journal-title":"Curr Opin Neurobiol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nrn2149","article-title":"TRP channels in mechanosensation: direct or indirect activation?","volume":"8","author":"AP Christensen","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"14994","DOI":"10.1073\/pnas.222425399","article-title":"Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice","volume":"99","author":"F Di Palma","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1113\/jphysiol.2008.156992","article-title":"TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice","volume":"586","author":"AF van Aken","year":"2008","journal-title":"J Physiol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"e14317","DOI":"10.1371\/journal.pone.0014317","article-title":"Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice","volume":"5","author":"S Jors","year":"2010","journal-title":"PLoS One"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/978-3-642-54215-2_24","article-title":"TRPML1: an ion channel in the lysosome","volume":"222","author":"W Wang","year":"2014","journal-title":"Handb Exp Pharmacol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1172\/JCI200319826","article-title":"Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5","volume":"112","author":"JG Hoenderop","year":"2003","journal-title":"J Clin Invest"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature12833","article-title":"Primary cilia are specialized calcium signalling organelles","volume":"504","author":"M Delling","year":"2013","journal-title":"Nature"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells","volume":"33","author":"SM Nauli","year":"2003","journal-title":"Nat Genet"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1083\/jcb.200805124","article-title":"TRPP2 and TRPV4 form a polymodal sensory channel complex","volume":"182","author":"M Kottgen","year":"2008","journal-title":"J Cell Biol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1096\/fj.14-251652","article-title":"TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel","volume":"28","author":"J Du","year":"2014","journal-title":"Faseb J"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature17426","article-title":"Primary cilia are not calcium-responsive mechanosensors","volume":"531","author":"M Delling","year":"2016","journal-title":"Nature"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nn.3312","article-title":"Molecular architecture of the chick vestibular hair bundle","volume":"16","author":"JB Shin","year":"2013","journal-title":"Nat Neurosci"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1471-4159.2006.03842.x","article-title":"Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells","volume":"98","author":"ND LopezJimenez","year":"2006","journal-title":"J Neurochem"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bbrc.2009.05.069","article-title":"Acetic acid activates PKD1L3-PKD2L1 channel\u2014a candidate sour taste receptor","volume":"385","author":"S Ishii","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"12241","DOI":"10.1523\/JNEUROSCI.6531-10.2011","article-title":"Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells","volume":"31","author":"KA Steigelman","year":"2011","journal-title":"J Neurosci"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"11558","DOI":"10.1073\/pnas.0903684106","article-title":"Structural and molecular basis of the assembly of the TRPP2\/PKD1 complex","volume":"106","author":"Y Yu","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nature03066","article-title":"TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells","volume":"432","author":"DP Corey","year":"2004","journal-title":"Nature"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1073\/pnas.96.10.5791","article-title":"TRP2: a candidate transduction channel for mammalian pheromone sensory signaling","volume":"96","author":"ER Liman","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1126\/science.1069259","article-title":"Loss of sex discrimination and male-male aggression in mice deficient for TRP2","volume":"295","author":"L Stowers","year":"2002","journal-title":"Science"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1073\/pnas.0636123100","article-title":"Relaxed selective pressure on an essential component of pheromone transduction in primate evolution","volume":"100","author":"ER Liman","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"11633","DOI":"10.1523\/JNEUROSCI.4950-10.2011","article-title":"TRPM7 is required within zebrafish sensory neurons for the activation of touch-evoked escape behaviors","volume":"31","author":"SE Low","year":"2011","journal-title":"J Neurosci"},{"issue":"Suppl 2","key":"ref111","doi-asserted-by":"crossref","first-page":"14531","DOI":"10.1073\/pnas.2235619100","article-title":"Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans","volume":"100","author":"W Liedtke","year":"2003","journal-title":"Proc Natl Acad Sci U S 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