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Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach (2010). Available at <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/whqlibdoc.who.int\/publications\/2010\/9789241599764_eng.pdf\" xlink:type=\"simple\">http:\/\/whqlibdoc.who.int\/publications\/2010\/9789241599764_eng.pdf<\/ext-link>. Last date accessed: 20th of December 2015."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0168-8278(91)90084-O","article-title":"Classification of chronic viral hepatitis: a need for reassessment","volume":"13","author":"PJ Scheuer","year":"1991","journal-title":"J Hepatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1053\/j.gastro.2004.11.018","article-title":"Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C","volume":"128","author":"L Cast\u00e9ra","year":"2005","journal-title":"Gastroenterology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1086\/521857","article-title":"The use of transient elastometry for assessing liver fibrosis in patients with HIV and hepatitis C virus coinfection","volume":"45","author":"S Vergara","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.21178","article-title":"Development of a simple noninvasive index to predict significant fibrosis in patients with HIV\/HCV coinfection","volume":"43","author":"RK Sterling","year":"2006","journal-title":"Hepatology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1089\/aid.2011.0050","article-title":"Long-term efficacy, safety, and tolerability of rilpivirine (RPV, TMC278) in HIV type 1-infected antiretroviral-naive patients: week 192 results from a phase IIb randomized trial","volume":"28","author":"A Wilkin","year":"2012","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1093\/jac\/dkr083","article-title":"Liver tolerance of raltegravir-containing antiretroviral therapy in HIV-infected patients with chronic hepatitis C","volume":"66","author":"J Macias","year":"2011","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"19574","DOI":"10.7448\/IAS.17.4.19574","article-title":"Efficacy and safety of etravirine-containing regimens in a large cohort of HIV\/HCV coinfected patients according to liver fibrosis","volume":"17","author":"JL Casado","year":"2014","journal-title":"J Int AIDS Soc"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/jac\/dkn429","article-title":"Hepatic safety of tipranavir plus ritonavir (TPV\/r)-based antiretroviral combinations: effect of hepatitis virus co-infection and pre-existing fibrosis","volume":"63","author":"J Macias","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1089\/apc.2011.0109","article-title":"Liver toxicity of antiretroviral combinations including fosamprenavir plus ritonavir 1400\/100 mg once daily in HIV\/hepatitis C virus-coinfected patients","volume":"25","author":"N Merchante","year":"2011","journal-title":"AIDS Patient Care STDS"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/jac\/dkl214","article-title":"Incidence of and risk factors for severe hepatotoxicity of nelfinavir-containing regimens among HIV-infected patients with chronic hepatitis C","volume":"58","author":"JA Mira","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/jac\/dkn045","article-title":"Liver toxicity of antiretroviral combinations including atazanavir\/ritonavir in patients co-infected with HIV and hepatitis viruses: impact of pre-existing liver fibrosis","volume":"61","author":"JA Pineda","year":"2008","journal-title":"J Antimicrob Chemother"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0155842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T21:29:41Z","timestamp":1589664581000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0155842"}},"subtitle":[],"editor":[{"given":"Wenyu","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,19]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0155842","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,19]]}}}