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Sexually Transmitted Disease Surveillance, 2008. In: Services USDoHaH, editor. Atlanta, GA: http:\/\/www.cdc.gov\/std\/stats08\/toc.htm<\/ext-link>; November 2009."},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1128\/IAI.01244-13","article-title":"Hidden in plain sight: chlamydial gastrointestinal infection and its relevance to persistence in human genital infection","volume":"82","author":"RG Rank","year":"2014","journal-title":"Infection and immunity"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/gut.22.1.25","article-title":"Chlamydiae and inflammatory bowel disease","volume":"22","author":"PR Elliott","year":"1981","journal-title":"Gut"},{"key":"ref14","article-title":"The contribution of Chlamydia-specific CD8 T cells to upper genital tract pathology","author":"KR Vlcek","year":"2015","journal-title":"Immunology and cell biology"},{"issue":"7","key":"ref15","first-page":"980","article-title":"Vaccines for Chlamydia trachomatis infections","volume":"3","author":"LM de la 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