{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:43:24Z","timestamp":1792086204128,"version":"4.4.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T00:00:00Z","timestamp":1463961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Obihiro University of Agriculture and Veterinary Medicine"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0156116","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T18:33:41Z","timestamp":1464028421000},"page":"e0156116","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Effects of Extracts from Thai Piperaceae Plants against Infection with Toxoplasma gondii"],"prefix":"10.1371","volume":"11","author":[{"given":"Arpron","family":"Leesombun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sookruetai","family":"Boonmasawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Shimoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,5,23]]},"reference":[{"issue":"9425","key":"ref1","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis","volume":"363","author":"JG Montoya","year":"2004","journal-title":"Lancet"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ijpara.2009.02.004","article-title":"Toxoplasmosis: A history of clinical observations","volume":"39","author":"LM Weiss","year":"2009","journal-title":"Int J Parasitol"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.puhe.2007.08.009","article-title":"Congenital toxoplasmosis: Priorities for further health promotion action","volume":"122","author":"HM Elsheikha","year":"2008","journal-title":"Public Health"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s40124-014-0055-7","article-title":"Management of Congenital Toxoplasmosis","volume":"2","author":"R McLeod","year":"2014","journal-title":"Curr Pediatr Rep"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.exppara.2009.04.010","article-title":"<italic>Toxoplasma gondii<\/italic>: Effects of <italic>Artemisia annua<\/italic> L. on susceptibility to infection in experimental models <italic>in vitro<\/italic> and <italic>in vivo<\/italic>","volume":"122","author":"TC de Oliveira","year":"2009","journal-title":"Exp Parasitol"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4103\/0974-777X.83536","article-title":"Toxoplasmosis: A Global Threat","volume":"3","author":"JM Furtado","year":"2011","journal-title":"J Glob Infect Dis"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1086\/590149","article-title":"Management of <italic>Toxoplasma gondii<\/italic> infection during pregnancy","volume":"47","author":"JG Montoya","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11101-006-9058-5","article-title":"A review of <italic>Piper<\/italic> spp. (Piperaceae) phytochemistry, insecticidal activity and mode of action","volume":"7","author":"IM Scott","year":"2007","journal-title":"Phytochemistry Reviews"},{"issue":"7","key":"ref9","first-page":"1168","article-title":"Ethnobotany and species specific molecular markers of some medicinal sakhan (Piper, Piperaceae)","volume":"6","author":"S Runglawan","year":"2012","journal-title":"J Med Plants Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.17348\/era.4.0.223-231","article-title":"Ethnobotany of the genus <italic>Piper<\/italic> (Piperaceae) in Thailand","volume":"4","author":"A Chaveerach","year":"2006","journal-title":"Ethnobotany Research and Applications"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s00436-013-3294-6","article-title":"Antimalarial activities of medicinal plants and herbal formulations used in Thai traditional medicine","volume":"112","author":"A Thiengsusuk","year":"2013","journal-title":"Parasitol Res"},{"key":"ref12","first-page":"127","article-title":"<italic>In vitro<\/italic> cytotoxic activity of Benjakul herbal preparation and its active compounds against human lung, cervical and liver cancer cells","volume":"95","author":"S Ruangnoo","year":"2012","journal-title":"J Med Assoc Thai"},{"issue":"1","key":"ref13","first-page":"160","article-title":"Formulation and stability test of Benjakul extract tablets: a preliminary study","volume":"32","author":"M Suthanurak","year":"2010","journal-title":"Thai J Pharmacol"},{"issue":"5","key":"ref14","first-page":"276","article-title":"A Review on <italic>Piper betle<\/italic> L.: Nature\u2019s Promising Medicinal Reservoir","volume":"1","author":"VP Rekha","year":"2014","journal-title":"American Journal of Ethnomedicine"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1099\/jmm.0.009290-0","article-title":"Pro-apoptotic effect of the landrace Bangla Mahoba of <italic>Piper betle<\/italic> on <italic>Leishmania donovani<\/italic> may be due to the high content of eugenol","volume":"58","author":"P Misra","year":"2009","journal-title":"JMed Microbiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1080\/14786419.2013.821123","article-title":"Evaluation of antimicrobial and antimalarial activities of crude extract, fractions and 4-nerolidylcathecol from the aerial parts of <italic>Piper umbellata<\/italic> L. (Piperaceae)","volume":"27","author":"BS Bagatela","year":"2013","journal-title":"Nat Prod Res"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/molecules16010107","article-title":"Antimalarial activity of methanolic leaf extract of <italic>Piper betle<\/italic> L","volume":"16","author":"AH Al-Adhroey","year":"2011","journal-title":"Molecules"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2174\/1574891X10666150410120321","article-title":"Anti-<italic>Toxoplasma<\/italic> Activity of Natural Products: A Review","volume":"9","author":"JC Sep\u00falveda-Arias","year":"2014","journal-title":"Recent Pat Antiinfect Drug Discov"},{"issue":"13","key":"ref19","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0020-7519(03)00204-2","article-title":"Characterisation of <italic>Toxoplasma gondii<\/italic> engineered to express mouse interferon-gamma","volume":"33","author":"Y Nishikawa","year":"2003","journal-title":"Int J Parasitol"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.parint.2007.10.004","article-title":"Construction of <italic>Toxoplasma gondii<\/italic> bradyzoite expressing the green fluorescent protein","volume":"57","author":"Y Nishikawa","year":"2008","journal-title":"Parasitol Int"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1590\/S0036-46652006000100007","article-title":"ADULTICIDAL ACTIVITY AGAINST Stegomyia aegypti (DIPTERA: CULICIDAE) OF THREE Piper spp","volume":"48","author":"W Choochote","year":"2006","journal-title":"Rev Inst Med trop S Paulo"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.foodchem.2005.11.032","article-title":"Assessment of phenolic content and free radical-scavenging capacity of some Thai indigenous plants","volume":"100","author":"P Maisuthisakul","year":"2007","journal-title":"Food Chem"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1128\/IAI.73.2.695-702.2005","article-title":"Bioluminescence imaging of <italic>Toxoplasma gondii<\/italic> infection in living mice reveals dramatic differences between strains","volume":"73","author":"JP Saeij","year":"2005","journal-title":"Infect Immun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e13124","DOI":"10.1371\/journal.pone.0013124","article-title":"A rapid murine coma and behavior scale for quantitative assessment of murine cerebral malaria","volume":"5","author":"RW Carroll","year":"2010","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1742-2094-5-48","article-title":"Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection","volume":"5","author":"G Hermes","year":"2008","journal-title":"J Neuroinflammation"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1128\/IAI.00439-13","article-title":"Transcriptome analysis of mouse brain infected with <italic>Toxoplasma gondii<\/italic>","volume":"81","author":"S Tanaka","year":"2013","journal-title":"Infect Immun"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4103\/2230-8229.96997","article-title":"<italic>In vivo<\/italic> effect of some home spices extracts on the <italic>toxoplasma gondii<\/italic> tachyzoites","volume":"16","author":"NA Al-Zanbagi","year":"2009","journal-title":"J Family Community Med"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jksus.2014.04.006","article-title":"Phytochemical screening and antimicrobial activity of root and stem extracts of wild <italic>Eurycoma longifolia<\/italic> Jack (Tongkat Ali)","volume":"27","author":"Z Khanam","year":"2015","journal-title":"Journal of King Saud University\u2013Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1472-6882-12-91","article-title":"<italic>In vitro Anti-Toxoplasma gondii<\/italic> Activity of Root Extract\/Fractions of <italic>Eurycoma longifolia<\/italic> Jack","volume":"12","author":"N Kavitha","year":"2012","journal-title":"BMC Complement Altern Med"},{"key":"ref30","first-page":"92","article-title":"Anti-Parasitic Activity of <italic>Myristica Fragrans<\/italic> Houtt","volume":"2","author":"S Pillai","year":"2012","journal-title":"Essential Oil Against"},{"issue":"1","key":"ref31","first-page":"185","article-title":"Effect of artesunate on <italic>Toxoplasma gondii<\/italic>: <italic>in vitro<\/italic> and <italic>in vivo<\/italic> studies","volume":"38","author":"LA El Zawawy","year":"2008","journal-title":"J Egypt Soc Parasitol"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1128\/EC.00262-07","article-title":"Artemisinin induces calcium-dependent protein secretion in the protozoan parasite <italic>Toxoplasma gondii<\/italic>","volume":"6","author":"K Nagamune","year":"2007","journal-title":"Eukaryot. Cell"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.str.2015.02.011","article-title":"Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis","volume":"23","author":"V Jain","year":"2015","journal-title":"Structure"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0304-4017(03)00154-7","article-title":"Anti-protozoal efficacy of medicinal herb extracts against <italic>Toxoplasma gondii<\/italic> and <italic>Neospora caninum<\/italic>","volume":"116","author":"HJ Youn","year":"2003","journal-title":"Vet Parasitol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1476-0711-9-7","article-title":"<italic>In vitro<\/italic> antifungal activity of hydroxychavicol isolated from <italic>Piper betle<\/italic> L","volume":"9","author":"I Ali","year":"2010","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"ref36","first-page":"1","article-title":"The phytochemistry, traditional uses and pharmacology of <italic>Piper Betel<\/italic>. linn (Betel Leaf): A pan-asiatic medicinal plant","author":"F Fazal","year":"2014","journal-title":"Chin J Integr Med"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jep.2009.03.010","article-title":"<italic>In vitro<\/italic> screening for anthelmintic and antitumour activity of ethnomedicinal plants from Thailand","volume":"123","author":"K Atjanasuppat","year":"2009","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1021\/jf00126a011","article-title":"Identification of Fungicidal and Nematocidal Components in the Leaves of <italic>Piper betle<\/italic> (Piperaceae)","volume":"32","author":"HE Philip","year":"1984","journal-title":"J Agric Food Chem"},{"issue":"1\u20133","key":"ref39","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jep.2005.03.011","article-title":"Evaluation of plants used for antimalarial treatment by the Maasaiof Kenya","volume":"101","author":"A Koch","year":"2005","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1128\/AAC.39.3.763","article-title":"<italic>In vitro<\/italic> effects of sulfadiazine and its metabolites alone and in combination with pyrimethamine on <italic>Toxoplasma gondii<\/italic>","volume":"39","author":"E Schoondermark-van de Ven","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jep.2005.06.016","article-title":"Antidiabetic activities of aqueous and ethanolic extracts of <italic>Piper betle<\/italic> leaves in rats","volume":"102","author":"LS Arambewela","year":"2005","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"ref42","first-page":"93","article-title":"Review study on potential activity of <italic>Piper betle<\/italic>","volume":"3","author":"V Dwivedi","year":"2014","journal-title":"J Pharmacogn Phytochem"},{"issue":"2","key":"ref43","first-page":"10","article-title":"Phytochemistry, Pharmacological Profile and Therapeutic Uses of <italic>Piper Betle<\/italic> Linn.\u2013An Overview","volume":"1","author":"SA Bhalerao","year":"2013","journal-title":"J Pharmacogn Phytochem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0156116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T15:12:42Z","timestamp":1692371562000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0156116"}},"subtitle":[],"editor":[{"given":"Takafumi","family":"Tsuboi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,23]]},"references-count":43,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0156116","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,23]]}}}