{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:55:17Z","timestamp":1790841317382,"version":"4.1.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR and ANR-11-IDEX-0005-02"],"award-info":[{"award-number":["ANR and ANR-11-IDEX-0005-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0156138","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T23:21:02Z","timestamp":1466119262000},"page":"e0156138","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Network Modeling of Crohn\u2019s Disease Incidence"],"prefix":"10.1371","volume":"11","author":[{"given":"Jean-Marc","family":"Victor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Debret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Lesne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh","family":"Pascoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Carrivain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Wainrib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8446-6056","authenticated-orcid":false,"given":"Jean-Pierre","family":"Hugot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature10209","article-title":"Genetics and pathogenesis of inflammatory bowel disease","volume":"474","author":"B Khor","year":"2011","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"L Jostins","year":"2012","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/ng.733","article-title":"Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease","volume":"43","author":"Y Momozawa","year":"2011","journal-title":"Nat Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e1003723","DOI":"10.1371\/journal.pgen.1003723","article-title":"Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis","volume":"9","author":"M Beaudoin","year":"2013","journal-title":"PLoS Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/ng.762","article-title":"A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease","volume":"43","author":"P Brest","year":"2011","journal-title":"Nat Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1222794","article-title":"Systematic localization of common disease-associated variation in regulatory DNA","volume":"337","author":"MT Maurano","year":"2012","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nature08979","article-title":"Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls","volume":"464","author":"N Craddock","year":"2010","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.ajhg.2013.05.002","article-title":"Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease","volume":"92","author":"Z Wei","year":"2013","journal-title":"Am J Hum Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1056\/NEJMoa0907206","article-title":"Inflammatory bowel disease and mutations affecting the interleukin-10 receptor","volume":"361","author":"EO Glocker","year":"2009","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1136\/gutjnl-2011-300078","article-title":"NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2","volume":"61","author":"AM Muise","year":"2012","journal-title":"Gut"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.jaci.2014.04.031","article-title":"Characterization of Crohn disease in X-linked inhibitor of apoptosis-deficient male patients and female symptomatic carriers","volume":"134","author":"C Aguilar","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"ref12","first-page":"497","article-title":"Genetic susceptibility to a complex disease: the key role of functional redundancy","volume":"33","author":"G Debret","year":"2011","journal-title":"Hist Philos Life Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e1001273","DOI":"10.1371\/journal.pgen.1001273","article-title":"Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology","volume":"7","author":"EJ Rossin","year":"2011","journal-title":"PLoS Genetics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrm1570","article-title":"Reconstruction of cellular signalling networks and analysis of their properties","volume":"6","author":"JA Papin","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrg2918","article-title":"Network medicine: a network-based approach to human disease","volume":"12","author":"AL Barabasi","year":"2011","journal-title":"Nature Reviews Genetics"},{"key":"ref16","first-page":"1428","article-title":"Heritability in inflammatory bowel disease: from the first twin study to genome-wide association studies","volume":"21","author":"H Gordon","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1006\/jtbi.2001.2430","article-title":"The reliability theory of aging and longevity","volume":"213","author":"LA Gavrilov","year":"2001","journal-title":"J Theor Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/j.1365-2036.2011.04628.x","article-title":"The changing pattern of Crohn's disease incidence in northern France: a continuing increase in the 10- to 19-year-old age bracket (1988\u20132007)","volume":"33","author":"V Chouraki","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/gut.41.4.480","article-title":"Incidence of Crohn's disease in Stockholm County 1955\u20131989","volume":"41","author":"A Lapidus","year":"1997","journal-title":"Gut"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/ibd.20310","article-title":"Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986\u20132005: a KASID study","volume":"14","author":"SK Yang","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1053\/j.gastro.2011.01.055","article-title":"Epidemiology and natural history of inflammatory bowel diseases","volume":"140","author":"J Cosnes","year":"2011","journal-title":"Gastroenterology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/ibd.20029","article-title":"Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted County, Minnesota, 1940\u20132000","volume":"13","author":"CG Loftus","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1136\/gut.29.3.346","article-title":"Cardiff Crohn's disease jubilee: the incidence over 50 years","volume":"29","author":"JD Rose","year":"1988","journal-title":"Gut"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"NA Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1001\/jama.251.1.73","article-title":"Landmark article Oct 15, 1932. Regional ileitis. A pathological and clinical entity. By Burril B. Crohn, Leon Ginzburg, and Gordon D. Oppenheimer","volume":"251","author":"BB Crohn","year":"1984","journal-title":"JAMA"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1365-2036.2007.03576.x","article-title":"The incidence of Crohn's disease in Cardiff over the last 75 years: an update for 1996\u20132005","volume":"27","author":"S Gunesh","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"ref27","unstructured":"Th\u00e9venot R. Essai pour une histoire du froid artificiel dans le monde. Institut International du froid, Paris (1978)."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1016\/S0140-6736(03)15024-6","article-title":"Crohn's disease: the cold chain hypothesis","volume":"362","author":"JP Hugot","year":"2003","journal-title":"Lancet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease","volume":"411","author":"JP Hugot","year":"2001","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.schres.2007.09.027","article-title":"Age-specific familial risks of psychotic disorders and schizophrenia: A nation-wide epidemiological study from Sweden"","volume":"97","author":"X Li","year":"2007","journal-title":"Schizophr Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/jech.41.1.5","article-title":"Epidemiology of multiple sclerosis in the north-east (Grampian region) of Scotland-an update","volume":"41","author":"JG Phadke","year":"1987","journal-title":"J Epidemiol Community Health"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1002\/art.1780351211","article-title":"Ankylosing spondylitis in Rochester, Minnesota, 1935\u20131989. Is the epidemiology changing?","volume":"35","author":"LD Carbone","year":"1992","journal-title":"Arthritis Rheum"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0156138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T17:59:11Z","timestamp":1718647151000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0156138"}},"subtitle":[],"editor":[{"given":"Dimitris L.","family":"Kontoyiannis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,16]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0156138","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,16]]}}}