{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:20:33Z","timestamp":1777353633009,"version":"3.51.4"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 104-2314-B-038-025"],"award-info":[{"award-number":["MOST 104-2314-B-038-025"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014730","name":"Taipei City Government","doi-asserted-by":"crossref","award":["104XDAA00078"],"award-info":[{"award-number":["104XDAA00078"]}],"id":[{"id":"10.13039\/501100014730","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NTUT-TMU Joint Research Program","award":["NTUT-TMU-102-03"],"award-info":[{"award-number":["NTUT-TMU-102-03"]}]},{"name":"Taipei Medical University Aim for the Top University Project\u2013Cancer Translational Center","award":["TMUTOP103002-3"],"award-info":[{"award-number":["TMUTOP103002-3"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0156260","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T17:43:19Z","timestamp":1464284599000},"page":"e0156260","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["MicroRNA-1301-Mediated RanGAP1 Downregulation Induces BCR-ABL Nuclear Entrapment to Enhance Imatinib Efficacy in Chronic Myeloid Leukemia Cells"],"prefix":"10.1371","volume":"11","author":[{"given":"Tsung-Yao","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ku-Chung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsing-Jin Eugene","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann-Jeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun-Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chwen-Ming","family":"Shih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1182\/blood-2013-03-490003","article-title":"The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: from the perspective of a large group of CML experts","volume":"121","year":"2013","journal-title":"Blood"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1182\/blood-2004-08-3097","article-title":"The development of imatinib as a therapeutic agent for chronic myeloid leukemia","volume":"105","author":"M Deininger","year":"2005","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1200\/JCO.2013.52.9123","article-title":"Cost sharing and adherence to tyrosine kinase inhibitors for patients with chronic myeloid leukemia","volume":"32","author":"SB Dusetzina","year":"2014","journal-title":"J Clin Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1200\/JCO.2010.32.0598","article-title":"Tolerability-adapted imatinib 800 mg\/d versus 400 mg\/d versus 400 mg\/d plus interferon-\u03b1 in newly diagnosed chronic myeloid leukemia","volume":"29","author":"R Hehlmann","year":"2011","journal-title":"J Clin Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nrc1567","article-title":"Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia","volume":"5","author":"R Ren","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/j.1460-2075.1996.tb00503.x","article-title":"The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products","volume":"15","author":"ST Wen","year":"1996","journal-title":"EMBO J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"7457","DOI":"10.1073\/pnas.95.13.7457","article-title":"Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase","volume":"95","author":"S Taagepera","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e17020","DOI":"10.1371\/journal.pone.0017020","article-title":"Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL","volume":"6","author":"M Preyer","year":"2011","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/21704","article-title":"p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage","volume":"399","author":"ZM Yuan","year":"1999","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/84683","article-title":"Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase","volume":"7","author":"P Vigneri","year":"2001","journal-title":"Nat Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.18632\/oncotarget.1339","article-title":"Induction of apoptosis by directing oncogenic Bcr-Abl into the nucleus","volume":"4","author":"ZL Huang","year":"2013","journal-title":"Oncotarget"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1134\/S0006297907130032","article-title":"Nucleocytoplasmic transport of proteins","volume":"72","author":"AV Sorokin","year":"2007","journal-title":"Biochemistry (Mosc)"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1600-0854.2005.00270.x","article-title":"Mechanisms of receptor-mediated nuclear import and nuclear export","volume":"6","author":"LF Pemberton","year":"2005","journal-title":"Traffic"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13045-014-0085-1","article-title":"Nucleo-cytoplasmic transport as a therapeutic target of cancer","volume":"7","author":"GL Gravina","year":"2014","journal-title":"J Hematol Oncol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1476-4598-8-102","article-title":"MicroRNAs in colorectal cancer: translation of molecular biology into clinical application","volume":"8","author":"O Slaby","year":"2009","journal-title":"Mol Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.1038\/sj.onc.1209913","article-title":"A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes","volume":"25","author":"OA Kent","year":"2006","journal-title":"Oncogene"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.3324\/haematol.2009.020636","article-title":"Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia","volume":"95","author":"S Flamant","year":"2010","journal-title":"Haematologica"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1161\/CIRCULATIONAHA.108.804294","article-title":"Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight\/obese middle-aged and older humans","volume":"119","author":"GL Pierce","year":"2009","journal-title":"Circulation"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1128\/MCB.24.24.10529-10541.2004","article-title":"Negative modulation of androgen receptor transcriptional activity by Daxx","volume":"24","author":"DY Lin","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"BP Lewis","year":"2005","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e111777","DOI":"10.1371\/journal.pone.0111777","article-title":"Regulation of RAB5C is important for the growth inhibitory effects of MiR-509 in human precursor-B acute lymphoblastic leukemia","volume":"9","author":"YS Tan","year":"2014","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1182\/blood-2014-08-588855","article-title":"shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance","volume":"125","author":"JS Khorashad","year":"2015","journal-title":"Blood"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e79863","DOI":"10.1371\/journal.pone.0079863","article-title":"Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma","volume":"8","author":"KC Chang","year":"2013","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0092-8674(00)80371-2","article-title":"CRM1 is an export receptor for leucine-rich nuclear export signals","volume":"90","author":"M Fornerod","year":"1997","journal-title":"Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/36894","article-title":"CRM1 is responsible for intracellular transport mediated by the nuclear export signal","volume":"390","author":"M Fukuda","year":"1997","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1034\/j.1600-0854.2000.010602.x","article-title":"The molecular mechanism of transport of macromolecules through nuclear pore complexes","volume":"1","author":"R Bayliss","year":"2000","journal-title":"Traffic"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1182\/blood-2005-05-2123","article-title":"BCR-ABL nuclear entrapment kills human CML cells: ex vivo study on 35 patients with the combination of imatinib mesylate and leptomycin B","volume":"107","author":"A Aloisi","year":"2006","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/leu.2008.367","article-title":"Nuclear entrapment of BCR-ABL by combining imatinib mesylate with leptomycin B does not eliminate CD34+ chronic myeloid leukaemia cells","volume":"23","author":"EK Allan","year":"2009","journal-title":"Leukemia"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/bjc.1996.415","article-title":"Phase I trial of elactocin","volume":"74","author":"ES Newlands","year":"1996","journal-title":"Br J Cancer"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"34475","DOI":"10.1074\/jbc.M301051200","article-title":"c-Abl tyrosine kinase selectively regulates p73 nuclear matrix association","volume":"278","author":"M Ben-Yehoyada","year":"2003","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"283863","DOI":"10.1155\/2010\/283863","article-title":"p73-Binding Partners and Their Functional Significance","volume":"2010","author":"T Ozaki","year":"2010","journal-title":"Int J Proteomics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/sj.cdd.4402264","article-title":"RelA\/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells","volume":"15","author":"R Cianfrocca","year":"2008","journal-title":"Cell Death Differ"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1158\/1535-7163.MCT-08-0299","article-title":"Trichostatin A up-regulates p73 and induces Bax-dependent apoptosis in cisplatin-resistant ovarian cancer cells","volume":"7","author":"M Muscolini","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.canlet.2010.09.019","article-title":"MicroRNAs, cancer and cancer stem cells","volume":"300","author":"AL Zimmerman","year":"2011","journal-title":"Cancer Lett"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.canlet.2015.02.031","article-title":"Restoration of miR-424 suppresses BCR-ABL activity and sensitizes CML cells to imatinib treatment","volume":"360","author":"O Hershkovitz-Rokah","year":"2015","journal-title":"Cancer Lett"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1182\/blood-2007-10-116475","article-title":"Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study","volume":"111","author":"RA Larson","year":"2008","journal-title":"Blood"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.leukres.2012.08.014","article-title":"Imatinib increases apoptosis index through modulation of survivin subcellular localization in the blast phase of CML cells","volume":"36","author":"PS Bernardo","year":"2012","journal-title":"Leuk Res"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0173828","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0156260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T21:59:48Z","timestamp":1589666388000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0156260"}},"subtitle":[],"editor":[{"given":"Persio","family":"Dello Sbarba","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,26]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0156260","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0173828","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,26]]}}}