{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:11:56Z","timestamp":1789092716714,"version":"build-2803163510"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T00:00:00Z","timestamp":1464134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0156261","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T13:47:43Z","timestamp":1464184063000},"page":"e0156261","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Psychiatric Diagnoses in Individuals with Non-Syndromic Oral Clefts: A Danish Population-Based Cohort Study"],"prefix":"10.1371","volume":"11","author":[{"given":"Dorthe Almind","family":"Pedersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George L.","family":"Wehby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaare","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,5,25]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1597\/1545-1569(1999)036<0096:TCDFCP>2.3.CO;2","article-title":"The 20th century Danish facial cleft population\u2014epidemiological and genetic-epidemiological studies","volume":"36","author":"K Christensen","year":"1999","journal-title":"Cleft Palate Craniofac J"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1597\/03-139.1","article-title":"Changing lifestyles and oral clefts occurrence in Denmark","volume":"42","author":"C Bille","year":"2005","journal-title":"Cleft Palate Craniofac J"},{"key":"ref3","article-title":"Inheritance of harelip and cleft palate","author":"P Fogh-Andersen","year":"1942","journal-title":"Nyt Nordisk Forlag, Anold Busck"},{"issue":"9703","key":"ref4","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60695-4","article-title":"Cleft lip and palate","volume":"374","author":"PA Mossey","year":"2009","journal-title":"Lancet"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.ijporl.2015.04.024","article-title":"Frequency and socio-psychological impact of taunting in school-age patients with cleft lip-palate surgical repair","volume":"79","author":"A Lorot-Marchand","year":"2015","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1597\/05-080","article-title":"Self-reports of psychosocial functioning among children and young adults with cleft lip and palate","volume":"43","author":"O Hunt","year":"2006","journal-title":"Cleft Palate Craniofac J"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/028443102753478327","article-title":"Facial appearance in adults who had cleft lip and palate treated in childhood","volume":"36","author":"A Marcusson","year":"2002","journal-title":"Scandinavian journal of plastic and reconstructive surgery and hand surgery \/ Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1597\/11-055","article-title":"Oral health-related quality of life in children with orofacial clefts","volume":"50","author":"JA Ward","year":"2013","journal-title":"Cleft Palate Craniofac J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1472-6963-12-58","article-title":"The effects of oral clefts on hospital use throughout the lifespan","volume":"12","author":"GL Wehby","year":"2012","journal-title":"BMC Health Serv Res"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10198-014-0612-6","article-title":"Long-term effects of oral clefts on health care utilization: a sibling comparison","volume":"16","author":"M Pedersen","year":"2015","journal-title":"The European Journal of Health Economics"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1597\/09-047","article-title":"Academic achievement in individuals with cleft: a population-based register study","volume":"49","author":"M Persson","year":"2012","journal-title":"Cleft Palate Craniofac J"},{"key":"ref12","article-title":"Academic Achievement of Children and Adolescents With Oral Clefts","author":"GL Wehby","year":"2014","journal-title":"Pediatrics"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1597\/08-281","article-title":"EDITOR&apos;S CHOICE: Quality of Life Varies With Gender and Age Among Adults Treated for Unilateral Cleft Lip and Palate","volume":"47","author":"M Mani","year":"2010","journal-title":"Cleft Palate Craniofac J"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1597\/08-093.1","article-title":"Coping with a cleft: psychosocial adjustment of adolescents with a cleft lip and palate and their parents","volume":"46","author":"ZE Berger","year":"2009","journal-title":"Cleft Palate Craniofac J"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1597\/10-007","article-title":"Psychosocial functioning in children with and without orofacial clefts and their parents","volume":"49","author":"BR Collett","year":"2012","journal-title":"Cleft Palate Craniofac J"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/ejo\/cji004","article-title":"The psychosocial effects of cleft lip and palate: a systematic review","volume":"27","author":"O Hunt","year":"2005","journal-title":"Eur J Orthod"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1601-0825.2009.01588.x","article-title":"The impact of orofacial clefts on quality of life and healthcare use and costs","volume":"16","author":"GL Wehby","year":"2010","journal-title":"Oral Dis"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/ajmg.c.31435","article-title":"Developmental trajectories in 22q11.2 deletion syndrome","volume":"169","author":"A Swillen","year":"2015","journal-title":"American journal of medical genetics Part C, Seminars in medical genetics"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1176\/appi.ajp.2013.13070864","article-title":"Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome","volume":"171","author":"M Schneider","year":"2014","journal-title":"The American journal of psychiatry"},{"issue":"8","key":"ref20","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/archpedi.161.8.753","article-title":"Abnormal brain structure in children with isolated clefts of the lip or palate","volume":"161","author":"P Nopoulos","year":"2007","journal-title":"Archives of pediatrics & adolescent medicine"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00125817-200201000-00001","article-title":"Structural brain abnormalities in adult males with clefts of the lip and\/or palate. Genetics in medicine: official journal of the","volume":"4","author":"P Nopoulos","year":"2002","journal-title":"American College of Medical Genetics"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1552-6569.2001.tb00072.x","article-title":"Increased incidence of a midline brain anomaly in patients with nonsyndromic clefts of the lip and\/or palate","volume":"11","author":"P Nopoulos","year":"2001","journal-title":"Journal of neuroimaging: official journal of the American Society of Neuroimaging"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1002\/ajmg.a.35835","article-title":"Corpus callosum shape is altered in individuals with nonsyndromic cleft lip and palate","volume":"161A","author":"SM Weinberg","year":"2013","journal-title":"Am J Med Genet A"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0006-3223(96)00209-0","article-title":"Cavum septi pellucidi in normals and patients with schizophrenia as detected by magnetic resonance imaging","volume":"41","author":"P Nopoulos","year":"1997","journal-title":"Biological psychiatry"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1177\/088307389801300305","article-title":"Cavum septi pellucidi and cavum vergae in normal and developmentally delayed populations","volume":"13","author":"JB Bodensteiner","year":"1998","journal-title":"Journal of child neurology"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.genhosppsych.2011.06.006","article-title":"Psychiatric assessment of children with nonsyndromic cleft lip and palate","volume":"33","author":"T Demir","year":"2011","journal-title":"General hospital psychiatry"},{"key":"ref27","article-title":"Separation Anxiety in Children Ages 4 Through 9 with Oral Clefts","author":"MC Tyler","year":"2013","journal-title":"Cleft Palate Craniofac J"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11689-010-9060-5","article-title":"Hyperactivity, impulsivity, and inattention in boys with cleft lip and palate: relationship to ventromedial prefrontal cortex morphology","volume":"2","author":"P Nopoulos","year":"2010","journal-title":"Journal of neurodevelopmental disorders"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1601-0825.2011.01847.x","article-title":"Oral clefts and behavioral health of young children","volume":"18","author":"GL Wehby","year":"2012","journal-title":"Oral Dis"},{"issue":"7453","key":"ref30","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1136\/bmj.38106.559120.7C","article-title":"Long term follow up study of survival associated with cleft lip and palate at birth","volume":"328","author":"K Christensen","year":"2004","journal-title":"BMJ (Clinical research ed)"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"e005306","DOI":"10.1136\/bmjopen-2014-005306","article-title":"Psychotropic drug use in adolescents born with an orofacial cleft: a population-based study","volume":"5","author":"S Nilsson","year":"2015","journal-title":"BMJ open"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/02844319509008968","article-title":"Psychosocial adjustment in Norwegian adults who had undergone standardised treatment of complete cleft lip and palate. II. Self-reported problems and concerns with appearance","volume":"29","author":"T Ramstad","year":"1995","journal-title":"Scandinavian journal of plastic and reconstructive surgery and hand surgery \/ Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1597\/1545-1569(2002)039<0392:FCAPDA>2.0.CO;2","article-title":"Facial clefting and psychiatric diseases: a follow-up of the Danish 1936\u20131987 Facial Cleft cohort","volume":"39","author":"K Christensen","year":"2002","journal-title":"Cleft Palate Craniofac J"},{"issue":"3","key":"ref34","first-page":"654","article-title":"Selection bias in genetic-epidemiological studies of cleft lip and palate","volume":"51","author":"K Christensen","year":"1992","journal-title":"Am J Hum Genet"},{"issue":"4","key":"ref35","first-page":"441","article-title":"The Danish Civil Registration System. A cohort of eight million persons","volume":"53","author":"CB Pedersen","year":"2006","journal-title":"Dan Med Bull"},{"issue":"7 Suppl","key":"ref36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The Danish Civil Registration System","volume":"39","author":"CB Pedersen","year":"2011","journal-title":"Scand J Public Health"},{"issue":"7 Suppl","key":"ref37","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/1403494810395825","article-title":"The Danish Psychiatric Central Research Register","volume":"39","author":"O Mors","year":"2011","journal-title":"Scand J Public Health"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0924-9338(99)80685-3","article-title":"Validity of diagnoses and other clinical register data in patients with affective disorder","volume":"13","author":"L Kessing","year":"1998","journal-title":"European psychiatry: the journal of the Association of European Psychiatrists"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000107084","article-title":"Validity of dementia diagnoses in the Danish hospital registers","volume":"24","author":"TK Phung","year":"2007","journal-title":"Dementia and geriatric cognitive disorders"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1745-0179-5-4","article-title":"Validity of the diagnosis of a single depressive episode in a case register","volume":"5","author":"C Bock","year":"2009","journal-title":"Clinical practice and epidemiology in mental health: CP & EMH"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10803-009-0818-0","article-title":"Validity of childhood autism in the Danish Psychiatric Central Register: findings from a cohort sample born 1990\u20131999","volume":"40","author":"MB Lauritsen","year":"2010","journal-title":"Journal of autism and developmental disorders"},{"issue":"2","key":"ref42","first-page":"A4578","article-title":"The validity of the schizophrenia diagnosis in the Danish Psychiatric Central Research Register is good","volume":"60","author":"P Uggerby","year":"2013","journal-title":"Danish medical journal"},{"issue":"7 Suppl","key":"ref43","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/1403494811399958","article-title":"The Danish Register of Causes of Death","volume":"39","author":"K Helweg-Larsen","year":"2011","journal-title":"Scand J Public Health"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1001\/jamapsychiatry.2014.16","article-title":"A comprehensive nationwide study of the incidence rate and lifetime risk for treated mental disorders","volume":"71","author":"CB Pedersen","year":"2014","journal-title":"JAMA psychiatry"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.psychres.2003.06.001","article-title":"Minor physical anomalies in patients with schizophrenia and their parents: prevalence and pattern of craniofacial abnormalities","volume":"125","author":"D Gourion","year":"2004","journal-title":"Psychiatry research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0156261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T22:51:22Z","timestamp":1540335082000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0156261"}},"subtitle":[],"editor":[{"given":"Brion","family":"Maher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,25]]},"references-count":45,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0156261","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,25]]}}}