{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:34:31Z","timestamp":1790418871980,"version":"4.1.0"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0156299","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T13:51:19Z","timestamp":1464270679000},"page":"e0156299","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":75,"title":["Clinical Impact of MALDI-TOF MS Identification and Rapid Susceptibility Testing on Adequate Antimicrobial Treatment in Sepsis with Positive Blood Cultures"],"prefix":"10.1371","volume":"11","author":[{"given":"Alexia","family":"Verroken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydwine","family":"Defourny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"le Polain de Waroux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u00efla","family":"Belkhir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Fran\u00e7ois","family":"Laterre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Delm\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youri","family":"Glupczynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"ref1","unstructured":"Centers for Disease Control and Prevention [Internet]. Atlanta. National Center for Emerging and Zoonotic Infectious diseases. Division of healthcare Qaulity promotion. Basic information and patient resources. CS257671C. [updated 2015 October 5]. Available from: http:\/\/www.cdc.gov\/sepsis\/pdfs\/sepsis-fact-sheet.pdf<\/ext-link>."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1128\/JCM.41.7.3119-3125.2003","article-title":"Effects of rapid detection of bloodstream infections on length of hospitalization and hospital charges","volume":"41","author":"SE Beekmann","year":"2003","journal-title":"J Clin Microbiol"},{"issue":"Suppl 3","key":"ref3","doi-asserted-by":"crossref","first-page":"S177","DOI":"10.1086\/519472","article-title":"Principles of antibiotic therapy in severe infections: optimizing the therapeutic approach by use of laboratory and clinical data","volume":"45","author":"S Deresinski","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/jac\/dkm497","article-title":"Rapid identification and antimicrobial susceptibility testing reduce antibiotic use and accelerate pathogen-directed antibiotic use","volume":"61","author":"JJ Kerremans","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1111\/j.1469-0691.2010.03311.x","article-title":"Matrix-assisted laser desorption ionization time-of-flight mass spectrometry, a revolution in clinical microbial identification","volume":"16","author":"A Bizzini","year":"2010","journal-title":"Clin Microbiol infect"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/cid\/cis1204","article-title":"Impact of matrix-assisted laser desorption ionization time-of-flight mass spectrometry on the clinical management of patients with Gram-negative bacteremia: a prospective observational study","volume":"56","author":"O Clerc","year":"2013","journal-title":"Clin Inf Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/cid\/cit498","article-title":"Impact of rapid organism identification via matrix-assisted laser desorption\/ionization time-of-flight combined with antimicrobial stewardship team intervention in adult patients with bacteremia and candidemia","volume":"57","author":"AM Huang","year":"2013","journal-title":"Clin Inf Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/1469-0691.12282","article-title":"Impact of rapid microbial identification directly from positive blood cultures using matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry on patient management","volume":"19","author":"D Martiny","year":"2013","journal-title":"Clin Microbiol Inf"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"e32589","DOI":"10.1371\/journal.pone.0032589","article-title":"Direct matrix-assisted laser desorption ionization time-of-flight mass spectrometry improves appropriateness of antibiotic treatment of bacteremia","volume":"7","author":"AL Vlek","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3343\/alm.2015.35.4.454","article-title":"Direct Identification of Staphylococcus aureus and Determination of Methicillin Susceptibility From Positive Blood-Culture Bottles in a Bact\/ALERT System Using Binax Now S. aureus and PBP2a Tests","volume":"35","author":"S Heraud","year":"2015","journal-title":"Ann Lab Med"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1128\/JCM.00524-13","article-title":"Evaluation of the betaLACTA test, a novel commercial chromogenic test for rapid detection of ceftazidime-nonsusceptible Pseudomonas aeruginosa isolates","volume":"51","author":"T Laurent","year":"2013","journal-title":"J Clin Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1128\/JCM.01936-13","article-title":"Evaluation of the \u03b2Lacta test, a rapid test detecting resistance to third-generation cephalopsorins in clinical strains of Enterobacteriaceae","volume":"51","author":"A Renvois\u00e9","year":"2013","journal-title":"J Clin Microbiol"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.diagmicrobio.2015.07.005","article-title":"Early detection with the beta-LACTA test of extended-spectrum beta-lactamase-producing Enterobacteriaceae in blood cultures","volume":"83","author":"V Walewski","year":"2015","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10096-014-2242-4","article-title":"Reducing time to identification of positive blood cultures with MALDI-TOF MS analysis after a 5-h subculture","volume":"34","author":"A Verroken","year":"2015","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref15","unstructured":"Centers for Disease Control and Prevention [Internet]. Atlanta. National Healthcare Safety Network CDC\/NHSN bloodstream infection event (central line-associated infection and non-central line-associated bloodstream infection). [updated 2016 January]. Available online at: http:\/\/www.cdc.gov\/nhsn\/PDFs\/pscManual\/4PSC_CLABScurrent.pdf<\/ext-link>."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"827416","DOI":"10.1155\/2015\/827416","article-title":"Rapid identification of pathogens in positive blood culture of patients with sepsis: review and meta-analysis of the performance of the sepsityper kit","volume":"2015","author":"NG Morgenthaler","year":"2015","journal-title":"Int J Microbiol"},{"issue":"7\u20138","key":"ref17","first-page":"289","article-title":"Performance of a matrix-assisted laser desorption ionization-time-of-flight mass spectrometry system for the identification of bacterial isolates in the clinical routine laboratory","volume":"55","author":"U Eigner","year":"2009","journal-title":"Clin Lab"},{"key":"ref18","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. [Internet]. Basel, Switzerland. Breakpoint tables for interpretation of MICs and zone diameters. Version 3.1.2013. Available online at: http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Breakpoint_tables\/Breakpoint_table_v_3.1.pdf<\/ext-link>."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/1471-2180-11-156","article-title":"Evaluation of direct inoculation of the BD PHOENIX system from positive BACTEC blood cultures for both Gram-positive cocci and Gram-negative rods","volume":"11","author":"J Beuving","year":"2011","journal-title":"BMC Microbiol"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/jac\/dkl527","article-title":"Emergence of ArmA and RmtB aminoglycoside resistance 16S rRNA methylases in Belgium","volume":"59","author":"P Bogaerts","year":"2007","journal-title":"J Antimicrob Chemother"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1093\/jac\/dkt065","article-title":"Validation of carbapenemase and extended-spectrum beta-lactamase multiplex endpoint PCR assays acoording to ISO 15189","volume":"68","author":"P Bogaerts","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ijmm.2015.04.004","article-title":"MALDI-TOF mass spectrometry following short incubation on a solid medium is a valuable tool for rapid pathogen identification from positive blood cultures","volume":"305","author":"R Kohlmann","year":"2015","journal-title":"Int J Med Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/j.1469-0691.2009.03044.x","article-title":"Assessment of the usefulness of performing bacterial identification and antimicrobial susceptibility testing 24 h a day in a clinical microbiology laboratory","volume":"16","author":"M Eveillard","year":"2010","journal-title":"Clin Microbiol Inf"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/1469-0691.12318","article-title":"Rapid detection of carbapenemase-producing Enterobacteriaceae from blood cultures","volume":"20","author":"L Dortet","year":"2013","journal-title":"Clin Microbiol Inf"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0160537","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0156299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T22:51:43Z","timestamp":1540335103000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0156299"}},"subtitle":[],"editor":[{"given":"Martin","family":"Rottman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,26]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0156299","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0160537","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,26]]}}}