{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:34:15Z","timestamp":1779399255724,"version":"3.53.1"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T00:00:00Z","timestamp":1464652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0156353","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T13:29:42Z","timestamp":1464701382000},"page":"e0156353","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Effect of Chronic Athletic Activity on Brown Fat in Young Women"],"prefix":"10.1371","volume":"11","author":[{"given":"Vibha","family":"Singhal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana D.","family":"Maffazioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate E.","family":"Ackerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa F.","family":"Elia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Woolley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Kolodny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Cypess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusmita","family":"Misra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,5,31]]},"reference":[{"issue":"7","key":"ref1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.2337\/db10-0004","article-title":"Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans","volume":"59","author":"C Pfannenberg","year":"2010","journal-title":"Diabetes"},{"issue":"15","key":"ref2","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","article-title":"Identification and importance of brown adipose tissue in adult humans","volume":"360","author":"AM Cypess","year":"2009","journal-title":"N Engl J Med"},{"issue":"15","key":"ref3","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJMoa0808718","article-title":"Cold-activated brown adipose tissue in healthy men","volume":"360","author":"WD van Marken Lichtenbelt","year":"2009","journal-title":"The New England journal of medicine"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/thy.2007.0254","article-title":"Thyroid hormone and adipocyte differentiation","volume":"18","author":"MJ Obregon","year":"2008","journal-title":"Thyroid: official journal of the American Thyroid Association"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13293-015-0025-y","article-title":"Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice","volume":"6","author":"A Grefhorst","year":"2015","journal-title":"Biol Sex Differ"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/cen.12620","article-title":"Association between habitual physical activity and brown adipose tissue activity in individuals undergoing PET-CT scan","volume":"82","author":"PC Dinas","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/ijo.2015.130","article-title":"Low brown adipose tissue activity in endurance-trained compared with lean sedentary men","volume":"39","author":"MJ Vosselman","year":"2015","journal-title":"Int J Obes (Lond)"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"E584","DOI":"10.1210\/jc.2011-2246","article-title":"Young women with cold-activated brown adipose tissue have higher bone mineral density and lower Pref-1 than women without brown adipose tissue: a study in women with anorexia nervosa, women recovered from anorexia nervosa, and normal-weight women","volume":"97","author":"MA Bredella","year":"2012","journal-title":"The Journal of clinical endocrinology and metabolism"},{"issue":"10","key":"ref9","first-page":"1867","article-title":"American College of Sports Medicine position stand. The female athlete triad","volume":"39","author":"A Nattiv","year":"2007","journal-title":"Medicine and science in sports and exercise"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.fertnstert.2006.11.171","article-title":"Severity of energy-related menstrual disturbances increases in proportion to indices of energy conservation in exercising women","volume":"88","author":"MJ De Souza","year":"2007","journal-title":"Fertility and sterility"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.bone.2012.12.046","article-title":"IGFBP-2 is a negative predictor of cold-induced brown fat and bone mineral density in young non-obese women","volume":"53","author":"MA Bredella","year":"2013","journal-title":"Bone"},{"issue":"25","key":"ref12","doi-asserted-by":"crossref","first-page":"10001","DOI":"10.1073\/pnas.1207911109","article-title":"Cold but not sympathomimetics activates human brown adipose tissue in vivo","volume":"109","author":"AM Cypess","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cmet.2014.07.025","article-title":"Brown fat in humans: consensus points and experimental guidelines","volume":"20","author":"AM Cypess","year":"2014","journal-title":"Cell Metab"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1172\/JCI60433","article-title":"Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans","volume":"122","author":"V Ouellet","year":"2012","journal-title":"The Journal of clinical investigation"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1210\/jc.2010-0989","article-title":"Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans","volume":"96","author":"V Ouellet","year":"2011","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"8889","DOI":"10.1038\/srep08889","article-title":"Irisin\u2014a myth rather than an exercise-inducible myokine","volume":"5","author":"E Albrecht","year":"2015","journal-title":"Sci Rep"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.jada.2006.03.015","article-title":"Relationship of ghrelin and leptin hormones with body mass index and waist circumference in a random sample of adults","volume":"106","author":"V Monti","year":"2006","journal-title":"J Am Diet Assoc"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1530\/EJE-15-0875","article-title":"Leptin secretory dynamics and associated disordered eating psychopathology across the weight spectrum","volume":"174","author":"C Baskaran","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1139\/y79-039","article-title":"Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: the dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis","volume":"57","author":"DO Foster","year":"1979","journal-title":"Canadian journal of physiology and pharmacology"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cmet.2011.06.020","article-title":"White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis","volume":"14","author":"L Cao","year":"2011","journal-title":"Cell Metab"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.numecd.2012.01.013","article-title":"Exercise as a new physiological stimulus for brown adipose tissue activity","volume":"23","author":"R De Matteis","year":"2013","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"49","key":"ref22","doi-asserted-by":"crossref","first-page":"34129","DOI":"10.1074\/jbc.M114.591008","article-title":"Thermogenic capacity is antagonistically regulated in classical brown and white subcutaneous fat depots by high fat diet and endurance training in rats: impact on whole-body energy expenditure","volume":"289","author":"MV Wu","year":"2014","journal-title":"The Journal of biological chemistry"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nm.3112","article-title":"Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat","volume":"19","author":"AM Cypess","year":"2013","journal-title":"Nat Med"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cell.2012.05.016","article-title":"Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human","volume":"150","author":"J Wu","year":"2012","journal-title":"Cell"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ijo.2013.82","article-title":"Functional thermogenic beige adipogenesis is inducible in human neck fat","volume":"38","author":"P Lee","year":"2014","journal-title":"Int J Obes (Lond)"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"E373","DOI":"10.1152\/ajpendo.00041.2005","article-title":"Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents","volume":"289","author":"M Misra","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"e111990","DOI":"10.1371\/journal.pone.0111990","article-title":"Uptake of aortic 18F-FDG is correlated with low-density lipoprotein cholesterol and leptin in a general population","volume":"9","author":"A Haraguchi","year":"2014","journal-title":"PloS one"},{"issue":"7382","key":"ref28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"P Bostrom","year":"2012","journal-title":"Nature"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0160129","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T00:00:00Z","timestamp":1470787200000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0156353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T14:12:53Z","timestamp":1540217573000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0156353"}},"subtitle":[],"editor":[{"given":"David J.","family":"Handelsman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,5,31]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0156353","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0160129","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,31]]}}}