{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:39:20Z","timestamp":1792157960656,"version":"4.4.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T00:00:00Z","timestamp":1464825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0156607","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T13:36:16Z","timestamp":1464874576000},"page":"e0156607","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["A Polymorphism in RNF213 Is a Susceptibility Gene for Intracranial Atherosclerosis"],"prefix":"10.1371","volume":"11","author":[{"given":"Oh Young","family":"Bang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Won","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihoon","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Ji","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je Young","family":"Yeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Seok","family":"Ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pyoung","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Chyul","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.mehy.2005.05.017","article-title":"A possible explanation for the racial difference in distribution of large-arterial cerebrovascular disease: ancestral European settlers evolved genetic resistance to atherosclerosis, but confined to the intracranial arteries","volume":"65","author":"W Mak","year":"2005","journal-title":"Med Hypotheses"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1161\/01.STR.26.1.14","article-title":"Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction. The Northern Manhattan Stroke Study","volume":"26","author":"RL Sacco","year":"1995","journal-title":"Stroke"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.atherosclerosissup.2006.01.003","article-title":"CVD risk factors and ethnicity\u2014a homogeneous relationship?","volume":"7","author":"NG Forouhi","year":"2006","journal-title":"Atheroscler Suppl"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1161\/STROKEAHA.107.496588","article-title":"Metabolic syndrome and ischemic stroke risk: Northern Manhattan Study","volume":"39","author":"B Boden-Albala","year":"2008","journal-title":"Stroke"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jns.2009.03.033","article-title":"Impact of metabolic syndrome on distribution of cervicocephalic atherosclerosis: data from a diverse race-ethnic group","volume":"284","author":"OY Bang","year":"2009","journal-title":"J Neurol Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5853\/jos.2014.16.1.27","article-title":"Intracranial atherosclerosis: current understanding and perspectives","volume":"16","author":"OY Bang","year":"2014","journal-title":"J Stroke"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5853\/jos.2015.01760","article-title":"The Pathophysiology of Moyamoya Disease","volume":"18","author":"OY Bang","year":"2016","journal-title":"An Update. J Stroke"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/jhg.2010.132","article-title":"A genome-wide association study identifies RNF213 as the first Moyamoya disease gene","volume":"56","author":"F Kamada","year":"2011","journal-title":"J Hum Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e22542","DOI":"10.1371\/journal.pone.0022542","article-title":"Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development","volume":"6","author":"W Liu","year":"2011","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1161\/STROKEAHA.112.663864","article-title":"Identification of a genetic variant common to moyamoya disease and intracranial major artery stenosis\/occlusion","volume":"43","author":"S Miyawaki","year":"2012","journal-title":"Stroke"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1161\/STROKEAHA.113.002477","article-title":"Genetic Variant RNF213 c.14576G&gt;A in Various Phenotypes of Intracranial Major Artery Stenosis\/Occlusion","volume":"44","author":"S Miyawaki","year":"2013","journal-title":"Stroke"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e0130663","DOI":"10.1371\/journal.pone.0130663","article-title":"Adult Moyamoya Disease: A Burden of Intracranial Stenosis in East Asians?","volume":"10","author":"OY Bang","year":"2015","journal-title":"PLoS One"},{"key":"ref13","article-title":"Differential Vascular Pathophysiologic Types of Intracranial Atherosclerotic Stroke: A High-Resolution Wall Magnetic Resonance Imaging Study","author":"S Ryoo","year":"2015","journal-title":"Stroke"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5853\/jos.2013.15.1.27","article-title":"Biomarkers for stroke","volume":"15","author":"SJ Kim","year":"2013","journal-title":"J Stroke"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S1474-4422(12)70234-X","article-title":"Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies","volume":"11","author":"M Traylor","year":"2012","journal-title":"Lancet Neurol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1212\/WNL.0b013e318249f71f","article-title":"Homozygous c.14576G&gt;A variant of RNF213 predicts early-onset and severe form of moyamoya disease","volume":"78","author":"S Miyatake","year":"2012","journal-title":"Neurology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1161\/STROKEAHA.114.004761","article-title":"High-resolution magnetic resonance wall imaging findings of Moyamoya disease","volume":"45","author":"S Ryoo","year":"2014","journal-title":"Stroke"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1111\/ene.12202","article-title":"High resolution MRI difference between moyamoya disease and intracranial atherosclerosis","volume":"20","author":"YJ Kim","year":"2013","journal-title":"Eur J Neurol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2176\/nmc.52.299","article-title":"Distribution of moyamoya disease susceptibility polymorphism p.R4810K in RNF213 in East and Southeast Asian Populations","volume":"52","author":"W Liu","year":"2012","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12199-012-0299-1","article-title":"P.R4810K, a polymorphism of RNF213, the susceptibility gene for moyamoya disease, is associated with blood pressure","volume":"18","author":"A Koizumi","year":"2013","journal-title":"Environ Health Prev Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.ATV.0000070546.16946.3A","article-title":"Caveolin, caveolae, and endothelial cell function","volume":"23","author":"PG Frank","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"10661","DOI":"10.1074\/jbc.M110354200","article-title":"Caveolin-1 expression enhances endothelial capillary tubule formation","volume":"277","author":"J Liu","year":"2002","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.2353\/ajpath.2009.090171","article-title":"Vascular permeability and pathological angiogenesis in caveolin-1-null mice","volume":"175","author":"SH Chang","year":"2009","journal-title":"Am J Pathol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/geno.1998.5723","article-title":"Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors","volume":"56","author":"AM Fra","year":"1999","journal-title":"Genomics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ajhg.2009.04.007","article-title":"Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease","volume":"84","author":"DC Guo","year":"2009","journal-title":"Am J Hum Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5853\/jos.2014.16.2.65","article-title":"Genetics and Biomarkers of Moyamoya Disease: Significance of RNF213 as a Susceptibility Gene","volume":"16","author":"M Fujimura","year":"2014","journal-title":"J Stroke"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/STROKEAHA.109.562264","article-title":"Association of thyroid autoantibodies with moyamoya-type cerebrovascular disease: a prospective study","volume":"41","author":"SJ Kim","year":"2010","journal-title":"Stroke"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1161\/STROKEAHA.110.608471","article-title":"Increased thyroid function and elevated thyroid autoantibodies in pediatric patients with moyamoya disease: a case-control study","volume":"42","author":"H Li","year":"2011","journal-title":"Stroke"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1161\/STROKEAHA.111.000307","article-title":"Moyamoya disease in a primarily white, midwestern US population: increased prevalence of autoimmune disease","volume":"44","author":"RS Bower","year":"2013","journal-title":"Stroke"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/ijs.12177","article-title":"Elevated thyroid autoantibodies and intracranial stenosis in stroke at an early age","volume":"9","author":"Z Shi","year":"2014","journal-title":"Int J Stroke"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e48179","DOI":"10.1371\/journal.pone.0048179","article-title":"Molecular analysis of RNF213 gene for moyamoya disease in the Chinese Han population","volume":"7","author":"Z Wu","year":"2012","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1161\/STROKEAHA.114.006244","article-title":"RNF213 rare variants in an ethnically diverse population with Moyamoya disease","volume":"45","author":"AC Cecchi","year":"2014","journal-title":"Stroke"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4103\/0028-3886.107927","article-title":"RNF213 polymorphism and Moyamoya disease: A systematic review and meta-analysis","volume":"61","author":"J Ma","year":"2013","journal-title":"Neurol India"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/jnnp-2011-301387","article-title":"Regional differences in incidence and patient characteristics of moyamoya disease: a systematic review","volume":"83","author":"R Kleinloog","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0156607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T09:18:18Z","timestamp":1540027098000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0156607"}},"subtitle":[],"editor":[{"given":"Xiao-Feng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,2]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0156607","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,2]]}}}