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microenvironment: preclinical evidence for its association with chronic lymphocytic leukemia treatments","volume":"97","author":"B Stamatopoulos","year":"2012","journal-title":"Haematologica"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"e1056","DOI":"10.7717\/peerj.1056","article-title":"Influence of rimonabant treatment on peripheral blood mononuclear cells; flow cytometry analysis and gene expression profiling","volume":"3","author":"S Almestrand","year":"2015","journal-title":"PeerJ"},{"issue":"3","key":"ref81","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1182\/blood-2004-03-1182","article-title":"Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway","volume":"105","author":"T Powles","year":"2005","journal-title":"Blood"},{"issue":"7","key":"ref82","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.febslet.2006.02.024","article-title":"Cannabinoid derivatives induce cell death in 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