{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:13:47Z","timestamp":1792030427693,"version":"4.4.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0156788","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T17:50:33Z","timestamp":1464976233000},"page":"e0156788","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Procaine Inhibits Osteo\/Odontogenesis through Wnt\/\u03b2-Catenin Inactivation"],"prefix":"10.1371","volume":"11","author":[{"given":"Carmen","family":"Herencia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Miguel","family":"Diaz-Tocados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Jurado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addy","family":"Montes de Oca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Encarnaci\u00f3n","family":"Rodr\u00edguez-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mart\u00edn-Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio M.","family":"Mart\u00ednez-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Almad\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan R.","family":"Mu\u00f1oz-Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1177\/0022034514552491","article-title":"Global burden of severe periodontitis in 1990\u20132010: a systematic review and meta-regression","volume":"93","author":"NJ Kassebaum","year":"2014","journal-title":"J Dent Res"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4103\/1947-2714.159325","article-title":"Association between Periodontitis and Alzheimer&apos;s Disease","volume":"7","author":"K Abbayya","year":"2015","journal-title":"N Am J Med Sci"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"G Hajishengallis","year":"2015","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1600-0765.2011.01354.x","article-title":"FoxOs, Wnts and oxidative stress-induced bone loss: new players in the periodontitis arena?","volume":"46","author":"C Galli","year":"2011","journal-title":"J Periodontal Res"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.14219\/jada.2014.112","article-title":"Diabetes and periodontal therapy","volume":"145","author":"BL Pihlstrom","year":"2014","journal-title":"J Am Dent Assoc"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1902\/jop.2014.140286","article-title":"Alveolar bone turnover and periodontal ligament width are controlled by Wnt","volume":"86","author":"WH Lim","year":"2015","journal-title":"J Periodontol"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ajodo.2014.05.027","article-title":"Downregulation of Wnt causes root resorption","volume":"146","author":"WH Lim","year":"2014","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"e89525","DOI":"10.1371\/journal.pone.0089525","article-title":"Magnesium inhibits Wnt\/beta-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells","volume":"9","author":"OA Montes de","year":"2014","journal-title":"PLoS One"},{"issue":"16","key":"ref9","first-page":"4984","article-title":"Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells","volume":"63","author":"A Villar-Garea","year":"2003","journal-title":"Cancer Res"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/cmdc.200900017","article-title":"Molecular modeling and molecular dynamics studies of hydralazine with human DNA methyltransferase 1","volume":"4","author":"N Singh","year":"2009","journal-title":"ChemMedChem"},{"issue":"6","key":"ref11","first-page":"1479","article-title":"Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells","volume":"22","author":"Z Gao","year":"2009","journal-title":"Oncol Rep"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1177\/0022034514535214","article-title":"NOD2 Mediates Odontoblast Differentiation and RANKL Expression","volume":"93","author":"SI Lee","year":"2014","journal-title":"J Dent Res"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1177\/154405910808700907","article-title":"Matrix Gla protein inhibition of tooth mineralization","volume":"87","author":"NR Kaipatur","year":"2008","journal-title":"J Dent Res"},{"issue":"11","key":"ref14","first-page":"1669","article-title":"Vascular calcification: mutual interaction between bone and blood vessel","volume":"20","author":"A Yamaguchi","year":"2010","journal-title":"Clin Calcium"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1161\/CIRCRESAHA.110.219071","article-title":"Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification","volume":"107","author":"Y Yao","year":"2010","journal-title":"Circ Res"},{"issue":"Pt 15","key":"ref16","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1242\/jeb.204.15.2657","article-title":"Calcification in the planula and polyp of the hydroid Hydractinia symbiolongicarpus (Cnidaria, Hydrozoa)","volume":"204","author":"CL Rogers","year":"2001","journal-title":"J Exp Biol"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1002\/jbmr.93","article-title":"High-phosphate-induced calcification is related to SM22alpha promoter methylation in vascular smooth muscle cells","volume":"25","author":"OA Montes de","year":"2010","journal-title":"J Bone Miner Res"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.devcel.2005.03.016","article-title":"Wnt\/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis","volume":"8","author":"TF Day","year":"2005","journal-title":"Dev Cell"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1096\/fj.08-106302","article-title":"FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt\/beta-catenin signaling-dependent Runx2 expression","volume":"22","author":"Z Hamidouche","year":"2008","journal-title":"FASEB J"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/jbmr.266","article-title":"Glycogen synthase kinase-3alpha\/beta inhibition promotes in vivo amplification of endogenous mesenchymal progenitors with osteogenic and adipogenic potential and their differentiation to the osteogenic lineage","volume":"26","author":"A Gambardella","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.bone.2007.12.006","article-title":"Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma","volume":"42","author":"YW Qiang","year":"2008","journal-title":"Bone"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/cbin.10340","article-title":"Lithium chloride promotes the odontoblast differentiation of hair follicle neural crest cells by activating Wnt\/beta-catenin signaling","volume":"39","author":"T Shan","year":"2015","journal-title":"Cell Biol Int"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ijos.2014.12","article-title":"Dental and periodontal phenotype in sclerostin knockout mice","volume":"6","author":"U Kuchler","year":"2014","journal-title":"Int J Oral Sci"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/jcpe.12245","article-title":"Involvement of the Wnt-beta-catenin signalling antagonists, sclerostin and dickkopf-related protein 1, in chronic periodontitis","volume":"41","author":"MH Napimoga","year":"2014","journal-title":"J Clin Periodontol"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1002\/jbmr.1984","article-title":"Sclerostin antibody stimulates bone regeneration after experimental periodontitis","volume":"28","author":"AD Taut","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1096\/fj.14-265496","article-title":"Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model","volume":"29","author":"Y Ren","year":"2015","journal-title":"FASEB J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0156788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T01:47:46Z","timestamp":1656640066000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0156788"}},"subtitle":[],"editor":[{"given":"Rajeev","family":"Samant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,3]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0156788","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,3]]}}}