{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:50:19Z","timestamp":1770965419328,"version":"3.50.1"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","award":["H1311119"],"award-info":[{"award-number":["H1311119"]}],"id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0156789","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T13:52:03Z","timestamp":1464961923000},"page":"e0156789","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Prevalence and Prognostic Role of BRCA1\/2 Variants in Unselected Chinese Breast Cancer Patients"],"prefix":"10.1371","volume":"11","author":[{"given":"Xiaorong","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengwei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuxiang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuesong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuxiao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinying","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1200\/JCO.2006.09.1066","article-title":"Meta-analysis of BRCA1 and BRCA2 penetrance","volume":"25","author":"S Chen","year":"2007","journal-title":"J Clin Oncol"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00439-013-1299-y","article-title":"The complex genetic landscape of familial breast cancer","volume":"132","author":"L Melchor","year":"2013","journal-title":"Hum Genet"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4048\/jbc.2013.16.4.357","article-title":"Distribution of BRCA1 and BRCA2 Mutations in Asian Patients with Breast Cancer","volume":"16","author":"H Kim","year":"2013","journal-title":"J Breast Cancer"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1158\/1055-9965.EPI-03-0196","article-title":"BRCA1 and BRCA2 mutations in women from Shanghai China","volume":"13","author":"NM Suter","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"e0125571","DOI":"10.1371\/journal.pone.0125571","article-title":"Identification of a comprehensive spectrum of genetic factors for hereditary breast cancer in a Chinese population by next-generation sequencing","volume":"10","author":"X Yang","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrc3181","article-title":"BRCA1 and BRCA2: different roles in a common pathway of genome protection","volume":"12","author":"R Roy","year":"2012","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1470-2045(14)71135-0","article-title":"Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial","volume":"16","author":"AM Oza","year":"2015","journal-title":"Lancet Oncol"},{"issue":"9737","key":"ref8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0140-6736(10)60892-6","article-title":"Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial","volume":"376","author":"A Tutt","year":"2010","journal-title":"Lancet"},{"issue":"21","key":"ref9","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1200\/JCO.2011.39.8545","article-title":"BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group","volume":"30","author":"K Alsop","year":"2012","journal-title":"J Clin Oncol"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/S1470-2045(14)70228-1","article-title":"Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial","volume":"15","author":"J Ledermann","year":"2014","journal-title":"Lancet Oncol"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nrc1457","article-title":"Hallmarks of 'BRCAness' in sporadic cancers","volume":"4","author":"N Turner","year":"2004","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1200\/JCO.2010.33.0068","article-title":"Breast cancer prognosis in BRCA1 and BRCA2 mutation carriers: an International Prospective Breast Cancer Family Registry population-based cohort study","volume":"30","author":"PJ Goodwin","year":"2012","journal-title":"J Clin Oncol"},{"issue":"26","key":"ref13","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1200\/JCO.2012.45.3571","article-title":"Ten-year survival in patients with BRCA1-negative and BRCA1-positive breast cancer","volume":"31","author":"T Huzarski","year":"2013","journal-title":"J Clin Oncol"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1158\/1078-0432.CCR-10-2560","article-title":"Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer","volume":"17","author":"AM Gonzalez-Angulo","year":"2011","journal-title":"Clin Cancer Res"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3892\/ol.2013.1684","article-title":"Prognostic role of mutation in patients with triple-negative breast cancer","volume":"7","author":"J Maksimenko","year":"2014","journal-title":"Oncol Lett"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1158\/1078-0432.CCR-14-1816","article-title":"Effects of BRCA1- and BRCA2-related mutations on ovarian and breast cancer survival: a meta-analysis","volume":"21","author":"Q Zhong","year":"2015","journal-title":"Clin Cancer Res"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"019","DOI":"10.23937\/2378-3648\/1410019","article-title":"Development of a Comprehensive NGS Workflow for the Analysis of Tumor BRCA1 and BRCA2 Mutations and Large Rearrangements","volume":"2","author":"Z Dong","year":"2015","journal-title":"J Genet Genome Res"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/GIM.0b013e31816b5cae","article-title":"ACMG recommendations for standards for interpretation and reporting of sequence variations: Revisions 2007","volume":"10","author":"CS Richards","year":"2008","journal-title":"Genet Med"},{"issue":"4","key":"ref19","first-page":"237","article-title":"Guideline for testing of estrogen and progesterone receptors in breast cancer","volume":"44","author":"H Bu","year":"2015","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"issue":"4","key":"ref20","first-page":"262","article-title":"Guidelines for HER2 detection in breast cancer, the 2014 version","volume":"43","author":"XW Bian","year":"2014","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1093\/annonc\/mdt303","article-title":"Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013","volume":"24","author":"A Goldhirsch","year":"2013","journal-title":"Ann Oncol"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"e43994","DOI":"10.1371\/journal.pone.0043994","article-title":"Identification of BRCA1\/2 founder mutations in Southern Chinese breast cancer patients using gene sequencing and high resolution DNA melting analysis","volume":"7","author":"A Kwong","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s10549-012-2159-5","article-title":"Characteristics and spectrum of BRCA1 and BRCA2 mutations in 3,922 Korean patients with breast and ovarian cancer","volume":"134","author":"H Kim","year":"2012","journal-title":"Breast Cancer Res Treat"},{"issue":"7418","key":"ref24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nature11412","article-title":"Comprehensive molecular portraits of human breast tumours","volume":"490","year":"2012","journal-title":"Nature"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1200\/JCO.2014.57.1414","article-title":"Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer","volume":"33","author":"FJ Couch","year":"2015","journal-title":"J Clin Oncol"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4048\/jbc.2014.17.2.129","article-title":"Characteristics of BRCA1\/2 Mutation-Positive Breast Cancers in Korea: A Comparison Study Based on Multicenter Data and the Korean Breast Cancer Registry","volume":"17","author":"JH Yu","year":"2014","journal-title":"J Breast Cancer"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10549-007-9708-3","article-title":"The prevalence of BRCA1 and BRCA2 germline mutations in high-risk breast cancer patients of Chinese Han nationality: two recurrent mutations were identified","volume":"110","author":"WF Li","year":"2008","journal-title":"Breast Cancer Res Treat"},{"issue":"26","key":"ref28","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1200\/JCO.2008.16.6231","article-title":"Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer","volume":"26","author":"DP Atchley","year":"2008","journal-title":"J Clin Oncol"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/ijc.22789","article-title":"Surveillance for familial breast cancer: Differences in outcome according to BRCA mutation status","volume":"121","author":"P Moller","year":"2007","journal-title":"Int J Cancer"},{"issue":"8","key":"ref30","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1200\/JCO.2007.14.4147","article-title":"Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer","volume":"26","author":"C Liedtke","year":"2008","journal-title":"J Clin Oncol"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJMoa070608","article-title":"Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations","volume":"357","author":"G Rennert","year":"2007","journal-title":"N Engl J Med"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/annonc\/mdu559","article-title":"Prevalence of BRCA1 mutations and responses to neoadjuvant chemotherapy among BRCA1 carriers and non-carriers with triple-negative breast cancer","volume":"26","author":"C Wang","year":"2015","journal-title":"Ann Oncol"},{"issue":"7353","key":"ref33","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","year":"2011","journal-title":"Nature"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1158\/1078-0432.CCR-13-2287","article-title":"Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas","volume":"20","author":"KP Pennington","year":"2014","journal-title":"Clin Cancer Res"},{"issue":"22","key":"ref35","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1200\/JCO.2009.27.2997","article-title":"Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer","volume":"28","author":"BT Hennessy","year":"2010","journal-title":"J Clin Oncol"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/sj.bjc.6600859","article-title":"BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells","volume":"88","author":"P Tassone","year":"2003","journal-title":"Br J Cancer"},{"issue":"19","key":"ref37","first-page":"6221","article-title":"BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis","volume":"63","author":"JE Quinn","year":"2003","journal-title":"Cancer Res"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1634\/theoncologist.2013-0039","article-title":"Differential chemotherapeutic sensitivity for breast tumors with "BRCAness": a review","volume":"18","author":"P Chalasani","year":"2013","journal-title":"Oncologist"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0156789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T03:20:35Z","timestamp":1567999235000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0156789"}},"subtitle":[],"editor":[{"given":"Alvaro","family":"Galli","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,3]]},"references-count":38,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0156789","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,3]]}}}