{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:54:58Z","timestamp":1789178098660,"version":"build-2803163510"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T00:00:00Z","timestamp":1465516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0157395","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T20:58:16Z","timestamp":1465592296000},"page":"e0157395","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells"],"prefix":"10.1371","volume":"11","author":[{"given":"Toshiaki","family":"Yasuoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kuwahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saho","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpei","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Yasukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.immunol.21.120601.141057","article-title":"The regulatory role of Valpha14 NKT cells in innate and acquired immune response","volume":"21","author":"M Taniguchi","year":"2003","journal-title":"Annual review of immunology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1146\/annurev.immunol.23.021704.115742","article-title":"Toward an understanding of NKT cell biology: progress and paradoxes","volume":"23","author":"M Kronenberg","year":"2005","journal-title":"Annual review of immunology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3389\/fimmu.2015.00400","article-title":"Recognition of Microbial Glycolipids by Natural Killer T Cells","volume":"6","author":"DM Zajonc","year":"2015","journal-title":"Frontiers in immunology"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"15662","DOI":"10.3390\/molecules181215662","article-title":"Stimulation of natural killer T cells by glycolipids","volume":"18","author":"BL Anderson","year":"2013","journal-title":"Molecules"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/1568008054863772","article-title":"Therapeutic potential of glycolipid ligands for natural killer (NK) T cells in the suppression of autoimmune diseases","volume":"5","author":"S Miyake","year":"2005","journal-title":"Current drug targets Immune, endocrine and metabolic disorders"},{"issue":"5356","key":"ref6","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1126\/science.279.5356.1541","article-title":"Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol","volume":"279","author":"S Joyce","year":"1998","journal-title":"Science (New York, NY"},{"issue":"5702","key":"ref7","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1126\/science.1103440","article-title":"Lysosomal glycosphingolipid recognition by NKT cells","volume":"306","author":"D Zhou","year":"2004","journal-title":"Science (New York, NY"},{"issue":"14","key":"ref8","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1073\/pnas.0611139104","article-title":"Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency","volume":"104","author":"S Porubsky","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"33","key":"ref9","doi-asserted-by":"crossref","first-page":"29409","DOI":"10.1074\/jbc.M502333200","article-title":"Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway","volume":"280","author":"M Yamashita","year":"2005","journal-title":"The Journal of biological chemistry"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1600-065X.2010.00962.x","article-title":"Transcriptional control of invariant NKT cell development","volume":"238","author":"R Das","year":"2010","journal-title":"Immunological reviews"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.coi.2013.01.003","article-title":"Transcriptional regulation of the NKT cell lineage","volume":"25","author":"MG Constantinides","year":"2013","journal-title":"Current opinion in immunology"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.smim.2015.02.005","article-title":"The transcriptional programs of iNKT cells","volume":"27","author":"EY Kim","year":"2015","journal-title":"Seminars in immunology"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.immuni.2008.07.011","article-title":"The transcription factor PLZF directs the effector program of the NKT cell lineage","volume":"29","author":"AK Savage","year":"2008","journal-title":"Immunity"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.1641","article-title":"The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions","volume":"9","author":"D Kovalovsky","year":"2008","journal-title":"Nature immunology"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"6746","DOI":"10.4049\/jimmunol.1000776","article-title":"PLZF induces the spontaneous acquisition of memory\/effector functions in T cells independently of NKT cell-related signals","volume":"184","author":"D Kovalovsky","year":"2010","journal-title":"J Immunol"},{"issue":"46","key":"ref16","doi-asserted-by":"crossref","first-page":"17919","DOI":"10.1073\/pnas.0805733105","article-title":"The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells","volume":"105","author":"J Raberger","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"ref17","first-page":"1789","article-title":"Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2","volume":"12","author":"M Zornig","year":"1996","journal-title":"Oncogene"},{"issue":"46","key":"ref18","doi-asserted-by":"crossref","first-page":"32056","DOI":"10.1074\/jbc.M802320200","article-title":"Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor","volume":"283","author":"DE Montoya-Durango","year":"2008","journal-title":"The Journal of biological chemistry"},{"issue":"23","key":"ref19","doi-asserted-by":"crossref","first-page":"10338","DOI":"10.1128\/MCB.25.23.10338-10351.2005","article-title":"Gfi1 coordinates epigenetic repression of p21Cip\/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1","volume":"25","author":"Z Duan","year":"2005","journal-title":"Mol Cell Biol"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.molcel.2007.06.039","article-title":"Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1","volume":"27","author":"S Saleque","year":"2007","journal-title":"Mol Cell"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-065X.2010.00952.x","article-title":"Molecular mechanisms by which T-bet regulates T-helper cell commitment","volume":"238","author":"SA Miller","year":"2010","journal-title":"Immunological reviews"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.smim.2011.08.006","article-title":"Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation","volume":"23","author":"T Moroy","year":"2011","journal-title":"Seminars in immunology"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1074-7613(02)00317-5","article-title":"Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation","volume":"16","author":"J Zhu","year":"2002","journal-title":"Immunity"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"6263","DOI":"10.1128\/MCB.16.11.6263","article-title":"The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal","volume":"16","author":"HL Grimes","year":"1996","journal-title":"Mol Cell Biol"},{"issue":"42","key":"ref25","doi-asserted-by":"crossref","first-page":"28216","DOI":"10.1074\/jbc.M804174200","article-title":"Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation","volume":"283","author":"R Shinnakasu","year":"2008","journal-title":"The Journal of biological chemistry"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/intimm\/dxp054","article-title":"Gfi1 negatively regulates T(h)17 differentiation by inhibiting RORgammat activity","volume":"21","author":"K Ichiyama","year":"2009","journal-title":"International immunology"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.celrep.2012.02.007","article-title":"PI3K-Akt-mTORC1-S6K1\/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORgamma","volume":"1","author":"Y Kurebayashi","year":"2012","journal-title":"Cell reports"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1084\/jem.20081666","article-title":"Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells","volume":"206","author":"J Zhu","year":"2009","journal-title":"The Journal of experimental medicine"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"e53666","DOI":"10.1371\/journal.pone.0053666","article-title":"Differential transcriptional regulation of meis1 by Gfi1b and its co-factors LSD1 and CoREST","volume":"8","author":"AH Chowdhury","year":"2013","journal-title":"PloS one"},{"issue":"48","key":"ref30","doi-asserted-by":"crossref","first-page":"18214","DOI":"10.1073\/pnas.0608981103","article-title":"Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion","volume":"103","author":"J Zhu","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/ni.2362","article-title":"The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-beta and suppresses T(H)2 differentiation","volume":"13","author":"M Kuwahara","year":"2012","journal-title":"Nature immunology"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1084\/jem.20050456","article-title":"Characterization of the early stages of thymic NKT cell development","volume":"202","author":"K Benlagha","year":"2005","journal-title":"The Journal of experimental medicine"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1038\/leu.2010.195","article-title":"Gfi1 and Gfi1b: key regulators of hematopoiesis","volume":"24","author":"LT van der Meer","year":"2010","journal-title":"Leukemia"},{"issue":"39","key":"ref34","doi-asserted-by":"crossref","first-page":"40906","DOI":"10.1074\/jbc.M400808200","article-title":"Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development","volume":"279","author":"R Yucel","year":"2004","journal-title":"The Journal of biological chemistry"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1615\/CritRevImmunol.2014010088","article-title":"iNKT cells: innate lymphocytes with a diverse response","volume":"34","author":"M Monteiro","year":"2014","journal-title":"Critical reviews in immunology"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"e1001255","DOI":"10.1371\/journal.pbio.1001255","article-title":"Development and function of invariant natural killer T cells producing T(h)2- and T(h)17-cytokines","volume":"10","author":"H Watarai","year":"2012","journal-title":"PLoS biology"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/imm.12580","article-title":"Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells","volume":"147","author":"J Suzuki","year":"2016","journal-title":"Immunology"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.4049\/jimmunol.1100270","article-title":"IL-15Ralpha of radiation-resistant cells is necessary and sufficient for thymic invariant NKT cell survival and functional maturation","volume":"187","author":"CL Chang","year":"2011","journal-title":"J Immunol"},{"issue":"12","key":"ref39","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.4049\/jimmunol.1003965","article-title":"IL-15 regulates homeostasis and terminal maturation of NKT cells","volume":"187","author":"LE Gordy","year":"2011","journal-title":"J Immunol"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/mi.2013.122","article-title":"IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival","volume":"7","author":"KE Webster","year":"2014","journal-title":"Mucosal immunology"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ccr.2013.01.011","article-title":"Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia","volume":"23","author":"C Khandanpour","year":"2013","journal-title":"Cancer cell"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/stem.575","article-title":"Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease","volume":"29","author":"C Khandanpour","year":"2011","journal-title":"Stem cells"},{"issue":"7","key":"ref43","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1182\/blood-2005-08-3103","article-title":"T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells","volume":"107","author":"JL Matsuda","year":"2006","journal-title":"Blood"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S1074-7613(04)00076-7","article-title":"T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells","volume":"20","author":"MJ Townsend","year":"2004","journal-title":"Immunity"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0157395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T17:21:30Z","timestamp":1540228890000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0157395"}},"subtitle":[],"editor":[{"given":"Maria","family":"Leite-de-Moraes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,10]]},"references-count":44,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0157395","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,10]]}}}