{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:11:13Z","timestamp":1793657473820,"version":"4.5.1"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T00:00:00Z","timestamp":1466121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Metagenics. Inc"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0157417","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T13:28:58Z","timestamp":1466170138000},"page":"e0157417","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":140,"title":["Association of Vasomotor and Other Menopausal Symptoms with Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.1371","volume":"11","author":[{"given":"Taulant","family":"Muka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Oliver-Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Colpani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setor","family":"Kunutsor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susmita","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Kavousi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar H.","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,6,17]]},"reference":[{"issue":"3","key":"ref1","first-page":"351","article-title":"A prospective population-based study of menopausal symptoms","volume":"96","author":"L Dennerstein","year":"2000","journal-title":"Obstet Gynecol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2147\/IJWH.S39027","article-title":"Burden of vasomotor symptoms in France, Germany, Italy, Spain, and the United Kingdom","volume":"5","author":"MD Dibonaventura","year":"2013","journal-title":"Int J Womens Health"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.maturitas.2013.03.003","article-title":"Self-reported menopausal symptoms in a racially diverse population and soy food consumption","volume":"75","author":"SD Reed","year":"2013","journal-title":"Maturitas"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1001\/archinte.166.12.1262","article-title":"Severe hot flashes are associated with chronic insomnia","volume":"166","author":"MM Ohayon","year":"2006","journal-title":"Arch Intern Med"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1207\/s15327558ijbm1302_8","article-title":"Association between hot flashes, sleep complaints, and psychological functioning among healthy menopausal women","volume":"13","author":"RC Thurston","year":"2006","journal-title":"Int J Behav Med"},{"issue":"Suppl 12B","key":"ref6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.amjmed.2005.09.042","article-title":"Diagnosis and management of mood disorders during the menopausal transition","volume":"118","author":"LS Cohen","year":"2005","journal-title":"Am J Med"},{"issue":"17","key":"ref7","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1001\/archinte.163.17.2041","article-title":"Prevalence and correlates of panic attacks in postmenopausal women: results from an ancillary study to the Women&apos;s Health Initiative","volume":"163","author":"JW Smoller","year":"2003","journal-title":"Arch Intern Med"},{"issue":"16","key":"ref8","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1093\/eurheartj\/ehm296","article-title":"Management of cardiovascular risk in the peri-menopausal woman: a consensus statement of European cardiologists and gynaecologists","volume":"28","author":"P Collins","year":"2007","journal-title":"Eur Heart J"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1161\/HYPERTENSIONAHA.107.106526","article-title":"Menopausal complaints are associated with cardiovascular risk factors","volume":"51","author":"GC Gast","year":"2008","journal-title":"Hypertension"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1161\/01.CIR.99.9.1165","article-title":"Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14 786 middle-aged men and women in Finland","volume":"99","author":"P Jousilahti","year":"1999","journal-title":"Circulation"},{"issue":"8","key":"ref11","first-page":"2354","article-title":"Core body temperature and circadian rhythm of hot flashes in menopausal women","volume":"80","author":"RR Freedman","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/1754045313489645","article-title":"The 2013 British Menopause Society &amp; Women&apos;s Health Concern recommendations on hormone replacement therapy","volume":"19","author":"N Panay","year":"2013","journal-title":"Menopause Int"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.maturitas.2015.04.016","article-title":"Vasomotor symptoms in women and cardiovascular risk markers: Systematic review and meta-analysis","volume":"81","author":"OH Franco","year":"2015","journal-title":"Maturitas"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"D Moher","year":"2009","journal-title":"PLoS Med"},{"issue":"15","key":"ref15","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"DF Stroup","year":"2000","journal-title":"JAMA"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"A Stang","year":"2010","journal-title":"European journal of epidemiology"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/gme.0b013e3181f464fb","article-title":"Vasomotor menopausal symptoms are associated with increased risk of coronary heart disease","volume":"18","author":"GC Gast","year":"2011","journal-title":"Menopause"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1089\/jwh.2012.3918","article-title":"Sleep duration, insomnia, and coronary heart disease among postmenopausal women in the Women&apos;s Health Initiative","volume":"22","author":"M Sands-Lincoln","year":"2013","journal-title":"J Womens Health (Larchmt)"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1001\/archpsyc.64.10.1153","article-title":"Panic attacks and risk of incident cardiovascular events among postmenopausal women in the Women&apos;s Health Initiative Observational Study","volume":"64","author":"JW Smoller","year":"2007","journal-title":"Arch Gen Psychiatry"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1001\/archinte.164.3.289","article-title":"Depression and cardiovascular sequelae in postmenopausal women. The Women&apos;s Health Initiative (WHI)","volume":"164","author":"S Wassertheil-Smoller","year":"2004","journal-title":"Arch Intern Med"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1097\/gme.0b013e3181a4866b","article-title":"Vasomotor symptoms and mortality: the Rancho Bernardo Study","volume":"16","author":"J Svartberg","year":"2009","journal-title":"Menopause"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/gme.0b013e3182014849","article-title":"Vasomotor symptoms and cardiovascular events in postmenopausal women","volume":"18","author":"ED Szmuilowicz","year":"2011","journal-title":"Menopause"},{"issue":"8","key":"ref23","first-page":"988","article-title":"Cardiovascular events and mortality in newly and chronically depressed persons &gt; 70 years of age","volume":"81","author":"BW Penninx","year":"1998","journal-title":"Am J Cardiol"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/gps.1735","article-title":"Stronger symptoms of depression predict high coronary heart disease mortality in older men and women","volume":"22","author":"M Ahto","year":"2007","journal-title":"Int J Geriatr Psychiatry"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1001\/archinte.160.9.1261","article-title":"Depression as an antecedent to heart disease among women and men in the NHANES I study. National Health and Nutrition Examination Survey","volume":"160","author":"AK Ferketich","year":"2000","journal-title":"Arch Intern Med"},{"issue":"19","key":"ref26","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1001\/archinte.158.19.2129","article-title":"Association between depressive symptoms and mortality in older women. Study of Osteoporotic Fractures Research Group","volume":"158","author":"MA Whooley","year":"1998","journal-title":"Arch Intern Med"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/sleep\/33.6.739","article-title":"The effect of short sleep duration on coronary heart disease risk is greatest among those with sleep disturbance: a prospective study from the Whitehall II cohort","volume":"33","author":"T Chandola","year":"2010","journal-title":"Sleep"},{"issue":"21","key":"ref28","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1001\/archinte.158.21.2341","article-title":"Depression and risk of coronary heart disease in elderly men and women: New Haven EPESE, 1982\u20131991. Established Populations for the Epidemiologic Studies of the Elderly","volume":"158","author":"CF Mendes de Leon","year":"1998","journal-title":"Arch Intern Med"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/ajh\/hpt125","article-title":"Hot flashes and blood pressure in middle-aged Japanese women","volume":"27","author":"H Kagitani","year":"2014","journal-title":"American journal of hypertension"},{"issue":"3","key":"ref30","first-page":"466","article-title":"The Darwinian concept of allostasis. Epigenetic programming","volume":"80","author":"AM Pascual-Leone Pascual","year":"2015","journal-title":"An R Acad Farm"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1177\/2047487314520785","article-title":"Depressive disorder, coronary heart disease, and stroke: dose-response and reverse causation effects in the Whitehall II cohort study","volume":"21","author":"EJ Brunner","year":"2014","journal-title":"Eur J Prev Cardiol"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2190\/PM.41.4.f","article-title":"Anxiety disorders, hypertension, and cardiovascular risk: a review","volume":"41","author":"MS Player","year":"2011","journal-title":"Int J Psychiatry Med"},{"issue":"24","key":"ref33","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1093\/eurheartj\/ehn477","article-title":"Panic disorder and risk of new onset coronary heart disease, acute myocardial infarction, and cardiac mortality: cohort study using the general practice research database","volume":"29","author":"K Walters","year":"2008","journal-title":"Eur Heart J"},{"issue":"12","key":"ref34","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1093\/eurheartj\/ehr007","article-title":"Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies","volume":"32","author":"FP Cappuccio","year":"2011","journal-title":"Eur Heart J"},{"issue":"21","key":"ref35","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/eurheartj\/eht019","article-title":"Insomnia and the risk of incident heart failure: a population study","volume":"35","author":"LE Laugsand","year":"2014","journal-title":"Eur Heart J"},{"issue":"10","key":"ref36","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.sleep.2012.06.020","article-title":"Associations of relative weight with subsequent changes over time in insomnia symptoms: a follow-up study among middle-aged women and men","volume":"13","author":"T Lallukka","year":"2012","journal-title":"Sleep Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2458-9-14","article-title":"Depression and body mass index, a u-shaped association","volume":"9","author":"LM de Wit","year":"2009","journal-title":"BMC Public Health"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/CIRCULATIONAHA.110.968776","article-title":"Physical, psychological and chemical triggers of acute cardiovascular events: preventive strategies","volume":"124","author":"MA Mittleman","year":"2011","journal-title":"Circulation"},{"issue":"Suppl 1","key":"ref39","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1097\/01.psy.0000162254.61556.d5","article-title":"Depression, the autonomic nervous system, and coronary heart disease","volume":"67","author":"RM Carney","year":"2005","journal-title":"Psychosom Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1196\/annals.1296.062","article-title":"Cardiac sympathetic nerve biology and brain monoamine turnover in panic disorder","volume":"1018","author":"M Esler","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"ref41","first-page":"43","article-title":"HRT use by New Zealand women: knowledge, reasons for use and information sources","volume":"34","author":"MS Breheny","year":"2000","journal-title":"N Z Fam Physician"},{"issue":"7","key":"ref42","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1001\/jama.290.7.898","article-title":"Prevalence of conventional risk factors in patients with coronary heart disease","volume":"290","author":"UN Khot","year":"2003","journal-title":"JAMA"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.2337\/dc05-2482","article-title":"Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes","volume":"29","author":"DB Carr","year":"2006","journal-title":"Diabetes Care"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1161\/CIRCULATIONAHA.112.128751","article-title":"Elevated blood pressure in pregnancy and subsequent chronic disease risk","volume":"127","author":"T Mannisto","year":"2013","journal-title":"Circulation"},{"issue":"11","key":"ref45","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1161\/CIR.0b013e31820faaf8","article-title":"Effectiveness-based guidelines for the prevention of cardiovascular disease in women\u20142011 update: a guideline from the american heart association","volume":"123","author":"L Mosca","year":"2011","journal-title":"Circulation"},{"issue":"6","key":"ref46","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/gme.0b013e3182014849","article-title":"Vasomotor symptoms and cardiovascular events in postmenopausal women","volume":"18","author":"ED Szmuilowicz","year":"2011","journal-title":"Menopause"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/13697137.2010.507886","article-title":"Age of menopause and impact of climacteric symptoms by geographical region","volume":"13","author":"S Palacios","year":"2010","journal-title":"Climacteric"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0157417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T18:00:42Z","timestamp":1656698442000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0157417"}},"subtitle":[],"editor":[{"given":"Margaret M","family":"DeAngelis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,17]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0157417","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,17]]}}}