{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:25:43Z","timestamp":1790393143681,"version":"4.1.0"},"reference-count":94,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T00:00:00Z","timestamp":1466553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"March of Dimes Foundation (US), Cincinatti Center"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0157614","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T23:18:49Z","timestamp":1466637529000},"page":"e0157614","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":112,"title":["Amnion-Epithelial-Cell-Derived Exosomes Demonstrate Physiologic State of Cell under Oxidative Stress"],"prefix":"10.1371","volume":"11","author":[{"given":"Samantha","family":"Sheller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Papaconstantinou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rheanna","family":"Urrabaz-Garza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Saade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Salomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramkumar","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1749-6632.1997.tb48548.x","article-title":"The endocrinology of human parturition","volume":"828","author":"ML Casey","year":"1997","journal-title":"Ann N Y Acad Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1447-0756.2005.00342.x","article-title":"Fetal signals and parturition","volume":"31","author":"JRG Challis","year":"2005","journal-title":"J Obstet Gynaecol Res"},{"key":"ref3","first-page":"760","article-title":"Preterm Labor: One Syndrome","volume":"345","author":"R Romero","year":"2014","journal-title":"Many Causes. Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0167-0115(02)00105-2","article-title":"Hormone trajectories leading to human birth","volume":"108","author":"R Smith","year":"2002","journal-title":"Regul Pept"},{"key":"ref5","first-page":"435","article-title":"AGLBARJE-FG. Parturition: activation of stimulatory pathways or loss of uterine quiescence?","volume":"395","author":"S Phaneuf","year":"1995","journal-title":"Adv Exp Med Biol"},{"key":"ref6","article-title":"Maternal, Fetal, & Neonatal Physiology","author":"S Blackburn","year":"2014"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.ejogrb.2009.02.044","article-title":"Integration of endocrine and mechanical signals in the regulation of myometrial functions during pregnancy and labour","volume":"144","author":"O Shynlova","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/1933719112446084","article-title":"Physiologic uterine inflammation and labor onset: integration of endocrine and mechanical signals","volume":"20","author":"O Shynlova","year":"2013","journal-title":"Reprod Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajog.2015.05.041","article-title":"Chorioamniotic membrane senescence: a signal for parturition?","volume":"213","author":"F Behnia","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0300-595X(81)80038-2","article-title":"The placenta as an experimental model","volume":"10","author":"H Fox","year":"1981","journal-title":"Clin Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0031136","article-title":"Short fetal leukocyte telomere length and preterm prelabor rupture of the membranes","volume":"7","author":"R Menon","year":"2012","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e83416","DOI":"10.1371\/journal.pone.0083416","article-title":"Senescence of primary amniotic cells via oxidative DNA damage","volume":"8","author":"R Menon","year":"2013","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e0137188","DOI":"10.1371\/journal.pone.0137188","article-title":"Telomere Fragment Induced Amnion Cell Senescence: A Contributor to Parturition?","volume":"10","author":"J Polettini","year":"2015","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.ajpath.2014.02.011","article-title":"Histological Evidence of Oxidative Stress and Premature Senescence in Preterm Premature Rupture of the Human Fetal Membranes Recapitulated in Vitro","volume":"184","author":"R Menon","year":"2014","journal-title":"Am J Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression","volume":"5","author":"J-P Copp\u00e9","year":"2010","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e113799","DOI":"10.1371\/journal.pone.0113799","article-title":"HMGB1 promotes a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes","volume":"9","author":"S Bredeson","year":"2014","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2015.00203","article-title":"Emerging Roles of Exosomes in Normal and Pathological Conditions: New Insights for Diagnosis and Therapeutic Applications","volume":"6","author":"J De Toro","year":"2015","journal-title":"Front Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1095\/biolreprod.108.075481","article-title":"Human Villous Trophoblasts Express and Secrete Placenta-Specific MicroRNAs into Maternal Circulation via Exosomes","volume":"81","author":"S-S Luo","year":"2009","journal-title":"Biol Reprod"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2014.00518","article-title":"Immunotherapeutic Potential of Extracellular Vesicles","volume":"5","author":"B Zhang","year":"2014","journal-title":"Front Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nrrheum.2014.19","article-title":"Emerging role of extracellular vesicles in inflammatory diseases","volume":"10","author":"EI Buzas","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1039\/C5LC00240K","article-title":"Exosome isolation: a microfluidic road-map","volume":"15","author":"A Liga","year":"2015","journal-title":"Lab Chip"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"657086","DOI":"10.1155\/2015\/657086","article-title":"Exosomes: novel biomarkers for clinical diagnosis","volume":"2015","author":"J Lin","year":"2015","journal-title":"ScientificWorldJournal"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/sji.12247","article-title":"Exosomes\u2014Structure, Biogenesis and Biological Role in Non-Small-Cell Lung Cancer","volume":"81","author":"M Frydrychowicz","year":"2015","journal-title":"Scand J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.tig.2015.06.001","article-title":"Accessing Genetic Information with Liquid Biopsies","volume":"31","author":"X Cai","year":"2015","journal-title":"Trends Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1042\/BST0390559","article-title":"Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis","volume":"39","author":"S Rana","year":"2011","journal-title":"Biochem Soc Trans"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: Exosomes, microvesicles, and friends","volume":"200","author":"G Raposo","year":"2013","journal-title":"J Cell Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1034\/j.1600-0854.2002.30502.x","article-title":"The biogenesis and functions of exosomes","volume":"3","author":"W Stoorvogel","year":"2002","journal-title":"Traffic"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3390\/genes4020152","article-title":"Signaling pathways in exosomes biogenesis, secretion and fate","volume":"4","author":"L Urbanelli","year":"2013","journal-title":"Genes"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.3390\/ijms14035338","article-title":"Exosomes as intercellular signaling organelles involved in health and disease: Basic science and clinical applications","volume":"14","author":"C Corrado","year":"2013","journal-title":"Int J Mol Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1111\/j.1600-0854.2011.01225.x","article-title":"Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses","volume":"12","author":"A Bobrie","year":"2011","journal-title":"Traffic"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1016\/j.ajog.2015.07.001","article-title":"Placental exosomes in normal and complicated pregnancy","volume":"213","author":"MD Mitchell","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1600-0897.2006.00435.x","article-title":"Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences","volume":"56","author":"A Sabapatha","year":"2006","journal-title":"Am J Reprod Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e98667","DOI":"10.1371\/journal.pone.0098667","article-title":"A gestational profile of placental exosomes in maternal plasma and their effects on endothelial cell migration","volume":"9","author":"C Salomon","year":"2014","journal-title":"PLoS One"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3389\/fphar.2014.00175","article-title":"Extravillous trophoblast cells-derived exosomes promote vascular smooth muscle cell migration","volume":"5","author":"C Salomon","year":"2014","journal-title":"Front Pharmacol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/1479-5876-12-204","article-title":"Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy","volume":"12","author":"S Sarker","year":"2014","journal-title":"J Transl Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/j.placenta.2013.11.002","article-title":"Review: Placenta-specific microRNAs in exosomes\u2014Good things come in nano-packages","volume":"35","author":"Y Ouyang","year":"2014","journal-title":"Placenta"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/molehr\/gas013","article-title":"The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes","volume":"18","author":"RB Donker","year":"2012","journal-title":"Mol Hum Reprod"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"a023036","DOI":"10.1101\/cshperspect.a023036","article-title":"The Function of TrophomiRs and Other MicroRNAs in the Human Placenta","volume":"5","author":"Y Sadovsky","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"598","DOI":"10.2337\/db15-0966","article-title":"Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation","volume":"65","author":"C Salomon","year":"2016","journal-title":"Diabetes"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"E1280","DOI":"10.1210\/jc.2015-2270","article-title":"The Effect of Glucose on the Release and Bioactivity of Exosomes From First Trimester Trophoblast Cells","volume":"100","author":"GE Rice","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e79636","DOI":"10.1371\/journal.pone.0079636","article-title":"Hypoxia-induced changes in the bioactivity of cytotrophoblast-derived exosomes","volume":"8","author":"C Salomon","year":"2013","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0068451","article-title":"Exosomal Signaling during Hypoxia Mediates Microvascular Endothelial Cell Migration and Vasculogenesis","volume":"8","author":"C Salomon","year":"2013","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.placenta.2013.12.012","article-title":"Expression profiles of fetal membrane nicotinamide adenine dinucleotide phosphate oxidases (NOX) 2 and 3 differentiates spontaneous preterm birth and pPROM pathophysiologies","volume":"35","author":"J Polettini","year":"2014","journal-title":"Placenta"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"S402","DOI":"10.1016\/j.ajog.2013.10.861","article-title":"828: Screening of lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) enzyme expression and activity in human fetal membranes","volume":"210","author":"J Polettini","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"ref45","first-page":"e3037","article-title":"Isolation and characterization of RNA-containing exosomes","author":"C L\u00e4sser","year":"2012","journal-title":"J Vis Expnet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1755-8166-5-27","article-title":"Exosome-delivered microRNAs of \u201cchromosome 19 microRNA cluster\u201d as immunomodulators in pregnancy and tumorigenesis","volume":"5","author":"J Bullerdiek","year":"2012","journal-title":"Mol Cytogenet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.placenta.2007.11.016","article-title":"Circulating Microparticles in Normal Pregnancy and Pre-Eclampsia","volume":"29","author":"CWG Redman","year":"2008","journal-title":"Placenta"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.placenta.2012.10.005","article-title":"Immunomodulatory molecules are released from the first trimester and term placenta via exosomes","volume":"33","author":"SK Kshirsagar","year":"2012","journal-title":"Placenta"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jri.2009.02.007","article-title":"Quantitative comparison of stem cell marker-positive cells in fetal and term human amnion","volume":"81","author":"M Izumi","year":"2009","journal-title":"J Reprod Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.diff.2010.03.002","article-title":"Rapid and efficient reprogramming of human amnion-derived cells into pluripotency by three factors OCT4\/SOX2\/NANOG","volume":"80","author":"H Zhao","year":"2010","journal-title":"Differentiation"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1089\/cell.2013.0090","article-title":"Characterization of Amniotic Stem Cells","volume":"16","author":"C Koike","year":"2014","journal-title":"Cell Reprogram"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3727\/096368912X655055","article-title":"Establishment of Immortalized Human Amniotic Mesenchymal Stem Cells","volume":"22","author":"Z Teng","year":"2013","journal-title":"Cell Transplant"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.4081\/ejh.2012.e33","article-title":"Isolation and biological characterization of chicken amnion epithelial cells","volume":"56","author":"Y Gao","year":"2012","journal-title":"Eur J Histochem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.2174\/156652412803833625","article-title":"Human amnion-derived cells as a reliable source of stem cells","volume":"12","author":"S Saito","year":"2012","journal-title":"Curr Mol Med"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2014.00442","article-title":"Tetraspanins in Extracellular Vesicle Formation and Function","volume":"5","author":"Z Andreu","year":"2014","journal-title":"Front Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1056\/NEJMcibr1404324","article-title":"Cell-free Fetal DNA\u2014A Trigger for Parturition","volume":"370","author":"EG Phimister","year":"2014","journal-title":"N Engl J Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"35509","DOI":"10.18632\/oncotarget.5899","article-title":"DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging","volume":"6","author":"F Olivieri","year":"2015","journal-title":"Oncotarget"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/jcp.20626","article-title":"Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytes","volume":"207","author":"T Karrasch","year":"2006","journal-title":"J Cell Physiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.placenta.2008.05.004","article-title":"Effects of cadmium on MAPK signalling pathways and HSP70 expression in a human trophoblast cell line","volume":"29","author":"P Valbonesi","year":"2008","journal-title":"Placenta"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/aji.12496","article-title":"Mechanistic Differences Leading to Infectious and Sterile Inflammation","volume":"75","author":"F Behnia","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ceb.2014.09.001","article-title":"Signaling pathway cooperation in TGF-\u03b2-induced epithelial-mesenchymal transition","volume":"31","author":"R Derynck","year":"2014","journal-title":"Curr Opin Cell Biol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"587193","DOI":"10.1155\/2015\/587193","article-title":"TGF\u03b2 Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis","volume":"2015","author":"P Papageorgis","year":"2015","journal-title":"J Oncol"},{"key":"ref63","first-page":"5","article-title":"New Insights into the Crossroads between EMT and Stemness in the Context of Cancer","author":"I Fabregat","year":"2016","journal-title":"J Clin Med"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.3892\/or.2016.4661","article-title":"Nobiletin inhibits epithelial-mesenchymal transition of human non-small cell lung cancer cells by antagonizing the TGF-\u03b21\/Smad3 signaling pathway","volume":"35","author":"C Da","year":"2016","journal-title":"Oncol Rep"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.3892\/or.2016.4664","article-title":"Rhapontigenin inhibits TGF-\u03b2-mediated epithelial\u2011mesenchymal transition via the PI3K\/AKT\/mTOR pathway and is not associated with HIF-1\u03b1 degradation","volume":"35","author":"Y-H Yeh","journal-title":"Oncol Rep"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3109\/14767050903168465","article-title":"The clinical significance of eosinophils in the amniotic fluid in preterm labor","volume":"23","author":"R Romero","year":"2010","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/AOG.0b013e3182204eaa","article-title":"Amniotic fluid eicosanoids in preterm and term births: effects of risk factors for spontaneous preterm labor","volume":"118","author":"R Menon","year":"2011","journal-title":"Obstet Gynecol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3389\/fimmu.2014.00567","article-title":"Oxidative stress damage as a detrimental factor in preterm birth pathology","volume":"5","author":"R Menon","year":"2014","journal-title":"Front Immunol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1083\/jcb.201212113","article-title":"Exosomes: Looking back three decades and into the future","volume":"200","author":"C V Harding","year":"2013","journal-title":"J Cell Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1007\/s00018-011-0689-3","article-title":"Membrane vesicles, current state-of-the-art: Emerging role of extracellular vesicles","volume":"68","author":"B Gy\u00f6rgy","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0015-0282(98)00044-2","article-title":"Vectorial secretion of vascular endothelial growth factor by polarized human endometrial epithelial cells","volume":"69","author":"D Hornung","year":"1998","journal-title":"Fertil Steril"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1210\/jcem.87.6.8609","article-title":"Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium","volume":"87","author":"S Mesiano","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"ref73","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1210\/jc.2007-0077","article-title":"Nuclear progesterone receptors in the human pregnancy myometrium: Evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A","volume":"92","author":"A a. Merlino","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-2006-956771","article-title":"Myometrial progesterone responsiveness","volume":"25","author":"S Mesiano","year":"2007","journal-title":"Semin Reprod Med"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/1933719110382922","article-title":"Progesterone receptors in the human pregnancy uterus: do they hold the key to birth timing?","volume":"18","author":"S Mesiano","year":"2011","journal-title":"Reprod Sci"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1210\/me.2013-1196","article-title":"Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells","volume":"28","author":"GE Dressing","year":"2014","journal-title":"Mol Endocrinol"},{"issue":"32","key":"ref77","doi-asserted-by":"crossref","first-page":"19546","DOI":"10.1074\/jbc.271.32.19546","article-title":"Stoichiometry and Site-specific Phosphorylation of Human Progesterone Receptor in Native Target Cells and in the Baculovirus Expression System","volume":"271","author":"C a. Beck","year":"1996","journal-title":"J Biol Chem"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1074\/jbc.271.2.1209","article-title":"Two Types of Anti-progestins Have Distinct Effects on Site-specific Phosphorylation of Human Progesterone Receptor","volume":"271","author":"CA Beck","year":"1996","journal-title":"J Biol Chem"},{"key":"ref79","first-page":"1029","article-title":"Identification of a group of Ser-Pro motif hormone-inducible phosphorylation sites in the human progesterone receptor","volume":"9","author":"Y Zhang","year":"1995","journal-title":"Mol Endocrinol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.4161\/auto.26558","article-title":"Autophagy as a mechanism of antiviral defense at the maternal-fetal interface","volume":"9","author":"E Delorme-Axford","year":"2013","journal-title":"Autophagy"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3109\/10641955.2013.832772","article-title":"MicroRNAs: are they the missing link between hypoxia and pre-eclampsia?","volume":"33","author":"JYZ Li","year":"2014","journal-title":"Hypertens pregnancy"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1096\/fj.13-239053","article-title":"Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia","volume":"28","author":"A Vargas","year":"2014","journal-title":"FASEB J"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1095\/biolreprod.114.121616","article-title":"Human exosomal placenta-associated miR-517a-3p modulates the expression of PRKG1 mRNA in Jurkat cells","volume":"91","author":"S Kambe","year":"2014","journal-title":"Biol Reprod"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1600-0897.2010.00822.x","article-title":"The Role of Placental Exosomes in Reproduction","volume":"63","author":"L Mincheva-Nilsson","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/aji.12311","article-title":"Placenta-Derived Exosomes and Syncytiotrophoblast Microparticles and their Role in Human Reproduction: Immune Modulation for Pregnancy Success","volume":"72","author":"L Mincheva-Nilsson","year":"2014","journal-title":"Am J Reprod Immunol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.placenta.2014.02.009","article-title":"Intercellular communication by exosomes in placenta: A possible role in cell fusion?","volume":"35","author":"M Record","year":"2014","journal-title":"Placenta"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.4049\/jimmunol.1301885","article-title":"Exosomes secreted by human placenta carry functional Fas ligand and TRAIL molecules and convey apoptosis in activated immune cells, suggesting exosome-mediated immune privilege of the fetus","volume":"191","author":"A-C Stenqvist","year":"2013","journal-title":"J Immunol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"e20245","DOI":"10.1371\/journal.pone.0020245","article-title":"The immunomodulatory role of syncytiotrophoblast microvesicles","volume":"6","author":"J Southcombe","year":"2011","journal-title":"PLoS One"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.yexcr.2011.01.014","article-title":"Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells","volume":"317","author":"S Atay","year":"2011","journal-title":"Exp Cell Res"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0897.2010.00880.x","article-title":"Trophoblast-derived exosomes mediate monocyte recruitment and differentiation","volume":"65","author":"S Atay","year":"2011","journal-title":"Am J Reprod Immunol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1600-0897.2011.00995.x","article-title":"Human trophoblast-derived exosomal fibronectin induces pro-inflammatory IL-1\u03b2 production by macrophages","volume":"66","author":"S Atay","year":"2011","journal-title":"Am J Reprod Immunol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.placenta.2011.12.006","article-title":"Review: Does size matter? Placental debris and the pathophysiology of pre-eclampsia","volume":"33","author":"CWG Redman","year":"2012","journal-title":"Placenta"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/693157","article-title":"The Possible Role of Extravillous Trophoblast-Derived Exosomes on the Uterine Spiral Arterial Remodeling under Both Normal and Pathological Conditions","volume":"2014","author":"C Salomon","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1479-5876-12-4","article-title":"Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200","volume":"12","author":"M Kobayashi","year":"2014","journal-title":"J Transl Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0157614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T22:28:33Z","timestamp":1748989713000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0157614"}},"subtitle":[],"editor":[{"given":"Kang","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,22]]},"references-count":94,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0157614","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,22]]}}}