{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T02:13:16Z","timestamp":1773454396552,"version":"3.50.1"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T00:00:00Z","timestamp":1467763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014804","name":"Mackay Medical College","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014804","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0157647","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T17:52:10Z","timestamp":1467827530000},"page":"e0157647","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pigment Epithelium Derived Factor Peptide Protects Murine Hepatocytes from Carbon Tetrachloride-Induced Injury"],"prefix":"10.1371","volume":"11","author":[{"given":"Shou-Chuan","family":"Shih","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Chuan","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Show-Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeou-Ping","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/lt.21001","article-title":"Delivery of antioxidative enzyme genes protects against ischemia\/reperfusion-induced liver injury in mice","volume":"12","author":"SQ He","year":"2006","journal-title":"Liver Transpl"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"37481","DOI":"10.1074\/jbc.M506412200","article-title":"Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production","volume":"280","author":"M Korenaga","year":"2005","journal-title":"J Biol Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jhep.2013.03.033","article-title":"Decoding cell death signals in liver inflammation","volume":"59","author":"C Brenner","year":"2013","journal-title":"J Hepatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/CIRCRESAHA.112.268946","article-title":"Mitochondrial control of cellular life, stress, and death","volume":"111","author":"L Galluzzi","year":"2012","journal-title":"Circ Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"LW Weber","year":"2003","journal-title":"Crit Rev Toxicol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/hep.20259","article-title":"Antiangiogenic property of pigment epithelium-derived factor in hepatocellular carcinoma","volume":"40","author":"K Matsumoto","year":"2004","journal-title":"Hepatology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.2353\/ajpath.2010.091085","article-title":"Pigment epithelium-derived factor is an intrinsic antifibrosis factor targeting hepatic stellate cells","volume":"177","author":"TC Ho","year":"2010","journal-title":"Am J Pathol"},{"key":"ref8","first-page":"655144","article-title":"Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer","author":"S Filleur","year":"2005","journal-title":"Cancer Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e95443","DOI":"10.1371\/journal.pone.0095443","article-title":"Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor","volume":"9","author":"TH Tsai","year":"2014","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1167\/iovs.09-4455","article-title":"Effects of human recombinant PEDF protein and PEDF-derived peptide 34-mer on choroidal neovascularization","volume":"51","author":"J Amaral","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/(SICI)1097-4547(19990915)57:6<789::AID-JNR4>3.0.CO;2-M","article-title":"Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell death","volume":"57","author":"W Cao","year":"1999","journal-title":"J Neurosci Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1076\/ceyr.22.4.245.5506","article-title":"Pigment epithelium derived factor as a neuroprotective agent against ischemic retinal injury","volume":"22","author":"N Ogata","year":"2001","journal-title":"Curr Eye Res"},{"key":"ref13","first-page":"1646","article-title":"In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor","volume":"42","author":"W Cao","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1038\/srep05637","article-title":"PEDF and PEDF-derived peptide 44mer protect cardiomyocytes against hypoxia-induced apoptosis and necroptosis via anti-oxidative effect","volume":"11","author":"X Gao","year":"2014","journal-title":"Sci Rep"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"9378","DOI":"10.1523\/JNEUROSCI.22-21-09378.2002","article-title":"Identification of the neuroprotective molecular region of pigment epithelium-derived factor and its binding sites on motor neurons","volume":"22","author":"MM Bilak","year":"2002","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"C159","DOI":"10.1152\/ajpcell.00344.2014","article-title":"PEDF-derived peptide promotes skeletal muscle regeneration through its mitogenic effect on muscle progenitor cells","volume":"309","author":"TC Ho","year":"2015","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1093\/jn\/133.8.2505","article-title":"Magnesium deficiency induces apoptosis in primary cultures of rat hepatocytes","volume":"133","author":"H Martin","year":"2003","journal-title":"J Nutr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"G631","DOI":"10.1152\/ajpgi.00185.2007","article-title":"Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis","volume":"293","author":"G Son","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e92515","DOI":"10.1371\/journal.pone.0092515","article-title":"Involvement of the TNF and FasL produced by CD11b Kupffer cells\/macrophages in CCl4-induced acute hepatic injury","volume":"9","author":"A Sato","year":"2014","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/0016-5085(95)90149-3","article-title":"Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor","volume":"108","author":"MJ Czaja","year":"1995","journal-title":"Gastroenterology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jhep.2004.11.043","article-title":"Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression","volume":"42","author":"MB Bansal","year":"2005","journal-title":"J Hepatol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"G498","DOI":"10.1152\/ajpgi.00525.2011","article-title":"Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP","volume":"303","author":"JM Schattenberg","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1053\/j.gastro.2004.07.019","article-title":"Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses","volume":"127","author":"T Takehara","year":"2004","journal-title":"Gastroenterology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"12250","DOI":"10.3390\/molecules200712250","article-title":"Protective Effect of Procyanidin B2 against CCl4-Induced Acute Liver Injury in Mice","volume":"20","author":"BY Yang","year":"2015","journal-title":"Molecules"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/jme.1.02008","article-title":"Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy","volume":"37","author":"SX Zhang","year":"2006","journal-title":"J Mol Endocrinol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1073\/pnas.89.12.5408","article-title":"Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1","volume":"89","author":"FA Oberhammer","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"10480","DOI":"10.1074\/jbc.M809259200","article-title":"Laminin receptor involvement in the anti-angiogenic activity of pigment epithelium-derived factor","volume":"284","author":"A Bernard","year":"2009","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"38022","DOI":"10.1074\/jbc.M600353200","article-title":"Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor","volume":"281","author":"L Notari","year":"2006","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1128\/MCB.01211-10","article-title":"Identification of a novel inhibitor of the canonical Wnt pathway","volume":"31","author":"K Park","year":"2011","journal-title":"Mol Cell Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1053\/j.gastro.2014.06.043","article-title":"Roles for chemokines in liver disease","volume":"147","author":"F Marra","year":"2014","journal-title":"Gastroenterology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1016\/j.foodchem.2013.03.061","article-title":"Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury","volume":"141","author":"GJ Huang","year":"2013","journal-title":"Food Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jep.2008.08.017","article-title":"Antioxidant and hepatoprotective activity of aqueous extract of Solanum fastigiatum (false &quot;Jurubeba&quot;) against paracetamol-induced liver damage in mice","volume":"120","author":"SM Sabir","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/BF02980070","article-title":"The preventive inhibition of chondroitin sulfate against the CCl4-induced oxidative stress of subcellular level","volume":"27","author":"JY Lee","year":"2004","journal-title":"Arch Pharm Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.exer.2009.09.014","article-title":"PEDF prevents reactive oxygen species generation and retinal endothelial cell damage at high glucose levels","volume":"90","author":"E Banumathi","year":"2010","journal-title":"Exp Eye Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/0041-008X(84)90115-7","article-title":"Glutathione depletion by methyl chloride and association with lipid peroxidation in mice and rats","volume":"72","author":"DJ Kornbrust","year":"1984","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1053\/jhep.2003.50472","article-title":"Kupffer cells engulment of apoptotic bodies stimulates death ligand and cytokine expression","volume":"38","author":"A Canbay","year":"2003","journal-title":"Hepatology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/hep.510240545","article-title":"Apoptosis of neutrophils and their elimination by Kupffer Cells in rat liver","volume":"24","author":"J Shi","year":"1996","journal-title":"Hepatology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/hep.25624","article-title":"Fibronectin is essential for survival but is dispensable for proliferation of hepatocytes in acute liver injury in mice","volume":"56","author":"K Moriya","year":"2012","journal-title":"Hepatology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/labinvest.2009.129","article-title":"The protective role of pregnane X receptor in lipopolysaccharide\/D-galactosamine-induced acute liver injury","volume":"90","author":"K Wang","year":"2010","journal-title":"Lab Invest"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1053\/j.gastro.2008.09.065","article-title":"Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator","volume":"136","author":"C Chung","year":"2009","journal-title":"Gastroenterology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2353\/ajpath.2010.090242","article-title":"Pigment epithelium-derived factor inhibits lysosomal degradation of Bcl-xL and apoptosis in HepG2 cells","volume":"176","author":"T Kawaguchi","year":"2010","journal-title":"Am J Pathol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1002\/hep.23532","article-title":"Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific signal transducer and activator of transcription 3 gene knockout mice","volume":"51","author":"N Horiguchi","year":"2010","journal-title":"Hepatology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/hep.23427","article-title":"The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat Kupffer cells","volume":"51","author":"P Mandal","year":"2010","journal-title":"Hepatology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/stem.1393","article-title":"PEDF promotes self-renewal of limbal stem cell and accelerates corneal epithelial wound healing","volume":"31","author":"TC Ho","year":"2013","journal-title":"Stem Cells"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"23928","DOI":"10.1074\/jbc.M113.487884","article-title":"Pigment epithelium-derived factor (PEDF) prevents retinal cell death via PEDF Receptor (PEDF-R): identification of a functional ligand binding site","volume":"288","author":"P Subramanian","year":"2013","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.exer.2014.08.004","article-title":"Enhanced survival of retinal ganglion cells is mediated by M\u00fcller glial cell-derived PEDF","volume":"127","author":"JD Unterlauft","year":"2014","journal-title":"Exp Eye Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/cdd.2013.137","article-title":"Proline oxidase-adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation","volume":"21","author":"D Lettieri Barbato","year":"2014","journal-title":"Cell Death Differ"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jhep.2007.10.012","article-title":"Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL)","volume":"48","author":"C Chung","year":"2008","journal-title":"J Hepatol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0157647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T04:21:10Z","timestamp":1692418870000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0157647"}},"subtitle":[],"editor":[{"given":"Carlos M","family":"Rodriguez-Ortigosa","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,7,6]]},"references-count":48,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0157647","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,6]]}}}