{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:53:55Z","timestamp":1740146035759,"version":"3.37.3"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T00:00:00Z","timestamp":1466640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-13-BSV1-0021-02"],"award-info":[{"award-number":["ANR-13-BSV1-0021-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007379","name":"Fondation pour l'Aide \u00e0 la Recherche sur la Scl\u00e9rose en Plaques","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DIM081013833"],"award-info":[{"award-number":["DIM081013833"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008319","name":"Fondation Arthritis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0157740","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T17:50:01Z","timestamp":1466704201000},"page":"e0157740","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of the Single Immunodominant Region of the Native Human CC Chemokine Receptor 6 Recognized by Mouse Monoclonal Antibodies"],"prefix":"10.1371","volume":"11","author":[{"given":"Karim","family":"Dorgham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Dejou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Piesse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Gorochov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"P\u00e8ne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7454-1836","authenticated-orcid":true,"given":"Hans","family":"Yssel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,6,23]]},"reference":[{"issue":"23","key":"ref1","doi-asserted-by":"crossref","first-page":"14893","DOI":"10.1074\/jbc.272.23.14893","article-title":"Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC","volume":"272","author":"M Baba","year":"1997","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1084\/jem.186.6.837","article-title":"CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3 alpha and is highly expressed in human dendritic cells","volume":"186","author":"DR Greaves","year":"1997","journal-title":"Journal of Experimental Medicine"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4049\/jimmunol.162.1.186","article-title":"CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3\u03b1","volume":"162","author":"F Liao","year":"1999","journal-title":"Journal of Immunology"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S1074-7613(00)80201-0","article-title":"CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue","volume":"12","author":"DN Cook","year":"2000","journal-title":"Immunity"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.immuni.2006.01.005","article-title":"Dendritic cells rapidly recruited into epithelial tissues via CCR6\/CCL20 are responsible for CD8(+) T cell crosspriming in vivo","volume":"24","author":"M Le Borgne","year":"2006","journal-title":"Immunity"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.micinf.2006.12.002","article-title":"Protective immunity and delayed type hypersensitivity reaction are uncoupled in experimental Leishmania major infection of CCR6-negative mice","volume":"9","author":"A Lechner","year":"2007","journal-title":"Microbes and Infection"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.immuni.2006.02.015","article-title":"CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches","volume":"24","author":"RM Salazar-Gonzalez","year":"2006","journal-title":"Immunity"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1172\/JCI11297","article-title":"CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses","volume":"107","author":"R Varona","year":"2001","journal-title":"Journal of Clinical Investigation"},{"issue":"5439","key":"ref9","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.286.5439.525","article-title":"\u03b2-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6","volume":"286","author":"D Yang","year":"1999","journal-title":"Science"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/ni1467","article-title":"Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells","volume":"8","author":"EV Acosta-Rodriguez","year":"2007","journal-title":"Nature Immunology"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.20070663","article-title":"Phenotypic and functional features of human Th17 cells","volume":"204","author":"F Annunziato","year":"2007","journal-title":"Journal of Experimental Medicine"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"214","DOI":"10.4049\/jimmunol.180.1.214","article-title":"Human T cells that are able to produce EL-17 express the chemokine receptor CCR6","volume":"180","author":"SP Singh","year":"2008","journal-title":"Journal of Immunology"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1182\/blood.V96.7.2338","article-title":"Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3 alpha\/CCL20 in human B cells","volume":"96","author":"R Krzysiek","year":"2000","journal-title":"Blood"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nri3855","article-title":"Transcriptional regulation of innate lymphoid cell fate","volume":"15","author":"N Serafini","year":"2015","journal-title":"Nature Reviews Immunology"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1084\/jem.188.2.373","article-title":"Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites","volume":"188","author":"MC Dieu","year":"1998","journal-title":"Journal of Experimental Medicine"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ni.1716","article-title":"C-C chemokine receptor 6-regulated entry of T-H-17 cells into the CNS through the choroid plexus is required for the initiation of EAE","volume":"10","author":"A Reboldi","year":"2009","journal-title":"Nature Immunology"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.4049\/jimmunol.0713169","article-title":"Inhibition of CCR6 Function Reduces the Severity of Experimental Autoimmune Encephalomyelitis via Effects on the Priming Phase of the Immune Response","volume":"182","author":"A Liston","year":"2009","journal-title":"Journal of Immunology"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1084\/jem.20071397","article-title":"Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model","volume":"204","author":"K Hirota","year":"2007","journal-title":"J Exp Med"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ng.583","article-title":"A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility","volume":"42","author":"Y Kochi","year":"2010","journal-title":"Nature Genetics"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/ng.582","article-title":"Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci","volume":"42","author":"EA Stahl","year":"2010","journal-title":"Nature Genetics"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1056\/NEJMoa0706383","article-title":"B-cell depletion with Rituximab in relapsing-remitting multiple sclerosis","volume":"358","author":"SL Hauser","year":"2008","journal-title":"New England Journal of Medicine"},{"issue":"5258","key":"ref22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.272.5258.60","article-title":"Lymphocyte homing and homeostasis","volume":"272","author":"EC Butcher","year":"1996","journal-title":"Science"},{"issue":"5349","key":"ref23","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1126\/science.279.5349.381","article-title":"Chemokines and the arrest of lymphocytes rolling under flow conditions","volume":"279","author":"JJ Campbell","year":"1998","journal-title":"Science"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.4049\/jimmunol.1000597","article-title":"CCL20 and \u03b2-Defensin-2 Induce Arrest of Human Th17 Cells on Inflamed Endothelium In Vitro under Flow Conditions","volume":"186","author":"S Ghannam","year":"2011","journal-title":"Journal of Immunology"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"7423","DOI":"10.4049\/jimmunol.180.11.7423","article-title":"Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes","volume":"180","author":"J Pene","year":"2008","journal-title":"Journal of Immunology"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im0719s47","article-title":"Generation and maintenance of cloned human T cell lines","author":"H Yssel","year":"2002","journal-title":"Curr Protoc Immunol"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0022-1759(84)90450-2","article-title":"Serum-free medium for generation and propagation of functional human cyto-toxic and helper t-cell clones","volume":"72","author":"H Yssel","year":"1984","journal-title":"Journal of Immunological Methods"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0014-4827(77)90089-1","article-title":"Insitu detection of mycoplasma contamination in cell-cultures by fluorescent hoechst-33258 stain","volume":"104","author":"TR Chen","year":"1977","journal-title":"Experimental Cell Research"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/dbb3e614-dc4c-40dd-b9e0-37787ae6b150","article-title":"Structure, Antimicrobial Activities and Mode of Interaction with Membranes of Bovel Phylloseptins from the Painted-Belly Leaf Frog, Phyllomedusa sauvagii","volume":"8","author":"Z Raja","year":"2013","journal-title":"Plos One"},{"key":"ref30","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im0205s102","article-title":"Production of monoclonal antibodies","volume":"102","author":"WM Yokoyama","year":"2013","journal-title":"Current protocols in immunology \/ edited by John E Coligan"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1089\/aid.2005.21.82","article-title":"Immunogenicity of HIV type 1 gp120 CD4 binding site phage mimotopes","volume":"21","author":"K Dorgham","year":"2005","journal-title":"Aids Research and Human Retroviruses"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"W503","DOI":"10.1093\/nar\/gkn316","article-title":"IMGT\/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis","volume":"36","author":"X Brochet","year":"2008","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"ref33","first-page":"695","article-title":"IMGT\/V-QUEST: IMGT standardized analysis of the immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences","volume":"2011","author":"V Giudicelli","year":"2011","journal-title":"Cold Spring Harb Protoc"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev.pharmtox.42.091901.115838","article-title":"Structure junction, and inhibition of chemokines","volume":"42","author":"EJ Fernandez","year":"2002","journal-title":"Annual Review of Pharmacology and Toxicology"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/BF02254367","article-title":"Molecular characterization of CCR6: Involvement of multiple domains in ligand binding and receptor signaling","volume":"11","author":"LS Ai","year":"2004","journal-title":"Journal of Biomedical Science"},{"issue":"26","key":"ref36","doi-asserted-by":"crossref","first-page":"8332","DOI":"10.1021\/bi025855y","article-title":"Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling","volume":"41","author":"LS Ai","year":"2002","journal-title":"Biochemistry"},{"issue":"6152","key":"ref37","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1126\/science.1241475","article-title":"Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex","volume":"341","author":"Q Tan","year":"2013","journal-title":"Science"},{"issue":"6226","key":"ref38","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1126\/science.1261064","article-title":"Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine","volume":"347","author":"L Qin","year":"2015","journal-title":"Science"},{"issue":"6007","key":"ref39","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1126\/science.1194396","article-title":"Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists","volume":"330","author":"B Wu","year":"2010","journal-title":"Science"},{"issue":"6226","key":"ref40","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1126\/science.aaa5026","article-title":"Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor","volume":"347","author":"JS Burg","year":"2015","journal-title":"Science"},{"issue":"34","key":"ref41","doi-asserted-by":"crossref","first-page":"32335","DOI":"10.1074\/jbc.M301209200","article-title":"A novel cyclic peptide immunization strategy for preventing HIV-1\/AIDS infection and progression","volume":"278","author":"S Misumi","year":"2003","journal-title":"Journal of Biological Chemistry"},{"issue":"23","key":"ref42","doi-asserted-by":"crossref","first-page":"11614","DOI":"10.1128\/JVI.75.23.11614-11620.2001","article-title":"A cyclic dodecapeptide-multiple-antigen peptide conjugate from the undecapeptidyl arch (from Arg(168) to Cys(178)) of extracellular loop 2 in CCR5 as a novel human immunodeficiency virus type 1 vaccine","volume":"75","author":"S Misumi","year":"2001","journal-title":"Journal of Virology"},{"issue":"5","key":"ref43","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/jlb.66.5.837","article-title":"Down-regulation of the beta-chemokine receptor CCR6 in dendritic cells mediated by TNF-alpha and IL-4","volume":"66","author":"L Carramolino","year":"1999","journal-title":"J Leukoc Biol"},{"key":"ref44","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im0202s01","article-title":"Isotype determination of antibodies","author":"P Hornbeck","year":"2001","journal-title":"Current protocols in immunology \/ edited by John E Coligan"},{"issue":"9","key":"ref45","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/ni.f.210","article-title":"Moving targets: cell migration inhibitors as new anti-inflammatory therapies","volume":"9","author":"CR Mackay","year":"2008","journal-title":"Nature Immunology"},{"issue":"6","key":"ref46","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1111\/j.1476-5381.2011.01551.x","article-title":"Pharmacological modulation of chemokine receptor function","volume":"165","author":"DJ Scholten","year":"2012","journal-title":"British Journal of Pharmacology"},{"issue":"1\u20132","key":"ref47","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0014-5793(98)01450-1","article-title":"Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3 alpha","volume":"440","author":"R Varona","year":"1998","journal-title":"Febs Letters"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2353\/ajpath.2009.080273","article-title":"CD83(+)CCR7(-) Dendritic Cells Accumulate in the Subepithelial Dome and Internalize Translocated Escherichia coli HB101 in the Peyer's Patches of Heal Crohn's Disease","volume":"174","author":"SaY Salim","year":"2009","journal-title":"American Journal of Pathology"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s13277-010-0113-x","article-title":"Expression of the chemokine receptor CCR6 correlates with a favorable prognosis in patients with adenocarcinoma of the lung","volume":"32","author":"Y Minamiya","year":"2011","journal-title":"Tumor Biology"},{"key":"ref50","article-title":"Human monoclonal antibodies against human chemokine receptor ccr6: Google Patents","volume":"2013","author":"E Kim","year":"2013"},{"key":"ref51","article-title":"Anticorps anti-ccr6 humain: Google Patents","volume":"2013","author":"Y Isoda","year":"2013"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"e227","DOI":"10.1016\/j.ddtec.2012.09.006","article-title":"Targeting chemokines and chemokine receptors with antibodies","volume":"9","author":"DM Alex Klarenbeek","year":"2012","journal-title":"Drug discovery today Technologies"},{"issue":"9","key":"ref53","article-title":"Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies","volume":"7","author":"B-J Ma","year":"2011","journal-title":"Plos Pathogens"},{"issue":"236","key":"ref54","article-title":"Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV","volume":"6","author":"D Sok","year":"2014","journal-title":"Science Translational Medicine"},{"issue":"2","key":"ref55","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4049\/jimmunol.1401553","article-title":"CCR6-Dependent Positioning of Memory B Cells Is Essential for Their Ability To Mount a Recall Response to Antigen","volume":"194","author":"R Elgueta","year":"2015","journal-title":"Journal of Immunology"},{"issue":"9","key":"ref56","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1093\/rheumatology\/keq116","article-title":"Efficacy and safety of various repeat treatment dosing regimens of rituximab in patients with active rheumatoid arthritis: results of a Phase III randomized study (MIRROR)","volume":"49","author":"A Rubbert-Roth","year":"2010","journal-title":"Rheumatology"},{"issue":"18","key":"ref57","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1182\/blood-2012-10-458695","article-title":"Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients","volume":"121","author":"A Dufour","year":"2013","journal-title":"Blood"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1182\/blood-2013-12-538975","article-title":"PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia","volume":"124","author":"M Weisser","year":"2014","journal-title":"Blood"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0157740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T00:19:07Z","timestamp":1692404347000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0157740"}},"subtitle":[],"editor":[{"given":"Shixia","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,23]]},"references-count":58,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0157740","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,6,23]]}}}