{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:34:27Z","timestamp":1792802067516,"version":"4.5.0"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Research Council (BE)","id":[{"id":"https:\/\/ror.org\/0472cxd90","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001862","name":"the Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Parkinson Foundation of Sweden"},{"DOI":"10.13039\/501100003173","name":"Crafoordska Stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Swedish Federal Government under the ALF agreement"},{"name":"the Swedish Federal Government under the ALF agreement"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0157755","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T15:42:41Z","timestamp":1467301361000},"page":"e0157755","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Alterations of Diffusion Kurtosis and Neurite Density Measures in Deep Grey Matter and White Matter in Parkinson\u2019s Disease"],"prefix":"10.1371","volume":"11","author":[{"given":"Yulia","family":"Surova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Lampinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"L\u00e4tt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Widner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Swedish BioFINDER study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"van Westen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,6,30]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson&apos;s disease","volume":"5","author":"LM de Lau","year":"2006","journal-title":"Lancet Neurol"},{"issue":"Pt 8","key":"ref2","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1093\/brain\/122.8.1421","article-title":"The substantia nigra of the human brain. I. Nigrosomes and the nigral matrix, a compartmental organization based on calbindin D(28K) immunohistochemistry","volume":"122","author":"P Damier","year":"1999","journal-title":"Brain"},{"issue":"14","key":"ref3","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1056\/NEJM198804073181402","article-title":"Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson&apos;s disease. Pathophysiologic and clinical implications","volume":"318","author":"SJ Kish","year":"1988","journal-title":"N Engl J Med"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00441-004-0956-9","article-title":"Stages in the development of Parkinson&apos;s disease-related pathology","volume":"318","author":"H Braak","year":"2004","journal-title":"Cell Tissue Res"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrneurol.2012.242","article-title":"100 years of Lewy pathology","volume":"9","author":"M Goedert","year":"2013","journal-title":"Nat Rev Neurol"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1212\/WNL.40.10.1529","article-title":"Variable expression of Parkinson&apos;s disease: a base-line analysis of the DATATOP cohort. The Parkinson Study Group","volume":"40","author":"J Jankovic","year":"1990","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-7091-6360-3_1","article-title":"Post mortem studies in Parkinson&apos;s disease\u2014is it possible to detect brain areas for specific symptoms?","volume":"56","author":"KA Jellinger","year":"1999","journal-title":"J Neural Transm Suppl"},{"issue":"Pt 11","key":"ref8","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/brain\/awp234","article-title":"A clinico-pathological study of subtypes in Parkinson&apos;s disease","volume":"132","author":"M Selikhova","year":"2009","journal-title":"Brain"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ncpneuro0773","article-title":"Technology insight: imaging neurodegeneration in Parkinson&apos;s disease","volume":"4","author":"DJ Brooks","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1212\/WNL.0b013e318284070c","article-title":"Diffusion tensor imaging in parkinsonian syndromes: a systematic review and meta-analysis","volume":"80","author":"CJ Cochrane","year":"2013","journal-title":"Neurology"},{"key":"ref11","first-page":"2569","article-title":"Motion and eddy-current correction in high b-value diffusion MRI: Systematic registration errors and how to avoid them","author":"M Nilsson","year":"2014","journal-title":"Proceedings of the ISMRM"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1093\/brain\/awq212","article-title":"Magnetic resonance imaging markers of Parkinson&apos;s disease nigrostriatal signature","volume":"133","author":"P Peran","year":"2010","journal-title":"Brain"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3174\/ajnr.A3178","article-title":"Thalamic projection fiber integrity in de novo Parkinson disease","volume":"34","author":"PJ Planetta","year":"2013","journal-title":"AJNR Am J Neuroradiol"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.neuroimage.2003.12.005","article-title":"Trace of diffusion tensor differentiates the Parkinson variant of multiple system atrophy and Parkinson&apos;s disease","volume":"21","author":"MF Schocke","year":"2004","journal-title":"Neuroimage"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.parkreldis.2014.10.003","article-title":"Alterations of mean diffusivity of pedunculopontine nucleus pathway in Parkinson&apos;s disease patients with freezing of gait","volume":"21","author":"J Youn","year":"2015","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/mds.23917","article-title":"Regional alterations of brain microstructure in Parkinson&apos;s disease using diffusion tensor imaging","volume":"27","author":"W Zhan","year":"2012","journal-title":"Mov Disord"},{"issue":"Pt 10","key":"ref17","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1093\/brain\/awl166","article-title":"Apparent diffusion coefficient measurements of the middle cerebellar peduncle differentiate the Parkinson variant of MSA from Parkinson&apos;s disease and progressive supranuclear palsy","volume":"129","author":"G Nicoletti","year":"2006","journal-title":"Brain"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/mds.21204","article-title":"Diffusion-weighted magnetic resonance imaging differentiates Parkinsonian variant of multiple-system atrophy from progressive supranuclear palsy","volume":"22","author":"DC Paviour","year":"2007","journal-title":"Mov Disord"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3174\/ajnr.A3832","article-title":"Changes in the thalamus in atypical parkinsonism detected using shape analysis and diffusion tensor imaging","volume":"35","author":"CP Hess","year":"2014","journal-title":"AJNR Am J Neuroradiol"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00234-015-1515-7","article-title":"Conventional 3T brain MRI and diffusion tensor imaging in the diagnostic workup of early stage parkinsonism","volume":"57","author":"FJ Meijer","year":"2015","journal-title":"Neuroradiology"},{"issue":"Pt 10","key":"ref21","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1093\/brain\/awn195","article-title":"Diffusion-weighted brain imaging study of patients with clinical diagnosis of corticobasal degeneration, progressive supranuclear palsy and Parkinson&apos;s disease","volume":"131","author":"G Rizzo","year":"2008","journal-title":"Brain"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s00234-011-0983-7","article-title":"In vivo evaluation of white matter pathology in patients of progressive supranuclear palsy using TBSS","volume":"54","author":"J Saini","year":"2012","journal-title":"Neuroradiology"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1212\/01.WNL.0000141853.27081.BD","article-title":"Altered cortical visual processing in PD with hallucinations: an fMRI study","volume":"63","author":"GT Stebbins","year":"2004","journal-title":"Neurology"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1148\/radiol.11102277","article-title":"Parkinson disease: diagnostic utility of diffusion kurtosis imaging","volume":"261","author":"JJ Wang","year":"2011","journal-title":"Radiology"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00234-015-1563-z","article-title":"Disease-specific structural changes in thalamus and dentatorubrothalamic tract in progressive supranuclear palsy","volume":"57","author":"Y Surova","year":"2015","journal-title":"Neuroradiology"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.3174\/ajnr.A1615","article-title":"Diffusion tensor imaging shows different topographic involvement of the thalamus in progressive supranuclear palsy and corticobasal degeneration","volume":"30","author":"A Erbetta","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"issue":"8","key":"ref27","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1007\/s00415-015-7779-3","article-title":"Neuroimaging evidence of gray and white matter damage and clinical correlates in progressive supranuclear palsy","volume":"262","author":"MC Piattella","year":"2015","journal-title":"J Neurol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neubiorev.2015.09.007","article-title":"Neuroimaging of Parkinson&apos;s disease: Expanding views","volume":"59","author":"CP Weingarten","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/hbm.22256","article-title":"DTI correlates of distinct cognitive impairments in Parkinson&apos;s disease","volume":"35","author":"Z Zheng","year":"2014","journal-title":"Hum Brain Mapp"},{"issue":"7","key":"ref30","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/nbm.1518","article-title":"MRI quantification of non-Gaussian water diffusion by kurtosis analysis","volume":"23","author":"JH Jensen","year":"2010","journal-title":"NMR Biomed"},{"key":"ref31","first-page":"2772","article-title":"Neurite Density Imaging (NDI): rapid acquisition and estimation of the intracellular volume fraction","author":"B Lampinen","year":"2015","journal-title":"Proceedings of the ISMRM"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1212\/WNL.0000000000001098","article-title":"CSF biomarkers and clinical progression of Parkinson disease","volume":"84","author":"S Hall","year":"2015","journal-title":"Neurology"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archneur.56.1.33","article-title":"Diagnostic criteria for Parkinson disease","volume":"56","author":"DJ Gelb","year":"1999","journal-title":"Arch Neurol"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1212\/01.wnl.0000324625.00404.15","article-title":"Second consensus statement on the diagnosis of multiple system atrophy","volume":"71","author":"S Gilman","year":"2008","journal-title":"Neurology"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.47.1.1","article-title":"Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop","volume":"47","author":"I Litvan","year":"1996","journal-title":"Neurology"},{"key":"ref36","first-page":"153","article-title":"Recent developments in Parkinson\u2019s Disease","volume":"vol 2","author":"S Fahn","year":"1987"},{"key":"ref37","first-page":"152","article-title":"In: Gillingham FJ","author":"RS Schwab","year":"1969"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.parkreldis.2004.06.003","article-title":"Measuring gait and gait-related activities in Parkinson&apos;s patients own home environment: a reliability, responsiveness and feasibility study","volume":"11","author":"LI Lim","year":"2005","journal-title":"Parkinsonism Relat Disord"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1532-5415.1991.tb01616.x","article-title":"The timed &quot;Up &amp; Go&quot;: a test of basic functional mobility for frail elderly persons","volume":"39","author":"D Podsiadlo","year":"1991","journal-title":"J Am Geriatr Soc"},{"key":"ref40","first-page":"321","article-title":"Handbook of Sensory Physiology","author":"AR Fregly","year":"1974"},{"issue":"3 Pt 2","key":"ref41","first-page":"1201","article-title":"Clinical utility of color-form naming in Alzheimer&apos;s disease: preliminary evidence","volume":"99","author":"NP Nielsen","year":"2004","journal-title":"Percept Mot Skills"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1109\/TMI.2009.2037915","article-title":"Optimal experimental design for diffusion kurtosis imaging","volume":"29","author":"DH Poot","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"issue":"7","key":"ref43","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/nbm.1543","article-title":"Twenty-five pitfalls in the analysis of diffusion MRI data","volume":"23","author":"DK Jones","year":"2010","journal-title":"NMR Biomed"},{"key":"ref44","article-title":"Gibbs ringing in diffusion MRI","author":"J Veraart","year":"2015","journal-title":"Magn Reson Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.neuroimage.2015.06.068","article-title":"The effect of Gibbs ringing artifacts on measures derived from diffusion MRI","volume":"120","author":"D Perrone","year":"2015","journal-title":"Neuroimage"},{"key":"ref46","article-title":"Gibbs-ringing artifact removal based on local subvoxel-shifts","author":"E Kellner","year":"2015","journal-title":"Magn Reson Med"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/hbm.20848","article-title":"Comparing isotropic and anisotropic smoothing for voxel-based DTI analyses: A simulation study","volume":"31","author":"W Van Hecke","year":"2010","journal-title":"Hum Brain Mapp"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/jmri.23857","article-title":"Regional values of diffusional kurtosis estimates in the healthy brain","volume":"37","author":"J Latt","year":"2013","journal-title":"J Magn Reson Imaging"},{"issue":"4","key":"ref49","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuroimage.2012.03.072","article-title":"NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain","volume":"61","author":"H Zhang","year":"2012","journal-title":"Neuroimage"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/cmr.a.10065","article-title":"Computer Simulations in Solid-State NMR. III. Powder Averaging","volume":"18A","author":"M Ed\u00e9n","year":"2002","journal-title":"Concepts in Magnetic Resonance Part A"},{"issue":"12","key":"ref51","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/nbm.2999","article-title":"Orientationally invariant metrics of apparent compartment eccentricity from double pulsed field gradient diffusion experiments","volume":"26","author":"SN Jespersen","year":"2013","journal-title":"NMR Biomed"},{"key":"ref52","first-page":"1","article-title":"Microanisotropy imaging: quantification of microscopic diffusion anisotropy and orientational order parameter by diffusion MRI with magic-angle spinning of the q-vector","volume":"27","author":"S Lasic","year":"2014","journal-title":"Frontiers in Physics | Biophysics"},{"issue":"10","key":"ref53","doi-asserted-by":"crossref","first-page":"104201","DOI":"10.1063\/1.4913502","article-title":"NMR diffusion-encoding with axial symmetry and variable anisotropy: Distinguishing between prolate and oblate microscopic diffusion tensors with unknown orientation distribution","volume":"142","author":"S Eriksson","year":"2015","journal-title":"J Chem Phys"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neuroimage.2014.12.009","article-title":"One diffusion acquisition and different white matter models: how does microstructure change in human early development based on WMTI and NODDI?","volume":"107","author":"IO Jelescu","year":"2015","journal-title":"Neuroimage"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/nbm.3450","article-title":"Degeneracy in model parameter estimation for multi-compartmental diffusion in neuronal tissue","volume":"29","author":"IO Jelescu","year":"2016","journal-title":"NMR Biomed"},{"key":"ref56","article-title":"Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: an Approach to Cerebral Imaging","author":"J Talairach","year":"1988"},{"issue":"12","key":"ref57","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1212\/01.WNL.0000165960.04422.D0","article-title":"New and reliable MRI diagnosis for progressive supranuclear palsy","volume":"64","author":"H Oba","year":"2005","journal-title":"Neurology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/ima.22005","article-title":"MRtrix: Diffusion tractography in crossing fiber regions","volume":"22","author":"JD Tournier","year":"2012","journal-title":"Int J Imaging Syst Technol"},{"issue":"1412","key":"ref59","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1098\/rstb.2001.0915","article-title":"A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM)","volume":"356","author":"J Mazziotta","year":"2001","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref60","article-title":"Spatial normalisation. 2012 3 September. Report","author":"JLR Andersson","year":"2007"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuropsychologia.2012.11.018","article-title":"Distinct subdivisions of the cingulum bundle revealed by diffusion MRI fibre tracking: implications for neuropsychological investigations","volume":"51","author":"DK Jones","year":"2013","journal-title":"Neuropsychologia"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.neuroimage.2007.02.049","article-title":"Reproducibility of quantitative tractography methods applied to cerebral white matter","volume":"36","author":"S Wakana","year":"2007","journal-title":"Neuroimage"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neulet.2013.06.050","article-title":"Alterations of mean diffusivity in brain white matter and deep gray matter in Parkinson&apos;s disease","volume":"550","author":"HJ Kim","year":"2013","journal-title":"Neurosci Lett"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neuroimage.2013.02.078","article-title":"Variability in diffusion kurtosis imaging: impact on study design, statistical power and interpretation","volume":"76","author":"F Szczepankiewicz","year":"2013","journal-title":"Neuroimage"},{"issue":"3","key":"ref65","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00234-014-1327-1","article-title":"A preliminary diffusional kurtosis imaging study of Parkinson disease: comparison with conventional diffusion tensor imaging","volume":"56","author":"K Kamagata","year":"2014","journal-title":"Neuroradiology"},{"issue":"6","key":"ref66","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1093\/cercor\/bhh186","article-title":"Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study","volume":"15","author":"N Makris","year":"2005","journal-title":"Cereb Cortex"},{"issue":"10","key":"ref67","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1136\/jnnp.2003.031237","article-title":"Hippocampal and prefrontal atrophy in patients with early non-demented Parkinson&apos;s disease is related to cognitive impairment","volume":"75","author":"A Bruck","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"ref68","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1046\/j.1468-1331.2000.00066.x","article-title":"Researching a differential impairment of frontal functions and explicit memory in early Parkinson&apos;s disease","volume":"7","author":"E Farina","year":"2000","journal-title":"Eur J Neurol"},{"issue":"4","key":"ref69","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/1531-8249(200004)47:4<493::AID-ANA13>3.0.CO;2-4","article-title":"In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson&apos;s disease","volume":"47","author":"CS Lee","year":"2000","journal-title":"Ann Neurol"},{"issue":"Pt 5","key":"ref70","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/brain\/109.5.845","article-title":"Frontal lobe dysfunction in Parkinson&apos;s disease. The cortical focus of neostriatal outflow","volume":"109","author":"AE Taylor","year":"1986","journal-title":"Brain"},{"issue":"5","key":"ref71","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s00401-014-1265-3","article-title":"The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset","volume":"127","author":"J Levin","year":"2014","journal-title":"Acta Neuropathol"},{"key":"ref72","article-title":"Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease","author":"K Kamagata","year":"2015","journal-title":"Eur Radiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0157755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T21:14:07Z","timestamp":1718658847000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0157755"}},"subtitle":[],"editor":[{"given":"Alexander","family":"Leemans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,30]]},"references-count":72,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0157755","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,30]]}}}