{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:59:30Z","timestamp":1778507970669,"version":"3.51.4"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0157798","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T19:25:18Z","timestamp":1466105118000},"page":"e0157798","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis"],"prefix":"10.1371","volume":"11","author":[{"given":"Yaoyao","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengwei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","article-title":"Functional gastroduodenal disorders","volume":"130","author":"J Tack","year":"2006","journal-title":"Gastroenterology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/j.gastro.2009.03.039","article-title":"Anxiety is associated with uninvestigated and functional dyspepsia (Rome III criteria) in a Swedish population-based study","volume":"137","author":"P Aro","year":"2009","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1136\/gutjnl-2011-300474","article-title":"The brain\u2014gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study","volume":"61","author":"NA Koloski","year":"2012","journal-title":"Gut"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1080\/00365520510012190","article-title":"Prevalence and health\/social impacts of functional dyspepsia in Taiwan: A study based on the Rome Criteria Questionnaire Survey assisted by endoscopic exclusion among a physical check-up population","volume":"40","author":"CL Lu","year":"2005","journal-title":"Scand J Gastroenterol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1111\/j.1572-0241.2004.40052.x","article-title":"The prevalence and risk factors of functional dyspepsia in a multiethnic population in the United States","volume":"99","author":"Y Shaib","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5056\/jnm.2014.20.1.104","article-title":"Impact of sleep disorders, quality of life and gastric emptying in distinct subtypes of functional dyspepsia in Japan","volume":"20","author":"H Yamawaki","year":"2014","journal-title":"J Neurogastroenterol Motil"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0269-2813.2004.01807.x","article-title":"Impact of functional gastrointestinal disorders on health-related quality of life: a population-based case-control study","volume":"19","author":"SLS Halder","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1572-0241.2000.01735.x","article-title":"The Impact of functional gastrointestinal disorders on quality of life","volume":"95","author":"NA Koloski","year":"2000","journal-title":"Am J Gstroenterol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/j.1440-1746.2011.07037.x","article-title":"Asian consensus report on functional dyspepsia","volume":"27","author":"H Miwa","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.cgh.2006.09.012","article-title":"Effects of proton-pump inhibitors on functional dyspepsia: a meta-analysis of randomized placebo-controlled trials","volume":"5","author":"WH Wang","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00535-010-0334-1","article-title":"Proton pump inhibitor versus prokinetic therapy in patients with functional dyspepsia: is therapeutic response predicted by Rome III subgroups?","volume":"46","author":"YC Hsu","year":"2010","journal-title":"J Gastroenterol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1053\/gast.2003.50155","article-title":"Heterogeneity of symptom pattern, psychosocial factors, and pathophysiological mechanisms in severe functional dyspepsia","volume":"124","author":"B Fischler","year":"2003","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0016-5085(98)70012-5","article-title":"Role of impaired gastric accommodation to a meal in functional dyspepsia","volume":"115","author":"J Tack","year":"1998","journal-title":"Gastroenterology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1111\/j.1572-0241.2008.02021.x","article-title":"Effects of amitriptyline on gastric sensorimotor function and postprandial symptoms in healthy individuals: a randomized, double-blind, placebo-controlled trial","volume":"103","author":"EP Bouras","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1046\/j.1365-2036.2003.01469.x","article-title":"Influence of the selective serotonin re-uptake inhibitor, paroxetine, on gastric sensorimotor function in humans","volume":"17","author":"J Tack","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"G130","DOI":"10.1152\/ajpgi.00266.2002","article-title":"Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health","volume":"284","author":"HJ Chial","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref17","first-page":"E131","article-title":"Treatment of functional chest pain with antidepressants: a meta-analysis","volume":"15","author":"W Wang","year":"2012","journal-title":"Pain Physician"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1001\/archinte.162.1.19","article-title":"The effect of antidepressant treatment on chronic back pain: a meta-analysis","volume":"162","author":"SM Salerno","year":"2002","journal-title":"Arch Intern Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1136\/gut.2008.163162","article-title":"Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systematic review and meta-analysis","volume":"58","author":"AC Ford","year":"2009","journal-title":"Gut"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.3748\/wjg.15.1548","article-title":"Efficacy of tricyclic antidepressants in irritable bowel syndrome: A meta-analysis","volume":"15","author":"R Rahimi","year":"2009","journal-title":"World J Gastroenterol"},{"key":"ref21","first-page":"597","article-title":"CNS or classic drugs for the treatment of pain in functional dyspepsia? A systematic review and meta-analysis of the literature","volume":"11","author":"C Passos Mdo","year":"2008","journal-title":"Pain Physician"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1007\/s00535-005-1687-8","article-title":"Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review","volume":"40","author":"M Hojo","year":"2005","journal-title":"J Gastroenterol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0002-9343(00)00384-3","article-title":"Treatment of functional gastrointestinal disorders with antidepressant medications: A meta-analysis","volume":"108","author":"JL Jackson","year":"2000","journal-title":"Am J Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"D Moher","year":"2009","journal-title":"PLoS Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: Is blinding necessary?","volume":"17","author":"AR Jadad","year":"1996","journal-title":"Control Clin Trials"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1053\/j.gastro.2015.04.020","article-title":"Effect of amitriptyline and escitalopram on functional dyspepsia: A multicenter, randomized controlled study","volume":"149","author":"NJ Talley","year":"2015","journal-title":"Gastroenterology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"S822","DOI":"10.1016\/S0016-5085(15)32795-5","article-title":"Efficacy and safety of nortriptyline in functional dyspepsia in asians: A randomized double-blind placebo-controlled trial","volume":"148","author":"U Kaosombatwattana","year":"2015","journal-title":"Gastroenterology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6127","DOI":"10.3748\/wjg.v18.i42.6127","article-title":"Treatment of functional dyspepsia with sertraline: a double-blind randomized placebo-controlled pilot study","volume":"18","author":"VP Tan","year":"2012","journal-title":"World J Gastroenterol"},{"key":"ref29","article-title":"A randomized, double-Blind, placebo-controlled trial of low dose imipramine for treatment of refractory functional dyspepsia (FD)","author":"JC Wu","year":"2011","journal-title":"Gastroenterology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1365-2036.2011.04775.x","article-title":"Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsia, a double-blind placebo-controlled study","volume":"34","author":"B Braak","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.cgh.2008.02.051","article-title":"Effect of the antidepressant venlafaxine in functional dyspepsia: a randomized, double-blind, placebo-controlled trial","volume":"6","author":"LA van Kerkhoven","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/j.1365-2036.2008.03677.x","article-title":"Clinical trial: a randomized controlled cross-over study of flupenthixol + melitracen in functional dyspepsia","volume":"27","author":"JG Hashash","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1572-0241.1998.00160.x","article-title":"Effect of amitryptiline on symptoms, sleep, visceral perception in patients with functional dyspepsia","volume":"93","author":"H Mertz","year":"1998","journal-title":"Am J Gstroenterol"},{"key":"ref34","first-page":"302","article-title":"Efficacy of deanxit on the treatment of patients with epigastric pain syndrome","volume":"28","author":"W Zhao","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"ref35","first-page":"760","article-title":"Flupentixol and melitracen in the treatment of functional dyspepsia curative effect research","volume":"28","author":"Z Qiu","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"ref36","first-page":"2895","article-title":"Efficacy assessment of mirtazapine in the treatment of severe functional dyspepsia: An analysis of 22 cases","volume":"19","author":"JM Song","year":"2011","journal-title":"World Chinese Journal of Digestology"},{"key":"ref37","first-page":"S337","article-title":"Mirtazapine improves early satiation, nutrient intake, weight recovery and quality of life in functional dyspepsia with weight loss: A double-blind, randomized, placebo-ontrolled pilot study","volume":"144","author":"H Giao Ly","year":"2013","journal-title":"Gastroenterology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1365-2036.2005.02473.x","article-title":"New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline","volume":"21","author":"M Otaka","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3109\/00365529609006404","article-title":"A new pharmacologic treatment of functional gastrointestinal disorder A double-blind placebo-control","volume":"31","author":"L Tanum","year":"1996","journal-title":"Scand J of gastroenterol"},{"key":"ref40","first-page":"4953","article-title":"Relationship between functional dyspepsia and psychological factor and the efficacy of anti-depression drug in adjuvant treatment","volume":"8","author":"Z Li","year":"2004","journal-title":"Chinese Journal of Clinical Rehabilitation"},{"key":"ref41","first-page":"293","article-title":"Itopride combined with flupentixol and melitracen in functional dyspepsia","volume":"27","author":"FY Gao","year":"2011","journal-title":"Zhongguo Xinyao yu Linchuang Zazhi"},{"key":"ref42","first-page":"340","article-title":"Low-dose flupentixol and melitracen improves symptoms of functional dyspepsia","volume":"19","author":"Y Chen","year":"2014","journal-title":"Chinese Journal of Gastroenterology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"324","DOI":"10.11569\/wcjd.v23.i2.324","article-title":"Deanxit improves anxiety and depression in patients with functional dyspepsia","volume":"23","author":"QX Guo","year":"2015","journal-title":"World Chinese Journal of Digestology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S1590-8658(03)00061-6","article-title":"5-HT4 Receptors contribute to the motor stimulating effect of levosulpiride in the guinea-pig gastrointestinal tract","volume":"35","author":"M Tonini","year":"2003","journal-title":"Dig Liver Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/1043-6618(95)80052-2","article-title":"Pharmacotoxicological aspects of levosulpiride","volume":"31","author":"F Rossi","year":"1995","journal-title":"Pharmacol Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1440-1746.2006.04493.x","article-title":"Meta-analysis of the effects of prokinetic agents in patients with functional dyspepsia","volume":"22","author":"T Hiyama","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/j.1365-2036.2006.02845.x","article-title":"Predictors of the placebo response in functional dyspepsia","volume":"23","author":"NJ Talley","year":"2006","journal-title":"Aliment Pharmacol Ther"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0157798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T03:00:20Z","timestamp":1540350020000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0157798"}},"subtitle":[],"editor":[{"given":"John","family":"Green","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,16]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0157798","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,16]]}}}