{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:21:36Z","timestamp":1792455696551,"version":"4.5.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T00:00:00Z","timestamp":1466640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0158059","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T13:43:23Z","timestamp":1466689403000},"page":"e0158059","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Effect of Different Exercise Intensities on the Myotendinous Junction Plasticity"],"prefix":"10.1371","volume":"11","author":[{"given":"Davide","family":"Curzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Sartini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Guescini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Lattanzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Di Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Ambrogini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Savelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilberto","family":"Stocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Cuppini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Falcieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,6,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1136\/bjsm.2004.014571","article-title":"UEFA Champions League study: a prospective study of injuries in professional football during the 2001\u20132002 season","volume":"39","author":"M Wald\u00e9n","year":"2005","journal-title":"Br J Sports Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1365-201x.2001.00834.x","article-title":"Eccentric exercise-induced injuries to contractile and cytoskeletal muscle fibre components","volume":"171","author":"J Frid\u00e9n","year":"2001","journal-title":"Acta Physiol Scand"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/0363546506294679","article-title":"Acute first-time hamstring strains during high-speed running: a longitudinal study including clinical and magnetic resonance imaging findings","volume":"35","author":"CM Askling","year":"2007","journal-title":"Am J Sport Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s00256-008-0546-0","article-title":"MR observations of long-term musculotendon remodeling following a hamstring strain injury","volume":"37","author":"A Silder","year":"2008","journal-title":"Skelet Radiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1111\/sms.12221","article-title":"The human myotendinous junction: an ultrastructural and 3D analysis study","volume":"25","author":"AB Knudsen","year":"2015","journal-title":"Scand J Med Sci Sports"},{"key":"ref6","first-page":"465","article-title":"Morphological adaptation and protein modulation of myotendinous junction following moderate aerobic training","volume":"30","author":"D Curzi","year":"2015","journal-title":"Histol Histopathol"},{"key":"ref7","first-page":"105","article-title":"Involvement of the muscle-tendon junction in skeletal muscle atrophy: an ultrastructural study","volume":"52","author":"L De Palma","year":"2011","journal-title":"Rom J Morphol Embryol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1432-0436.2006.00118.x","article-title":"Differentially expressed genes and morphological changes during lengthened immobilization in rat soleus muscle","volume":"75","author":"JW Kim","year":"2007","journal-title":"Differentiation"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.crvi.2006.01.008","article-title":"Structural remodeling of unweighted soleus myotendinous junction in monkey","volume":"329","author":"S Roffino","year":"2006","journal-title":"C R Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.4081\/ejh.2013.e37","article-title":"Growth hormone plus resistance exercise attenuate structural changes in rat myotendinous junctions resulting from chronic unloading","volume":"57","author":"D Curzi","year":"2013","journal-title":"Eur J Histochem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tips.2007.02.002","article-title":"Beneficial health effects of exercise\u2014the role of IL-6 as a myokine","volume":"28","author":"BK Pedersen","year":"2007","journal-title":"Trends Pharmacol Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00441-011-1266-7","article-title":"Development of the zebrafish myoseptum with emphasis on the myotendinous junction","volume":"346","author":"B Charvet","year":"2011","journal-title":"Cell Tissue Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/jor.1100090405","article-title":"Recombinant human insulin-like growth factor-I stimulates in vitro matrix synthesis and cell proliferation in rabbit flexor tendon","volume":"9","author":"SO Abrahamsson","year":"1991","journal-title":"J Orthop Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/01.PRS.0000101529.47062.34","article-title":"Flexor tendon wound healing in vitro: lactate up-regulation of TGF-beta expression and functional activity","volume":"113","author":"N Yalamanchi","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.1113\/jphysiol.2013.261263","article-title":"Tendon and skeletal muscle matrix gene expression and functional responses to immobilisation and rehabilitation in young males: effect of growth hormone administration","volume":"591","author":"AP Boesen","year":"2013","journal-title":"J Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1530\/EJE-10-0818","article-title":"GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients","volume":"163","author":"S Doessing","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1139\/o2012-024","article-title":"Repetitive mechanical stretching modulates transforming growth factor-\u03b2 induced collagen synthesis and apoptosis in human patellar tendon fibroblasts","volume":"90","author":"C Jiang","year":"2012","journal-title":"Biochem Cell Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0300-9629(93)90513-4","article-title":"Anaerobic threshold in rats","volume":"106","author":"W Pilis","year":"1993","journal-title":"Comp Biochem Physiol Comp Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1111\/ejn.12130","article-title":"Motor activity affects adult skeletal muscle re-innervation acting via tyrosine kinase receptors","volume":"37","author":"S Sartini","year":"2013","journal-title":"Eur J Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.4081\/ejh.2012.19","article-title":"How physical exercise changes rat myotendinous junctions: an ultrastructural study","volume":"56","author":"D Curzi","year":"2012","journal-title":"Eur J Histochem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/1471-2105-9-326","article-title":"A new real-time PCR method to overcome significant quantitative inaccuracy due to slight amplification inhibition","volume":"9","author":"M Guescini","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/1471-2105-11-186","article-title":"Shape based kinetic outlier detection in real-time PCR","volume":"11","author":"D. Sisti","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"M.W Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.cyto.2015.03.013","article-title":"The effect of endurance training and downhill running on the expression of IL-1\u03b2, IL-6, and TNF-\u03b1 and HSP72 in rat skeletal muscle","volume":"73","author":"A Isanejad","year":"2015","journal-title":"Cytokine"},{"key":"ref25","first-page":"402175","article-title":"Effect of exercise intensity on isoform-specific expressions of NT-PGC-1 \u03b1 mRNA in mouse skeletal muscle","volume":"2014","author":"X Wen","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1055\/s-2000-3774","article-title":"Modulation of structural protein content of the myotendinous junction following eccentric contractions","volume":"21","author":"J Frenette","year":"2000","journal-title":"Int J Sports Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF00221636","article-title":"Structural changes at the myogenic cell surface during the formation of myotendinous junctions","volume":"257","author":"JG Tidball","year":"1989","journal-title":"Cell Tissue Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1002\/jor.20878","article-title":"Treadmill running exercise results in the presence of numerous myofibroblasts in mouse patellar tendons","volume":"27","author":"M Szczodry","year":"2009","journal-title":"J Orthop Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1152\/jappl.1992.73.1.59","article-title":"Reduction in myotendinous junction surface area of rats subjected to 4-day spaceflight","volume":"73","author":"JG Tidball","year":"1992","journal-title":"J Appl Physiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1152\/japplphysiol.00403.2003","article-title":"Role of TGF-beta1 in relation to exercise-induced type I collagen synthesis in human tendinous tissue","volume":"95","author":"K Heinemeier","year":"2003","journal-title":"J Appl Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1152\/japplphysiol.01205.2005","article-title":"Exercise-dependent IGF-I, IGFBPs, and type I collagen changes in human peritendinous connective tissue determined by microdialysis","volume":"102","author":"JL Olesen","year":"2007","journal-title":"J Appl Physiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/gt.2015.32","article-title":"Use of ultrasound-targeted microbubble destruction to transfect IGF-1 cDNA to enhance the regeneration of rat wounded Achilles tendon in vivo","volume":"22","author":"Y Tang","year":"2015","journal-title":"Gene Ther"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0158059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T23:25:29Z","timestamp":1568071529000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0158059"}},"subtitle":[],"editor":[{"given":"Andrew","family":"Philp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,23]]},"references-count":32,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0158059","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,23]]}}}