{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:33:47Z","timestamp":1790649227184,"version":"4.1.0"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T00:00:00Z","timestamp":1467158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0158460","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T18:08:38Z","timestamp":1467223718000},"page":"e0158460","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":94,"title":["Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer\u2019s Disease Patients Measured Using [18F] THK-5351"],"prefix":"10.1371","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0893-5420","authenticated-orcid":false,"given":"Samuel N.","family":"Lockhart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne L.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiko","family":"Ishiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shozo","family":"Furumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Yanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukitsuka","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Hiraoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Watanuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Jagust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,6,29]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"H Braak","year":"1991","journal-title":"Acta Neuropathol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00401-014-1349-0","article-title":"Primary age-related tauopathy (PART): a common pathology associated with human aging","volume":"128","author":"JF Crary","year":"2014","journal-title":"Acta Neuropathol"},{"issue":"4537","key":"ref3","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.6120571","article-title":"Alzheimer&apos;s disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea","volume":"215","author":"DJ Selkoe","year":"1982","journal-title":"Science"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"H Braak","year":"2006","journal-title":"Acta Neuropathol"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"a006189","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in Alzheimer disease","volume":"1","author":"A Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer&apos;s disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"CR Jack","year":"2013","journal-title":"Lancet Neurol"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature","volume":"71","author":"PT Nelson","year":"2012","journal-title":"J Neuropathol Exp Neurol"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/archneurol.2008.596","article-title":"Cerebrospinal fluid {beta}-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain","volume":"66","author":"T Tapiola","year":"2009","journal-title":"Arch Neurol"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s11910-014-0500-6","article-title":"Tau PET imaging in Alzheimer&apos;s disease","volume":"14","author":"N Okamura","year":"2014","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S1474-4422(14)70252-2","article-title":"Tau imaging: early progress and future directions","volume":"14","author":"VL Villemagne","year":"2015","journal-title":"Lancet Neurol"},{"issue":"25","key":"ref11","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1056\/NEJMoa054625","article-title":"PET of brain amyloid and tau in mild cognitive impairment","volume":"355","author":"GW Small","year":"2006","journal-title":"N Engl J Med"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3233\/JAD-122059","article-title":"Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807","volume":"34","author":"DT Chien","year":"2013","journal-title":"J Alz Dis"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neuron.2013.07.037","article-title":"Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls","volume":"79","author":"M Maruyama","year":"2013","journal-title":"Neuron"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.2967\/jnumed.112.117341","article-title":"Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease","volume":"54","author":"N Okamura","year":"2013","journal-title":"J Nucl Med"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2967\/jnumed.108.057612","article-title":"Consideration of Optimal Time Window for Pittsburgh Compound B PET Summed Uptake Measurements","volume":"50","author":"RL McNamee","year":"2009","journal-title":"J Nucl Med"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/00004647-199609000-00008","article-title":"Distribution volume ratios without blood sampling from graphical analysis of PET data","volume":"16","author":"J Logan","year":"1996","journal-title":"J Cereb Blood Flow Metab"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/sj.jcbfm.9600146","article-title":"Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B","volume":"25","author":"JC Price","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"issue":"12","key":"ref18","first-page":"1959","article-title":"Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis","volume":"46","author":"BJ Lopresti","year":"2005","journal-title":"J Nucl Med"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/jcbfm.1993.6","article-title":"Comparison of bolus and infusion methods for receptor quantitation: application to [18F]cyclofoxy and positron emission tomography","volume":"13","author":"RE Carson","year":"1993","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3 Pt 1","key":"ref20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/nimg.1996.0066","article-title":"Simplified reference tissue model for PET receptor studies","volume":"4","author":"AA Lammertsma","year":"1996","journal-title":"Neuroimage"},{"issue":"Pt 6","key":"ref21","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1093\/brain\/awu064","article-title":"Non-invasive assessment of Alzheimer&apos;s disease neurofibrillary pathology using 18F-THK5105 PET","volume":"137","author":"N Okamura","year":"2014","journal-title":"Brain"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2967\/jnumed.115.164848","article-title":"18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease","volume":"57","author":"R Harada","year":"2016","journal-title":"J Nucl Med"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/ana.22320","article-title":"Imaging central nervous system myelin by positron emission tomography in multiple sclerosis using [methyl-<sup>11<\/sup>C]-2-(4&apos;-methylaminophenyl)- 6-hydroxybenzothiazole","volume":"69","author":"B Stankoff","year":"2011","journal-title":"Ann Neurol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0158460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T07:54:08Z","timestamp":1568102048000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0158460"}},"subtitle":[],"editor":[{"given":"Karl","family":"Herholz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,6,29]]},"references-count":23,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,6,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0158460","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,29]]}}}