{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:49:51Z","timestamp":1780368591731,"version":"3.54.1"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI059642 (P.I.George M. Hilliard)"],"award-info":[{"award-number":["AI059642 (P.I.George M. Hilliard)"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI057986"],"award-info":[{"award-number":["AI057986"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W911NF- 11-1-0136"],"award-info":[{"award-number":["W911NF- 11-1-0136"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0158631","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T17:35:27Z","timestamp":1471541727000},"page":"e0158631","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparative Transcriptional Analyses of Francisella tularensis and Francisella novicida"],"prefix":"10.1371","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2922-078X","authenticated-orcid":true,"given":"Siva T.","family":"Sarva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Waldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Belland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl E.","family":"Klose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,8,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nrmicro1045","article-title":"Tularaemia: bioterrorism defence renews interest in Francisella tularensis","volume":"2","author":"PC Oyston","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1183\/09031936.03.00088903","article-title":"Tularemia","volume":"21","author":"A Tarnvik","year":"2003","journal-title":"Eur Respir J"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1051\/vetres:2005006","article-title":"Tularemia: emergence\/re-emergence","volume":"36","author":"JM Petersen","year":"2005","journal-title":"Vet Res"},{"issue":"Pt 8","key":"ref4","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1099\/ijs.0.022830-0","article-title":"Objections to the transfer of Francisella novicida to the subspecies rank of Francisella tularensis","volume":"60","author":"A Johansson","year":"2010","journal-title":"Int J Syst Evol Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fcimb.2014.00035","article-title":"Comparative review of Francisella tularensis and Francisella novicida","volume":"4","author":"LC Kingry","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"key":"ref6","first-page":"42","article-title":"Differentiation of geographic races of Francisella tularensis on the basis of citrulline ureidase activity","volume":"1","author":"IV Rodionova","year":"1970","journal-title":"Lab Delo"},{"issue":"2","key":"ref7","first-page":"457","article-title":"Citrulline ureidase activity in geographical races of Francisella tularensis","volume":"179","author":"IV Rodionova","year":"1968","journal-title":"Dokl Akad Nauk SSSR"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1128\/JCM.30.1.172-175.1992","article-title":"Characterization and classification of strains of Francisella tularensis isolated in the central Asian focus of the Soviet Union and in Japan","volume":"30","author":"G Sandstrom","year":"1992","journal-title":"J Clin Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/CMR.15.4.631-646.2002","article-title":"Tularemia","volume":"15","author":"J Ellis","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"6430","DOI":"10.1128\/JB.186.19.6430-6436.2004","article-title":"A <italic>Francisella tularensis<\/italic> Pathogenicity Island Required for Intramacrophage Growth","volume":"186","author":"FE Nano","year":"2004","journal-title":"J Bacteriol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1128\/IAI.65.6.2183-2189.1997","article-title":"Identification of proteins of <italic>Francisella tularensis<\/italic> induced during growth in macrophages and cloning of the gene encoding a prominently induced 23-kilodalton protein","volume":"65","author":"I Golovliov","year":"1997","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/j.1365-2958.2009.06947.x","article-title":"The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence","volume":"74","author":"JR Barker","year":"2009","journal-title":"Molecular microbiology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1073\/pnas.0307690101","article-title":"MglA regulates transcription of virulence factors necessary for <italic>Francisella tularensis<\/italic> intra-amoebae and intra-macrophage survival","volume":"101","author":"CM Lauriano","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1128\/IAI.00351-07","article-title":"Identification of an orphan response regulator required for the virulence of Francisella spp. and transcription of pathogenicity island genes","volume":"75","author":"NP Mohapatra","year":"2007","journal-title":"Infection and immunity"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1371\/journal.ppat.0030084","article-title":"Twin RNA Polymerase-associated proteins control virulence gene expression in Francisella tularensis","volume":"3","author":"JC Charity","year":"2007","journal-title":"PLoS Pathog"},{"issue":"19","key":"ref16","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1128\/JB.01700-14","article-title":"Coordinate control of virulence gene expression in Francisella tularensis involves direct interaction between key regulators","volume":"196","author":"AE Rohlfing","year":"2014","journal-title":"J Bacteriol"},{"issue":"14","key":"ref17","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1073\/pnas.0609675104","article-title":"In vivo negative selection screen identifies genes required for Francisella virulence","volume":"104","author":"DS Weiss","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1128\/IAI.01865-06","article-title":"Genome-wide identification of Francisella tularensis virulence determinants","volume":"75","author":"J Su","year":"2007","journal-title":"Infection and immunity"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1128\/IAI.00978-08","article-title":"Genome-wide Screen in Francisella novicida for Genes required for pulmonary and systemic infection in mice","volume":"77","author":"PS Kraemer","year":"2009","journal-title":"Infection and immunity"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1128\/IAI.01318-08","article-title":"Francisella tularensis genes required for inhibition of the neutrophil respiratory burst and intramacrophage growth identified by random transposon mutagenesis of strain LVS","volume":"77","author":"GS Schulert","year":"2009","journal-title":"Infection and immunity"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1128\/AEM.02882-07","article-title":"Identification of Differentially regulated Francisella tularensis genes by use of a newly developed Tn5-based transposon delivery system","volume":"74","author":"BW Buchan","year":"2008","journal-title":"Appl Environ Microbiol"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1128\/IAI.00238-07","article-title":"Identification of Francisella tularensis Himar1-based transposon mutants defective for replication in macrophages","volume":"75","author":"TM Maier","year":"2007","journal-title":"Infection and immunity"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2180-6-69","article-title":"Identification of transposon insertion mutants of Francisella tularensis tularensis strain Schu S4 deficient in intracellular replication in the hepatic cell line HepG2","volume":"6","author":"A Qin","year":"2006","journal-title":"BMC Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ng1499","article-title":"The complete genome sequence of Francisella tularensis, the causative agent of tularemia","volume":"37","author":"P Larsson","year":"2005","journal-title":"Nat Genet"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"e352","DOI":"10.1371\/journal.pone.0000352","article-title":"Genome sequencing shows that European isolates of Francisella tularensis subspecies tularensis are almost identical to US laboratory strain Schu S4","volume":"2","author":"RR Chaudhuri","year":"2007","journal-title":"PloS one"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"e947","DOI":"10.1371\/journal.pone.0000947","article-title":"Complete genomic characterization of a pathogenic A.II strain of Francisella tularensis subspecies tularensis","volume":"2","author":"SM Beckstrom-Sternberg","year":"2007","journal-title":"PloS one"},{"issue":"19","key":"ref27","doi-asserted-by":"crossref","first-page":"6977","DOI":"10.1128\/JB.00506-06","article-title":"Chromosome rearrangement and diversification of Francisella tularensis revealed by the type B (OSU18) genome sequence","volume":"188","author":"JF Petrosino","year":"2006","journal-title":"J Bacteriol"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"6895","DOI":"10.1128\/IAI.01006-06","article-title":"Potential source of Francisella tularensis live vaccine strain attenuation determined by genome comparison","volume":"74","author":"L Rohmer","year":"2006","journal-title":"Infection and immunity"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1128\/IAI.00196-09","article-title":"Reintroduction of two deleted virulence loci restores full virulence to the live vaccine strain of Francisella tularensis","volume":"77","author":"E Salomonsson","year":"2009","journal-title":"Infection and immunity"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"R102","DOI":"10.1186\/gb-2007-8-6-r102","article-title":"Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains","volume":"8","author":"L Rohmer","year":"2007","journal-title":"Genome Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1128\/AEM.13.2.232-235.1965","article-title":"Evaluation of Live Tularemia Vaccine Prepared in a Chemically Defined Medium","volume":"13","author":"RE Chamberlain","year":"1965","journal-title":"Appl Microbiol"},{"issue":"23","key":"ref32","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1093\/nar\/27.23.4636","article-title":"Improved microbial gene identification with GLIMMER","volume":"27","author":"AL Delcher","year":"1999","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1093\/nar\/gkq1065","article-title":"Developmental expression of non-coding RNAs in Chlamydia trachomatis during normal and persistent growth","volume":"39","author":"YM Abdelrahman","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1021\/pr070107m","article-title":"Proteome cataloging and relative quantification of Francisella tularensis tularensis strain Schu4 in 2D PAGE using preparative isoelectric focusing","volume":"6","author":"RH Waldo","year":"2007","journal-title":"J Proteome Res"},{"issue":"22","key":"ref35","doi-asserted-by":"crossref","first-page":"6855","DOI":"10.1128\/JB.00995-09","article-title":"Global transcriptional response to spermine, a component of the intramacrophage environment, reveals regulation of Francisella gene expression through insertion sequence elements","volume":"191","author":"PE Carlson Jr.","year":"2009","journal-title":"J Bacteriol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3389\/fmicb.2015.00513","article-title":"Architecture and roles of periplasmic adaptor proteins in tripartite e ffl ux assemblies","volume":"6","author":"MF Symmons","year":"2015","journal-title":"Front Microbiol"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1128\/CMR.00117-14","article-title":"The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria","volume":"28","author":"XZ Li","year":"2015","journal-title":"Clin Microbiol Rev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fmicb.2015.00100","article-title":"Mechanism of coupling drug transport reactions located in two different membranes","volume":"6","author":"HI Zgurskaya","year":"2015","journal-title":"Front Microbiol"},{"issue":"34","key":"ref39","doi-asserted-by":"crossref","first-page":"12897","DOI":"10.1073\/pnas.0602582103","article-title":"Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence","volume":"103","author":"H Gil","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1574-6968.2007.01033.x","article-title":"The AcrAB RND efflux system from the live vaccine strain of Francisella tularensis is a multiple drug efflux system that is required for virulence in mice","volume":"279","author":"XR Bina","year":"2008","journal-title":"FEMS Microbiol Lett"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/mmi.12509","article-title":"EmrA1 membrane fusion protein of Francisella tularensis LVS is required for resistance to oxidative stress, intramacrophage survival and virulence in mice","volume":"91","author":"Z Ma","year":"2014","journal-title":"Molecular microbiology"},{"issue":"11","key":"ref42","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1128\/JB.00027-06","article-title":"Characterization of the siderophore of Francisella tularensis and role of fslA in siderophore production","volume":"188","author":"JT Sullivan","year":"2006","journal-title":"J Bacteriol"},{"issue":"7","key":"ref43","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1128\/IAI.01975-05","article-title":"Identification of Francisella tularensis genes affected by iron limitation","volume":"74","author":"K Deng","year":"2006","journal-title":"Infection and immunity"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1574-6968.2008.01237.x","article-title":"Characterization of fig operon mutants of Francisella novicida U112","volume":"285","author":"K Kiss","year":"2008","journal-title":"FEMS Microbiol Lett"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"e93558","DOI":"10.1371\/journal.pone.0093558","article-title":"The reduced genome of the Francisella tularensis live vaccine strain (LVS) encodes two iron acquisition systems essential for optimal growth and virulence","volume":"9","author":"NM Perez","year":"2014","journal-title":"PloS one"},{"issue":"18","key":"ref46","doi-asserted-by":"crossref","first-page":"10973","DOI":"10.1074\/jbc.271.18.10973","article-title":"Characterization and sequencing of a respiratory burst-inhibiting acid phosphatase from Francisella tularensis","volume":"271","author":"TJ Reilly","year":"1996","journal-title":"J Biol Chem"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1128\/IAI.01226-06","article-title":"AcpA is a Francisella acid phosphatase that affects intramacrophage survival and virulence","volume":"75","author":"NP Mohapatra","year":"2007","journal-title":"Infection and immunity"},{"issue":"8","key":"ref48","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1128\/IAI.00262-08","article-title":"Combined deletion of four Francisella novicida acid phosphatases attenuates virulence and macrophage vacuolar escape","volume":"76","author":"NP Mohapatra","year":"2008","journal-title":"Infection and immunity"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"e56834","DOI":"10.1371\/journal.pone.0056834","article-title":"Type A Francisella tularensis acid phosphatases contribute to pathogenesis","volume":"8","author":"NP Mohapatra","year":"2013","journal-title":"PloS one"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1128\/IAI.00965-09","article-title":"Acid phosphatases do not contribute to the pathogenesis of type A Francisella tularensis","volume":"78","author":"R Child","year":"2010","journal-title":"Infection and immunity"},{"issue":"24","key":"ref51","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1002\/pmic.201000248","article-title":"Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains","volume":"10","author":"K Konecna","year":"2010","journal-title":"Proteomics"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1128\/IAI.06245-11","article-title":"The acid phosphatase AcpA is secreted in vitro and in macrophages by Francisella spp","volume":"80","author":"S Dai","year":"2012","journal-title":"Infection and immunity"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1146\/annurev.micro.54.1.881","article-title":"Iron metabolism in pathogenic bacteria","volume":"54","author":"C Ratledge","year":"2000","journal-title":"Annu Rev Microbiol"},{"issue":"12","key":"ref54","doi-asserted-by":"crossref","first-page":"e28480","DOI":"10.1371\/journal.pone.0028480","article-title":"Brucella abortus choloylglycine hydrolase affects cell envelope composition and host cell internalization","volume":"6","author":"MI Marchesini","year":"2011","journal-title":"PloS one"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1046\/j.1365-2958.2002.03080.x","article-title":"Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis","volume":"45","author":"O Dussurget","year":"2002","journal-title":"Molecular microbiology"},{"issue":"8","key":"ref56","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ijmm.2013.06.008","article-title":"Polyamines: emerging players in bacteria-host interactions","volume":"303","author":"ML Di Martino","year":"2013","journal-title":"Int J Med Microbiol"},{"issue":"10","key":"ref57","doi-asserted-by":"crossref","first-page":"6668","DOI":"10.1128\/IAI.73.10.6668-6673.2005","article-title":"Expression of the Rickettsia prowazekii pld or tlyC gene in Salmonella enterica serovar Typhimurium mediates phagosomal escape","volume":"73","author":"T Whitworth","year":"2005","journal-title":"Infection and immunity"},{"issue":"13","key":"ref58","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1128\/JB.00198-08","article-title":"The Francisella pathogenicity island protein PdpD is required for full virulence and associates with homologues of the type VI secretion system","volume":"190","author":"JS Ludu","year":"2008","journal-title":"J Bacteriol"},{"issue":"Pt 7","key":"ref59","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1099\/mic.0.2008\/018077-0","article-title":"Characterization of the Francisella tularensis subsp. novicida type IV pilus","volume":"154","author":"X Zogaj","year":"2008","journal-title":"Microbiology"},{"issue":"30","key":"ref60","doi-asserted-by":"crossref","first-page":"25191","DOI":"10.1074\/jbc.M112.371856","article-title":"Paralogous outer membrane proteins mediate uptake of different forms of iron and synergistically govern virulence in Francisella tularensis tularensis","volume":"287","author":"G Ramakrishnan","year":"2012","journal-title":"J Biol Chem"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"8345","DOI":"10.1128\/IAI.73.12.8345-8352.2005","article-title":"A mutant of Francisella tularensis strain Schu S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine","volume":"73","author":"S Twine","year":"2005","journal-title":"Infection and immunity"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"e18201","DOI":"10.1371\/journal.pone.0018201","article-title":"Evasion of IFN-gamma signaling by Francisella novicida is dependent upon Francisella outer membrane protein C","volume":"6","author":"KC Nallaparaju","year":"2011","journal-title":"PloS one"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1111\/j.1365-2958.2006.05061.x","article-title":"Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis","volume":"59","author":"AL Forslund","year":"2006","journal-title":"Molecular microbiology"},{"issue":"4","key":"ref64","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1365-2958.2011.07858.x","article-title":"The N-acetyl-D-glucosamine repressor NagC of Vibrio fischeri facilitates colonization of Euprymna scolopes","volume":"82","author":"T Miyashiro","year":"2011","journal-title":"Molecular microbiology"},{"issue":"12","key":"ref65","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1128\/IAI.01250-06","article-title":"Identification of MglA-regulated genes reveals novel virulence factors in Francisella tularensis","volume":"74","author":"A Brotcke","year":"2006","journal-title":"Infection and immunity"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0158631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T07:47:00Z","timestamp":1601020020000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0158631"}},"subtitle":[],"editor":[{"given":"Chandra Shekhar","family":"Bakshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,18]]},"references-count":65,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0158631","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,18]]}}}