{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T05:24:54Z","timestamp":1744608294609,"version":"3.37.3"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 81300390"],"award-info":[{"award-number":["NSFC 81300390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0158827","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T17:33:13Z","timestamp":1470159193000},"page":"e0158827","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Flow Cytometric Immunophenotyping Is Sensitive for the Early Diagnosis of De Novo Aggressive Natural Killer Cell Leukemia (ANKL): A Multicenter Retrospective Analysis"],"prefix":"10.1371","volume":"11","author":[{"given":"Yi","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingping","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longlong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yicheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengju","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinniu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,8,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1093\/annonc\/mdp418","article-title":"Prognostic factors for mature natural killer (NK) cell neoplasms: aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type","volume":"21","author":"R Suzuki","year":"2010","journal-title":"Ann Oncol"},{"key":"ref2","first-page":"697","article-title":"Aggressive natural killer cell leukemia in an adult with establishment of an NK cell line","volume":"67","author":"L Fernandez","year":"1986","journal-title":"Blood Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2141.1990.tb02615.x","article-title":"Aggressive natural killer cell leukaemia\/lymphoma. A report of four cases and review of the literature. Possible existence of a new clinical entity originating from the third lineage of lymphoid cells","volume":"75","author":"N Imamura","year":"1990","journal-title":"Br J Haematol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1182\/blood.V89.12.4501","article-title":"Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm","volume":"89","author":"J Chan","year":"1997","journal-title":"Blood"},{"key":"ref5","first-page":"1343","article-title":"Aggressive natural killer cell leukemia: clinical features and treatment outcome","volume":"87","author":"S Song","year":"2002","journal-title":"Haematologica"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/sj.leu.2403262","article-title":"Aggressive natural killer-cell leukemia revisited: large granular lymphocyte leukemia of cytotoxic NK cells","volume":"18","author":"R Suzuki","year":"2004","journal-title":"Leukemia"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1080\/10428190400004513","article-title":"Aggressive Natural Killer-cell leukemia: report of five cases and review of the literature","volume":"45","author":"A Ruskova","year":"2004","journal-title":"Leuk Lymphoma"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/10245330400026162","article-title":"NK-cell neoplasms in Japan","volume":"10","author":"K Oshimi","year":"2005","journal-title":"Hematology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/sj.leu.2403732","article-title":"Significance of chemokine receptor expression in aggressive NK cell leukemia","volume":"19","author":"H Makishima","year":"2005","journal-title":"Leukemia"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/annonc\/mdi037","article-title":"Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years","volume":"16","author":"WY Au","year":"2005","journal-title":"Ann Oncol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1532\/IJH97.A10612","article-title":"Aggressive natural killer cell leukemia: report of a Chinese series and review of the literature","volume":"85","author":"J Ryder","year":"2007","journal-title":"Int J Hematol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000193225","article-title":"Aggressive natural killer cell leukemia: is Epstein-Barr virus negativity an indicator of a favorable prognosis?","volume":"120","author":"YH Ko","year":"2008","journal-title":"Acta Haematol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3343\/kjlm.2009.29.6.491","article-title":"Frequent CD7 antigen loss in aggressive natural killer-cell leukemia: a useful diagnostic marker","volume":"29","author":"EH Yoo","year":"2009","journal-title":"Korean J Lab Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3960\/jslrt.51.21","article-title":"The diagnosis and management of extranodal NK\/T cell lymphoma, nasal-type and aggressive NK-cell leukemia","volume":"51","author":"Y-L Kwong","year":"2011","journal-title":"J Clin Exp Hematopathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3960\/jslrt.52.101","article-title":"Three cases of aggressive natural killer cell leukemia with a lethal hemorrhagic complication","volume":"52","author":"Y Okuno","year":"2012","journal-title":"J Clin Exp Hematopathol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00277-012-1574-3","article-title":"Flow cytometric immunophenotyping is of great value to diagnosis of natural killer cell neoplasms involving bone marrow and peripheral blood","volume":"92","author":"NG Jiang","year":"2013","journal-title":"Ann Hematol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/MAJ.0b013e3182764b59","article-title":"Adult aggressive natural killer cell leukemia","volume":"346","author":"H Zhang","year":"2013","journal-title":"Am J Med Sci"},{"key":"ref18","first-page":"3423","article-title":"Six cases of aggressive natural killer-cell leukemia in a Chinese population","volume":"7","author":"Q Zhang","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3109\/10428194.2014.905772","article-title":"Aggressive mature natural killer cell neoplasms: report on a series of 12 European patients with emphasis on flow cytometry based immunophenotype and DNA content of neoplastic natural killer cells","volume":"56","author":"M Lima","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"ref20","first-page":"276","article-title":"WHO classification of tumors of haematopoietic and lymphoid tissue","author":"J Chan","year":"2008"},{"key":"ref21","first-page":"285","article-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"J Chan","year":"2008"},{"key":"ref22","first-page":"274","article-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"N Villamor","year":"2008"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1182\/blood-2003-12-4197","article-title":"Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients","volume":"104","author":"W-Y Au","year":"2004","journal-title":"Blood"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1086\/508173","article-title":"Seroprevalence of cytomegalovirus infection in the United States, 1988\u20131994","volume":"43","author":"S Staras","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3389\/fimmu.2013.00499","article-title":"Signatures of human NK cell development and terminal differentiation","volume":"4","author":"M Luetke-Eversloh","year":"2013","journal-title":"Front Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-2567.2008.03027.x","article-title":"CD56bright natural killer (NK) cells: an important NK cell subset","volume":"126","author":"A Poli","year":"2009","journal-title":"Immunology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1182\/blood-2010-04-281675","article-title":"Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education","volume":"116","author":"NK Bjorkstrom","year":"2010","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.4049\/jimmunol.172.3.1455","article-title":"The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-Like receptors and become cytolytic","volume":"172","author":"G Ferlazzo","year":"2004","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.4049\/jimmunol.178.8.4947","article-title":"CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation","volume":"178","author":"C Romagnani","year":"2007","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1182\/blood-2010-04-282301","article-title":"CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset","volume":"116","author":"S Lopez-Verges","year":"2010","journal-title":"Blood"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.trsl.2014.01.010","article-title":"Abnormal immunophenotype provides a key diagnostic marker: a report of 29 cases of de novo aggressive natural killer cell leukemia","volume":"163","author":"C Li","year":"2014","journal-title":"Transl Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3109\/07853890.2014.882105","article-title":"Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations","volume":"46","author":"HL Rajala","year":"2014","journal-title":"Ann Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1056\/NEJMoa1114885","article-title":"Somatic STAT3 mutations in large granular lymphocytic leukemia","volume":"366","author":"H Koskela","year":"2012","journal-title":"N Engl J Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.blre.2014.02.001","article-title":"The pathogenesis and treatment of large granular lymphocyte leukemia","volume":"28","author":"SN Steinway","year":"2014","journal-title":"Blood Rev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.4049\/jimmunol.1400534","article-title":"Notch signaling at later stages of NK cell development enhances KIR expression and functional maturation","volume":"193","author":"M Felices","year":"2014","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1002\/eji.200425146","article-title":"Comparative analysis of NK cell subset distribution in normal and lymphoproliferative disease of granular lymphocyte conditions","volume":"34","author":"V Pascal","year":"2004","journal-title":"Eur J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/ajh.20659","article-title":"NK-cell repertoire is feasible for diagnosing Epstein-Barr virus-infected NK-cell lymphoproliferative disease and evaluating the treatment effect","volume":"81","author":"A Sawada","year":"2006","journal-title":"Am J Hematol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1309\/Q49CRJ030L22MHLF","article-title":"The immunophenotypic attributes of NK cells and NK cell lineage lymphoproliferative disorders","volume":"127","author":"WG Morice","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.blre.2005.10.001","article-title":"Human natural killer cell development and biology","volume":"20","author":"SS Farag","year":"2006","journal-title":"Blood Rev"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000365632","article-title":"Human natural killer cells: origin, receptors, function, and clinical applications","volume":"164","author":"L Moretta","year":"2014","journal-title":"Int Arch Allergy Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1182\/blood-2009-09-245746","article-title":"Education of human natural killer cells by activating killer cell immunoglobulin-like receptors","volume":"115","author":"C Fauriat","year":"2010","journal-title":"Blood"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fimmu.2014.00133","article-title":"Effects of Peptide on NK cell-mediated MHC I recognition","volume":"5","author":"SA Cassidy","year":"2014","journal-title":"Front Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1750-1172-8-95","article-title":"Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis","volume":"8","author":"M Lima","year":"2013","journal-title":"Orphanet Journal of Rare Diseases"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1182\/blood-2014-01-553024","article-title":"Role for early-differentiated natural killer cells in infectious mononucleosis","volume":"124","author":"T Azzi","year":"2014","journal-title":"Blood"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1182\/blood-2012-10-461442","article-title":"Influence of KIR gene copy number on natural killer cell education","volume":"121","author":"V Beziat","year":"2013","journal-title":"Blood"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1182\/blood-2012-10-459545","article-title":"NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs","volume":"121","author":"V B\u00e9ziat","year":"2013","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fimmu.2014.00072","article-title":"Activating KIRs in chronic lymphoproliferative disorder of NK cells: protection from viruses and disease induction?","volume":"5","author":"R Zambello","year":"2014","journal-title":"Front Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/sj.leu.2404634","article-title":"Genotypic evaluation of killer immunoglobulin-like receptors in NK-type lymphoproliferative disease of granular lymphocytes","volume":"21","author":"E Scquizzato","year":"2007","journal-title":"Leukemia"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1746-1596-8-43","article-title":"Aggressive natural killer-cell leukemia with jaundice and spontaneous splenic rupture: a case report and review of the literature","volume":"8","author":"LM Gao","year":"2013","journal-title":"Diagn Pathol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.leukres.2006.10.020","article-title":"Chemokine system and tissue infiltration in aggressive NK-cell leukemia","volume":"31","author":"H Makishima","year":"2007","journal-title":"Leuk Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3816\/CLM.2006.n.022","article-title":"Fas ligand-mediated lethal hepatitis after rapid lysis of a localized natural killer cell lymphoma","volume":"6","author":"D Ghez","year":"2006","journal-title":"Clin Lymphoma Myeloma"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1182\/blood.V100.4.1449.h81602001449_1449_1453","article-title":"Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia","volume":"100","author":"JH Liu","year":"2002","journal-title":"Blood"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1097\/RLU.0b013e318219b38f","article-title":"F-18 FDG PET\/CT findings of aggressive NK-cell leukemia","volume":"36","author":"T Derlin","year":"2011","journal-title":"Clin Nucl Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1600-0609.2008.01090.x","article-title":"Promising approach for aggressive NK cell leukaemia with allogeneic haematopoietic cell transplantation","volume":"81","author":"T Ito","year":"2008","journal-title":"Eur J Haematol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.2169\/internalmedicine.49.3814","article-title":"Successful allogeneic hematopoietic stem cell transplantation for aggressive NK cell leukemia","volume":"49","author":"S Ichikawa","year":"2010","journal-title":"Intern Med"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1349-7006.2012.02251.x","article-title":"Aggressive natural killer cell leukemia: therapeutic potential of L-asparaginase and allogeneic hematopoietic stem cell transplantation","volume":"103","author":"F Ishida","year":"2012","journal-title":"Cancer Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0158827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T19:15:32Z","timestamp":1656962132000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0158827"}},"subtitle":[],"editor":[{"given":"Niklas K","family":"Bj\u00f6rkstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,2]]},"references-count":56,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0158827","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,8,2]]}}}