{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:44:08Z","timestamp":1785408248579,"version":"3.56.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T00:00:00Z","timestamp":1467763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Heart, Lung, and Blood Institute (US)","award":["1K23HL123634-01"],"award-info":[{"award-number":["1K23HL123634-01"]}]},{"name":"American Heart Association (US)","award":["13CRP17300016"],"award-info":[{"award-number":["13CRP17300016"]}]},{"name":"National Center for Advancing Translational Sciences (US)","award":["UL1 TR001082"],"award-info":[{"award-number":["UL1 TR001082"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0158981","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T17:52:58Z","timestamp":1467827578000},"page":"e0158981","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass"],"prefix":"10.1371","volume":"11","author":[{"given":"Jesse A.","family":"Davidson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhong","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Twite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Woodruff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Wischmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Klawitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/CIR.0b013e31823ac046","article-title":"Heart disease and stroke statistics\u20142012 update: a report from the American Heart Association","volume":"125","author":"VL Roger","year":"2012","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jtcvs.2011.06.021","article-title":"Congenital heart surgery in infants: effects of acute kidney injury on outcomes","volume":"143","author":"JJ Blinder","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/CIRCULATIONAHA.105.594804","article-title":"Brain injury in congenital heart disease","volume":"113","author":"JW Newburger","year":"2006","journal-title":"Circulation"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.cardfail.2012.03.001","article-title":"Prevalence, morbidity, and mortality of heart failure-related hospitalizations in children in the United States: a population-based study","volume":"18","author":"JW Rossano","year":"2012","journal-title":"J Card Fail"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.athoracsur.2005.06.038","article-title":"Splanchnic organ injury during coronary surgery with or without cardiopulmonary bypass: a randomized, controlled trial","volume":"81","author":"R Ascione","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jtcvs.2011.12.029","article-title":"Late remote ischemic preconditioning in children undergoing cardiopulmonary bypass: a randomized controlled trial","volume":"144","author":"MA Pavione","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e35070","DOI":"10.1371\/journal.pone.0035070","article-title":"STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass","volume":"7","author":"PR de Jong","year":"2012","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/0003-4975(96)00055-0","article-title":"Systemic inflammatory response syndrome after cardiac operations","volume":"61","author":"J Cremer","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.CIR.0000051365.81920.28","article-title":"Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease","volume":"107","author":"TM Hoffman","year":"2003","journal-title":"Circulation"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/gut.2007.128868","article-title":"Role of alkaline phosphatase in colitis in man and rats","volume":"58","author":"A Tuin","year":"2009","journal-title":"Gut"},{"key":"ref11","first-page":"1163","article-title":"Dephosphorylation of endotoxin by alkaline phosphatase in vivo","volume":"151","author":"K Poelstra","year":"1997","journal-title":"Am J Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1136\/gut.2010.211706","article-title":"Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota","volume":"59","author":"MS Malo","year":"2010","journal-title":"Gut"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"G467","DOI":"10.1152\/ajpgi.00364.2009","article-title":"Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase","volume":"299","author":"KT Chen","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.chom.2007.10.010","article-title":"Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota","volume":"2","author":"JM Bates","year":"2007","journal-title":"Cell Host Microbe"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/ibd.21377","article-title":"Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis","volume":"17","author":"S Ramasamy","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jss.2010.04.048","article-title":"The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis","volume":"163","author":"JS Whitehouse","year":"2010","journal-title":"J Surg Res"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1002\/hep.27715","article-title":"Liver alkaline phosphatase: a missing link between cholreresis and biliary inflammation","volume":"61","author":"R Poupon","year":"2015","journal-title":"Hepatology"},{"key":"ref18","article-title":"Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate","author":"E Peters","journal-title":"Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1093\/clinchem\/28.10.2007","article-title":"Alkaline phosphatase isoenzymes","volume":"28","author":"DW Moss","year":"1982","journal-title":"Clin Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"R160","DOI":"10.1186\/cc11483","article-title":"Alkaline phosphatase activity after cardiothoracic surgery in infants and correlation with post-operative support and inflammation: a prospective cohort study","volume":"16","author":"J Davidson","year":"2012","journal-title":"Crit Care"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/clinchem\/35.4.664","article-title":"Hypomagnesemia and low alkaline phosphatase activity in patients' serum after cardiac surgery","volume":"35","author":"G Lum","year":"1989","journal-title":"Clin Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2174\/187221309789257388","article-title":"Anti-inflammatory effects of alkaline phosphatase in coronary artery bypass surgery with cardiopulmonary bypass","volume":"3","author":"S Kats","year":"2009","journal-title":"Recent Pat Inflamm Allergy Drug Discov"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pharmthera.2005.04.013","article-title":"Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation","volume":"112","author":"MJ Bours","year":"2006","journal-title":"Pharmacol Ther"},{"issue":"24","key":"ref24","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1056\/NEJMra1205750","article-title":"Purinergic signaling during inflammation","volume":"367","author":"HK Eltzschig","year":"2012","journal-title":"N Engl J Med"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion-from mechanism to translation","volume":"17","author":"HK Eltzschig","year":"2001","journal-title":"Nature Medicine"},{"issue":"38","key":"ref26","doi-asserted-by":"crossref","first-page":"27315","DOI":"10.1074\/jbc.M113.484212","article-title":"Soluble ecto-5'-nucleotidase, alkaline phosphatase, and adenosine deaminase activities in neonatal blood favor elevated extracellular adenosine","volume":"288","author":"M Pettengill","year":"2013","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1007\/s11605-010-1405-6","article-title":"Local peritoneal irrigation with intestinal alkaline phosphatase is protective against peritonitis in mice","volume":"15","author":"F Ebrahimi","year":"2011","journal-title":"J Gastrointest Surg"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/01.shk.0000132485.05049.8a","article-title":"Protection against an Escherichia coli-induced sepsis by alkaline phosphatase in mice","volume":"22","author":"WR Verweij","year":"2004","journal-title":"Shock"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1124\/jpet.103.056606","article-title":"Calf intestinal alkaline phosphatase, a novel therapeutic drug for lipopolysaccharide (LPS)-mediated diseases, attenuates LPS toxicity in mice and piglets","volume":"307","author":"C Beumer","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/ibd.21161","article-title":"Exogenous alkaline phosphatase for the treatment of patients with moderate to severe ulcerative colitis","volume":"16","author":"M Lukas","year":"2010","journal-title":"Inflamm Bowel Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/CCM.0b013e31819598af","article-title":"Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients","volume":"37","author":"S Heemskerk","year":"2009","journal-title":"Crit Care Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/cc11159","article-title":"Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial","volume":"16","author":"P Pickkers","year":"2012","journal-title":"Crit Care"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/j.bbadis.2013.07.016","article-title":"A novel hypothesis for an alkaline phosphatase \u2018rescue\u2019 mechanism in the hepatic acute phase immune response","author":"AF Pike","year":"2013","journal-title":"Biochemica et Biophysica Acta"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11302-012-9309-4","article-title":"Cellular function and molecular structure of ecto-nucleotidases","volume":"8","author":"H Zimmermann","year":"2012","journal-title":"Purinergic Signalling"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bbamcr.2008.01.024","article-title":"Nucleotide and nucleoside-converting ectoenzymes: Important modulators of purinergic signaling cascade","volume":"1783","author":"GG Yegutkin","year":"2008","journal-title":"Biochemica et Biophysica Acta"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"G467","DOI":"10.1152\/ajpgi.00364.2009","article-title":"Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase","volume":"299","author":"KT Chen","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0009-9120(02)00330-2","article-title":"Alkaline phosphatases reduce toxicity of lipopolysaccharides in vivo and in vitro through dephosphorylation","volume":"35","author":"I Koyama","year":"2002","journal-title":"Clinical Biochemistry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0002-8703(74)90237-3","article-title":"Serum enzymes after cardiac surgery under profound hypothermia with circulatory arrest and limited cardiopulmonary bypass","volume":"88","author":"JM Neutze","year":"1974","journal-title":"Am Heart J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"8127","DOI":"10.4049\/jimmunol.178.12.8127","article-title":"Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury","volume":"178","author":"T Eckle","year":"2007","journal-title":"Journal of Immunology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.4049\/jimmunol.1003671","article-title":"Tissue-resident ecto-5\u2019 nucleotidase (CD73) regulates leukocyte trafficking in the ischemic brain","volume":"188","author":"D Petrovic-Djergovic","year":"2012","journal-title":"Journal of immunology"},{"issue":"5","key":"ref41","first-page":"236","article-title":"Bovine intestinal alkaline phosphatase reduces inflammation after induction of acute myocardial infarction in mice","volume":"2","author":"D Fiechter","year":"2011","journal-title":"Cardiol Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0158981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T14:35:02Z","timestamp":1600871702000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0158981"}},"subtitle":[],"editor":[{"given":"Nupur","family":"Gangopadhyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,7,6]]},"references-count":41,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0158981","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,6]]}}}