{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:05:55Z","timestamp":1768071955716,"version":"3.49.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0159051","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T17:55:08Z","timestamp":1468000508000},"page":"e0159051","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["PA6 Stromal Cell Co-Culture Enhances SH-SY5Y and VSC4.1 Neuroblastoma Differentiation to Mature Phenotypes"],"prefix":"10.1371","volume":"11","author":[{"given":"Ross","family":"Ferguson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasanta","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neuro.2008.11.001","article-title":"Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research","volume":"30","author":"Y-T Cheung","year":"2009","journal-title":"Neurotoxicology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1046\/j.1471-4159.2000.0752259.x","article-title":"Protective effects of riluzole on dopamine neurons: involvement of oxidative stress and cellular energy metabolism","volume":"75","author":"A Storch","year":"2000","journal-title":"J Neurochem"},{"key":"ref3","first-page":"n\/a","article-title":"SNJ-1945, a calpain inhibitor, protects SH-SY5Y cells against MPP <sup>+<\/sup> and rotenone","author":"VH Knaryan","year":"2013","journal-title":"J Neurochem"},{"key":"ref4","first-page":"2643","article-title":"Morphology and Growth, Tumorigenicity, and Cytogenetics of Human Neuroblastoma Cells in Continuous Culture","volume":"33","author":"JL Biedler","year":"1973","journal-title":"Cancer Res"},{"key":"ref5","first-page":"219","article-title":"Phenotypic Diversification in Human Neuroblastoma Cells: Expression of Distinct Neural Crest Lineages","volume":"49","author":"V Ciccarone","year":"1989","journal-title":"Cancer Res"},{"key":"ref6","first-page":"912","article-title":"Are SH-SY5Y and MN9D cell lines truly dopaminergic?","volume":"21","author":"S Inoka","year":"2007","journal-title":"FASEB J"},{"key":"ref7","first-page":"1086","article-title":"SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson\u2019s disease","volume":"123","author":"H Xie","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1046\/j.1471-4159.1994.63062365.x","article-title":"Apoptotic Cell Death of a Hybrid Motoneuron Cell Line Induced by Immunoglobulins from Patients with Amyotrophic Lateral Sclerosis","volume":"63","author":"ME Alexianu","year":"1994","journal-title":"J Neurochem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1073\/pnas.91.8.3393","article-title":"Cytotoxicity of immunoglobulins from amyotrophic lateral sclerosis patients on a hybrid motoneuron cell line","volume":"91","author":"RG Smith","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0045-6039(83)90006-4","article-title":"Kinetics and concentration effects of TPA-induced differentiation of cultured human neuroblastoma cells","volume":"12","author":"S P\u00e5hlman","year":"1983","journal-title":"Cell Differ"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0165-3806(87)90156-8","article-title":"Muscarinic receptors in human SH-SY5Y neuroblastoma cell line: regulation by phorbol ester and retinoic acid-induced differentiation","volume":"430","author":"A Adem","year":"1987","journal-title":"Brain Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF03033178","article-title":"Terminally differentiated SH-SY5Y cells provide a model system for studying neuroprotective effects of dopamine agonists","volume":"5","author":"SP Presgraves","year":"2004","journal-title":"Neurotox Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0045-6039(84)90038-1","article-title":"Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation","volume":"14","author":"S P\u00e5hlman","year":"1984","journal-title":"Cell Differ"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-3-211-73574-9_3","article-title":"Neuronal differentiation and long-term culture of the human neuroblastoma line SH-SY5Y","author":"R Constantinescu","year":"2007","journal-title":"J Neural Transm Suppl"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1046\/j.1471-4159.2000.0750991.x","article-title":"Sequential Treatment of SH-SY5Y Cells with Retinoic Acid and Brain-Derived Neurotrophic Factor Gives Rise to Fully Differentiated, Neurotrophic Factor-Dependent, Human Neuron-Like Cells","volume":"75","author":"M Encinas","year":"2000","journal-title":"J Neurochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ghir.2007.03.002","article-title":"Dose-specific or dose-dependent effect of growth hormone treatment on the proliferation and differentiation of cultured neuronal cells","volume":"17","author":"E Lyuh","year":"2007","journal-title":"Growth Horm IGF Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jcp.1041120113","article-title":"Hormonal responsiveness of a preadipose cell line derived from newborn mouse calvaria","volume":"112","author":"H-A Kodama","year":"1982","journal-title":"J Cell Physiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0896-6273(00)00083-0","article-title":"Induction of Midbrain Dopaminergic Neurons from ES Cells by Stromal Cell\u2013Derived Inducing Activity","volume":"28","author":"H Kawasaki","year":"2000","journal-title":"Neuron"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1634\/stemcells.22-6-925","article-title":"Dopaminergic differentiation of human embryonic stem cells","volume":"22","author":"X Zeng","year":"2004","journal-title":"Stem Cells Dayt Ohio"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/76536","article-title":"Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells","volume":"18","author":"SH Lee","year":"2000","journal-title":"Nat Biotechnol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e85736","DOI":"10.1371\/journal.pone.0085736","article-title":"Comparative study of efficacy of dopaminergic neuron differentiation between embryonic stem cell and protein-based induced pluripotent stem cell","volume":"9","author":"Y-W Kwon","year":"2014","journal-title":"PloS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/hmg\/ddm290","article-title":"Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension\/pathfinding and survival of motor neurons","volume":"17","author":"V Subramanian","year":"2008","journal-title":"Hum Mol Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/ncomms2126","article-title":"Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons","volume":"3","author":"N Thiyagarajan","year":"2012","journal-title":"Nat Commun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1212\/01.WNL.0000144344.39103.F6","article-title":"A novel candidate region for ALS on chromosome 14q11.2","volume":"63","author":"MJ Greenway","year":"2004","journal-title":"Neurology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1093\/hmg\/ddm095","article-title":"A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis","volume":"16","author":"V Subramanian","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e6606","DOI":"10.1371\/journal.pone.0006606","article-title":"A Novel Combination of Factors, Termed SPIE, which Promotes Dopaminergic Neuron Differentiation from Human Embryonic Stem Cells","volume":"4","author":"T Vazin","year":"2009","journal-title":"PLoS ONE"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/jnr.23355","article-title":"Adipocytes derived from PA6 cells reliably promote the differentiation of dopaminergic neurons from human embryonic stem cells","volume":"92","author":"M o Guloglu","year":"2014","journal-title":"J Neurosci Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.bbrc.2013.09.069","article-title":"Co-culture with neurotrophic factor secreting cells induced from adipose-derived stem cells: promotes neurogenic differentiation","volume":"440","author":"S Razavi","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e63862","DOI":"10.1371\/journal.pone.0063862","article-title":"Phenotypic Characterization of Retinoic Acid Differentiated SH-SY5Y Cells by Transcriptional Profiling","volume":"8","author":"JA Korecka","year":"2013","journal-title":"PLoS ONE"},{"key":"ref30","first-page":"741","article-title":"Coordinate morphological and biochemical interconversion of human neuroblastoma cells","volume":"71","author":"RA Ross","year":"1983","journal-title":"J Natl Cancer Inst"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0159051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T20:05:26Z","timestamp":1540325126000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0159051"}},"subtitle":[],"editor":[{"given":"Bernadette","family":"Allinquant","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,7,8]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0159051","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,8]]}}}