{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:06:44Z","timestamp":1790233604996,"version":"4.1.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T00:00:00Z","timestamp":1468454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning","award":["2014R1A2A2A01006839; NRF-2015R1A2A1A15054332"],"award-info":[{"award-number":["2014R1A2A2A01006839; NRF-2015R1A2A1A15054332"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0159112","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T20:10:55Z","timestamp":1468527055000},"page":"e0159112","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-M\u00fcllerian Hormone in Human Granulosa Cells"],"prefix":"10.1371","volume":"11","author":[{"given":"Hanyong","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miae","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Eun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghwa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeehyeon","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,7,14]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0092-8674(86)90783-X","article-title":"Isolation of the bovine and human genes for Mullerian inhibiting substance and expression of the human gene in animal cells","volume":"45","author":"RL Cate","year":"1986","journal-title":"Cell"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1210\/endo.140.12.7204","article-title":"Control of primordial follicle recruitment by anti-Mullerian hormone in the mouse ovary","volume":"140","author":"AL Durlinger","year":"1999","journal-title":"Endocrinology"},{"issue":"4B","key":"ref3","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1051\/rnd:19880708","article-title":"Anti-mullerian hormone in sheep follicles","volume":"28","author":"J Bezard","year":"1988","journal-title":"Reprod Nutr Dev"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/humrep\/det446","article-title":"Anti-Mullerian hormone is a more accurate predictor of individual time to menopause than mother's age at menopause","volume":"29","author":"M Dolleman","year":"2014","journal-title":"Hum Reprod"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.tem.2008.08.002","article-title":"Anti-Mullerian hormone and ovarian dysfunction","volume":"19","author":"FJ Broekmans","year":"2008","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/humrep\/del346","article-title":"Serum anti-Mullerian hormone expression in women with premature ovarian failure","volume":"22","author":"G Meduri","year":"2007","journal-title":"Hum Reprod"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/9629","article-title":"A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans","volume":"22","author":"JC Achermann","year":"1999","journal-title":"Nat Genet"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1210\/jc.2006-1672","article-title":"Heterozygous missense mutations in steroidogenic factor 1 (SF1\/Ad4BP, NR5A1) are associated with 46,XY disorders of sex development with normal adrenal function","volume":"92","author":"L Lin","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1210\/edrv.18.3.0301","article-title":"Steroidogenic factor 1: a key determinant of endocrine development and function","volume":"18","author":"KL Parker","year":"1997","journal-title":"Endocr Rev"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0092-8674(94)90211-9","article-title":"A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation","volume":"77","author":"X Luo","year":"1994","journal-title":"Cell"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1095\/biolreprod.108.069435","article-title":"Impaired follicle development and infertility in female mice lacking steroidogenic factor 1 in ovarian granulosa cells","volume":"79","author":"C Pelusi","year":"2008","journal-title":"Biol Reprod"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1210\/mend.12.7.0131","article-title":"The murine Dax-1 promoter is stimulated by SF-1 (steroidogenic factor-1) and inhibited by COUP-TF (chicken ovalbumin upstream promoter-transcription factor) via a composite nuclear receptor-regulatory element","volume":"12","author":"RN Yu","year":"1998","journal-title":"Mol Endocrinol"},{"issue":"28","key":"ref13","doi-asserted-by":"crossref","first-page":"9052","DOI":"10.1021\/bi960057r","article-title":"Steroidogenic factor 1-dependent promoter activity of the human steroidogenic acute regulatory protein (StAR) gene","volume":"35","author":"T Sugawara","year":"1996","journal-title":"Biochemistry"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1242\/dev.120.10.2787","article-title":"Sex-dependent expression of a transcription factor, Ad4BP, regulating steroidogenic P-450 genes in the gonads during prenatal and postnatal rat development","volume":"120","author":"O Hatano","year":"1994","journal-title":"Development"},{"issue":"6","key":"ref15","first-page":"776","article-title":"Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues","volume":"7","author":"JP Lynch","year":"1993","journal-title":"Mol Endocrinol"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0092-8674(94)90050-7","article-title":"Nuclear receptor steroidogenic factor 1 regulates the mullerian inhibiting substance gene: a link to the sex determination cascade","volume":"77","author":"WH Shen","year":"1994","journal-title":"Cell"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1128\/MCB.17.3.1476","article-title":"DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita","volume":"17","author":"M Ito","year":"1997","journal-title":"Mol Cell Biol"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0092-8674(00)81172-1","article-title":"Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression","volume":"93","author":"MW Nachtigal","year":"1998","journal-title":"Cell"},{"issue":"30","key":"ref19","doi-asserted-by":"crossref","first-page":"28101","DOI":"10.1074\/jbc.M304067200","article-title":"SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro","volume":"278","author":"G Schepers","year":"2003","journal-title":"J Biol Chem"},{"issue":"8","key":"ref20","first-page":"1388","article-title":"Transcription factor GATA-4 enhances Mullerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1","volume":"13","author":"JJ Tremblay","year":"1999","journal-title":"Mol Endocrinol"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"6653","DOI":"10.1128\/MCB.18.11.6653","article-title":"Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Mullerian hormone gene","volume":"18","author":"P De Santa Barbara","year":"1998","journal-title":"Mol Cell Biol"},{"issue":"17","key":"ref22","doi-asserted-by":"crossref","first-page":"6000","DOI":"10.1128\/MCB.23.17.6000-6012.2003","article-title":"Expression of MIS in the testis is downregulated by tumor necrosis factor alpha through the negative regulation of SF-1 transactivation by NF-kappa B","volume":"23","author":"CY Hong","year":"2003","journal-title":"Mol Cell Biol"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ymgme.2006.03.005","article-title":"Foxl2 function in ovarian development","volume":"88","author":"NH Uhlenhaut","year":"2006","journal-title":"Mol Genet Metab"},{"issue":"1\u20132","key":"ref24","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mce.2013.09.034","article-title":"Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors","volume":"385","author":"VG Thackray","year":"2014","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/84781","article-title":"The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis\/ptosis\/epicanthus inversus syndrome","volume":"27","author":"L Crisponi","year":"2001","journal-title":"Nat Genet"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/hmg\/ddh124","article-title":"Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development","volume":"13","author":"M Uda","year":"2004","journal-title":"Hum Mol Genet"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1242\/dev.00969","article-title":"The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance","volume":"131","author":"D Schmidt","year":"2004","journal-title":"Development"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.cell.2009.11.021","article-title":"Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation","volume":"139","author":"NH Uhlenhaut","year":"2009","journal-title":"Cell"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.fertnstert.2014.05.031","article-title":"Positive cross talk between FOXL2 and antimullerian hormone regulates ovarian reserve","volume":"102","author":"M Park","year":"2014","journal-title":"Fertil Steril"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1210\/me.2009-0375","article-title":"FOXL2 interacts with steroidogenic factor-1 (SF-1) and represses SF-1-induced CYP17 transcription in granulosa cells","volume":"24","author":"M Park","year":"2010","journal-title":"Mol Endocrinol"},{"issue":"15","key":"ref31","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/hmg\/10.15.1591","article-title":"Spectrum of FOXL2 gene mutations in blepharophimosis-ptosis-epicanthus inversus (BPES) families demonstrates a genotype\u2014phenotype correlation","volume":"10","author":"E De Baere","year":"2001","journal-title":"Hum Mol Genet"},{"issue":"1\u20132","key":"ref32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000140595","article-title":"Quantitative morphological investigations of the follicular system in women; variations at different ages","volume":"14","author":"E Block","year":"1952","journal-title":"Acta Anat (Basel)"},{"key":"ref33","first-page":"294","article-title":"Follicle variations during the genital cycle of woman","volume":"183","author":"E Block","year":"1953","journal-title":"Arch Gynakol"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.fertnstert.2006.11.191","article-title":"Establishment of ovarian reserve: a quantitative morphometric study of the developing human ovary","volume":"88","author":"A Forabosco","year":"2007","journal-title":"Fertil Steril"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/humrep\/dem408","article-title":"A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause","volume":"23","author":"KR Hansen","year":"2008","journal-title":"Hum Reprod"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1210\/jcem-65-6-1231","article-title":"Follicular depletion during the menopausal transition: evidence for accelerated loss and ultimate exhaustion","volume":"65","author":"SJ Richardson","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/humupd\/dmu020","article-title":"Anti-Mullerian hormone: ovarian reserve testing and its potential clinical implications","volume":"20","author":"SL Broer","year":"2014","journal-title":"Hum Reprod Update"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0015-0282(01)03201-0","article-title":"Early follicular serum mullerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles","volume":"77","author":"DB Seifer","year":"2002","journal-title":"Fertil Steril"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/humupd\/dmp036","article-title":"Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART)","volume":"16","author":"A La Marca","year":"2010","journal-title":"Hum Reprod Update"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cca.2014.07.029","article-title":"AMH: An ovarian reserve biomarker in assisted reproduction","volume":"437","author":"C Peluso","year":"2014","journal-title":"Clin Chim Acta"},{"issue":"11","key":"ref41","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1210\/endo.142.11.8486","article-title":"Anti-Mullerian hormone attenuates the effects of FSH on follicle development in the mouse ovary","volume":"142","author":"AL Durlinger","year":"2001","journal-title":"Endocrinology"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/molehr\/gah015","article-title":"Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment","volume":"10","author":"C Weenen","year":"2004","journal-title":"Mol Hum Reprod"},{"issue":"1\u20132","key":"ref43","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.mce.2010.06.012","article-title":"The challenge of modeling nuclear receptor regulatory networks in mammalian cells","volume":"334","author":"V Jagannathan","year":"2011","journal-title":"Mol Cell Endocrinol"},{"issue":"7","key":"ref44","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1210\/me.2009-0519","article-title":"Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease","volume":"24","author":"BP Schimmer","year":"2010","journal-title":"Mol Endocrinol"},{"issue":"1","key":"ref45","first-page":"107","article-title":"Premature ovarian failure and ovarian autoimmunity","volume":"18","author":"A Hoek","year":"1997","journal-title":"Endocr Rev"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1258\/0007142001903445","article-title":"Premature ovarian failure","volume":"56","author":"GS Conway","year":"2000","journal-title":"Br Med Bull"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1210\/endo.143.3.8691","article-title":"Anti-Mullerian hormone inhibits initiation of primordial follicle growth in the mouse ovary","volume":"143","author":"AL Durlinger","year":"2002","journal-title":"Endocrinology"},{"issue":"8","key":"ref48","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1210\/en.2002-0137","article-title":"Differential expression of steroidogenic factor-1 and FTF\/LRH-1 in the rodent ovary","volume":"144","author":"AE Falender","year":"2003","journal-title":"Endocrinology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0159112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T03:17:52Z","timestamp":1656818272000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0159112"}},"subtitle":[],"editor":[{"given":"Bin","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,7,14]]},"references-count":48,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0159112","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,14]]}}}