{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T04:40:03Z","timestamp":1749012003612,"version":"3.41.0"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0159951","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T17:29:30Z","timestamp":1469208570000},"page":"e0159951","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Protection by Nitric Oxide Donors of Isolated Rat Hearts Is Associated with Activation of Redox Metabolism and Ferritin Accumulation"],"prefix":"10.1371","volume":"11","author":[{"given":"Hilbert","family":"Grievink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina","family":"Zeltcer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Drenger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Berenshtein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mordechai","family":"Chevion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"issue":"36","key":"ref1","doi-asserted-by":"crossref","first-page":"10811","DOI":"10.1021\/bi971414g","article-title":"Analysis of neuronal NO synthase under single-turnover conditions: conversion of Nomega-hydroxyarginine to nitric oxide and citrulline","volume":"36","author":"HM Abu-Soud","year":"1997","journal-title":"Biochemistry"},{"issue":"17","key":"ref2","doi-asserted-by":"crossref","first-page":"12231","DOI":"10.1016\/S0021-9258(18)31375-9","article-title":"Nitric oxide synthase structure and mechanism","volume":"268","author":"MA Marletta","year":"1993","journal-title":"J Biol Chem"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.tibs.2006.02.003","article-title":"Nitric oxide signaling: no longer simply on or off","volume":"31","author":"SP Cary","year":"2006","journal-title":"Trends Biochem Sci"},{"issue":"68","key":"ref4","doi-asserted-by":"crossref","first-page":"re2","DOI":"10.1126\/scisignal.268re2","article-title":"Signaling by gasotransmitters","volume":"2","author":"AK Mustafa","year":"2009","journal-title":"Sci Signal"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1152\/physrev.00042.2007","article-title":"eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues","volume":"89","author":"JL Balligand","year":"2009","journal-title":"Physiol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF00240058","article-title":"Donors of nitric oxide mimic effects of ischaemic preconditioning on reperfusion induced arrhythmias in isolated rat heart","volume":"160\u2013161","author":"M Bilinska","year":"1996","journal-title":"Mol Cell Biochem"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"H2752","DOI":"10.1152\/ajpheart.2000.279.6.H2752","article-title":"Nitric oxide: a trigger for classic preconditioning?","volume":"279","author":"A Lochner","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1006\/jmcc.2000.1152","article-title":"Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning","volume":"32","author":"A Nakano","year":"2000","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1476-5381.1992.tb14501.x","article-title":"Preconditioning of the ischaemic myocardium; involvement of the L-arginine nitric oxide pathway","volume":"107","author":"A Vegh","year":"1992","journal-title":"Br J Pharmacol"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1152\/physrev.00009.2003","article-title":"Preconditioning the myocardium: from cellular physiology to clinical cardiology","volume":"83","author":"DM Yellon","year":"2003","journal-title":"Physiol Rev"},{"issue":"18","key":"ref11","doi-asserted-by":"crossref","first-page":"9733","DOI":"10.1074\/jbc.M115.687806","article-title":"Preconditioning c-Kit-positive Human Cardiac Stem Cells with a Nitric Oxide Donor Enhances Cell Survival through Activation of Survival Signaling Pathways","volume":"291","author":"L Teng","year":"2016","journal-title":"J Biol Chem"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1021\/bi00602a025","article-title":"Analogous effect of protons and inositol hexaphosphate on the alteration of structure of nitrosyl fetal human hemoglobin","volume":"17","author":"M Chevion","year":"1978","journal-title":"Biochemistry"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1073\/pnas.0304653101","article-title":"Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: role of mitochondrial respiratory complexes and heat shock proteins","volume":"101","author":"A Ramachandran","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"16","key":"ref14","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1021\/bi00285a026","article-title":"Reaction of nitric oxide with heme proteins: studies on metmyoglobin, opossum methemoglobin, and microperoxidase","volume":"22","author":"VS Sharma","year":"1983","journal-title":"Biochemistry"},{"issue":"23","key":"ref15","doi-asserted-by":"crossref","first-page":"7435","DOI":"10.1021\/bi025756k","article-title":"Nitric oxide and peroxynitrite activate the iron regulatory protein-1 of J774A.1 macrophages by direct disassembly of the Fe-S cluster of cytoplasmic aconitase","volume":"41","author":"G Cairo","year":"2002","journal-title":"Biochemistry"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0891-5849(95)00034-U","article-title":"The reaction of NO. with O2.- and HO2.: a pulse radiolysis study","volume":"19","author":"S Goldstein","year":"1995","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1074\/jbc.275.5.3031","article-title":"Tyrosine nitration by simultaneous generation of (.)NO and O-(2) under physiological conditions. How the radicals do the job","volume":"275","author":"S Goldstein","year":"2000","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0076-6879(08)36004-2","article-title":"The chemistry of peroxynitrite: implications for biological activity","volume":"436","author":"S Goldstein","year":"2008","journal-title":"Methods Enzymol"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.abb.2008.10.034","article-title":"Protein tyrosine nitration\u2014an update","volume":"484","author":"H Ischiropoulos","year":"2009","journal-title":"Arch Biochem Biophys"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1006\/abbi.2000.1940","article-title":"Proteolytic degradation of tyrosine nitrated proteins","volume":"380","author":"JM Souza","year":"2000","journal-title":"Arch Biochem Biophys"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"E46","DOI":"10.1038\/35055152","article-title":"S-nitrosylation: spectrum and specificity","volume":"3","author":"DT Hess","year":"2001","journal-title":"Nat Cell Biol"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1073\/pnas.89.1.444","article-title":"S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds","volume":"89","author":"JS Stamler","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5090","key":"ref23","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1126\/science.1281928","article-title":"Biochemistry of nitric oxide and its redox-activated forms","volume":"258","author":"JS Stamler","year":"1992","journal-title":"Science"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1023\/A:1020788603046","article-title":"Role of nitric oxide in cellular iron metabolism","volume":"16","author":"S Kim","year":"2003","journal-title":"Biometals"},{"issue":"46","key":"ref25","doi-asserted-by":"crossref","first-page":"33035","DOI":"10.1074\/jbc.274.46.33035","article-title":"Control of transferrin receptor expression via nitric oxide-mediated modulation of iron-regulatory protein 2","volume":"274","author":"S Kim","year":"1999","journal-title":"J Biol Chem"},{"issue":"6438","key":"ref26","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/364626a0","article-title":"A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds","volume":"364","author":"SA Lipton","year":"1993","journal-title":"Nature"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0092-8674(94)90269-0","article-title":"Redox signaling: nitrosylation and related target interactions of nitric oxide","volume":"78","author":"JS Stamler","year":"1994","journal-title":"Cell"},{"issue":"256","key":"ref28","doi-asserted-by":"crossref","first-page":"rs1","DOI":"10.1126\/scisignal.2003252","article-title":"Nitric oxide regulates mitochondrial fatty acid metabolism through reversible protein S-nitrosylation","volume":"6","author":"PT Doulias","year":"2013","journal-title":"Sci Signal"},{"issue":"23","key":"ref29","doi-asserted-by":"crossref","first-page":"12920","DOI":"10.1073\/pnas.231472998","article-title":"Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals","volume":"98","author":"J Moskovitz","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbapap.2004.09.003","article-title":"Methionine sulfoxide reductases: ubiquitous enzymes involved in antioxidant defense, protein regulation, and prevention of aging-associated diseases","volume":"1703","author":"J Moskovitz","year":"2005","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s11357-011-9268-7","article-title":"Aging is an organ-specific process: changes in homeostasis of iron and redox proteins in the rat","volume":"34","author":"BE Bulvik","year":"2012","journal-title":"Age (Dordr)"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.mad.2008.10.002","article-title":"Iron, ferritin and proteins of the methionine-centered redox cycle in young and old rat hearts","volume":"130","author":"B Bulvik","year":"2009","journal-title":"Mech Ageing Dev"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.yjmcc.2008.08.011","article-title":"Heart protection by ischemic preconditioning: a novel pathway initiated by iron and mediated by ferritin","volume":"45","author":"M Chevion","year":"2008","journal-title":"J Mol Cell Cardiol"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"e48947","DOI":"10.1371\/journal.pone.0048947","article-title":"Cardiac protection by preconditioning is generated via an iron-signal created by proteasomal degradation of iron proteins","volume":"7","author":"BE Bulvik","year":"2012","journal-title":"PLoS One"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1196\/annals.1345.016","article-title":"Ferritin as an iron concentrator and chelator target","volume":"1054","author":"X Liu","year":"2005","journal-title":"Ann N Y Acad Sci"},{"issue":"1\u20132","key":"ref36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1023\/A:1015923202082","article-title":"Roles of ferritin and iron in ischemic preconditioning of the heart","volume":"234-235","author":"E Berenshtein","year":"2002","journal-title":"Mol Cell Biochem"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1073\/pnas.90.3.1102","article-title":"Copper and iron are mobilized following myocardial ischemia: possible predictive criteria for tissue injury","volume":"90","author":"M Chevion","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref38","first-page":"35","article-title":"Function and regulation of transferrin and ferritin","volume":"35","author":"P Ponka","year":"1998","journal-title":"Semin Hematol"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cmet.2006.02.003","article-title":"Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis","volume":"3","author":"WH Tong","year":"2006","journal-title":"Cell Metab"},{"issue":"3\u20134","key":"ref40","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10534-006-9047-6","article-title":"Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis","volume":"20","author":"WH Tong","year":"2007","journal-title":"Biometals"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"e62948","DOI":"10.1371\/journal.pone.0062948","article-title":"The bitter fate of the sweet heart: impairment of iron homeostasis in diabetic heart leads to failure in myocardial protection by preconditioning","volume":"8","author":"V Vinokur","year":"2013","journal-title":"PLoS One"},{"issue":"18","key":"ref42","doi-asserted-by":"crossref","first-page":"9585","DOI":"10.1073\/pnas.94.18.9585","article-title":"The yeast peptide-methionine sulfoxide reductase functions as an antioxidant in vivo","volume":"94","author":"J Moskovitz","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0014-5793(00)01446-0","article-title":"Upregulation of thioredoxin (TRX) expression in giant cell myocarditis in rats","volume":"472","author":"K Shioji","year":"2000","journal-title":"FEBS Lett"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1080\/10715760290029128","article-title":"A simple and rapid method for the determination of "free" iron in biological fluids","volume":"36","author":"UA Nilsson","year":"2002","journal-title":"Free Radic Res"},{"issue":"11","key":"ref45","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1006\/jmcc.2001.1462","article-title":"Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research","volume":"33","author":"R Bolli","year":"2001","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0008-6363(02)00675-2","article-title":"The cardioprotective and mitochondrial depolarising properties of exogenous nitric oxide in mouse heart","volume":"57","author":"RM Bell","year":"2003","journal-title":"Cardiovasc Res"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/cr000040l","article-title":"Nitric oxide donors: chemical activities and biological applications","volume":"102","author":"PG Wang","year":"2002","journal-title":"Chem Rev"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/01.RES.87.3.170","article-title":"Physiological effects of peroxynitrite: potential products of the environment","volume":"87","author":"J Vinten-Johansen","year":"2000","journal-title":"Circ Res"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/S0022-3565(24)35370-4","article-title":"Peroxynitrite, a two-edged sword in post-ischemic myocardial injury-dichotomy of action in crystalloid- versus blood-perfused hearts","volume":"292","author":"XL Ma","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"issue":"19","key":"ref50","first-page":"II384","article-title":"Peroxynitrite, the breakdown product of nitric oxide, is beneficial in blood cardioplegia but injurious in crystalloid cardioplegia","volume":"100","author":"RS Ronson","year":"1999","journal-title":"Circulation"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"H1433","DOI":"10.1152\/ajpheart.00882.2003","article-title":"Exogenous nitric oxide generates ROS and induces cardioprotection: involvement of PKG, mitochondrial KATP channels, and ERK","volume":"286","author":"Z Xu","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0008-6363(96)00254-4","article-title":"Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts","volume":"33","author":"W Yasmin","year":"1997","journal-title":"Cardiovasc Res"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.yjmcc.2011.09.009","article-title":"Redox modification of cell signaling in the cardiovascular system","volume":"52","author":"D Shao","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neulet.2012.11.017","article-title":"Induction of methionine sulfoxide reductase activity by pergolide, pergolide sulfoxide, and S-adenosyl-methionine in neuronal cells","volume":"533","author":"JM Franklin","year":"2012","journal-title":"Neurosci Lett"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.cbpa.2011.12.014","article-title":"Methionine sulfoxide reductases and methionine sulfoxide in the subterranean mole rat (Spalax): characterization of expression under various oxygen conditions","volume":"161","author":"J Moskovitz","year":"2012","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"issue":"7","key":"ref56","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.exger.2006.03.011","article-title":"Alterations in mitochondrial and cytosolic methionine sulfoxide reductase activity during cardiac ischemia and reperfusion","volume":"41","author":"CR Picot","year":"2006","journal-title":"Exp Gerontol"},{"issue":"Pt 2","key":"ref57","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1042\/bj20030443","article-title":"Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells","volume":"373","author":"S Vougier","year":"2003","journal-title":"Biochem J"},{"issue":"4","key":"ref58","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1046\/j.1471-4159.1999.0731660.x","article-title":"Decrease in peptide methionine sulfoxide reductase in Alzheimer's disease brain","volume":"73","author":"SP Gabbita","year":"1999","journal-title":"J Neurochem"},{"issue":"Pt 3","key":"ref59","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1042\/bj3550819","article-title":"Rat peptide methionine sulphoxide reductase: cloning of the cDNA, and down-regulation of gene expression and enzyme activity during aging","volume":"355","author":"I Petropoulos","year":"2001","journal-title":"Biochem J"},{"issue":"1\u20132","key":"ref60","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0165-2478(94)90038-8","article-title":"Adult T cell leukemia-derived factor\/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide","volume":"42","author":"H Nakamura","year":"1994","journal-title":"Immunol Lett"},{"issue":"2","key":"ref61","first-page":"145","article-title":"Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion","volume":"77","author":"T Tanaka","year":"1997","journal-title":"Lab Invest"},{"issue":"20","key":"ref62","doi-asserted-by":"crossref","first-page":"6102","DOI":"10.1046\/j.1432-1327.2000.01701.x","article-title":"Physiological functions of thioredoxin and thioredoxin reductase","volume":"267","author":"ES Arner","year":"2000","journal-title":"Eur J Biochem"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1089\/152308604771978372","article-title":"Intravenous administration of thioredoxin decreases brain damage following transient focal cerebral ischemia in mice","volume":"6","author":"I Hattori","year":"2004","journal-title":"Antioxid Redox Signal"},{"issue":"4","key":"ref64","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1046\/j.1523-1755.2003.00224.x","article-title":"Protective roles of thioredoxin, a redox-regulating protein, in renal ischemia\/reperfusion injury","volume":"64","author":"K Kasuno","year":"2003","journal-title":"Kidney Int"},{"issue":"6","key":"ref65","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0022-2828(03)00117-2","article-title":"Thioredoxin redox signaling in the ischemic heart: an insight with transgenic mice overexpressing Trx1","volume":"35","author":"T Turoczi","year":"2003","journal-title":"J Mol Cell Cardiol"},{"issue":"10","key":"ref66","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/ncb851","article-title":"Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69","volume":"4","author":"J Haendeler","year":"2002","journal-title":"Nat Cell Biol"},{"issue":"3","key":"ref67","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.biocel.2007.03.010","article-title":"Intracellular labile iron","volume":"40","author":"W Breuer","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"ref68","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0891-5849(88)90059-7","article-title":"A site-specific mechanism for free radical induced biological damage: the essential role of redox-active transition metals","volume":"5","author":"M Chevion","year":"1988","journal-title":"Free Radic Biol Med"},{"issue":"5953","key":"ref69","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1126\/science.1176326","article-title":"An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis","volume":"326","author":"AA Salahudeen","year":"2009","journal-title":"Science"},{"issue":"5953","key":"ref70","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.1176333","article-title":"Control of iron homeostasis by an iron-regulated ubiquitin ligase","volume":"326","author":"AA Vashisht","year":"2009","journal-title":"Science"},{"issue":"7","key":"ref71","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1182\/blood-2005-04-1365","article-title":"Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)","volume":"106","author":"B Galy","year":"2005","journal-title":"Blood"},{"issue":"2","key":"ref72","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/84859","article-title":"Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice","volume":"27","author":"T LaVaute","year":"2001","journal-title":"Nat Genet"},{"issue":"2","key":"ref73","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/sj.emboj.7600041","article-title":"Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis","volume":"23","author":"EG Meyron-Holtz","year":"2004","journal-title":"EMBO J"},{"issue":"3","key":"ref74","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0005-2728(96)00022-9","article-title":"The ferritins: molecular properties, iron storage function and cellular regulation","volume":"1275","author":"PM Harrison","year":"1996","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"ref75","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1006\/niox.1997.0132","article-title":"Ferritin may mediate SIN-1-induced protection against oxidative stress","volume":"1","author":"S Oberle","year":"1997","journal-title":"Nitric Oxide"},{"issue":"3","key":"ref76","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1182\/blood.V91.3.1059","article-title":"Nitric oxide-mediated induction of ferritin synthesis in J774 macrophages by inflammatory cytokines: role of selective iron regulatory protein-2 downregulation","volume":"91","author":"S Recalcati","year":"1998","journal-title":"Blood"},{"issue":"9","key":"ref77","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1002\/j.1460-2075.1993.tb06039.x","article-title":"Translational regulation via iron-responsive elements by the nitric oxide\/NO-synthase pathway","volume":"12","author":"G Weiss","year":"1993","journal-title":"EMBO J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0159951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T03:59:49Z","timestamp":1749009589000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0159951"}},"subtitle":[],"editor":[{"given":"Meijing","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,7,22]]},"references-count":77,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0159951","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,7,22]]}}}