{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:49:15Z","timestamp":1789958955816,"version":"4.0.1"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T00:00:00Z","timestamp":1470182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160011","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T13:43:35Z","timestamp":1470231815000},"page":"e0160011","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Drug-Induced- or Rheumatic- Valvular Heart Disease in Patients Exposed to Benfluorex?"],"prefix":"10.1371","volume":"11","author":[{"given":"Florent","family":"Le Ven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarrin","family":"Alavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Jobic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Etienne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Didier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Porcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1161\/CIRCULATIONAHA.112.111260","article-title":"Increased risk of left heart valve regurgitation associated with benfluorex use in patients with diabetes mellitus: a multicenter study","volume":"126","author":"C Tribouilloy","year":"2012","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"VT Nkomo","year":"2006","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1093\/eurheartj\/eht266","article-title":"Frequency of drug-induced valvular heart disease in patients previously exposd to benfluorex: a multicentre prospective study","volume":"34","author":"C Tribouilloy","year":"2013","journal-title":"European heart journal"},{"issue":"Suppl","key":"ref4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jac\/45.suppl_1.13","article-title":"Rheumatic fever\u2014is it still a problem?","volume":"45","author":"C Olivier","year":"2000","journal-title":"The Journal of antimicrobial chemotherapy"},{"key":"ref5","first-page":"27","article-title":"Present concepts of acute rheumatism","volume":"34","author":"S Leff","year":"1956","journal-title":"Klinicheskaia meditsina"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e10128","DOI":"10.1371\/journal.pone.0010128","article-title":"Benfluorex and unexplained valvular heart disease: a case-control study","volume":"5","author":"I Frachon","year":"2010","journal-title":"PloS one"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/pds.2044","article-title":"Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus","volume":"19","author":"A Weill","year":"2010","journal-title":"Pharmacoepidemiology and drug safety"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e38273","DOI":"10.1371\/journal.pone.0038273","article-title":"Echocardiographic evidence for valvular toxicity of benfluorex: a double-blind randomised trial in patients with type 2 diabetes mellitus","volume":"7","author":"G Derumeaux","year":"2012","journal-title":"PloS one"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/bmj.2.5915.365","article-title":"Development of heart valve lesions during methysergide therapy","volume":"2","author":"KA Misch","year":"1974","journal-title":"British medical journal"},{"key":"ref10","unstructured":"Afssaps PL. Propri\u00e9t\u00e9s Pharmacologiques du benfluorex. Rapport d'Afssaps (ANSM). 2010:12."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4065\/mcp.2009.0706","article-title":"Valvular heart disease: diagnosis and management","volume":"85","author":"K Maganti","year":"2010","journal-title":"Mayo Clinic proceedings"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/pds.3642","article-title":"Adverse effects of benfluorex on heart valves and pulmonary circulation","volume":"23","author":"C Szymanski","year":"2014","journal-title":"Pharmacoepidemiology and drug safety"},{"key":"ref13","first-page":"23","article-title":"Benfluorex-related diseases: A mid-course update by the College in charge of the statement of injuries","volume":"243","year":"2015","journal-title":"Archives de Maladies du Coeur et des Vaisseaux\u2014Pratique"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1056\/NEJM199809103391101","article-title":"The prevalence of cardiac valvular insufficiency assessed by transthoracic echocardiography in obese patients treated with appetite-suppressant drugs","volume":"339","author":"MA Khan","year":"1998","journal-title":"The New England journal of medicine"},{"key":"ref15","first-page":"723","article-title":"The epidemiology of acute rheumatic fever","volume":"18","author":"RM Acheson","year":"1965","journal-title":"J chron Dis 1965, Vol 18, pp 723\u2013734"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000354221","article-title":"Etiology of valvular heart disease in the 21st century","volume":"126","author":"KD Boudoulas","year":"2013","journal-title":"Cardiology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T09:27:46Z","timestamp":1540027666000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160011"}},"subtitle":[],"editor":[{"given":"Manuel","family":"Portol\u00e9s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":16,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160011","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,3]]}}}