{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:58:33Z","timestamp":1768316313609,"version":"3.49.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T00:00:00Z","timestamp":1469404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Fapemig","doi-asserted-by":"crossref","award":["CBB - PPM-00377-15"],"award-info":[{"award-number":["CBB - PPM-00377-15"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"Fapemig","doi-asserted-by":"crossref","award":["CBB-BPD-00526-14"],"award-info":[{"award-number":["CBB-BPD-00526-14"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Centro de Pesquisas Ren\u00e9 Rachou","award":["006.8315.108.00496"],"award-info":[{"award-number":["006.8315.108.00496"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160118","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T17:31:30Z","timestamp":1469467890000},"page":"e0160118","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Schistosoma mansoni Tegument (Smteg) Induces IL-10 and Modulates Experimental Airway Inflammation"],"prefix":"10.1371","volume":"11","author":[{"given":"F\u00e1bio Vitarelli","family":"Marinho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarice Carvalho","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara C.","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cintia M. G.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geovanni D.","family":"Cassali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio C.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucila G. G.","family":"Pacifico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina T.","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,7,25]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1258\/0007142001903625","article-title":"Th-2 cytokines in allergic disease","volume":"56","author":"DS Robinson","year":"2000","journal-title":"Br Med Bull"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/qshc.4.1.24","article-title":"National audit of acute severe asthma in adults admitted to hospital. Standards of Care Committee, British Thoracic Society","volume":"4","author":"MG Pearson","year":"1995","journal-title":"Qual Health Care"},{"issue":"7092","key":"ref3","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1136\/bmj.314.7092.1439","article-title":"Age specific trends in asthma mortality in England and Wales, 1983\u201395: results of an observational study","volume":"314","author":"MJ Campbell","year":"1997","journal-title":"BMJ"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1136\/thx.54.11.978","article-title":"Scottish Confidential Inquiry into Asthma Deaths (SCIAD), 1994\u20136","volume":"54","author":"CE Bucknall","year":"1999","journal-title":"Thorax"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.12998\/wjcc.v3.i3.301","article-title":"Evaluation of functional, autonomic and inflammatory outcomes in children with asthma","volume":"3","author":"EL de Freitas Dantas Gomes","year":"2015","journal-title":"World J Clin Cases"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/thorax.56.4.279","article-title":"Adverse effects of oral corticosteroids in relation to dose in patients with lung disease","volume":"56","author":"LJ Walsh","year":"2001","journal-title":"Thorax"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1046\/j.0306-5251.2001.bjcp.1385.x","article-title":"Public health impact of adverse bone effects of oral corticosteroids","volume":"51","author":"TP van Staa","year":"2001","journal-title":"Br J Clin Pharmacol"},{"key":"ref8","unstructured":"Global Strategy for Asthma Management and Prevention. 2014."},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1365-2222.2004.1916.x","article-title":"Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma","volume":"34","author":"ST Holgate","year":"2004","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2165\/00151829-200403030-00006","article-title":"Omalizumab: a review of its use in the management of allergic asthma","volume":"3","author":"LM Bang","year":"2004","journal-title":"Treat Respir Med"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000024433","article-title":"Inverse association between skin response to aeroallergens and Schistosoma mansoni infection","volume":"123","author":"MI Araujo","year":"2000","journal-title":"Int Arch Allergy Immunol"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.5415\/apallergy.2012.2.2.122","article-title":"Impact of helminth infection on childhood allergic diseases in an area in transition from high to low infection burden","volume":"2","author":"M Amarasekera","year":"2012","journal-title":"Asia Pac Allergy"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1067\/mai.2003.1381","article-title":"Schistosoma mansoni infection is associated with a reduced course of asthma","volume":"111","author":"M Medeiros Jr.","year":"2003","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00281-010-0200-5","article-title":"Regulatory T cells: roles of T cell receptor for their development and function","volume":"32","author":"N Ohkura","year":"2010","journal-title":"Semin Immunopathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.immunol.21.120601.141122","article-title":"Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses","volume":"22","author":"S Sakaguchi","year":"2004","journal-title":"Annu Rev Immunol"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1172\/JCI200423395","article-title":"CD4+ Tregs and immune control","volume":"114","author":"Z Fehervari","year":"2004","journal-title":"J Clin Invest"},{"issue":"Suppl 1","key":"ref17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1590\/S0074-02762006000900055","article-title":"Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals","volume":"101","author":"LS Cardoso","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1111\/j.1365-2222.2010.03502.x","article-title":"An intranasal administration of Lactococcus lactis strains expressing recombinant interleukin-10 modulates acute allergic airway inflammation in a murine model","volume":"40","author":"FA Marinho","year":"2010","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.immuni.2006.07.011","article-title":"Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms","volume":"25","author":"MO Li","year":"2006","journal-title":"Immunity"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","article-title":"Transforming growth factor-beta regulation of immune responses","volume":"24","author":"MO Li","year":"2006","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1128\/IAI.00783-07","article-title":"Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10","volume":"77","author":"LG Pacifico","year":"2009","journal-title":"Infect Immun"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1365-2249.2009.04084.x","article-title":"Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation","volume":"160","author":"LS Cardoso","year":"2010","journal-title":"Clin Exp Immunol"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/bies.20058","article-title":"The cytoskeleton and motor proteins of human schistosomes and their roles in surface maintenance and host-parasite interactions","volume":"26","author":"MK Jones","year":"2004","journal-title":"Bioessays"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ijpara.2006.01.007","article-title":"Functions of the tegument of schistosomes: clues from the proteome and lipidome","volume":"36","author":"JJ Van Hellemond","year":"2006","journal-title":"Int J Parasitol"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.actatropica.2012.07.007","article-title":"Schistosoma mansoni schistosomula tegument (Smteg) immunization in absence of adjuvant induce IL-10 production by CD4+ cells and failed to protect mice against challenge infection","volume":"124","author":"JM Araujo","year":"2012","journal-title":"Acta Trop"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.imlet.2009.06.004","article-title":"IL-12 and TNF-alpha production by dendritic cells stimulated with Schistosoma mansoni schistosomula tegument is TLR4- and MyD88-dependent","volume":"125","author":"FV Duraes","year":"2009","journal-title":"Immunol Lett"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0014-4894(74)90076-9","article-title":"Schistosoma mansoni: defined system for stepwise transformation of cercaria to schistosomule <italic>in vitro<\/italic>","volume":"36","author":"FJ Ramalho-Pinto","year":"1974","journal-title":"Exp Parasitol"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1164\/rccm.200607-1005OC","article-title":"Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease","volume":"176","author":"JC Horvat","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1365-3024.2009.01161.x","article-title":"Helminth infection inhibits airway allergic reaction and dendritic cells are involved in the modulation process","volume":"32","author":"P Liu","year":"2010","journal-title":"Parasite Immunol"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-3083.2010.02380.x","article-title":"Functional characterization of murine CD25 expressing B cells","volume":"71","author":"S Amu","year":"2010","journal-title":"Scand J Immunol"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1046\/j.1365-2222.2003.01580.x","article-title":"Local release of eosinophil peroxidase following segmental allergen provocation in asthma","volume":"33","author":"VJ Erpenbeck","year":"2003","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00441-010-1049-6","article-title":"Eosinophils in innate immunity: an evolving story","volume":"343","author":"R Shamri","year":"2011","journal-title":"Cell Tissue Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.24.021605.090720","article-title":"The eosinophil","volume":"24","author":"ME Rothenberg","year":"2006","journal-title":"Annu Rev Immunol"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1084\/jem.182.4.1169","article-title":"Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo","volume":"182","author":"PD Collins","year":"1995","journal-title":"J Exp Med"},{"issue":"7","key":"ref35","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1182\/blood.V91.7.2240","article-title":"Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow","volume":"91","author":"RT Palframan","year":"1998","journal-title":"Blood"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jaci.2012.06.034","article-title":"IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies","volume":"130","author":"JL Ingram","year":"2012","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1471-4906(01)01862-2","article-title":"Bypassing IgE and targeting T cells for specific immunotherapy of allergy","volume":"22","author":"CA Akdis","year":"2001","journal-title":"Trends Immunol"},{"issue":"7","key":"ref38","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"EJ Pearce","year":"2002","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1590\/S0100-879X1998000100024","article-title":"Cytokines as determinants of resistance and pathology in human Schistosoma mansoni infection","volume":"31","author":"R Correa-Oliveira","year":"1998","journal-title":"Braz J Med Biol Res"},{"issue":"7","key":"ref40","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.4049\/jimmunol.160.7.3555","article-title":"IgE versus IgG4 production can be differentially regulated by IL-10","volume":"160","author":"P Jeannin","year":"1998","journal-title":"J Immunol"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/sj.gene.6364284","article-title":"Asthma genetics 2006: the long and winding road to gene discovery","volume":"7","author":"C Ober","year":"2006","journal-title":"Genes Immun"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1017\/S1462399408000707","article-title":"Mechanisms in allergic airway inflammation\u2014lessons from studies in the mouse","volume":"10","author":"BO Shum","year":"2008","journal-title":"Expert Rev Mol Med"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.anai.2011.01.008","article-title":"Effects of aqueous extract of Echinodorus grandiflorus on the immune response in ovalbumin-induced pulmonary allergy","volume":"106","author":"AS Brugiolo","year":"2011","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T09:44:53Z","timestamp":1692438293000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160118"}},"subtitle":[],"editor":[{"given":"Christianne","family":"Bandeira de Melo","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,7,25]]},"references-count":43,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160118","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,25]]}}}