{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:16:28Z","timestamp":1790648188823,"version":"4.1.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T00:00:00Z","timestamp":1473638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Association des scl\u00e9rodermiques de France"},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Rhumatologie"},{"name":"Groupe Francophone de Recherche sur la scl\u00e9rodermie"},{"name":"Arthritis Fondation Courtin"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160283","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T17:31:21Z","timestamp":1473701481000},"page":"e0160283","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anti-Ephrin Type-B Receptor 2 (EphB2) and Anti-Three Prime Histone mRNA EXonuclease 1 (THEX1) Autoantibodies in Scleroderma and Lupus"],"prefix":"10.1371","volume":"11","author":[{"given":"Doua F.","family":"Azzouz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel V.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Arnoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Balandraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Dubucquoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hachulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Farge-Bancel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiet","family":"Tiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Cabane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Chiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00e9onore C.","family":"Caillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami B.","family":"Kanaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Robert","family":"Harl\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Granel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Diot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Roudier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Auger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie C.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,9,12]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12016-010-8198-y","article-title":"Diagnosis and classification of systemic sclerosis","volume":"40","author":"E Hachulla","year":"2011","journal-title":"Clinical reviews in allergy & immunology"},{"key":"ref2","article-title":"Classification et \u00e9valuation des scl\u00e9rodermies","author":"Y Allanore","year":"2007"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"F van den Hoogen","year":"2013","journal-title":"Arthritis and rheumatism"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrrheum.2009.238","article-title":"Autoantibodies as predictive tools in systemic sclerosis","volume":"6","author":"SI Nihtyanova","year":"2010","journal-title":"Nature reviews Rheumatology"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.autrev.2012.05.011","article-title":"Autoantibodies in systemic sclerosis","volume":"12","author":"S Mehra","year":"2013","journal-title":"Autoimmunity reviews"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/art.38219","article-title":"Prevalence of anti-RNA polymerase III antibodies in systemic sclerosis: New data from a French cohort and a systematic review and meta-analysis","volume":"66","author":"V Sobanski","year":"2014","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/ar628","article-title":"The clinical relevance of autoantibodies in scleroderma","volume":"5","author":"KT Ho","year":"2003","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.autrev.2005.10.012","article-title":"The genetic basis of autoantibody production","volume":"5","author":"JD Reveille","year":"2006","journal-title":"Autoimmunity reviews"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1136\/ard.2009.111906","article-title":"Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls","volume":"69","author":"FC Arnett","year":"2010","journal-title":"Annals of the rheumatic diseases"},{"key":"ref10","article-title":"Clinical risk assessment of organ manifestations in systemic sclerosis\u2014a report from the EULAR Scleroderma Trials And Research (EUSTAR) group data base","author":"UA Walker","year":"2007","journal-title":"Annals of the rheumatic diseases"},{"issue":"2","key":"ref11","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"EC LeRoy","year":"1988","journal-title":"The Journal of rheumatology"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.4065\/70.11.1068","article-title":"Classification of morphea (localized scleroderma)","volume":"70","author":"LS Peterson","year":"1995","journal-title":"Mayo Clinic proceedings"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"D Aletaha","year":"2010","journal-title":"Arthritis and rheumatism"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"EM Tan","year":"1982","journal-title":"Arthritis and rheumatism"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"MC Hochberg","year":"1997","journal-title":"Arthritis and rheumatism"},{"issue":"3","key":"ref16","first-page":"304","article-title":"Clinical application of the CASPAR criteria for psoriatic arthritis compared to other existing criteria","volume":"28","author":"L Congi","year":"2010","journal-title":"Clinical and experimental rheumatology"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1002\/art.21972","article-title":"Classification criteria for psoriatic arthritis: development of new criteria from a large international study","volume":"54","author":"W Taylor","year":"2006","journal-title":"Arthritis and rheumatism"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/ard.2010.135889","article-title":"The Assessment in Spondyloarthritis International Society (ASAS) classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general: the spondyloarthritis concept in progress","volume":"70","author":"H Zeidler","year":"2011","journal-title":"Annals of the rheumatic diseases"},{"issue":"7070","key":"ref19","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1136\/bmj.313.7070.1445","article-title":"Informed consent in human experimentation before the Nuremberg code","volume":"313","author":"J Vollmann","year":"1996","journal-title":"BMJ"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"R194","DOI":"10.1186\/ar3165","article-title":"Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis","volume":"12","author":"C Charpin","year":"2010","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3899\/jrheum.080516","article-title":"Abnormalities in the regulators of angiogenesis in patients with scleroderma","volume":"36","author":"LK Hummers","year":"2009","journal-title":"The Journal of rheumatology"},{"issue":"8","key":"ref22","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1002\/art.22010","article-title":"Expression of allograft inflammatory factor 1 in tissues from patients with systemic sclerosis and in vitro differential expression of its isoforms in response to transforming growth factor beta","volume":"54","author":"F Del Galdo","year":"2006","journal-title":"Arthritis and rheumatism"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1399-0039.2007.00830.x","article-title":"Allograft inflammatory factor-1 and tumor necrosis factor single nucleotide polymorphisms in systemic sclerosis","volume":"69","author":"FG Otieno","year":"2007","journal-title":"Tissue antigens"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1093\/rheumatology\/kem057","article-title":"An allograft inflammatory factor 1 (AIF1) single nucleotide polymorphism (SNP) is associated with anticentromere antibody positive systemic sclerosis","volume":"46","author":"F Alkassab","year":"2007","journal-title":"Rheumatology"},{"issue":"8","key":"ref25","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1093\/rheumatology\/keq448","article-title":"Enhanced expression of ephrins and thrombospondins in the dermis of patients with early diffuse systemic sclerosis: potential contribution to perturbed angiogenesis and fibrosis","volume":"50","author":"J Avouac","year":"2011","journal-title":"Rheumatology"},{"issue":"41","key":"ref26","doi-asserted-by":"crossref","first-page":"30447","DOI":"10.1074\/jbc.M602947200","article-title":"Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA","volume":"281","author":"XC Yang","year":"2006","journal-title":"The Journal of biological chemistry"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.tig.2014.05.003","article-title":"Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways","volume":"30","author":"MF Thomas","year":"2014","journal-title":"Trends in genetics: TIG"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/rheumatology\/40.7.750","article-title":"Monoclonal antibodies against human ribosomal P proteins penetrate into living cells and cause apoptosis of Jurkat T cells in culture","volume":"40","author":"KH Sun","year":"2001","journal-title":"Rheumatology"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1002\/eji.200838678","article-title":"Arginines in the CDR of anti-dsDNA autoantibodies facilitate cell internalization via electrostatic interactions","volume":"38","author":"YC Song","year":"2008","journal-title":"European journal of immunology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/B978-0-12-386503-8.00002-8","article-title":"Essential roles of EphB receptors and EphrinB ligands in endothelial cell function and angiogenesis","volume":"114","author":"O Salvucci","year":"2012","journal-title":"Adv Cancer Res"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/annrheumdis-2014-206386","article-title":"A gender gap in primary and secondary heart dysfunctions in systemic sclerosis: a EUSTAR prospective study","volume":"75","author":"M Elhai","year":"2016","journal-title":"Annals of the rheumatic diseases"},{"issue":"1\u20132","key":"ref32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.20452\/pamw.306","article-title":"Vasculopathy and vasculitis in systemic lupus erythematosus","volume":"118","author":"P Cieslik","year":"2008","journal-title":"Pol Arch Med Wewn"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1182\/blood-2006-05-023341","article-title":"EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling","volume":"108","author":"O Salvucci","year":"2006","journal-title":"Blood"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T18:16:51Z","timestamp":1749579411000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160283"}},"subtitle":[],"editor":[{"given":"Frederic","family":"Rieux-Laucat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,9,12]]},"references-count":33,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160283","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,12]]}}}