{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:47:23Z","timestamp":1784861243120,"version":"3.55.0"},"reference-count":15,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T00:00:00Z","timestamp":1470268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"name":"J\u00f8rgen Werner Schous Fond"},{"DOI":"10.13039\/501100007438","name":"Familien Hede-Nielsens Fond","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007438","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Det Videnskabelige Fond ved Horsens Sygehus"},{"DOI":"10.13039\/501100006356","name":"University of Southern Denmark","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160319","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T17:39:29Z","timestamp":1470332369000},"page":"e0160319","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Microarray-Based Analysis of Methylation of 1st Trimester Trisomic Placentas from Down Syndrome, Edwards Syndrome and Patau Syndrome"],"prefix":"10.1371","volume":"11","author":[{"given":"Lotte","family":"Hatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads M.","family":"Aagaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrine","family":"Bach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Graakjaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge E.","family":"Agerholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"K\u00f8lvraa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Bojesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,8,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2147\/TACG.S35602","article-title":"Identification of trisomy 18, trisomy 13, and Down syndrome from maternal plasma","volume":"7","author":"J Gekas","year":"2014","journal-title":"Appl Clin Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1373\/clinchem.2009.134114","article-title":"Noninvasive prenatal detection of trisomy 21 by an epigenetic-genetic chromosome-dosage approach","volume":"56","author":"YK Tong","year":"2010","journal-title":"Clin Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/pd.3947","article-title":"MeDIP real-time qPCR of maternal peripheral blood reliably identifies trisomy 21","volume":"32","author":"E Tsaliki","year":"2012","journal-title":"Prenat Diagn"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/pd.3853","article-title":"Discovery of epigenetic biomarkers for the noninvasive diagnosis of fetal disease","volume":"32","author":"K Bunce","year":"2012","journal-title":"Prenat Diagn"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1373\/clinchem.2006.074997","article-title":"Hypermethylated RASSF1A in maternal plasma: A universal fetal DNA marker that improves the reliability of noninvasive prenatal diagnosis","volume":"52","author":"KC Chan","year":"2006","journal-title":"Clin Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/pd.2335","article-title":"A microarray-based approach for the identification of epigenetic biomarkers for the noninvasive diagnosis of fetal disease","volume":"29","author":"T Chu","year":"2009","journal-title":"Prenat Diagn"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e0128918","DOI":"10.1371\/journal.pone.0128918","article-title":"Microarray-based analysis of methylation status of CpGs in placental DNA and maternal blood DNA&quot;\u2013Potential new epigenetic biomarkers for cell free fetal DNA-based diagnosis","volume":"10","author":"L Hatt","year":"2015","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e39014","DOI":"10.1371\/journal.pone.0039014","article-title":"DNA-methylation profiling of fetal tissues reveals marked epigenetic differences between chorionic and amniotic samples","volume":"7","author":"C Eckmann-Scholz","year":"2012","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e1003515","DOI":"10.1371\/journal.pgen.1003515","article-title":"Global DNA hypermethylation in down syndrome placenta","volume":"9","author":"S Jin","year":"2013","journal-title":"PLoS Genet"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1371\/journal.pcbi.0030039","article-title":"Discovering Motifs in Ranked Lists of DNA sequences","volume":"3","author":"Eran Eden","year":"2007","journal-title":"PLoS Computational Biology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1471-2105-10-48","article-title":"GOrilla: A Tool For Discovery And Visualization of Enriched GO Terms in Ranked Gene Lists","volume":"10","author":"Eran Eden","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1073\/pnas.1215145110","article-title":"The human placenta methylome","volume":"110","author":"DI Schroeder","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/clinchem\/48.3.421","article-title":"Predominant hematopoietic origin of cell-free DNA in plasma and serum after sex-mismatched bone marrow transplantation","volume":"48","author":"YY Lui","year":"2002","journal-title":"Clin Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1038\/oby.2012.138","article-title":"Increased death of adipose cells, a path to release cell-free DNA into systemic circulation of obese women","volume":"20","author":"M Haghiac","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e1001212","DOI":"10.1371\/journal.pgen.1001212","article-title":"Altered DNA methylation in leukocytes with trisomy 21","volume":"6","author":"K Kerkel","year":"2010","journal-title":"PLoS Genet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T19:52:17Z","timestamp":1600977137000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160319"}},"subtitle":[],"editor":[{"given":"Kelvin Yuen Kwong","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,4]]},"references-count":15,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160319","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,4]]}}}